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Bioorganic Chemistry
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Fariba Peytam, Mehdi Adib, Shabnam Mahernia, Mahmoud Rahmanian-Jazi, ... Massoud Amanlou.
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Jun He, Jie-kun Xu, Xue-ge Pan, Xian-sheng Ye, ... Wei-ku Zhang
Pages 1-5
3. Aminonaphthalimide hybrids of mitoxantrone and amonafide as anticancer and fluorescent cellular imaging agents
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Tác giả
Alex D. Johnson, Rodrianne Zammit, Jasmine Vella, Mario Valentino, ... David C. Magri
3. Discovery of certain benzyl/phenethyl thiazolidinone-indole hybrids as potential anti-proliferative agents: Synthesis, molecular modeling and tubulin polymerization inhibition study
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Tác giả
Dilep Kumar Sigalapalli, Venkatesh Pooladanda, Priti Singh, Manasa Kadagathur, ... Nagendra Babu Bathini.
3. Synthesis, molecular docking, and biological evaluation of 3-oxo-2-tolylhydrazinylidene-4,4,4-trifluorobutanoates bearing higher and natural alcohol moieties as new selective carboxylesterase inhibitors
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Tác giả
Galina F. Makhaeva, Natalia A. Elkina, Evgeny V. Shchegolkov, Natalia P. Boltneva, ... Rudy J. Richardson.
3. Discovery of novel indole-based aroylhydrazones as anticonvulsants: Pharmacophore-based design
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Tác giả
Violina T. Angelova, Miroslav Rangelov, Nadezhda Todorova, Miroslav Dangalov, ... Jana Tchekalarova.
3. Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains
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Tác giả
Yali Sang, Sheng Han, Shuwen Han, Christophe Pannecouque, ... Fener Chen.
3. Introducing article numbering to Journal of Bioorganic Chemistry
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3. Isoindolin-1-one derivatives as urease inhibitors: Design, synthesis, biological evaluation, molecular docking and in-silico ADME evaluation
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Fariba Peytam, Mehdi Adib, Shabnam Mahernia, Mahmoud Rahmanian-Jazi, ... Massoud Amanlou.
3. Design, synthesis and biological evaluation of certain CDK2 inhibitors based on pyrazole and pyrazolo[1,5-a] pyrimidine scaffold with apoptotic activity
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Tác giả
Ghada M.E. Ali, Diaa A. Ibrahim, Amira M. Elmetwali, Nasser S.M. Ismail.
3. Syntheses and evaluation of new Quinoline derivatives for inhibition of hnRNP K in regulating oncogene c-myc transcription
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Tác giả
Bing Shu, Ping Zeng, Shuangshuang Kang, Peng-Hui Li, ... Ding Li.
3. Synthesis and antioxidant activity of new lipophilic dihydropyridines
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Tác giả
Diego da Costa Cabrera, Eduarda Santa-Helena, Heloisa P. Leal, Renata Rodrigues de Moura, ... Marcelo G. Montes D'Oca.
3. Bioactive monoterpene indole alkaloids from Nauclea officinalis
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Tác giả
Yan-Ping Liu, Qing-Long Liu, Xiang-Lin Zhang, Hai-Yuan Niu, ... Yan-Hui Fu.
3. Unusual cadinane-type sesquiterpene glycosides with α-glucosidase inhibitory activities from the fruit of Cornus officinalis Sieb. et Zuuc.
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Tác giả
Jun He, Jie-kun Xu, Xue-ge Pan, Xian-sheng Ye, ... Wei-ku Zhang.
4. Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1
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Qiqi Wang, Qingzhe Zhang, Shanshan Luan, Kaiyin Yang, ... Hua Li.
4. New A2A adenosine receptor antagonists: a structure-based upside-down interaction in the receptor cavity
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Catia Lambertucci, Andrea Spinaci, Michela Buccioni, Diego Dal Ben, ... Rosaria Volpini.
4. Chemo-sensitizing activity of natural cadinanes from Heterotheca inuloides in human uterine sarcoma cells and their in silico interaction with ABC transporters
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José Luis Rodríguez-Chávez, Carlos A. Méndez-Cuesta, Teresa Ramírez-Apan, Verónica Egas, ... Guillermo Delgado.
4. Novel cytisine derivatives exert anti-liver fibrosis effect via PI3K/Akt/Smad pathway
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Tác giả
Sheng Tang, Yinghong Li, Yunyang Bao, Zhiting Dai, ... Danqing Song.
4. Synthesis, molecular modeling and biological evaluation of new pyrazolo[3,4-b]pyridine analogs as potential antimicrobial, antiquorum-sensing and anticancer agents
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N.S. El-Gohary, M.T. Gabr, M.I. Shaaban.
4. Targeting hepatocellular carcinoma: Synthesis of new pyrazole-based derivatives, biological evaluation, DNA binding, and molecular modeling studies
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Tác giả
Dina M. Omran, Mariam A. Ghaly, Shahenda M. El-Messery, Farid A. Badria, ... Ihsan A. Shehata.
4. Anti-diabetic potential of Pueraria lobata root extract through promoting insulin signaling by PTP1B inhibition
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Tác giả
Ran Sun, Xinxian Deng, Dongdong Zhang, Fangzhou Xie, ... Lei Fu.
4. A combinatorial approach of structure-based virtual screening and molecular dynamics simulation towards the discovery of a highly selective inhibitor for VP9 coat protein of Banna virus
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Tác giả
Parikshit Moitra.
4. Ursolic and oleanolic acid derivatives with cholinesterase inhibiting potential
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Anne Loesche, Alexander Köwitsch, Susana D. Lucas, Zayan Al-Halabi, ... René Csuk.
4. Anti-melanogenesis potential of a new series of Morita-Baylis-Hillman adducts in B16F10 melanoma cell line
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Emna Ketata, Haitham Elleuch, Aref Neifar, Wafa Mihoubi, ... Ali Gargouri.
4. Novel hybrids of benzothiazole-1,3,4-oxadiazole-4-thiazolidinone: Synthesis, in silico ADME study, molecular docking and in vivo anti-diabetic assessment
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Rubina Bhutani, Dharam Pal Pathak, Garima Kapoor, Asif Husain, Md. Azhar Iqbal.
4. Acridine-based (thio)semicarbazones and hydrazones: Synthesis, in vitro urease inhibition, molecular docking and in-silico ADME evaluation
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Ibanga Okon Isaac, Mariya al-Rashida, Shafiq Ur Rahman, Rima D. Alharthy, ... Jamshed Iqbal.
5. Synthesis of novel nitroreductase enzyme-activated nitric oxide prodrugs to site-specifically kill bacteria
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Hailey A.J. Hibbard, Melissa M. Reynolds.
5. Dual VEGFR-2/PIM-1 kinase inhibition towards surmounting the resistance to antiangiogenic agents via hybrid pyridine and thienopyridine-based scaffolds: Design, synthesis and biological evaluation
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Ola H. Rizk, Mohamed Teleb, Marwa M. Abu-Serie, Omaima G. Shaaban.
5. Bioactivatable reductive cleavage of azobenzene for controlling functional dumbbell oligodeoxynucleotides
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Tác giả
Huajun Lei, Mengwu Mo, Yujian He, Ya Wu, ... Li Wu.
5. Green synthesis of selenium-N-heterocyclic carbene compounds: Evaluation of antimicrobial and anticancer potential
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Amna Kamal, Mansoureh Nazari V., Muhammad Yaseen, Muhammad Adnan Iqbal, ... Haq Nawaz Bhatti.
5. Design and synthesis of new benzoxazole/benzothiazole-phthalimide hybrids as antitumor-apoptotic agents
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John N. Philoppes, Phoebe F. Lamie.
5. Probing the high potency of pyrazolyl pyrimidinetriones and thioxopyrimidinediones as selective and efficient non-nucleotide inhibitors of recombinant human ectonucleotidases
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Hina Andleeb, Shahid Hameed, Syeda Abida Ejaz, Imtiaz Khan, ... Jamshed Iqbal.
5. Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase
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Jing Guo, Xiaoxia Gu, Mengzhu Zheng, Yonghui Zhang, ... Hua Li.
5. Discovery of a novel series of hDHODH inhibitors with anti-pulmonary fibrotic activities
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Kuan Lu, Yanfang Zhao, Guodong Wu, Hao Hu, ... Yuyang Jiang.
5. Synthesis of benzothiazole derivatives as a potent α-glucosidase inhibitor
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Mohammed Gollapalli, Muhammad Taha, Muhammad Tariq Javid, Noor Barak Almandil, ... Yasser A. Bamarouf.
5. An alkali tolerant α-l-rhamnosidase from Fusarium moniliforme MTCC-2088 used in de-rhamnosylation of natural glycosides
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Dhirendra Kumar, Sarita Yadav, Sudha Yadava, K.D.S. Yadav.
5. New iridal-type triterpenoid derivatives with cytotoxic activities from Belamcanda chinensis
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Jiayuan Li, Gang Ni, Li Li, Yanfei Liu, ... Dequan Yu.
5. How the surface functionalized nanoparticles affect conformation and activity of proteins: Exploring through protein-nanoparticle interactions
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Sathish Dyawanapelly, Pihu Mehrotra, Goutam Ghosh, Dhanashree D Jagtap, ... Ratnesh Jain.
6. Design and synthesis of substituted dihydropyrimidinone derivatives as cytotoxic and tubulin polymerization inhibitors
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Sravani Sana, Ramya Tokala, Deepti Madanlal Bajaj, Narayana Nagesh, ... Nagula Shankaraiah.
6. Novel conjugates with dual suppression of glutathione S-transferases and tryptophan-2,3-dioxygenase activities for improving hepatocellular carcinoma therapy
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Shixian Hua, Xinyi Wang, Feihong Chen, Shaohua Gou.
6. An efficient method for the synthesis of novel derivatives 4-{5-[4-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-yl)-phenyl]-3-trifluoromethyl-pyrazol-1-yl}-benzenesulfonamide and their anti-inflammatory potential
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Ghulam Mustafa, Andrea Angeli, Muhammad Zia-ur-Rehman, Nosheen Akbar, ... Claudiu T. Supuran.
6. Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens
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Cibele Nicolaski Pedron, Iris Araújo, Pedro Ismael da Silva Junior, Fernanda Dias da Silva, ... Vani Xavier Oliveira Junior.
6. An efficient one-pot synthesis of polyphenolic amino acids and evaluation of their radical-scavenging activity
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Tác giả
Luís S. Monteiro, Fátima Paiva-Martins, Sandra Oliveira, Inês Machado, Marlene Costa.
6. Identification of novel imidazole flavonoids as potent and selective inhibitors of protein tyrosine phosphatase
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Tác giả
Ling Zhang, Yu Ge, Qing Ming Wang, Cheng-He Zhou.
6. Cucurbitane-type compounds from Momordica charantia: Isolation, in vitro antidiabetic, anti-inflammatory activities and in silico modeling approaches
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Tác giả
Siddanagouda R. Shivanagoudra, Wilmer H. Perera, Jose L. Perez, Giridhar Athrey, ... Bhimanagouda S. Patil.
6. Aminoalkoxyfluorenones and aminoalkoxybiphenyls: DNA binding modes
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Tác giả
Svitlana O. Zanoza, Kyrylo O. Klimenko, George V. Maltzev, Tetiana I. Bykova, ... Mikhail L. Bondarev.
6. Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site
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Tác giả
Wenlong Li, Honghao Sun, Feijie Xu, Wen Shuai, ... Jinyi Xu.
6. Immobilized Baliospermum montanum hydroxynitrile lyase catalyzed synthesis of chiral cyanohydrins
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Tác giả
Nisha Jangir, Santosh Kumar Padhi.
6. Biology-oriented drug synthesis (BIODS), in vitro urease inhibitory activity, and in silico study of S-naproxen derivatives
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Tác giả
Ghulam Mohiuddin, Khalid Mohammed Khan, Uzma Salar, Kanwal, ... Shahnaz Perveen.
6. Bioactive staurosporine derivatives from the Streptomyces sp. NB-A13
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Biao Zhou, Zhi-Juan Hu, Hao-Jian Zhang, Jia-Qi Li, ... Zhong-Jun Ma.
7. Synthesis and anti-tyrosinase mechanism of the substituted vanillyl cinnamate analogues
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Zefeng Zhao, Guangxin Liu, Yufeng Meng, Jiale Tian, ... Xiaohui Zheng.
7. Novel N-benzylpyridinium moiety linked to arylisoxazole derivatives as selective butyrylcholinesterase inhibitors: Synthesis, biological evaluation, and docking study
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Tác giả
Fahimeh Vafadarnejad, Elahe Karimpour-Razkenari, Bilqees Sameem, Mina Saeedi, ... Tahmineh Akbarzadeh.
7. Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of phthalimide-sulfonylurea hybrids as PPARγ and SUR agonists
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Tác giả
Mohamed Ayman El-Zahabi, Eman R. Elbendary, Faida H. Bamanie, Mohamed F. Radwan, ... Ibrahim H. Eissa.
7. Improving the catalytic efficiency of aldo-keto reductase KmAKR towards t-butyl 6-cyano-(3R,5R)-dihydroxyhexanoate via semi-rational design
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Tác giả
Han Yu, Shuai Qiu, Feng Cheng, Ying-Nan Cheng, ... Yu-Guo Zheng.
7. Syntesis of thio- and seleno-acetamides bearing benzenesulfonamide as potent inhibitors of human carbonic anhydrase II and XII
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Tác giả
Damiano Tanini, Antonella Capperucci, Martina Scopelliti, Andrea Milaneschi, ... Claudiu T. Supuran.
7. Vieloplains A-G, seven new guaiane-type sesquiterpenoid dimers from Xylopia vielana
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Tác giả
Yangguo Xie, Xianglong Zhong, Yongzhen Xiao, Shenglan Zhu, ... Weidong Zhang.
7. Tyrosinase inhibition and anti-melanin generation effect of cinnamamide analogues
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Tác giả
Sultan Ullah, Chaeun Park, Muhammad Ikram, Dongwan Kang, ... Hyung Ryong Moon.
7. Trifluoromethylated carboline compounds targeting DNA: Synthesis, binding and anti-proliferative effects on human cancer cell lines
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Tác giả
Sarita Sarkar, Olga I. Shmatova, Valentine G. Nenajdenko, Kakali Bhadra.
7. The monoamine oxidase inhibition properties of C6-mono- and N3/C6-disubstituted derivatives of 4(3H)-quinazolinone
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Tác giả
Malikotsi A. Qhobosheane, Lesetja J. Legoabe, Anél Petzer, Jacobus P. Petzer.
7. Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors
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Tác giả
Fatih Tok, Bedia Koçyiğit-Kaymakçıoğlu, Begüm Nurpelin Sağlık, Serkan Levent, ... Zafer Asım Kaplancıklı.
7. Synthesis of new pyrazoles and pyrozolo [3,4-b] pyridines as anti-inflammatory agents by inhibition of COX-2 enzyme
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Tác giả
Lamia W. Mohamed, Mohamed A. Shaaban, Ashraf F. Zaher, Shimaa M. Alhamaky, Ayman M. Elsahar.
7. Identification and Structure–Activity Relationship (SAR) of potent and selective oxadiazole-based agonists of sphingosine-1-phosphate receptor (S1P1)
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Tác giả
Tianqi Liu, Jing Jin, Yonghui Chen, Qiumu Xi, ... Dali Yin.
8. Design, synthesis and preliminary in-vitro studies of novel boronated monocarbonyl analogues of Curcumin (BMAC) for antitumor and β-amiloyd disaggregation activity
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Tác giả
Emanuele Azzi, Diego Alberti, Stefano Parisotto, Alberto Oppedisano, ... Annamaria Deagostino.
8. Synthesis, biological activity and molecular modeling of a new series of condensed 1,2,4-triazoles
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Tác giả
Youness El Bakri, Ilias Marmouzi, Meryem El Jemli, El Hassane Anouar, ... El Mokhtar Essassi.
8. Flavonols and 4-thioflavonols as potential acetylcholinesterase and butyrylcholinesterase inhibitors: Synthesis, structure-activity relationship and molecular docking studies
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Tác giả
Ehsan Ullah Mughal, Amina Sadiq, Jamshaid Ashraf, Muhammad Naveed Zafar, ... Chaudhary Omer Javed.
8. Cytotoxic and neuroprotective activities of constituents from Alternaria alternate, a fungal endophyte of Psidium littorale
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Tác giả
Jian Xu, Yun-Wei Hu, Wei Qu, Ming-Hua Chen, ... Jie Zhang.
8. Synthesis and in vitro anticancer evaluation of some fused indazoles, quinazolines and quinolines as potential EGFR inhibitors
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Tác giả
Esraa A. Abdelsalam, Wafaa A. Zaghary, Kamilia M. Amin, Nageh A. Abou Taleb, ... Sherif F. Hammad.
8. Synthesis and anti-tumor activity of [1,4] dioxino [2,3-f] quinazoline derivatives as dual inhibitors of c-Met and VEGFR-2
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Tác giả
Dengshuai Wei, Haoru Fan, Kun Zheng, Xuemei Qin, ... Liming Hu.
8. Development of novel 2-substituted acylaminoethylsulfonamide derivatives as fungicides against Botrytis cinerea
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Tác giả
Minlong Wang, Ying Du, Chunhui Liu, Xinling Yang, ... Xinghai Li.
8. New thiazol-hydrazono-coumarin hybrids targeting human cervical cancer cells: Synthesis, CDK2 inhibition, QSAR and molecular docking studies
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Tác giả
Somaia S. Abd El-Karim, Yasmin M. Syam, Ahmed M. El Kerdawy, Tamer M. Abdelghany.
8. Synthesis and biological activity of a potent optically pure autoinducer-2 quorum sensing agonist
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Tác giả
Osvaldo S. Ascenso, Inês M. Torcato, Ana Sofia Miguel, João C. Marques, ... Christopher D. Maycock.
8. Design, synthesis and cytotoxicity of chimeric erlotinib-alkylphospholipid hybrids
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Tác giả
Md. Maqusood Alam, Ahmed H.E. Hassan, Kun Won Lee, Min Chang Cho, ... Yong Sup Lee.
8. Synthesis of novel N-(1,3-thiazol-2-yl)benzamide clubbed oxadiazole scaffolds: Urease inhibition, Lipinski rule and molecular docking analyses
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Tác giả
Muhammad Athar Abbasi, Hussain Raza, Aziz-ur-Rehman, Sabahat Zahra Siddiqui, ... Sung-Yum Seo.
8. Lead compounds and key residues of ribosomal protein S1 in drug-resistant Mycobacterium tuberculosis
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Tác giả
Yunbao Zhi, Yazhuang Dai, Juanjuan Yang, Shuhua Tan, ... Kejiang Lin.
9. Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments
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Tác giả
Yeheng Zhou, Wei Sun, Jiale Peng, Hui Yan, ... Zhili Zuo
9. Germacrane-type sesquiterpenoids with cytotoxic activity from Sigesbeckia orientalis
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Tác giả
Na Liu, Cong Wu, Jin-hai Yu, Kong-kai Zhu, ... Hua Zhang.
9. Anti-inflammatory and antiproliferative prenylated carbazole alkaloids from Clausena vestita
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Tác giả
Yan-Ping Liu, Shi Hu, Yun-Yao Liu, Ming-Ming Zhang, ... Yan-Hui Fu.
9. Probing the binding mechanism of capecitabine to human serum albumin using spectrometric methods, molecular modeling, and chemometrics approach
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Tác giả
S. Fatemeh Mousavi, Mohammad Hossein Fatemi.
9. Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors
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Tác giả
Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Liridon Çoçaj, ... Şükrü Beydemir.
9. Substituted 1,3-dioxoisoindoline-4-aminoquinolines coupled via amide linkers: Synthesis, antiplasmodial and cytotoxic evaluation
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Tác giả
Anu Rani, Jenny Legac, Philip J. Rosenthal, Vipan Kumar.
9. The comparative study of the DNA binding and biological activities of the quaternized dicnq as a dicationic form and its platinum(II) heteroleptic cationic complex
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Tác giả
Ufuk Yıldız, Abdurrahman Şengül, Irfan Kandemir, Füsun Cömert, ... Burak Coban.
9. Identification of ortho-naphthoquinones as anti-AML agents by highly efficient oxidation of phenols
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Tác giả
Huidan Huang, Ming Yan, Jianqiu Chen, Biao Yuan, ... Chongjiang Cao.
9. Biphenyl-3-oxo-1,2,4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory
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Tác giả
Prabhash Nath Tripathi, Pavan Srivastava, Piyoosh Sharma, Manish Kumar Tripathi, ... Sushant K. Shrivastava.
9. Switching of Trp-214 intrinsic rotamer population in human serum albumin: An insight into the aftermath of embracing therapeutic bioorganic luminophore azapodophyllotoxin into sudlow site I
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Tác giả
Soham Mukherjee, Kapil Ganorkar, Ajay Kumar, Naina Sehra, Sujit Kumar Ghosh.
9. bioNMR-based identification of natural anti-Aβ compounds in Peucedanum ostruthium
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Tác giả
Alessandro Palmioli, Sara Bertuzzi, Ada De Luigi, Laura Colombo, ... Cristina Airoldi
Nội dung
9. The isolation, absolute configuration and activities of 18(4 → 3)-abeo-abietane lactones from Tripterygium wilfordii
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Tác giả
Lin Ni, Li Li, Yingda Zang, Chuang-jun Li, ... Dong-ming Zhang.
10. Design, synthesis and biological evaluation of some new 1,3,4-thiadiazine-thiourea derivatives as potential antitumor agents against non-small cell lung cancer cells
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Tác giả
Fatma A.F. Ragab, Salah A. Abdel-Aziz, Marwa Kamel, Abdelsalam Mohamed A. Ouf, Heba Abdelrasheed Allam.
10. Vernodalidimer L, a sesquiterpene lactone dimer from Vernonia extensa and anti-tumor effects of vernodalin, vernolepin, and vernolide on HepG2 liver cancer cells
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Tác giả
Sanit Thongnest, Pornsuda Chawengrum, Siriporn Keeratichamroen, Kriengsak Lirdprapamongkol, ... Somsak Ruchirawat.
10. Optimization of a single HPLC-PDA method for quantifying Metformin, Gliclazide, Pioglitazone, Dapagliflozin, Empagliflozin, Saxagliptin, Linagliptin and Teneligliptin using central composite design
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Tác giả
Ravi Kant, Ramesh Babu Bodla, Garima Kapoor, Rubina Bhutani.
10. New phenolic Mannich bases with piperazines and their bioactivities
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Tác giả
Halise Inci Gul, Mehtap Tugrak, Mustafa Gul, Sertac Mazlumoglu, ... Claudiu T. Supuran.
10. Catechol thioethers with physiologically active fragments: Electrochemistry, antioxidant and cryoprotective activities
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Tác giả
Ivan V. Smolyaninov, Olga V. Pitikova, Eugenia O. Korchagina, Andrey I. Poddel'sky, ... Nadezhda T. Berberova.
10. Synthesis, antitumor testing and molecular modeling study of some new 6-substituted amido, azo or thioureido-quinazolin-4(3H)-ones
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Tác giả
Mohamed A. Sabry, Heba A. Ewida, Ghada S. Hassan, Mariam A. Ghaly, Hussein I. El-Subbagh.
10. Synthesis of benzensulfonamides linked to quinazoline scaffolds as novel carbonic anhydrase inhibitors
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Tác giả
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Sivia Bua, Alessio Nocentini, ... Claudiu T. Supuran.
10. Synthesis and evaluation of novel fused pyrimidine derivatives as GPR119 agonists
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Tác giả
Yuanying Fang, Lijuan Xiong, Jianguo Hu, Shaokun Zhang, ... Zunhua Yang.
10. In vitro and in silico evaluation of new thiazole compounds as monoamine oxidase inhibitors
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Tác giả
Begüm Nurpelin Sağlık, Betül Kaya Çavuşoğlu, Derya Osmaniye, Serkan Levent, ... Yusuf Öztürk.
10. 1,4-Dihydroquinazolin-3(2H)-yl benzamide derivatives as anti-inflammatory and analgesic agents with an improved gastric profile: Design, synthesis, COX-1/2 inhibitory activity and molecular docking study
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Tác giả
Asmaa Sakr, Hend Kothayer, Samy M. Ibrahim, Mohamed M. Baraka, Samar Rezq.
10. Design, synthesis, structural characterization and in vitro evaluation of new 1,4-disubstituted-1,2,3-triazole derivatives against glioblastoma cells
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Tác giả
Veronica D. da Silva, Bruna M. de Faria, Eduardo Colombo, Lucas Ascari, ... Camilla D. Buarque
Nội dung
10. Pentamethinium salts as ligands for cancer: Sulfated polysaccharide co-receptors as possible therapeutic target
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Tác giả
Tomáš Bříza, Jarmila Králová, Silvie Rimpelová, Martin Havlík, ... Vladimír Král.
11. Identification of a potent and selective gametocytocidal antimalarial agent from the stem barks of Lophira lanceolata
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Tác giả
Annalisa Lopatriello, Harouna Soré, Annette Habluetzel, Silvia Parapini, ... Orazio Taglialatela-Scafati.
11. Chemical constituents from Lonicera japonica flower buds and their anti-hepatoma and anti-HBV activities
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Tác giả
Lanlan Ge, Lingyun Xiao, Haoqiang Wan, Jiemei Li, ... Xiaobin Zeng.
11. One-step immobilization and purification of genetic engineering CBD fusion EndoS on cellulose for antibodies Fc-glycan remodeling
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Kai Zhao, Feng Tang, Wei Shi, Haofei Hong, ... Zhimeng Wu.
11. Investigation of potent inhibitors of cholinesterase based on thiourea and pyrazoline derivatives: Synthesis, inhibition assay and molecular modeling studies
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Tác giả
Amara Mumtaz, Abdul Majeed, Sumera Zaib, Shafiq Ur Rahman, ... Jamshed Iqbal.
11. Antitrypanosomal activity and effect in plasma membrane permeability of (−)-bornyl p-coumarate isolated from Piper cernuum (Piperaceae)
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Thiago R. Morais, Thais A. Costa-Silva, Daiane D. Ferreira, Bianca J. Novais, ... João Henrique G. Lago.
11. Glucosamine-6-phosphate synthase inhibiting C3-β-cholesterol tethered spiro heterocyclic conjugates: Synthesis and their insight of DFT and docking study
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Govindasami Periyasami, Subban Kamalraj, Ramanathan Padmanaban, Santhakumar Yeswanth Kumar, ... Ali Aldalbahi.
11. Synthesis and characterization of novel bromophenols: Determination of their anticholinergic, antidiabetic and antioxidant activities
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Tác giả
Necla Öztaşkın, Rüya Kaya, Ahmet Maraş, Ertan Şahin, ... Süleyman Göksu.
11. 3-Hydroxyisoindolin-1-one derivates: Synthesis by palladium-catalyzed CH activation as BRD4 inhibitors against human acute myeloid leukemia (AML) cells
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Pan Chen, Yifei Yang, Lingyun Yang, Jiping Tian, ... Huibin Zhang.
11. Synthesis of novel quinoline-based thiadiazole, evaluation of their antileishmanial potential and molecular docking studies
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Noor Barak Almandil, Muhammad Taha, Fazal Rahim, Abdul Wadood, ... Mohammed Gollapalli.
11. Repurposing approach identifies new treatment options for invasive fungal disease
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Isis Regina Grenier Capoci, Daniella Renata Faria, Karina Mayumi Sakita, Franciele Abigail Vilugron Rodrigues-Vendramini, ... Bernard Maigret.
11. Trichosanhemiketal A and B: Two 13,14-seco-13,14-epoxyporiferastanes from the root of Trichosanthes kirilowii Maxim
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Manh Tuan Ha, Thanh Nam Phan, Jeong Ah Kim, Won Keun Oh, ... Byung Sun Min.
Nội dung
11. Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti-inflammatory COX-2 selective inhibitors
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Tác giả
Khaled R.A. Abdellatif, Wael A.A. Fadaly, Gehan M. Kamel, Yaseen A.M.M. Elshaier, Mohammed A. El-Magd.
12. Design, synthesis and biological evaluation of resveratrol-cinnamoyl derivates as tubulin polymerization inhibitors targeting the colchicine binding site
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Tác giả
Yong Yin, Bao-Ping Lian, Yuan-Zheng Xia, Yu-Ying Shao, Ling-Yi Kong.
12. Biflavones from Ginkgo biloba as inhibitors of human thrombin
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Tác giả
Tian-Ran Chen, Ling-Hua Wei, Xiao-Qing Guan, Chao Huang, ... Wen-Zhi Guo.
12. Revealing synergistic mechanism of multiple components in Stauntonia brachyanthera Hand.-Mazz. for gout by virtual screening and system pharmacological approach
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Qiong-qiong Hua, Ying Liu, Cai-hong Liu, Li Liu, Da-li Meng.
12. Substituted cinnamic anhydrides act as selective inhibitors of acetylcholinesterase
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Tác giả
Josephine M. Gießel, Immo Serbian, Anne Loesche, René Csuk.
12. Evaluation of the antitrypanosoma activity and SAR study of novel LINS03 derivatives
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Marina T. Varela, Thais A. Costa-Silva, João Henrique G. Lago, Andre G. Tempone, João Paulo S. Fernandes.
12. Facile one-pot synthesis, antiproliferative evaluation and structure-activity relationships of 3-amino-1H-indoles and 3-amino-1H-7-azaindoles
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Peng-Cheng Diao, Meng-Jin Hu, Hai-Kui Yang, Wen-Wei You, Pei-Liang Zhao.
12. Synthesis of compounds having antimicrobial activity from alginate
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Verónica Luque-Agudo, Jesús Albarrán-Velo, Mark E. Light, José M. Padrón, ... M. Victoria Gil.
12. Synthesis of 5-enamine-4-thiazolidinone derivatives with trypanocidal and anticancer activity
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Tác giả
Serhii Holota, Anna Kryshchyshyn, Halyna Derkach, Yaroslava Trufin, ... Roman Lesyk.
12. Expansion of the scaffold diversity for the development of highly selective butyrylcholinesterase (BChE) inhibitors: Discovery of new hits through the pharmacophore model generation, virtual screening and molecular dynamics simulation
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Tác giả
Xin Lu, Hongyu Yang, Qihang Li, Yao Chen, ... Haopeng Sun.
12. Biological evaluation and structure activity relationship of 9-methyl-1-phenyl-9H-pyrido[3,4-b]indole derivatives as anti-leishmanial agents
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Tác giả
Penta Ashok, Subhash Chander, Terry K. Smith, Rajnish Prakash Singh, ... Murugesan Sankaranarayanan.
12. Design, synthesis and molecular modeling study of certain VEGFR-2 inhibitors based on thienopyrimidne scaffold as cancer targeting agents
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Tác giả
Amna Ghith, Khairia M. Youssef, Nasser S.M. Ismail, Khaled A.M. Abouzid.
12. Design, synthesis and biological evaluation of N1-(isoquinolin-5-yl)-N2-phenylpyrrolidine-1,2-dicarboxamide derivatives as potent TRPV1 antagonists
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Mingxiang Gao, Cunbin Nie, Jinyu Li, Beibei Song, ... Hai Qian.
13. Exploration of Pd-catalysed four-component tandem reaction for one-pot assembly of pyrazolo[1,5-c]quinazolines as potential EGFR inhibitors
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Arshad J. Ansari, Gaurav Joshi, Umesh Prasad Yadav, Antim K. Maurya, ... Devesh M. Sawant.
13. Ultrasound mediated efficient synthesis of new 4-oxoquinazolin-3(4H)-yl)furan-2-carboxamides as potent tyrosinase inhibitors: Mechanistic approach through chemoinformatics and molecular docking studies
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Nilam C. Dige, Prasad G. Mahajan, Hussain Raza, Mubashir Hassan, ... Sung-Yum Seo.
13. Ureidobenzenesulfonamides as efficient inhibitors of carbonic anhydrase II
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Immo Serbian, Philipp Schwarzenberger, Anne Loesche, Sophie Hoenke, ... René Csuk.
13. Cytotoxicity of oleanolic and ursolic acid derivatives toward hepatocellular carcinoma and evaluation of NF-κB involvement
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Gianfranco Fontana, Maurizio Bruno, Monica Notarbartolo, Manuela Labbozzetta, ... Sergio Rosselli.
13. Synthesis, biological evaluation and molecular docking studies of novel 3,5-disubstituted 2,4-thiazolidinediones derivatives
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Alok Ranjan Srivastava, Rohit Bhatia, Pooja Chawla.
13. Potent and selective EGFR inhibitors based on 5-aryl-7H-pyrrolopyrimidin-4-amines
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Tác giả
Ann Christin Reiersølmoen, Thomas Ihle Aarhus, Sarah Eckelt, Kristin Gabestad Nørsett, ... Bård Helge Hoff.
13. Synthesis and antiproliferative activity of new 2-glyco-3-nitro-2H-chromenes
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Tác giả
Verónica Luque-Agudo, Jesús Albarrán-Velo, Mark E. Light, José M. Padrón, ... M. Victoria Gil.
13. Hydroxyl alkyl ammonium ionic liquid assisted green and one-pot regioselective access to functionalized pyrazolodihydropyridine core and their pharmacological evaluation
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Tác giả
Divyang M. Patel, Mayank G. Sharma, Ruturajsinh M. Vala, Irene Lagunes, ... Hitendra M. Patel.
13. The first synthesis, carbonic anhydrase inhibition and anticholinergic activities of some bromophenol derivatives with S including natural products
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Cetin Bayrak, Parham Taslimi, Halide Sedef Karaman, Ilhami Gulcin, Abdullah Menzek.
13. Heterocyclic cellular lipid peroxidation inhibitors inspired by the marine antioxidant barettin
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Christophe Labrière, Jeanette H. Andersen, Marte Albrigtsen, Jørn H. Hansen, Johan Svenson.
13. α-Pyrones, secondary metabolites from fungus Cephalotrichum microsporum and their bioactivities
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He Zhu, Dawei Li, Qingsong Yan, Yue An, ... Yixuan Zhang.
13. α-Pyrones, secondary metabolites from fungus Cephalotrichum microsporum and their bioactivities
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He Zhu, Dawei Li, Qingsong Yan, Yue An, ... Yixuan Zhang.
13. 1,2,4-Trisubstituted imidazolinones with dual carbonic anhydrase and p38 mitogen-activated protein kinase inhibitory activity
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Hanan H. Georgey, Fatma M. Manhi, Walaa R. Mahmoud, Nehad A. Mohamed, ... Claudiu T. Supuran.
14. Novel tribenzylaminobenzolsulphonylimine based on their pyrazine and pyridazines: Synthesis, characterization, antidiabetic, anticancer, anticholinergic, and molecular docking studies
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Tác giả
Gulnar Mamedova, Adila Mahmudova, Sabir Mamedov, Yavuz Erden, ... İlhami Gulçin.
14. Nusbiarylins, a new class of antimicrobial agents: Rational design of bacterial transcription inhibitors targeting the interaction between the NusB and NusE proteins
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Tác giả
Yangyi Qiu, Shu Ting Chan, Lin Lin, Tsun Lam Shek, ... Cong Ma.
14. Amide-tethered quinoline-resorcinol conjugates as a new class of HSP90 inhibitors suppressing the growth of prostate cancer cells
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Tác giả
Kunal Nepali, Mei-Hsiang Lin, Min-Wu Chao, Sheng-Jhih Peng, ... Jing-Ping Liou.
14. Exploiting the 7-methylimidazo[1,5-a]pyrazin-8(7H)-one scaffold for the development of novel chemical inhibitors for Bromodomain and Extraterminal Domain (BET) family
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Yifei Yang, Pan Chen, Leilei Zhao, Fangqing Zhang, ... Jinpei Zhou.
14. Tetrahydro-1H,5H-pyrazolo[1,2-a]pyrazole-1-carboxylates as inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
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Nika Strašek, Lara Lavrenčič, Andraž Oštrek, Dejan Slapšak, ... Jurij Svete.
14. 6-Methoxyflavonols from the aerial parts of Tetragonia tetragonoides (Pall.) Kuntze and their anti-inflammatory activity
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Yeong-Geun Lee, Hwan Lee, Jin Ah Ryuk, Joo Tae Hwang, ... Nam-In Baek.
14. Sesquiterpenes from Curcuma zedoaria rhizomes and their cytotoxicity against human gastric cancer AGS cells
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Tae Kyoung Lee, Dahae Lee, Seoung Rak Lee, Yoon-Joo Ko, ... Ki Hyun Kim.
14. Design, molecular docking and synthesis of novel 5,6-dichloro-2-methyl-1H-benzimidazole derivatives as potential urease enzyme inhibitors
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Emre Menteşe, Mustafa Emirik, Bahar Bilgin Sökmen.
14. 3, 9-di-O-substituted coumestrols incorporating basic amine side chains act as novel apoptosis inducers with improved pharmacological selectivity
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Guoshun Luo, Zhengpu Tang, Xinyu Li, Qiangqiang Hou, ... Hua Xiang.
14. Encapsulation of ciprofloxacin within modified xanthan gum- chitosan based hydrogel for drug delivery
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Demiana H. Hanna, Gamal R. Saad.
14. Dual effects of isoflavonoids from Pueraria lobata roots on estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells
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Soo-Yeon Ahn, Mun Seok Jo, Dahae Lee, Seon-Eun Baek, ... Ki Hyun Kim
14. Design, synthesis and biological evaluation of novel ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as potent carbonic anhydrase IX inhibitors
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Tác giả
Nabih Lolak, Suleyman Akocak, Silvia Bua, Claudiu T. Supuran.
15. Design, synthesis, in vitro and in vivo evaluation of novel pyrrolizine-based compounds with potential activity as cholinesterase inhibitors and anti-Alzheimer's agents
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Nehad Abou-Elmagd El-Sayed, Awatef El-Said Farag, Manal Abdel Fattah Ezzat, Hulya Akincioglu, ... Sahar Mahmoud Abou-Seri.
15. Novel 3,4-dihydro-4-oxoquinazoline-based acetohydrazides: Design, synthesis and evaluation of antitumor cytotoxicity and caspase activation activity
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Le Cong Huan, Phuong-Thao Tran, Cao Viet Phuong, Phan Huy Duc, ... Nguyen-Hai Nam.
15. Synthesis of new arylhydrazide bearing Schiff bases/thiazolidinone: α-Amylase, urease activities and their molecular docking studies
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Fazal Rahim, Muhammad Taha, Hayat Ullah, Abdul Wadood, ... Mohammed Gollapalli.
15. Design, synthesis of celecoxib-tolmetin drug hybrids as selective and potent COX-2 inhibitors
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Khaled R.A. Abdellatif, Eman K.A. Abdelall, Madlen B. Labib, Wael A.A. Fadaly, Taha H. Zidan.
15. Targeting malaria and leishmaniasis: Synthesis and pharmacological evaluation of novel pyrazole-1,3,4-oxadiazole hybrids. Part II
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Garima Verma, Mohemmed Faraz Khan, Lalit Mohan Nainwal, Mohd Ishaq, ... Mohammad Shaquiquzzaman.
15. Hydrazones as novel epigenetic modulators: Correlation between TET 1 protein inhibition activity and their iron(II) binding ability
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Milan Jakubek, Zdeněk Kejík, Robert Kaplánek, Veronika Antonyová, ... Vladimír Král.
15. Synthesis and evaluation of novel α-substituted chalcones with potent anti-cancer activities and ability to overcome multidrug resistance
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Sharon Riaz, Maheen Iqbal, Rahim Ullah, Rida Zahra, ... Rahman Shah Zaib Saleem.
15. Structures and biological evaluation of phenylpropanoid derivatives from Murraya koenigii
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Qinge Ma, Rongrui Wei, Ming Yang, Xiaoying Huang, ... Yalun Su.
15. Cloning, overexpression and characterization of a thermostable β-xylosidase from Thermotoga petrophila and cooperated transformation of ginsenoside extract to ginsenoside 20(S)-Rg3 with a β-glucosidase
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Shanshan Zhang, Jingcong Xie, Linguo Zhao, Jianjun Pei, ... Zhenzhong Wang.
15. The first target specific, highly diastereoselective synthesis, design and characterization of pyranoquinolinyl acrylic acid diastereomers as potential α-glucosidase inhibitors
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G. Lavanya, K. Venkatapathy, C.J. Magesh, M. Ramanathan, R. Jayasudha.
15. 2-Aryl-quinazolin-4(3H)-ones as an inhibitor of leishmania folate pathway: In vitro biological evaluation, mechanism studies and molecular docking
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Angel H. Romero, Noris Rodríguez, Henry Oviedo.
15. Design and synthesis of novel potent anticoagulant and anti-tyrosinase pyranopyrimidines and pyranotriazolopyrimidines: Insights from molecular docking and SAR analysis
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Meriem Debbabi, Vijaykumar D. Nimbarte, Samia Chekir, Sarra Chortani, ... Hichem Ben jannet.
16. The antiproliferative effect of spectinabilins from Streptomyces spectabilis on hepatocellular carcinoma cells in vitro and in vivo
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Xiaoxiao Gao, Hongzhi Yao, Yu Mu, Peipei Guan, ... Chenglin Jiang.
16. Biscoumarin-1,2,3-triazole hybrids as novel anti-diabetic agents: Design, synthesis, in vitro α-glucosidase inhibition, kinetic, and docking studies
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Tác giả
Mohammad Sadegh Asgari, Maryam Mohammadi-Khanaposhtani, Mitra Kiani, Parviz Rashidi Ranjbar, ... Mir Hamed Hajimiri.
16. Phytoscreening of Vochysiaceae species: Molecular identification by HPLC-ESI-MS/MS and evaluating of their antioxidant activity and inhibitory potential against human α-amylase and protein glycation
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R.R. Franco, A.B. Justino, M.M. Martins, C.G. Silva, ... F.S. Espindola.
16. Novel Pyrazoloquinolin-2-ones: Design, synthesis, docking studies, and biological evaluation as antiproliferative EGFR-TK inhibitors
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Mohammed A.I. Elbastawesy, Ashraf A. Aly, Mohamed Ramadan, Yaseen A.M.M. Elshaier, ... Gamal El-Din A Abuo-Rahma.
16. 3D-QSAR pharmacophore modelling, virtual screening and docking studies for lead discovery of a novel scaffold for VEGFR 2 inhibitors: Design, synthesis and biological evaluation
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Mahitab K. Sobhy, Samar Mowafy, Deena S. Lasheen, Nahla A. Farag, Khaled A.M. Abouzid.
16. Synthesis of some new C2 substituted dihydropyrimidines and their electrophysiological evaluation as L-/T-type calcium channel blockers
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Mohamed Teleb, Ola H. Rizk, Fang-Xiong Zhang, Frank R. Fronczek, ... Hesham Fahmy.
16. Iridoids from Valeriana jatamansi induce autophagy-associated cell death via the PDK1/Akt/mTOR pathway in HCT116 human colorectal carcinoma cells
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Yu-Zhu Tan, Cheng Peng, Chang-Jiang Hu, Hong-Xiang Li, ... Zhi-Xing Cao.
16. Design, synthesis and biological evaluation of N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide derivatives as novel P-glycoprotein inhibitors reversing multidrug resistance
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Qianqian Qiu, Jiaqi Zhou, Wei Shi, Mutta Kairuki, ... Hai Qian.
16. Identification of a pyrimidinetrione derivative as the potent DprE1 inhibitor by structure-based virtual ligand screening
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Ya Gao, Jinshan Xie, Ruotian Tang, Kaiyin Yang, ... Hua Li.
16. Novel salicylamide derivatives as potent multifunctional agents for the treatment of Alzheimer's disease: Design, synthesis and biological evaluation
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Tác giả
Qing Song, Yan Li, Zhongcheng Cao, Xiaoming Qiang, ... Yong Deng.
16. Preparation, characterization and in vitro activity of a docetaxel–albumin conjugate
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Jing Gao, Shougang Jiang, Xuewei Zhang, Yujie Fu, Zhiguo Liu.
16. Six new compounds from the flowers of Chrysanthemum morifolium and their biological activities
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Peng-Fei Yang, Ya-Nan Yang, Zi-Ming Feng, Jian-Shuang Jiang, Pei-Cheng Zhang.
17. Design, synthesis, biological evaluation, and molecular modeling studies of quinoline-ferulic acid hybrids as cholinesterase inhibitors
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Jun Mo, Hongyu Yang, Tingkai Chen, Qihang Li, ... Haopeng Sun.
17. Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold
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Zheng Li, Qiang Ren, Xuekun Wang, Zongtao Zhou, ... Qianqian Qiu.
17. 2,5-Disubstituted thiadiazoles as potent β-glucuronidase inhibitors; Synthesis, in vitro and in silico studies
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Tác giả
Muhammad Taha, Noor Barak Almandil, Umer Rashid, Muhammad Ali, ... Khalid Mohammed Khan.
17. Protective effect of hypoxylonol C and 4,5,4′,5′-tetrahydroxy-1,1′-binaphthyl isolated from Annulohypoxylon annulatum against streptozotocin-induced damage in INS-1 cells
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Dahae Lee, Pilju Choi, Buyng Su Hwang, Taejung Kim, ... Jungyeob Ham.
17. Molecular docking and experimental investigation of new indole derivative cyclooxygenase inhibitor to probe its binding mechanism with bovine serum albumin
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Tác giả
Tanveer A. Wani, Ahmed H. Bakheit, Seema Zargar, Mashooq A. Bhat, Abdulrahman A. Al-Majed.
17. Virtual screening of active compounds from Artemisia argyi and potential targets against gastric ulcer based on Network pharmacology
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Yue Wang, Yi-wei Sun, Yu-meng Wang, Yan Ju, Da-li Meng.
17. Synthesis of CC, CN coupled novel substituted dibutyl benzothiazepinone derivatives and evaluation of their thrombin inhibitory activity
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Tác giả
C.P. Baburajeev, Chakrabhavi Dhananjaya Mohan, Vijay Pandey, Shobith Rangappa, ... Basappa.
17. Mono- or di-substituted imidazole derivatives for inhibition of acetylcholine and butyrylcholine esterases
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Tác giả
Burak Kuzu, Meltem Tan, Parham Taslimi, İlhami Gülçin, ... Nurettin Menges.
17. Mitochondria-targeted triphenylphosphonium conjugated glycyrrhetinic acid derivatives as potent anticancer drugs
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Tác giả
Le Jin, Lumei Dai, Min Ji, Hengshan Wang.
17. 1,3,4-oxadiazole/chalcone hybrids: Design, synthesis, and inhibition of leukemia cell growth and EGFR, Src, IL-6 and STAT3 activities
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Tác giả
Marwa Ali A. Fathi, Amer Ali Abd El-Hafeez, Dalia Abdelhamid, Samar H. Abbas, ... Mohamed Abdel-Aziz.
17. Design and synthesis of novel quinazolinone-1,2,3-triazole hybrids as new anti-diabetic agents: In vitro α-glucosidase inhibition, kinetic, and docking study
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Tác giả
Mina Saeedi, Maryam Mohammadi-Khanaposhtani, Parvaneh Pourrabia, Nima Razzaghi, ... Tahmineh Akbarzadeh.
17. Design, and facile synthesis of 1,3 diaryl-3-(arylamino)propan-1-one derivatives as the potential alpha-amylase inhibitors and antioxidants
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Roqia Bashary, Gopal L. Khatik.
18. Discovery of novel oxoindolin derivatives as atypical dual inhibitors for DNA Gyrase and FabH
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Yu-Shun Yang, Mi-Mi Su, Jian-Fei Xu, Qi-Xing Liu, ... Hai-Liang Zhu.
18. Spirocyclic sulfonamides with carbonic anhydrase inhibitory and anti-neuropathic pain activity
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Y. Kalisha Vali, Rambabu Gundla, Om V. Singh, Yasinalli Tamboli, ... Claudiu T. Supuran.
18. The 5-hydrazino-3-methylisothiazole-4-carboxylic acid, its new 5-substituted derivatives and their antiproliferative activity
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Tác giả
Izabela Jęśkowiak, Marcin Mączyński, Justyna Trynda, Joanna Wietrzyk, Stanisław Ryng.
18. Facile synthesis and antimicrobial activity of CdS-Ag2S nanocomposites
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Tahir Iqbal, Faisal Ali, N.R. Khalid, M. Bilal Tahir, Mohsin Ijaz.
18. Design and synthesis of dye-conjugated hepsin inhibitors
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Kyul Kim, Hongmok Kwon, Doyoung Choi, Taehyeong Lim, ... Youngjoo Byun.
18. In-silico design and synthesis of N9-substituted β-Carbolines as PLK-1 inhibitors and their in-vitro/in-vivo tumor suppressing evaluation
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Gomathi Priya Jeyapal, Rajendiran Krishnasamy, Carolyn K. Suzuki, Sundararajan Venkatesh, M.J.N. Chandrasekar.
18. Synthesis and characterization of new thiosemicarbazones, as potent urease inhibitors: In vitro and in silico studies
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Muhammad Islam, Ajmal Khan, Muhammad Tariq Shehzad, Abdul Hameed, ... Ahmed Al-Harrasi.
18. Synthesis of substituted biphenyl methylene indolinones as apoptosis inducers and tubulin polymerization inhibitors
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Tác giả
Kavitha Donthiboina, Pratibha Anchi, P.V. Sri Ramya, Shailaja Karri, ... Ahmed Kamal.
18. Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibitors
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Tác giả
Serdar Burmaoglu, Ali Osman Yilmaz, M. Fatih Polat, Rüya Kaya, ... Oztekin Algul.
18. 1-(2-Hydroxy-5-((trimethylsilyl)ethynyl)phenyl)ethanone based α,β-unsaturated derivatives an alternate to non-sulfonamide carbonic anhydrase II inhibitors, synthesis via Sonogashira coupling, binding analysis, Lipinsk’s rule validation
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Tác giả
Jamaluddin Mahar, Aamer Saeed, Kevin D. Belfield, Fayaz Ali Larik, ... Sung-Yum Seo.
18. Synthesis of 1,2,4-triazole-5-on derivatives and determination of carbonic anhydrase II isoenzyme inhibition effects
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Tác giả
Safak Akin, Hasan Ayaloglu, Ergun Gultekin, Ahmet Colak, ... Melike Yildirim Akatin.
18. Synthesis and in vitro urease inhibitory activity of benzohydrazide derivatives, in silico and kinetic studies
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Azhar Abbas, Basharat Ali, Kanwal, Khalid Mohammed Khan, ... Shahnaz Perveen.
19. A mass spectrometric stochastic dynamic diffusion approach to selective quantitative and 3D structural analyses of native cyclodextrins by electrospray ionization and atmospheric pressure chemical ionization methods
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Bojidarka Ivanova, Michael Spiteller.
19. Design and synthesis of fluorogenic substrate-based probes for detecting Cathepsin B activity
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Shusheng Wang, Brady G. Vigliarolo, Morshed A. Chowdhury, Jennifer N.K. Nyarko, ... Christopher P. Phenix.
19. Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands
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Katarzyna Szczepańska, Tadeusz Karcz, Agata Siwek, Kamil J. Kuder, ... Katarzyna Kieć-Kononowicz.
19. Identification of nicotinamide aminonaphthyridine compounds as potent RET kinase inhibitors and antitumor activities against RET rearranged lung adenocarcinoma
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Tác giả
Modi Wang, N. Naganna, Herman O. Sintim.
19. EGFR inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and docking studies of novel xanthine derivatives carrying chalcone moiety as hybrid molecules
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Tác giả
Hesham A. Abou-Zied, Bahaa G.M. Youssif, Mamdouh F.A. Mohamed, Alaa M. Hayallah, Mohamed Abdel-Aziz.
19. Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials
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Hayriye Genç Bilgiçli, Ali Kestane, Parham Taslimi, Oguz Karabay, ... İlhami Gulçin.
19. Synthesis and evaluation of novel benzotropolones as Atg4B inhibiting autophagy blockers
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Muhammet Tanc, Matthias Cleenewerck, Ammar Kurdi, Ria Roelandt, ... Pieter Van der Veken.
19. Discovery of potent PTP1B inhibitors via structure-based drug design, synthesis and in vitro bioassay of Norathyriol derivatives
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Wenjie Xue, Jinlong Tian, Xiang Simon Wang, Jie Xia, Song Wu.
19. Synthesis of novel benzenesulfonamide bearing 1,2,3-triazole linked hydroxy-trifluoromethylpyrazolines and hydrazones as selective carbonic anhydrase isoforms IX and XII inhibitors
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Tác giả
Vikas Sharma, Rajiv Kumar, Silvia Bua, Claudiu T. Supuran, Pawan K. Sharma.
19. Antitrypanosomal activity of epi-polygodial from Drimys brasiliensis and its effects in cellular membrane models at the air-water interface
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Giulia Elisa Guimarães Gonçalves, Thiago Rahal Morais, Kaio de Souza Gomes, Thais Alves Costa-Silva, ... Luciano Caseli.
19. In vitro activities of a new fluoroquinolone derivative highly active against Chlamydia trachomatis
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Tác giả
Thi Huyen Vu, Nguyet-Thanh Ha-Duong, Alexandra Aubry, Estelle Capton, ... Nawal Serradji.
19. α-Tocopherol-ascorbic acid hybrid antioxidant based cationic amphiphile for gene delivery: Design, synthesis and transfection
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Tác giả
Venkanna Muripiti, Lohchania Brijesh, Hari Krishnareddy Rachamalla, Srujan Kumar Marepally, ... Srilakshmi V. Patri.
20. Design, synthesis, molecular modelling, ADME prediction and anti-hyperglycemic evaluation of new pyrazole-triazolopyrimidine hybrids as potent α-glucosidase inhibitors
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Tác giả
Vinay Pogaku, Kiran Gangarapu, Srinivas Basavoju, Kiran Kumar Tatapudi, Suresh Babu Katragadda.
20. Synthesis and biological evaluation of a novel series of curcumin-peptide derivatives as PepT1-mediated transport drugs
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Tác giả
Jiyun Zhang, Hongmei Wen, Fei Shen, Xinzhi Wang, ... Wei Li.
20. Utilization of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinone as a cap moiety in design of novel histone deacetylase inhibitors
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Tác giả
Mamdouh F.A. Mohamed, Bahaa G.M. Youssif, Montaser Sh. A. Shaykoon, Mostafa H. Abdelrahman, ... Gamal El-Din A. Abuo-Rahma.
20. Isolation and characterization of three pairs of indolediketopiperazine enantiomers containing infrequent N-methoxy substitution from the marine algal-derived endophytic fungus Acrostalagmus luteoalbus TK-43
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Tác giả
Jin Cao, Xiao-Ming Li, Ling-Hong Meng, Belma Konuklugil, ... Bin-Gui Wang.
20. Antitrypanosomal activity of isololiolide isolated from the marine hydroid Macrorhynchia philippina (Cnidaria, Hydrozoa)
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Tác giả
Marta L. Lima, Maiara M. Romanelli, Samanta E.T. Borborema, Deidre M. Johns, ... Andre G. Tempone.
20. Synthesis of novel Schiff bases and azol-β-lactam derivatives starting from morpholine and thiomorpholine and investigation of their antitubercular, antiurease activity, acethylcolinesterase inhibition effect and antioxidant capacity
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Tác giả
Yıldız Uygun Cebeci, Hacer Bayrak, Yakup Şirin.
20. Evaluation of guanylhydrazone derivatives as inhibitors of Candida rugosa digestive lipase: Biological, biophysical, theoretical studies and biotechnological application
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Tác giả
Camilla C. Santana, Edeíldo F. Silva-Júnior, João César N. Santos, Érica E. da S. Rodrigues, ... Luciano Aparecido M. Grillo.
20. COX-1/COX-2 inhibition assays and histopathological study of the new designed anti-inflammatory agent with a pyrazolopyrimidine core
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Tác giả
Eman K.A. Abdelall, Phoebe F. Lamie, Amira K.M. Ahmed, EL-Shaymaa EL-Nahass.
20. Identification of 1,2,4-triazoles as new thymidine phosphorylase inhibitors: Future anti-tumor drugs
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Tác giả
Sohail Anjum Shahzad, Muhammad Yar, Zulfiqar Ali Khan, Lubna Shahzadi, ... Marek Bajda
20. Ebsulfur as a potent scaffold for inhibition and labelling of New Delhi metallo-β-lactamase-1 in vitro and in vivo
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Tác giả
Jianpeng Su, Jiayun Liu, Cheng Chen, Yuejuan Zhang, Kewu Yang.
20. Synthesis and anti-proliferative activity of some new quinoline based 4,5-dihydropyrazoles and their thiazole hybrids as EGFR inhibitors
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Tác giả
Riham F. George, Eman M. Samir, Mennatullah N. Abdelhamed, Hatem A. Abdel-Aziz, Safinaz E-S. Abbas.
Nội dung
20. Hydrogen sulfide releasing enmein-type diterpenoid derivatives as apoptosis inducers through mitochondria-related pathways
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Tác giả
Fanxing Xu, Xiang Gao, Haonan Li, Shengtao Xu, ... Dahong Li.
21. Facile synthesis of 1,2,3-triazole-fused indolo- and pyrrolo[1,4]diazepines, DNA-binding and evaluation of their anticancer activity
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Tác giả
Jitendra Gour, Srikanth Gatadi, Venkatesh Pooladanda, Shaik Mahammad Ghouse, ... Srinivas Nanduri.
21. Physapubescin I from husk tomato suppresses SW1990 cancer cell growth by targeting kidney-type glutaminase
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Tác giả
Kai-Yin Yang, Can-Rong Wu, Meng-Zhu Zheng, Ruo-Tian Tang, ... Hua Li.
21. Synthesis, in-vitro α-glucosidase inhibition, antioxidant, in-vivo antidiabetic and molecular docking studies of pyrrolidine-2,5-dione and thiazolidine-2,4-dione derivatives
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Tác giả
Fida Hussain, Zeeshan Khan, Muhammad Saeed Jan, Sajjad Ahmad, ... Abdul Sadiq.
21. Anticancer properties of N-alkyl-2, 4-diphenylimidazo [1, 2-a] quinoxalin-1-amine derivatives; kinase inhibitors
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Tác giả
Zahra Rezaei, Mir Mahdi Didehvar, Mohammad Mahdavi, Homa Azizian, ... Mohsen Amini.
21. Synthesis, thymidine phosphorylase, angiogenic inhibition and molecular docking study of isoquinoline derivatives
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Tác giả
Khalid Zaman, Fazal Rahim, Muhammad Taha, Abdul Wadood, ... Ashfaq Ahmed.
21. Synthesis and in vitro antitumor activity of novel acylspermidine derivative N-(4-aminobutyl)-N-(3-aminopropyl)-8-hydroxy-dodecanamide (AAHD) against HepG2 cells
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Tác giả
Abdulrahman L. Al-Malki, Syed Shoeb Razvi, Furkhan Ahmed Mohammed, Mazin A. Zamzami, ... Said S. Moselhy.
21. Pomalidomide hybrids act as proteolysis targeting chimeras: Synthesis, anticancer activity and B-Raf degradation
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Tác giả
Hong Chen, Feihong Chen, Sinan Pei, Shaohua Gou.
21. Antimicrobial characteristics and biocompatibility of the surgical sutures coated with biosynthesized silver nanoparticles
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Tác giả
Tuba Baygar, Nurdan Sarac, Aysel Ugur, Inci Rana Karaca.
21. Docking- and pharmacophore-based virtual screening for the identification of novel Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with a thiobarbiturate scaffold
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Tác giả
Dongfeng Zhang, Yun Lin, Xi Chen, Wenting Zhao, ... Yu Lu.
21. Synthesis, molecular modeling and BACE-1 inhibitory study of tetrahydrobenzo[b] pyran derivatives
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Tác giả
Vijaya Bhaskar, Reshma Chowdary, Sheshagiri R. Dixit, Shrinivas D. Joshi.
21. 4-Substituted benzenesulfonamides featuring cyclic imides moieties exhibit potent and isoform-selective carbonic anhydrase II/IX inhibition
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Tác giả
Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Adel H. Ghiaty, Paola Gratteri, ... Alessio Nocentini.
21. Novel quinazolin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity
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Tác giả
Monika Pospisilova, Martin Andrs, Martina Seifrtova, Radim Havelek, ... Martina Rezacova.
22. Exploring calixarene-based clusters for efficient functional presentation of Streptococcus pneumoniae saccharides
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Tác giả
Marta Giuliani, Federica Faroldi, Laura Morelli, Enza Torre, ... Federica Compostella.
22. A dual-emission fluorescent probe for discriminating cysteine from homocysteine and glutathione in living cells and zebrafish models
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Tác giả
Zhengliang Lu, Yanan Lu, Xin Sun, Chunhua Fan, ... Liying Gao.
22. Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors
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Tác giả
Niccolò Chiaramonte, Silvia Bua, Andrea Angeli, Marta Ferraroni, ... Maria Novella Romanelli.
22. Ultrasound-assisted synthesis of novel chalcone, heterochalcone and bis-chalcone derivatives and the evaluation of their antioxidant properties and as acetylcholinesterase inhibitors
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Tác giả
Efraín Polo, Nicol Ibarra-Arellano, Luis Prent-Peñaloza, Alejandro Morales-Bayuelo, ... Margarita Gutiérrez.
22. Structure-based design and synthesis of new 4-methylcoumarin-based lignans as pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) inhibitors
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Tác giả
S. Santhosh Kumar, Ahil Sajeli Begum, Kirti Hira, Sarfaraj Niazi, ... Yoshinori Fujimoto.
22. Design, synthesis, anticancer evaluation, molecular docking and cell cycle analysis of 3-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidine derivatives as potent histone lysine demethylases (KDM) inhibitors and apoptosis inducers
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Tác giả
Nadia Hanafy Metwally, Mona Said Mohamed, Eman Ali Ragb.
22. Development of a versatile DNMT and HDAC inhibitor C02S modulating multiple cancer hallmarks for breast cancer therapy
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Tác giả
Zigao Yuan, Shaopeng Chen, Chunmei Gao, Qiuzi Dai, ... Yuyang Jiang.
22. Cordatols A–D, four new anti-inflammatory bis-monoterpenoids from Illigera cordata
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Tác giả
Min Zhou, Ruiqi Zhang, Xiaoli Zeng, Shengyong Zhang, ... Xiangzhong Huang.
22. Exploring the antimalarial potential of the methoxy-thiazinoquinone scaffold: Identification of a new lead candidate
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Tác giả
Concetta Imperatore, Marco Persico, Maria Senese, Anna Aiello, ... Marialuisa Menna.
22. Evaluation of blood-brain barrier penetration and examination of binding to human serum albumin of 7-O-arylpiperazinylcoumarins as potential antipsychotic agents
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Tác giả
Teresa Żołek, Orsolya Dömötör, Kinga Ostrowska, Éva A. Enyedy, Dorota Maciejewska.
22. Understanding the cytotoxic effects of new isovanillin derivatives through phospholipid Langmuir monolayers
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Tác giả
Ana C. de Carvalho, Natália Girola, Carlos R. de Figueiredo, André C. Machado, ... Thiago A.M. Veiga.
22. Design and development of novel p-aminobenzoic acid derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer’s disease
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Tác giả
Sushant K. Shrivastava, Saurabh K. Sinha, Pavan Srivastava, Prabhash N. Tripathi, ... Rakesh K. Srivastava.
23. Chiral resolution of a caged xanthone and evaluation across a broad spectrum of breast cancer subtypes
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Tác giả
Oraphin Chantarasriwong, Tanis J. Dorwart, Theodore Habarth Morales, Stephanie F. Maggio, ... Emmanuel A. Theodorakis.
23. Discovery of indoline derivatives that inhibit esophageal squamous cell carcinoma growth by Noxa mediated apoptosis
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Tác giả
Dong-Jun Fu, Miaomiao Li, Sai-Yang Zhang, Jiang-Feng Li, ... Tao Hu.
23. Thiohydantoin derivatives incorporating a pyrazole core: Design, synthesis and biological evaluation as dual inhibitors of topoisomerase-I and cycloxygenase-2 with anti-cancer and anti-inflammatory activities
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Tác giả
Khaled R.A. Abdellatif, Wael A.A. Fadaly, Yaser A. Mostafa, Dana M. Zaher, Hany A. Omar.
23. Synthesis, molecular docking and kinetic studies of novel quinolinyl based acyl thioureas as mushroom tyrosinase inhibitors and free radical scavengers
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Tác giả
Muhammad Naeem Mustafa, Aamer Saeed, Pervaiz Ali Channar, Fayaz Ali Larik, ... Sung-Yum Seo.
23. Biosynthesized silver nanoparticles for inhibition of antibacterial resistance and biofilm formation of methicillin-resistant coagulase negative Staphylococci
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Tác giả
Govindan Rajivgandhi, Muthuchamy Maruthupandy, Thillaichidambaram Muneeswaran, Muthusamy Anand, ... Wen-Jun Li.
23. Synthesis and molecular docking study of some 3,4-dihydrothieno[2,3-d]pyrimidine derivatives as potential antimicrobial agents
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Tác giả
Omaima G. Shaaban, Doaa A.E. Issa, Alaa A. El-Tombary, Shrouk M. Abd El Wahab, ... Ibrahim A. Abdelwahab.
23. Rhamnolipid inspired lipopeptides effective in preventing adhesion and biofilm formation of Candida albicans
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Tác giả
Milos Jovanovic, Jelena Radivojevic, Kevin O'Connor, Stevan Blagojevic, ... Vladimir Savic.
23. Natural product inspired allicin analogs as novel anti-cancer agents
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Tác giả
Ishani Bhaumik, Kunal Pal, Utsab Debnath, Parimal Karmakar, ... Anup Kumar Misra.
23. Synthesis, anticancer effect and molecular modeling of new thiazolylpyrazolyl coumarin derivatives targeting VEGFR-2 kinase and inducing cell cycle arrest and apoptosis
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Tác giả
Tahia K. Mohamed, Rasha Z. Batran, Samia A. Elseginy, Mamdouh M. Ali, Abeer E. Mahmoud.
23. Synthesis and biological evaluation of 7-(aminoalkyl)pyrazolo[1,5-a]pyrimidine derivatives as cathepsin K inhibitors
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Tác giả
Nejc Petek, Bogdan Štefane, Marko Novinec, Jurij Svete.
23. A novel bi-functional chalcone inhibits multi-drug resistant Staphylococcus aureus and potentiates the activity of fluoroquinolones
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Tác giả
Vivek Kumar Gupta, Rashmi Gaur, Atin Sharma, Jawed Akther, ... Ranjana Pathania.
23. Antimicrobial and antibiofilm activity of polyurethane/Hypericum perforatum extract (PHPE) composite
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Tác giả
Okay Nazlı, Tuba Baygar, Çiğdem Elif Demirci Dönmez, Özcan Dere, ... Selçuk Aktürk.
24. Design, synthesis and biological evaluation of flexible and rigid analogs of 4H-1,2,4-triazoles bearing 3,4,5-trimethoxyphenyl moiety as new antiproliferative agents
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Tác giả
Mahsa Ansari, Mohammad Shokrzadeh, Saeed Karima, Shima Rajaei, ... Saeed Emami.
24. Pyrazole[3,4-d]pyridazine derivatives: Molecular docking and explore of acetylcholinesterase and carbonic anhydrase enzymes inhibitors as anticholinergics potentials
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Tác giả
Parham Taslimi, Fikret Türkan, Adnan Cetin, Hakan Burhan, ... Fatih Şen.
24. Novel 2-aminopyridine liganded Pd(II) N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure and bioactivity properties
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Tác giả
Fatoş Erdemir, Duygu Barut Celepci, Aydın Aktaş, Yetkin Gök, ... İlhami Gulçin.
24. Synthesis, modeling and biological evaluation of some pyrazolo[3,4-d]pyrimidinones and pyrazolo[4,3-e][1,2,4]triazolo[4,3-a]pyrimidinones as anti-inflammatory agents
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Tác giả
Gina N. Tageldin, Tamer M. Ibrahim, Salwa M. Fahmy, Hayam M. Ashour, ... Ibrahim M. Labouta.
24. Synthesis of 1-benzyl-1H-benzimidazoles as galectin-1 mediated anticancer agents
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Tác giả
Nerella Sridhar Goud, S. Mahammad Ghouse, Jatoth Vishnu, D. Komal, ... Mallika Alvala.
24. Isolation, identification, and quantification of Pentylcurcumene from Geophila repens: A new class of cholinesterase inhibitor for Alzheimer’s disease
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Tác giả
Umesh Chandra Dash, Satish Kanhar, Anshuman Dixit, Jagnehswar Dandapat, Atish Kumar Sahoo.
24. Nitrogen-containing derivatives of O-tetramethylquercetin: Synthesis and biological profiles in prostate cancer cell models
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Tác giả
Pravien Rajaram, Ziran Jiang, Guanglin Chen, Alyssa Rivera, ... Qiao-Hong Chen.
24. Synthesis of water soluble pentacyclic dihydroxyterpene carboxylic acid derivatives coupled amino acids and their inhibition activities on α-glucosidase
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Tác giả
Zhen Zeng, Xiaoli Yin, Xueyuan Wang, Wuying Yang, ... Yanping Hong.
24. Lanceoleins A–G, hydroxychalcones, from the flowers of Coreopsis lanceolata and their chemopreventive effects against human colon cancer cells
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Tác giả
Hyoung-Geun Kim, Hyun-Ji Oh, Jung-Hwan Ko, Hae Seong Song, ... Nam-In Baek.
24. Discovery of a novel cathepsin inhibitor with dual autophagy-inducing and metastasis-inhibiting effects on breast cancer cells
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Tác giả
Lei Yuan, Jun Liu, Wenhui He, Youmei Bao, ... Enlong Ma.
24. Synthesis and 2D-QSAR study of dispiropyrrolodinyl-oxindole based alkaloids as cholinesterase inhibitors
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Tác giả
Aladdin M. Srour, Dina H. Dawood, Mohammed N.A. Khalil, Zienab M. Nofal.
24. Rationally designed molecules for resurgence of cyanide mitigated cytochrome c oxidase activity
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Tác giả
Harpreet Kaur, Palwinder Singh.
25. Microwave synthesis of novel halogenated β-enaminonitriles linked 9-bromo-1H-benzo[f]chromene moieties: Induces cell cycle arrest and apoptosis in human cancer cells via dual inhibition of topoisomerase I and II
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Tác giả
Ahmed M. Fouda, Mohammed A. Assiri, Ahmed Mora, Tarik E. Ali, ... Ahmed M. El-Agrody.
25. Coumarin tethered cyclic imides as efficacious glucose uptake agents and investigation of hit candidate to probe its binding mechanism with human serum albumin
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Tác giả
Dinesh S. Reddy, Manasa Kongot, Vishal Singh, Neha Maurya, ... Amit Kumar.
25. Synthesis, physicochemical and biological evaluation of tacrine derivative labeled with technetium-99m and gallium-68 as a prospective diagnostic tool for early diagnosis of Alzheimer’s disease
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Tác giả
Ewa Gniazdowska, Przemysław Koźmiński, Paweł Halik, Marek Bajda, ... Paweł Szymański.
25. New potent antifungal triazole alcohols containing N-benzylpiperazine carbodithioate moiety: Synthesis, in vitro evaluation and in silico study
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Tác giả
Yaser Mahmoudi, Hamid Badali, Seyedeh Mahdieh Hashemi, Mahsa Ansari, ... Saeed Emami.
25. Design, synthesis, in vivo, and in silico evaluation of new coumarin-1,2,4-oxadiazole hybrids as anticonvulsant agents
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Tác giả
Maryam Mohammadi-Khanaposhtani, Nematollah Ahangar, Sepideh Sobhani, Patrick Honarchian Masihi, ... Tahmineh Akbarzadeh.
25. Phenanthroimidazole derivatives act as potent inducer of autophagy by activating DNA damage pathway
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Tác giả
Hao Zhang, Yue Song, Li Li, Shuang-Yan Zhang, ... Xi-Cheng Wang.
25. Structure-based design, synthesis and biological evaluation of a newer series of pyrazolo[1,5-a]pyrimidine analogues as potential anti-tubercular agents
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Tác giả
Palmi Modi, Shivani Patel, Mahesh Chhabria.
25. Synthesis and bioevaluation of 6-chloropyridazin-3-yl hydrazones and 6-chloro-3-substituted-[1,2,4]triazolo[4,3-b]pyridazines as cytotoxic agents
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Tác giả
Mamta, Ranjana Aggarwal, Rachna Sadana, Jeziel Ilag, Garima Sumran.
25. Targeting microbial resistance: Synthesis, antibacterial evaluation, DNA binding and modeling study of new chalcone-based dithiocarbamate derivatives
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Tác giả
Marwa Ayman, Shahenda M. El-Messery, Elsayed E. Habib, Sara T. Al-Rashood, ... Ghada S. Hassan.
25. TDP-43 specific reduction induced by Di-hydrophobic tags conjugated peptides
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Tác giả
Na Gao, Yun-Peng Huang, Ting-Ting Chu, Qian-Qian Li, ... Yan-Mei Li.
25. Carbazole and hydrazone derivatives as new competitive inhibitors of tyrosinase: Experimental clues to binuclear copper active site binding
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Tác giả
Usman Ghani.
25. In vitro biological evaluation and molecular docking studies of natural and semisynthetic flavones from Gardenia oudiepe (Rubiaceae) as tyrosinase inhibitors
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Tác giả
M.D. Santi, C. Bouzidi, N.S. Gorod, M. Puiatti, ... M.G. Ortega.
26. Design, synthesis and evaluation of some 1,6-disubstituted-1H-benzo[d]imidazoles derivatives targeted PI3K as anticancer agents
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Tác giả
Huai-Wei Ding, Lu Yu, Meng-xuan Bai, Xiao-Chun Qin, ... Qing-Chun Zhao.
26. Synthesis of d-desthiobiotin-AI-2 as a novel chemical probe for autoinducer-2 quorum sensing receptors
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Tác giả
Vanessa Miranda, Inês M. Torcato, Karina B. Xavier, M. Rita Ventura.
26. Design, synthesis and biological evaluation of trinary benzocoumarin-thiazoles-azomethines derivatives as effective and selective inhibitors of alkaline phosphatase
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Tác giả
Pervaiz Ali Channar, Hina Irum, Abid Mahmood, Ghulam Shabir, ... Jamshed Iqbal.
26. Antibacterial activity of 3,3′-dihydroxycurcumin (DHC) is associated with membrane perturbation
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Tác giả
Carlos R. Polaquini, Luana G. Morão, Ana C. Nazaré, Guilherme S. Torrezan, ... Luis O. Regasini.
26. Pharmacological investigation of quinoxaline-bisthiazoles as multitarget-directed ligands for the treatment of Alzheimer’s disease
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Tác giả
Sneha R. Sagar, Devendra Pratap Singh, Rajesh D. Das, Nirupa B. Panchal, ... Kamala K. Vasu.
26. Hypoglycemic activity and mechanism of the sulfated rhamnose polysaccharides chromium(III) complex in type 2 diabetic mice
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Tác giả
Han Ye, Zhaopeng Shen, Jiefen Cui, Yujie Zhu, ... Peng Wang.
26. Anticancer and DNA binding studies of potential amino acids based quinazolinone analogs: Synthesis, SAR and molecular docking
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Tác giả
K.P. Rakesh, H.K. Kumara, H.M. Manukumar, D. Channe Gowda.
26. Tyrosinase and α-glucosidase inhibitory potential of compounds isolated from Quercus coccifera bark: In vitro and in silico perspectives
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Tác giả
Suat Sari, Burak Barut, Arzu Özel, Ayşe Kuruüzüm-Uz, Didem Şöhretoğlu.
26. Design and synthesis of new phthalazine-based derivatives as potential EGFR inhibitors for the treatment of hepatocellular carcinoma
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Tác giả
Ahmed T.A. Boraei, Hanaa K. Ashour, El Sayed H. El Tamany, Nahla Abdelmoaty, ... Mohamed S. Gomaa.
26. Synthesis and anti-inflammatory activity of sulfonamides and carboxylates incorporating trimellitimides: Dual cyclooxygenase/carbonic anhydrase inhibitory actions
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Tác giả
Alaa A.-M. Abdel-Aziz, Andrea Angeli, Adel S. El-Azab, Mohammed E.A. Hammouda, ... Claudiu T. Supuran.
26. Synthesis and evaluation of an AZD2461 [18F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant
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Tác giả
Sean W. Reilly, Laura N. Puentes, Alexander Schmitz, Chia-Ju Hsieh, ... Robert H. Mach.
26. α-Sulfonamidophosphonates as new anti-mycobacterial chemotypes: Design, development of synthetic methodology, and biological evaluation
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Tác giả
Srikant Bhagat, Metheku Supriya, Satish Pathak, Dharmarajan Sriram, Asit K. Chakraborti.
27. Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma
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Tác giả
Wen-Jun Wei, Weiyan Qi, Xin-Mei Gao, Ke-Na Feng, ... Kun Gao.
27. The application of safe for humans and the environment Polyversum antifungal agent containing living cells of Pythium oligandrum for biotransformation of prochiral ketones
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Tác giả
Renata Kołodziejska, Renata Studzińska, Agnieszka Tafelska-Kaczmarek, Hanna Pawluk, ... Alina Woźniak.
27. Designing of promising medicinal scaffolds for Alzheimer’s disease through enzyme inhibition, lead optimization, molecular docking and dynamic simulation approaches
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Tác giả
Mubashir Hassan, Muhammad Athar Abbasi, Aziz-ur-Rehman, Sabahat Zahra Siddiqui, ... Arif Malik.
27. A competent synthesis and efficient anti-inflammatory responses of isatinimino acridinedione moiety via suppression of in vivo NF-κB, COX-2 and iNOS signaling
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Tác giả
Govindasami Periyasami, Paulrayer Antonisamy, Karthikeyan Perumal, Antony Stalin, ... Asma A. Alothman.
27. Design, synthesis and biological activity of novel tacrine-isatin Schiff base hybrid derivatives
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Tác giả
E. Riazimontazer, H. Sadeghpour, H. Nadri, A. Sakhteman, ... N. Edraki.
27. Discovery and development of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as Bcl-2/Mcl-1 inhibitors
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Tác giả
Renshuai Liu, Lulu Liu, Xinying Yang, Hao Fang.
27. Characterization, quantitation, similarity evaluation and combination with Na+,K+-ATPase of cardiac glycosides from Streblus asper
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Tác giả
Yidan Bai, Wanfang Zhu, Yunhui Xu, Zijian Xie, ... Jie Zhang.
27. Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes
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Tác giả
Kaan Kucukoglu, Halise Inci Gul, Parham Taslimi, Ilhami Gulcin, Claudiu T. Supuran.
27. Synthesis and biological evaluation of some novel thiobenzimidazole derivatives as anti-renal cancer agents through inhibition of c-MET kinase
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Tác giả
Hany S. Ibrahim, Mohamed E. Albakri, Walaa R. Mahmoud, Heba Abdelrasheed Allam, ... Hatem A. Abdel-Aziz.
27. Phenylpropanoids and lignans from Prunus tomentosa seeds as efficient β-amyloid (Aβ) aggregation inhibitors
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Tác giả
Qingbo Liu, Jie Wang, Bin Lin, Zhuo-Yang Cheng, ... Shao-Jiang Song.
27. New benzimidazothiazole derivatives as anti-inflammatory, antitumor active agents: Synthesis, in-vitro and in-vivo screening and molecular modeling studies
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Tác giả
Mohamed M. El-Kerdawy, Mariam A. Ghaly, Sara A. Darwish, Hatem A. Abdel-Aziz, ... Ghada S. Hassan.
27. Schiff bases of tryptamine as potent inhibitors of nucleoside triphosphate diphosphohydrolases (NTPDases): Structure-activity relationship
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Tác giả
Kanwal, Khalid Mohammed Khan, Uzma Salar, Saira Afzal, ... Jamshed Iqbal.
28. Ebselen bearing polar functionality: Identification of potent antibacterial agents against multidrug-resistant Gram-negative bacteria
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Tác giả
Cheng Chen, Kewu Yang.
28. Synthesis, in-vitro cholinesterase inhibition, in-vivo anticonvulsant activity and in-silico exploration of N-(4-methylpyridin-2-yl)thiophene-2-carboxamide analogs
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Tác giả
Gulraiz Ahmad, Nasir Rasool, Komal Rizwan, Imran Imran, ... Umer Rashid.
28. Water soluble thioglycosylated BODIPYs for mitochondria targeted cytotoxicity
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Tác giả
Praseetha E. Kesavan, Vijayalakshmi Pandey, Md Kausar Raza, Shigeki Mori, Iti Gupta.
28. One-step synthesis of methylene-bridged bis-carbazole and evaluation of its antitumor activity and G-quadruplex DNA binding property
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Tác giả
Gang Li, Haodong Tang, Chuanfeng Liu, Xiaoyu Liao, ... Peng Yang.
28. Synthesis, molecular properties, anti-inflammatory and anticancer activities of novel 3-hydroxyflavone derivatives
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Tác giả
Mansour Znati, Claire Bordes, Valérian Forquet, Pierre Lantéri, ... Jalloul Bouajila.
28. Synthesis and systemic toxicity assessment of quinine-triazole scaffold with antiprotozoal potency
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Tác giả
Adarsh Sahu, Ram Kishore Agrawal, RajKishor Pandey.
28. Interaction of C20-substituted derivative of pregnenolone acetate with copper (II) leads to ROS generation, DNA cleavage and apoptosis in cervical cancer cells: Therapeutic potential of copper chelation for cancer treatment
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Tác giả
Atif Zafar, Swarnendra Singh, Sabahuddin Ahmad, Saman Khan, ... Imrana Naseem.
28. Toward a treatment of diabesity: Rational design, synthesis and biological evaluation of benzene-sulfonamide derivatives as a new class of PTP-1B inhibitors
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Tác giả
Nagat Ghareb, Norhan M. El-Sayed, Reda Abdelhameed, Koji Yamada, Mohamed Saleh Elgawish.
28. O-linked melatonin dimers as bivalent ligands targeting dimeric melatonin receptors
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Tác giả
Angeliki Karamitri, Mirna S. Sadek, Anne-Sophie Journé, Florence Gbahou, ... Darius P. Zlotos.
28. 3D-QSAR assisted identification of FABP4 inhibitors: An effective scaffold hopping analysis/QSAR evaluation
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Tác giả
Giuseppe Floresta, Agostino Cilibrizzi, Vincenzo Abbate, Ambra Spampinato, ... Antonio Rescifina.
28. Novel nalidixic acid derivatives targeting topoisomerase II enzyme; Design, synthesis, anticancer activity and effect on cell cycle profile
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Tác giả
Omneya M. Khalil, Ehab M. Gedawy, Afaf A. El-Malah, Mina E. Adly.
28. Imidazole-pyrazole hybrids: Synthesis, characterization and in-vitro bioevaluation against α-glucosidase enzyme with molecular docking studies
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Tác giả
Faryal Chaudhry, Sadia Naureen, Muhammad Ashraf, Mariya Al-Rashida, ... Misbahul Ain Khan.
29. STAT3-inhibitory activity of sesquiterpenoids and diterpenoids from Curcuma phaeocaulis
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Tác giả
Hyun-Jae Jang, Hyung-Jin Lim, Eun-Jae Park, Seung-Jae Lee, ... Mun-Chual Rho.
29. Synthesis, anticancer activity and molecular docking studies on 1,2-diarylbenzimidazole analogues as anti-tubulin agents
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Ya-Liang Zhang, Rong Yang, Lin-Ying Xia, Ruo-Jun Man, ... Hai-Liang Zhu.
29. Tyrosol from marine Fungi, a novel Quorum sensing inhibitor against Chromobacterium violaceum and Pseudomonas aeruginosa
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Tác giả
Aiping Chang, Shiwei Sun, Li Li, Xiaoyun Dai, ... Hu Zhu.
29. Synthesis, anti-diabetic evaluation and molecular docking studies of 4-(1-aryl-1H-1, 2, 3-triazol-4-yl)-1,4-dihydropyridine derivatives as novel 11-β hydroxysteroid dehydrogenase-1 (11β-HSD1) inhibitors
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Tác giả
E. Praveenkumar, Nirmala Gurrapu, Prashanth Kumar Kolluri, Vishwanadham Yerragunta, ... N.J.P. Subhashini.
29. Strophasterols E and F: Rearranged ergostane-type sterols from Pleurotus eryngii
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Takashi Kikuchi, Maya Isobe, Sawako Uno, Yasuko In, ... Takeshi Yamada.
29. Design, synthesis and photoinduced DNA cleavage studies of [1,2,4]-triazolo[4,3-a]quinoxalin-4(5H)-ones
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Tác giả
Garima Sumran, Ranjana Aggarwal, Ashwani Mittal, Aviral Aggarwal, Amit Gupta.
29. Inhibition of biofilm formation, quorum sensing activity and molecular docking study of isolated 3, 5, 7-Trihydroxyflavone from Alstonia scholaris leaf against P.aeruginosa
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Tác giả
M. Abinaya, M. Gayathri.
29. Discovery of new organoselenium compounds as antileishmanial agents
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Tác giả
Abdul-Malek S. Al-Tamimi, Mikel Etxebeste-Mitxeltorena, Carmen Sanmartín, Antonio Jiménez-Ruiz, ... Claudiu T. Supuran.
29. Orobanone analogues from acid-promoted aromatization rearrangement of curcumol inhibit hypoxia-inducible factor-1 (HIF-1) in cell-based reporter assays
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Yue-qing Li, Guang-zhe Li, Yi Dong, Xu Ma, ... Wei-jie Zhao.
29. Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/β-catenin signalling pathway agonists
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Tác giả
Duo-zhi Chen, Bi-juan Yang, Xiao-li He, Shi-rui Fan, ... Xiao-jiang Hao.
29. Molecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors
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Tác giả
Zhi-Qiang Cheng, Kong-Kai Zhu, Juan Zhang, Jia-Li Song, ... Hua Zhang.
29. Bioactive scalemic caged xanthones from the leaves of Garcinia bracteata
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Bao-Jun Zhang, Wen-Wei Fu, Rong Wu, Jin-Ling Yang, ... Hong-Xi Xu.
30. Lyophilized extracts from vegetable flours as valuable alternatives to purified oxygenases for the synthesis of oxylipins
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Tác giả
Claudia Sanfilippo, Angela Paterna, Daniela M. Biondi, Angela Patti.
30. Design, synthesis, and molecular docking study of new piperazine derivative as potential antimicrobial agents
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Tác giả
Mahadev Patil, Anurag Noonikara Poyil, Shrinivas D. Joshi, Shivaputra A. Patil, ... Alejandro Bugarin.
30. Design, synthesis, biological and in silico evaluation of coumarin-hydrazone derivatives as tubulin targeted antiproliferative agents
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Pilli Govindaiah, Naresh Dumala, Irshad Mattan, Paramjit Grover, M. Jaya Prakash.
30. Discovery of aromatic amides with triazole-core as potent reversal agents against P-glycoprotein-mediated multidrug resistance
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Qianqian Qiu, Jilan Zhu, Qiutong Chen, Ziqian Jiang, ... Xiaojuan Xu.
30. Phototoxicity of 7-oxycoumarins with keratinocytes in culture
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Tác giả
Christophe Guillon, Yi-Hua Jan, Diane E. Heck, Thomas M. Mariano, ... Ned D. Heindel.
30. α-bisabolol β-D-fucopyranoside as a potential modulator of β-amyloid peptide induced neurotoxicity: An in vitro & in silico study
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Tác giả
Mahalingam Jeyakumar, Sethuraman Sathya, Soniya Gandhi, Prabhakarrao Tharra, ... Kasi Pandima Devi.
30. Synthesis, molecular docking studies, and antimicrobial evaluation of new structurally diverse ureas
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Tác giả
Mahadev Patil, Anurag Noonikara Poyil, Shrinivas D. Joshi, Shivaputra A. Patil, ... Alejandro Bugarin.
30. Targeting cyclic nucleotide phosphodiesterase 5 (PDE5) in brain: Toward the development of a PET radioligand labeled with fluorine-18
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Tác giả
Barbara Wenzel, Jianrong Liu, Sladjana Dukic-Stefanovic, Winnie Deuther-Conrad, ... Aurelie Maisonial-Besset.
30. The mechanism of interactions between flavan-3-ols against a-glucosidase and their in vivo antihyperglycemic effects
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Ling-Ling Zhang, Lin Han, Shi-Yi Yang, Xue-Mei Meng, ... Min Wang.
30. Artemisianins A-D, new stereoisomers of seco-guaianolide involved heterodimeric [4+2] adducts from Artemisia argyi induce apoptosis via enhancement of endoplasmic reticulum stress
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Tác giả
Gui-Min Xue, Dong-Rong Zhu, Chao Han, Xiao-Bing Wang, ... Ling-Yi Kong.
30. Synthesis, in vitro urease inhibition and molecular docking studies of some novel quinazolin-4(3H)-one derivatives containing triazole, thiadiazole and thiosemicarbazide functionalities
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Tác giả
Emre Menteşe, Gülay Akyüz, Mustafa Emirik, Nimet Baltaş.
30. NMR fragment-based screening for development of the CD44-binding small molecules
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Marcin Pustuła, Mirosława Czub, Beata Łabuzek, Ewa Surmiak, ... Tad A. Holak.
31. Oleanolic acid oxime derivatives and their conjugates with aspirin modulate the NF-κB-mediated transcription in HepG2 hepatoma cells
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Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Jarosław Paluszczak, Hanna Szaefer, ... Wanda Baer-Dubowska.
31. Design, synthesis and molecular docking of benzophenone conjugated with oxadiazole sulphur bridge pyrazole pharmacophores as anti inflammatory and analgesic agents
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Zabiulla, A.R. Gulnaz, Yasser Hussein Eissa Mohammed, Shaukath Ara Khanum.
31. Chemical constituents of the root bark of Ulmus davidiana var. japonica and their potential biological activities
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Hae Min So, Jae Sik Yu, Zarha Khan, Lalita Subedi, ... Ki Hyun Kim.
31. Extraction, isolation and in vitro evaluation of affinisine from Tabernaemontana catharinensis in human melanoma cells
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Tác giả
Pauline Fagundes Rosales, Adriana Gower, Martha Lucia Ruiz Benitez, Bruna Silveira Pacheco, ... Sidnei Moura.
31. Design, synthesis and molecular modeling studies of new series of s-triazine derivatives as antimicrobial agents against multi-drug resistant clinical isolates
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Nesreen Saied Haiba, Hosam H. Khalil, Mohamed Abdel Moniem, Marwa H. El-Wakil, ... Sherine Nabil Khattab.
31. Design, synthesis and molecular docking of new N-4-piperazinyl ciprofloxacin-triazole hybrids with potential antimicrobial activity
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Tác giả
Hamada H.H. Mohammed, El-Shimaa M.N. Abdelhafez, Samar H. Abbas, Gamal A.I. Moustafa, ... Gamal El-Din A. Abuo-Rahma.
31. Bioassay-guided isolation of antioxidant and α-glucosidase inhibitory constituents from stem of Vigna angularis
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Feng Guo, Shuoyang Zhang, Xiuying Yan, Yuhan Dan, ... Zhiguo Yu.
31. Sesquiterpenoids from the roots of Inula helenium inhibit acute myelogenous leukemia progenitor cells
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Yahui Ding, Wenwei Pan, Junqing Xu, Tianpeng Wang, ... Quan Zhang.
31. Design, synthesis, biological evaluation and molecular modelling studies of indole glyoxylamides as a new class of potential pancreatic lipase inhibitors
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S.N.C. Sridhar, Saksham Palawat, Atish T. Paul.
31. Synthesis, molecular docking and cholinesterase inhibitory activity of hydroxylated 2-phenylbenzofuran derivatives
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Antonella Fais, Amit Kumar, Rosaria Medda, Francesca Pintus, ... Giovanna L. Delogu.
31. Novel tacrine-coumarin hybrids linked to 1,2,3-triazole as anti-Alzheimer’s compounds: In vitro and in vivo biological evaluation and docking study
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Zahra Najafi, Mohammad Mahdavi, Mina Saeedi, Elahe Karimpour-Razkenari, ... Tahmineh Akbarzadeh.
31. Design, synthesis and biological evaluation of fused naphthofuro[3,2-c] quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma
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Ashraf A. Aly, Essmat M. El-Sheref, Momtaz E.M. Bakheet, Mai A.E. Mourad, ... Tamer S. Kaoud.
32. Synthesis, characterization, anti-proliferative properties and DNA binding of benzochromene derivatives: Increased Bax/Bcl-2 ratio and caspase-dependent apoptosis in colorectal cancer cell line
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Mina Hanifeh Ahagh, Gholamreza Dehghan, Maryam Mehdipour, Reza Teimuri-Mofrad, ... Milad Asadi.
32. Synthesis and comparative carbonic anhydrase inhibition of new Schiff’s bases incorporating benzenesulfonamide, methanesulfonamide, and methylsulfonylbenzene scaffolds
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Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, ... Claudiu T. Supuran.
32. Design, synthesis and biological evaluation of 4-aminoquinoline-guanylthiourea derivatives as antimalarial agents
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Tác giả
Shweta Bhagat, Minhajul Arfeen, Gourav Das, Mridula Ramkumar, ... Prasad V. Bharatam.
32. Human neutrophil elastase (HNE) inhibitory polyprenylated acylphloroglucinols from the flowers of Hypericum ascyron
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Zuo Peng Li, Jeong Yoon Kim, Yeong Jun Ban, Ki Hun Park.
32. Synthesis and biological evaluation of aryl phosphoramidate prodrugs of fosfoxacin and its derivatives
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Mathilde Munier, Denis Tritsch, Didier Lièvremont, Michel Rohmer, Catherine Grosdemange-Billiard.
32. Fluoro-benzimidazole derivatives to cure Alzheimer’s disease: In-silico studies, synthesis, structure-activity relationship and in vivo evaluation for β secretase enzyme inhibition
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Tác giả
Sayyad Ali, Muhammad Hassham Hassan Bin Asad, Soham Maity, Wahid Zada, ... Izhar Hussain.
32. Sulfenamide derivatives can improve transporter-mediated cellular uptake of metformin and induce cytotoxicity in human breast adenocarcinoma cell lines
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Magdalena Markowicz-Piasecka, Johanna Huttunen, Joanna Sikora, Kristiina M. Huttunen.
32. Discovery of novel chalcone-dithiocarbamates as ROS-mediated apoptosis inducers by inhibiting catalase
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Dong-Jun Fu, Jia-Huan Li, Jia-Jia Yang, Ping Li, ... Sai-Yang Zhang.
32. Studies on lysozyme modifications induced by substituted p-benzoquinones
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Tác giả
Jisook Kim, Charles A. Thomas, Jacob M. Ewald, Neethu M. Kurien, ... Titus V. Albu.
32. New tirucallane triterpenoids from Picrasma quassioides with their potential antiproliferative activities on hepatoma cells
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Tác giả
Wen-Yu Zhao, Jing-Jie Chen, Chun-Xin Zou, Ying-Ying Zhang, ... Shao-Jiang Song.
32. Rhamnocitrin isolated from Prunus padus var. seoulensis: A potent and selective reversible inhibitor of human monoamine oxidase A
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Seung Cheol Baek, Mi Hyeon Park, Hyung Won Ryu, Jae Pil Lee, ... Hoon Kim.
32. Design, synthesis, anti-inflammatory, cytotoxic and cell based studies of some novel side chain analogues of myrrhanones A & B isolated from the gum resin of Commiphora mukul
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Tác giả
Uppuluri Venkata Mallavadhani, Madasu Chandrashekhar, Karri Shailaja, Sistla Ramakrishna.
33. Towards breast cancer targeting: Synthesis of tetrahydroindolocarbazoles, antibreast cancer evaluation, uPA inhibition, molecular genetic and molecular modelling studies
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Tác giả
Entesar M. Ahmed, Alaadin E. Sarhan, Dina H. El-Naggar, Reham R. Khattab, ... Mardia T. El Sayed.
33. Xanthones from the stems of Cudrania tricuspidata and their inhibitory effects on pancreatic lipase and fat accumulation
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Yang Hee Jo, Seon Beom Kim, Jong Hoon Ahn, Ayman Turk, ... Mi Kyeong Lee.
33. Arylboronate prodrugs of doxorubicin as promising chemotherapy for pancreatic cancer
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Charles Skarbek, Silvia Serra, Hichem Maslah, Estelle Rascol, Raphaël Labruère.
33. 6-Substituted purines as ROCK inhibitors with anti-metastatic activity
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Jiří Voller, Lenka Zahajská, Lucie Plíhalová, Jana Jeřábková, ... Miroslav Strnad.
33. Identification of 2(1H)-pyrimidinones as potential EGFR T790M inhibitors for the treatment of gefitinib-resistant non-small cell lung cancer
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Jianping Huang, Jiaxin Huang, Ning Wang, Luhong Wang, ... Xiaodong Ma.
33. Synthesis and biological evaluation of 3-functionalized 2-phenyl- and 2-alkylbenzo[b]furans as antiproliferative agents against human melanoma cell line
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Halina Kwiecień, Magdalena Perużyńska, Karolina Stachowicz, Katarzyna Piotrowska, ... Marek Droździk.
33. Synthesis of TPEN variants to improve cancer cells selective killing capacity
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Stephanie Schaefer-Ramadan, Maciej Barlog, Jim Roach, Mohammed Al-Hashimi, ... Khaled Machaca.
33. Anti-inflammatory drug approach: Synthesis and biological evaluation of novel pyrazolo[3,4-d]pyrimidine compounds
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Noor Atatreh, Amal M. Youssef, Mohammad A. Ghattas, Mohammad Al Sorkhy, ... Alaa S. Abd-El-Aziz.
33. Design, synthesis, molecular docking and biological activity evaluation of some novel indole derivatives as potent anticancer active agents and apoptosis inducers
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Ahmed M. Sh. El-Sharief, Yousry A. Ammar, Amany Belal, Marwa A.M. Sh. El-Sharief, ... Ahmed Ragab.
33. Synthesis and computer-aided analysis of the role of linker for novel ligands of the 5-HT6 serotonin receptor among substituted 1,3,5-triazinylpiperazines
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Dorota Łażewska, Rafał Kurczab, Małgorzata Więcek, Grzegorz Satała, ... Jadwiga Handzlik.
33. vChemical fabrication of graphene oxide nanosheets attenuates biofilm formation of human clinical pathogens
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Vaikundamoorthy Ramalingam, Sakthivel Raja, Subramaniam Sundaramahalingam, Rajendran Rajaram.
33. Pyranopyrazoles as efficient antimicrobial agents: Green, one pot and multicomponent approach
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Guda Mallikarjuna Reddy, Jarem Raul Garcia, Grigory V. Zyryanov, Gundala Sravya, Nemallapudi Bakthavatchala Reddy.
34. A structure-activity relationship study of Forkhead Domain Inhibitors (FDI): The importance of halogen binding interactions
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Seyed Amirhossein Tabatabaei Dakhili, David J. Pérez, Keshav Gopal, Seyed Yasin Tabatabaei Dakhili, ... Carlos A. Velázquez-Martínez.
34. Design and evaluation of non-carboxylate 5-arylidene-2-thioxo-4-imidazolidinones as novel non-competitive inhibitors of protein tyrosine phosphatase 1B
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Rosaria Ottanà, Paolo Paoli, Giulia Lori, Ilenia Adornato, ... Rosanna Maccari.
34. N-substituted noscapine derivatives as new antiprotozoal agents: Synthesis, antiparasitic activity and molecular docking study
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Kosar Babanezhad Harikandei, Peyman Salehi, Samad Nejad Ebrahimi, Morteza Bararjanian, ... Ahmed Al-Harrasi.
34. Muscle extract of Arothron immaculatus regulates the blood glucose level and the antioxidant system in high-fat diet and streptozotocin induced diabetic rats
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Karunanidhi Kaleshkumar, Rajendran Rajaram, Nambirajan Gayathri, Thilagar Sivasudha, ... Parasuraman Padmanabhan.
34. Synthesis and biological evaluation of bromophenol derivatives with cyclopropyl moiety: Ring opening of cyclopropane with monoester
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Murat Boztas, Parham Taslimi, Mirali Akbar Yavari, Ilhami Gulcin, ... Abdullah Menzek.
34. Synthesis of thymol-based pyrazolines: An effort to perceive novel potent-antimalarials
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Dushyant Singh Raghuvanshi, Narsingh Verma, Shiv Vardan Singh, Sonam Khare, ... Arvind Singh Negi.
34. Cytotoxic polyhydroxy serratene triterpenoids from Lycopodium complanatum
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Qiuzhu Dong, Zhenxing Zou, Xiaohui Jia, Xia Yu, ... Kangping Xu.
34. Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing
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Tác giả
Silvia Gobbi, Qingzhong Hu, Giacomo Foschi, Elena Catanzaro, ... Alessandra Bisi.
34. Synthesis of 1-(α-aminoalkyl)-2-naphthol and α-aminonitrile derivatives with molybdenum Schiff base complex covalently bonded on silica-coated magnetic nanoparticles and DNA interaction study of one type of derivatives using computational and spectroscopi
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Jamshid Rakhtshah, Behrouz Shaabani, Sadegh Salehzadeh, Neda Hosseinpour Moghadam.
34. Synthesis of 8-hydroxyquinoline glycoconjugates and preliminary assay of their β1,4-GalT inhibitory and anti-cancer properties
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Monika Krawczyk, Gabriela Pastuch-Gawolek, Anna Mrozek-Wilczkiewicz, Michal Kuczak, ... Robert Musiol.
34. Design, synthesis and bioevaluation of tricyclic fused ring system as dual binding site acetylcholinesterase inhibitors
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Tác giả
Saba Tahir Tanoli, Muhammad Ramzan, Abbas Hassan, Abdul Sadiq, ... Umer Rashid.
34. A deuterohemin peptide protects a transgenic Caenorhabditis elegans model of Alzheimer’s disease by inhibiting Aβ1–42 aggregation
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Jia Xu, Ye Yuan, Ruining Zhang, Yanhui Song, ... Liping Wang.
35. Extending the γ-class carbonic anhydrases inhibition profiles with phenolic compounds
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Alessio Nocentini, Sameh M. Osman, Sonia Del Prete, Clemente Capasso, ... Claudiu T. Supuran.
35. Chemical constituents from Alismatis Rhizoma and their anti-inflammatory activities in vitro and in vivo
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Tác giả
Shan-shan Liu, Wen-long Sheng, Yun Li, Shan-shan Zhang, ... Mei Zhang.
35. Mechanistic studies on Pyrobaculum calidifontis porphobilinogen synthase (5-aminolevulinic acid dehydratase)
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Tác giả
Naseema Azim, Qurratulann Afza Gardner, Naeem Rashid, Muhammad Akhtar.
35. Dihydrofolate reductase inhibition effect of 5-substituted pyrido[2,3-d]pyrimidines: Synthesis, antitumor activity and molecular modeling study
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Tác giả
Ola A. Abdelaziz, Walaa M. El Husseiny, Khalid B. Selim, Hassan M. Eisa.
35. A bright blue fluorescent dextran for two-photon in vivo imaging of blood vessels
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Tác giả
Seo Hyeon Lee, Young Ho Choe, Rae Hyung Kang, Yu Rim Kim, ... Dokyoung Kim.
35. Evaluation of thioamides, thiolactams and thioureas as hydrogen sulfide (H2S) donors for lowering blood pressure
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Tác giả
Ewelina Zaorska, Tomasz Hutsch, Marta Gawryś-Kopczyńska, Ryszard Ostaszewski, ... Dominik Koszelewski.
35. Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A1 and A2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells
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Tác giả
Matteo Falsini, Daniela Catarzi, Flavia Varano, Diego Dal Ben, ... Vittoria Colotta.
35. Discovery, synthesis and molecular corroborations of medicinally important novel pyrazoles; drug efficacy determinations through in silico, in vitro and cytotoxicity validations
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P. Thangarasu, A. Manikandan, S. Thamaraiselvi.
35. Synthesis, characterization, antioxidant power and acute toxicity of some new azo-benzamide and azo-imidazolone derivatives with in vivo and in vitro antimicrobial evaluation
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Mohammed Kareem Samad, Farouq Emam Hawaiz.
35. The synthesis and anticancer activities of chiral epoxy-substituted chromone analogs
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Hyunji Jo, Seung Hee Seo, Younghwa Na, Youngjoo Kwon.
35. Antileishmanial activity and ultrastructural changes of sesquiterpene lactones isolated from Calea pinnatifida (Asteraceae)
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Lhaís Araújo Caldas, Meire L. Yoshinaga, Marcelo J.P. Ferreira, João H.G. Lago, ... Patricia Sartorelli.
35. Design, synthesis, biological evaluation and dynamics simulation of indazole derivatives with antiangiogenic and antiproliferative anticancer activity
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Nevine M.Y. Elsayed, Rabah A.T. Serya, Mai F. Tolba, Marawan Ahmed, ... Khaled A.M. Abouzid.
36. New 4-N-phenylaminoquinoline derivatives as antioxidant, metal chelating and cholinesterase inhibitors for Alzheimer’s disease
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Tác giả
Rong Cai, Li-Ning Wang, Jing-Jing Fan, Shang-Qi Geng, Yu-Ming Liu.
36. Synthesis, biological evaluation and in silico modelling studies of 1,3,5-trisubstituted pyrazoles carrying benzenesulfonamide as potential anticancer agents and selective cancer-associated hCA IX isoenzyme inhibitors
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Cem Yamali, Halise Inci Gul, Abdulilah Ece, Silvia Bua, ... Claudiu T. Supuran.
36. Design, synthesis and biological evaluation of novel perimidine o-quinone derivatives as non-intercalative topoisomerase II catalytic inhibitors
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Du-Chao Zhou, Yu-Ting Lu, Yan-Wen Mai, Chen Zhang, ... Zhi-Shu Huang.
36. Synthesis and in vitro anti-tumor activity of carboranyl levodopa
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Yinghuai Zhu, Yongxiang Lin, Narayan S. Hosmane.
36. Design and development of 1,3,4-oxadiazole derivatives as potential inhibitors of acetylcholinesterase to ameliorate scopolamine-induced cognitive dysfunctions
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Tác giả
Puja Mishra, Piyoosh Sharma, Prabhash Nath Tripathi, Sukesh Kumar Gupta, ... Sushant Kumar Shrivastava.
36. Design, synthesis and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers
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Souad A. Elmetwally, Khaled F. Saied, Ibrahim H. Eissa, Eslam B. Elkaeed.
36. Design, synthesis and evaluation of chalcone Mannich base derivatives as multifunctional agents for the potential treatment of Alzheimer’s disease
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Xiaoyu Zhang, Qing Song, Zhongcheng Cao, Yan Li, ... Yong Deng.
36. Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors
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Tác giả
Fikret Turkan, Adnan Cetin, Parham Taslimi, Muhammet Karaman, İlhami Gulçin.
36. Novel hybrids of podophyllotoxin and formononetin inhibit the growth, migration and invasion of lung cancer cells
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Chengli Yang, Qiongli Xie, Xian Zeng, Nengyin Tao, ... Lei Zhang.
36. Combined molecular modeling and cholinesterase inhibition studies on some natural and semisynthetic O-alkylcoumarin derivatives
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Ilkay Erdogan Orhan, F. Sezer Senol Deniz, Ramin Ekhteiari Salmas, Serdar Durdagi, ... Serena Fiorito.
36. Design, synthesis and pharmacological evaluation of some substituted dihydropyrimidines with L-/T-type calcium channel blocking activities
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Mohamed Teleb, Ola H. Rizk, Fang-Xiong Zhang, Frank R. Fronczek, ... Hesham Fahmy.
36. New quinoline/chalcone hybrids as anti-cancer agents: Design, synthesis, and evaluations of cytotoxicity and PI3K inhibitory activity
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Samar H. Abbas, Amer Ali Abd El-Hafeez, Mai E. Shoman, Monica M. Montano, Heba A. Hassan.
37. Design, synthesis and biological evaluation of oxygenated chalcones as potent and selective MAO-B inhibitors
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Della Grace Thomas Parambi, Jong Min Oh, Seung Cheol Baek, Jae Pil Lee, ... Bijo Mathew.
37. Design, synthesis, in vitro evaluation, molecular docking and ADME properties studies of hybrid bis-coumarin with thiadiazole as a new inhibitor of Urease
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Tác giả
Munther Alomari, Muhammad Taha, Syahrul Imran, Waqas Jamil, ... Fazal Rahim.
37. A solid-phase method for synthesis of dimeric and trimeric ligands: Identification of potent bivalent ligands of 14-3-3σ
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Yeongju Lee, Brian Chung, Daseul Ko, Hyun-Suk Lim.
37. Development of pyrazole and spiropyrazoline analogs as multifunctional agents for treatment of Alzheimer’s disease
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Gopichand Gutti, Devendra Kumar, Pankaj Paliwal, Ankit Ganeshpurkar, ... Sushil Kumar Singh.
37. Design, synthesis and biological evaluation of pyrazolopyrimidinone based potent and selective PDE5 inhibitors for treatment of erectile dysfunction
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G. Lakshma Reddy, Mohd. Ishaq Dar, Abhinandan D. Hudwekar, Priya Mahajan, ... Sanghapal D. Sawant.
37. Synthesis and evaluation of redox-sensitive gonadotropin-releasing hormone receptor-targeting peptide conjugates
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Yuxuan Dai, Na Yue, Chunxia Liu, Xingguang Cai, ... Hai Qian.
37. Hyperpatulols A–I, spirocyclic acylphloroglucinol derivatives with anti-migration activities from the flowers of Hypericum patulum
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Yang-Yang Liu, Zhen Ao, Qi-Qi Xu, Dong-Rong Zhu, ... Ling-Yi Kong.
37. Purification and biochemical characterization of a novel copper, zinc superoxide dismutase from liver of camel (Camelus dromedarius): An antioxidant enzyme with unique properties
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Abdelbasset Chafik, Abdelkhalid Essamadi, Safinur Yildirim Çelik, Ahmet Mavi.
37. Novel lawsone-containing ruthenium(II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells
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Rone Aparecido De Grandis, Patrick Wellington da Silva dos Santos, Katia Mara de Oliveira, Ana Rita Tomazela Machado, ... Fernando Rogério Pavan.
37. Multi-target inhibitors against Alzheimer disease derived from 3-hydrazinyl 1,2,4-triazine scaffold containing pendant phenoxy methyl-1,2,3-triazole: Design, synthesis and biological evaluation
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Mahnaz Yazdani, Najmeh Edraki, Rashid Badri, Mehdi Khoshneviszadeh, ... Omidreza Firuzi.
37. Novel 4-(3-phenylpropionamido), 4-(2-phenoxyacetamido) and 4-(cinnamamido) substituted benzamides bearing the pyrazole or indazole nucleus: synthesis, biological evaluation and mechanism of action
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Demetrio Raffa, Antonella D'Anneo, Fabiana Plescia, Giuseppe Daidone, ... Benedetta Maggio.
37. Resistance modulatory and efflux-inhibitory activities of capsaicinoids and capsinoids
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Sandra Prasch, Alexandra G. Duran, Nuria Chinchilla, José M.G. Molinillo, ... Franz Bucar.
38. Novel triazole-tetrahydroisoquinoline hybrids as human aromatase inhibitors
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Chanamon Chamduang, Ratchanok Pingaew, Veda Prachayasittikul, Supaluk Prachayasittikul, ... Virapong Prachayasittikul.
38. Dual-targeting antitumor conjugates derived from platinum(IV) prodrugs and microtubule inhibitor CA-4 significantly exhibited potent ability to overcome cisplatin resistance
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Xiaochao Huang, Meng Wang, Chungu Wang, Weiwei Hu, ... Hengshan Wang.
38. Synthesis of novel methyl jasmonate derivatives and evaluation of their biological activity in various cancer cell lines
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Bilgesu Onur Sucu, Ozgecan Savlug Ipek, Sukran Ozdatli Kurtulus, Busra Emine Yazici, ... Mustafa Guzel.
38. Bioactive aporphine alkaloids from the stems of Dasymaschalon rostratum
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Zhangxin Yu, Changri Han, Xiaoping Song, Guangying Chen, Jinxiong Chen.
38. Cytotoxic diterpenoids as potential anticancer agents from the twigs of Casearia kurzii
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Feng Liu, Qi Zhang, Xueyuan Yang, Yaru Xi, ... Yuanqiang Guo.
38. Synthesis, antimicrobial, antioxidant, cytotoxic, antiurease and molecular docking studies of N-(3-trifluoromethyl)benzoyl-N′-aryl thiourea derivatives
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Aneela Maalik, Hina Rahim, Muhammad Saleem, Nighat Fatima, ... Amara Mumtaz.
38. NO inhibitory phytochemicals as potential anti-inflammatory agents from the twigs of Trigonostemon heterophyllus
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Yaru Xi, Lijun An, Xueyuan Yang, Ziteng Song, ... Yuanqiang Guo.
38. Design, synthesis and molecular docking of pyrazolo [3,4d] thiazole hybrids as potential anti-HIV-1 NNRT inhibitors
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H.M. Kasralikar, S.C. Jadhavar, S.V. Goswami, N.S. Kaminwar, S.R. Bhusare.
38. Click chemistry based multicomponent approach in the synthesis of spirochromenocarbazole tethered 1,2,3-triazoles as potential anticancer agents
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Pramod V. Chavan, Uday V. Desai, Prakash P. Wadgaonkar, Savita R Tapase, ... Dhiman Sarkar.
38. Xanthenone-based hydrazones as potent α-glucosidase inhibitors: Synthesis, solid state self-assembly and in silico studies
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Qamar-un-Nisa Tariq, Sana Malik, Ajmal Khan, Muhammad Moazzam Naseer, ... Zahid Shafiq.
38. Discovery of novel quinazolines as potential anti-tubulin agents occupying three zones of colchicine domain
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Wenlong Li, Ying Yin, Wen Shuai, Feijie Xu, ... Shengtao Xu.
38. New antibacterial and 5-lipoxygenase activities of synthetic benzyl phenyl ketones: Biological and docking studies
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Yesseny Vásquez-Martínez, Claudia Torrent, Giannina Toledo, Francisco Cabezas, ... Carolina Mascayano.
39. Inhibitory activity of Podospermum canum and its active components on collagenase, elastase and hyaluronidase enzymes
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Özlem Bahadır Acıkara, Mert Ilhan, Ekin Kurtul, Karel Šmejkal, Esra Küpeli Akkol.
39. Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates containing piperazine as inhibitors of PI3Kα
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Yong Yin, Yang Zhou, Shao Sha, Xun Wu, ... Hai-Liang Zhu.
39. Lysosome imaging in cancer cells by pyrene-benzothiazolium dyes: An alternative imaging approach for LAMP-1 expression based visualization methods to avoid background interference
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Chathura S. Abeywickrama, Kaveesha J. Wijesinghe, Robert V. Stahelin, Yi Pang.
39. Discovery of a novel DNA binding agent via design and synthesis of new thiazole hybrids and fused 1,2,4-triazines as potential antitumor agents: Computational, spectrometric and in silico studies
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Marwa H. El-Wakil, Amira F. El-Yazbi, Hayam M.A. Ashour, Mounir A. Khalil, ... Ibrahim M. Labouta.
39. Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II)
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Sarah D'Alessandro, Gloria Alfano, Luisa Di Cerbo, Simone Brogi, ... Stefania Butini.
39. Magmenthanes A-H: Eight new meroterpenoids from the bark of Magnolia officinalis var. Biloba
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Chuan Li, Chuang-Jun Li, Jie Ma, Ji-Wu Huang, ... Dong-Ming Zhang.
39. Design, synthesis, and carbonic anhydrase inhibition activity of benzenesulfonamide-linked novel pyrazoline derivatives
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Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Silvia Bua, Alessio Nocentini, ... Claudiu T. Supuran.
39. In vitro activity of steroidal dendrimers on Trypanosoma cruzi epimastigote form with PAMAM dendrons modified by “click” chemistry
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Laura Juárez-Chávez, Socorro Pina-Canseco, Delia Soto-Castro, Rosa Santillan, ... Eduardo Pérez-Campos.
39. Anti-enteroviral activity of new MDL-860 analogues: Synthesis, in vitro/in vivo studies and QSAR analysis
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Ivanka Nikolova, Ivaylo Slavchev, Martin Ravutsov, Miroslav Dangalov, ... Georgi M. Dobrikov.
39. Hydrolases-mediated transformation of oleuropein into demethyloleuropein
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Luca Cariati, Manuela Oliverio, Francesco G. Mutti, Sonia Bonacci, ... Antonio Procopio.
39. Design, synthesis and anti-Alzheimer’s activity of novel 1,2,3-triazole-chromenone carboxamide derivatives
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Arezoo Rastegari, Hamid Nadri, Mohammad Mahdavi, Alireza Moradi, ... Mina Saeedi.
39. Design, synthesis and anti-Alzheimer’s activity of novel 1,2,3-triazole-chromenone carboxamide derivatives
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Arezoo Rastegari, Hamid Nadri, Mohammad Mahdavi, Alireza Moradi, ... Mina Saeedi.
39. Synthesis, characterization, crystal structure of novel bis-thiomethylcyclohexanone derivatives and their inhibitory properties against some metabolic enzymes
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Abdullah Biçer, Parham Taslimi, Gül Yakalı, Ilhami Gülçin, ... Günseli Turgut Cin.
40. Design, synthesis, and anticancer activity of imidazo[2,1-b]oxazole-based RAF kinase inhibitors
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Mohammed S. Abdel-Maksoud, Usama M. Ammar, Mohammed I. El-Gamal, Mahmoud M. Gamal El-Din, ... Chang-Hyun Oh.
40. The modulating effect of lipid bilayer/p-coumaric acid interactions on electrical properties of model lipid membranes and human glioblastoma cells
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Monika Naumowicz, Magdalena Kusaczuk, Marcin Andrzej Kruszewski, Miroslav Gál, ... Joanna Kotyńska.
40. Ugi efficient synthesis, biological evaluation and molecular docking of coumarin-quinoline hybrids as apoptotic agents through mitochondria-related pathways
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Salman Taheri, Maryam Nazifi, Mahboubeh Mansourian, Leila Hosseinzadeh, Yalda Shokoohinia.
40. Search for multifunctional agents against Alzheimer’s disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives
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Jakub Jończyk, Krzysztof Lodarski, Marek Staszewski, Justyna Godyń, ... Marek Bajda.
40. Radical scavenging and anti-inflammatory activities of (hetero)arylethenesulfonyl fluorides: Synthesis and structure-activity relationship (SAR) and QSAR studies
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Ying Jiang, K.P. Rakesh, Njud S. Alharbi, H.K. Vivek, ... Hua-Li Qin.
40. Highly selective carbamate-based butyrylcholinesterase inhibitors derived from a naturally occurring pyranoisoflavone
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Chuanhai Wu, Yan-bei Tu, Ziyuan Li, Yan-fang Li.
40. Organometallic ruthenium(II)-arene complexes with triphenylphosphine amino acid bioconjugates: Synthesis, characterization and biological properties
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Margareta Pernar, Zoran Kokan, Juran Kralj, Zoran Glasovac, ... Srećko I. Kirin.
40. Synthesis and structure-activity relationship of tyrosinase inhibiting novel bi-heterocyclic acetamides: Mechanistic insights through enzyme inhibition, kinetics and computational studies
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Abdul Rehman Sadiq Butt, Muhammad Athar Abbasi, Aziz-ur-Rehman, Sabahat Zahra Siddiqui, ... Sung-Yum Seo.
40. Absolute configuration and anti-cancer effect of prenylated flavonoids and flavonostilbenes from Sophora pachycarpa: Possible involvement of Wnt signaling pathway
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Motahare Boozari, Samad Nejad Ebrahimi, Saba Soltani, Zahra Tayarani-Najaran, ... Mehrdad Iranshahi.
40. Design, synthesis and biological evaluation of novel indole derivatives as potential HDAC/BRD4 dual inhibitors and anti-leukemia agents
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Gaoliang Cheng, Zhi Wang, Jinyu Yang, Yu Bao, ... Dan Liu.
40. Synthesis, and anti-proliferative, Pim-1 kinase inhibitors and molecular docking of thiophenes derived from estrone
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Rafat M. Mohareb, Eman M. Samir, Peter A. Halim.
40. Side-chain cleaved phytoecdysteroid metabolites as activators of protein kinase B
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Halima Meriem Issaadi, József Csábi, Tusty-Jiuan Hsieh, Tamás Gáti, ... Attila Hunyadi.
41. Novel 2-arylbenzothiazole DNA gyrase inhibitors: Synthesis, antimicrobial evaluation, QSAR and molecular docking studies
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Iman A.Y. Ghannam, Eman A. Abd El-Meguid, Islam H. Ali, Donia H. Sheir, Ahmed M. El Kerdawy.
41. Design, synthesis and biological evaluation of theophylline containing variant acetylene derivatives as α-amylase inhibitors
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Radhakrishnam Raju Ruddarraju, Gangarapu Kiran, Adharvana Chari Murugulla, Ravichandar Maroju, ... Nukala Shravya Reddy.
41. Identification of novel peptidomimetics targeting the polo-box domain of polo-like kinase 1
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Zhiyan Li, Zhenguo Zhang, Huiyong Sun, Lili Xu, Cheng Jiang.
41. Design, synthesis and biological evaluation of novel thieno[3,2-d]pyrimidine and quinazoline derivatives as potent antitumor agents
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Hao Hu, Yuhong Dong, Ming Li, Ruxin Wang, ... Yanfang Zhao.
41. Design, synthesis, modeling studies and biological screening of novel pyrazole derivatives as potential analgesic and anti-inflammatory agents
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Azza T. Taher, Marwa T. Mostafa Sarg, Nermeen R. El-Sayed Ali, Noha Hilmy Elnagdi.
41. Design and synthesis of the novel oleanolic acid-cinnamic acid ester derivatives and glycyrrhetinic acid-cinnamic acid ester derivatives with cytotoxic properties
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Rui Wang, Wei Yang, Yiqing Fan, Wim Dehaen, ... Qiyong Huai.
41. Bioactive terpenoids from Euonymus verrucosus var. pauciflorus showing NO inhibitory activities
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Yuling Yang, Xueyuan Yang, Xuke Zhang, Ziteng Song, ... Yuanqiang Guo.
41. Investigation on the effect of alkyl chain linked mono-thioureas as Jack bean urease inhibitors, SAR, pharmacokinetics ADMET parameters and molecular docking studies
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Fayaz Ali Larik, Muhammad Faisal, Aamer Saeed, Pervaiz Ali Channar, ... Sung-Yum Seo.
41. Cell penetrable, clickable and tagless activity-based probe of human cathepsin L
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Dibyendu Dana, Jeremy Garcia, Ashif I. Bhuiyan, Pratikkumar Rathod, ... Sanjai K. Pathak.
41. N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines
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Jian Zhou, Arvind Negi, Styliana I. Mirallai, Rolf Warta, ... Paul V. Murphy.
41. Synthesis and carbonic anhydrase inhibitory properties of novel 4-(2-aminoethyl)benzenesulfonamide-dipeptide conjugates
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Hasan Küçükbay, Nesrin Buğday, F. Zehra Küçükbay, Emanuela Berrino, ... Claudiu T. Supuran.
41. 1,2,3-Triazole-based kojic acid analogs as potent tyrosinase inhibitors: Design, synthesis and biological evaluation
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Morteza Ashooriha, Mehdi Khoshneviszadeh, Mahsima Khoshneviszadeh, Seyed Ershad Moradi, ... Saeed Emami.
42. Critical evaluation of current Alzheimer’s drug discovery (2018–19) & futuristic Alzheimer drug model approach
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Tác giả
Atukuri Dorababu.
42. New series of fused pyrazolopyridines: Synthesis, molecular modeling, antimicrobial, antiquorum-sensing and antitumor activities
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N.S. El-Gohary, S.S. Hawas, M.T. Gabr, M.I. Shaaban, M.B. El-Ashmawy.
42. Synthesis, biological evaluation and molecular docking studies of bis-chalcone derivatives as xanthine oxidase inhibitors and anticancer agents
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Serdar Burmaoglu, Seyda Ozcan, Sevgi Balcioglu, Melis Gencel, ... Oztekin Algul.
42. 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORγt
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Chuyu Lao, Xiaoqing Zhou, Huanpeng Chen, Fengjiao Wei, ... Chuan Bai.
42. Synthesis, in vitro urease inhibitory potential and molecular docking study of Benzimidazole analogues
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Khalid Zaman, Fazal Rahim, Muhammad Taha, Hayat Ullah, ... Mohammed Gollapalli.
42. Discovery of Baicalin as NDM-1 inhibitor: Virtual screening, biological evaluation and molecular simulation
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Cheng Shi, Jingxiao Bao, Ying Sun, Xinyue Kang, ... Heng Zheng.
42. Design and synthesis of mono-and di-pyrazolyl-s-triazine derivatives, their anticancer profile in human cancer cell lines, and in vivo toxicity in zebrafish embryos
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Muhammad Farooq, Anamika Sharma, Zainab Almarhoon, Abudalla Al-Dhfyan, ... Fernando Albericio.
42. Synthesis, crystal structure and biological evaluation of new phosphoramide derivatives as urease inhibitors using docking, QSAR and kinetic studies
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Khodayar Gholivand, Mahsa Pooyan, Fahimeh Mohammadpanah, Foroogh Pirastefar, ... Ahmad Mani-Varnosfaderani.
42. Design, synthesis and biological study of hybrid drug candidates of nitric oxide releasing cucurbitacin-inspired estrone analogs for treatment of hepatocellular carcinoma
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Mahrous A. Abou-Salim, Mohamed A. Shaaban, Mohammed K. Abd El Hameid, Yaseen A.M.M. Elshaier, Fathi Halaweish.
42. Design and analysis of EphA2-SAM peptide ligands: A multi-disciplinary screening approach
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Flavia Anna Mercurio, Concetta Di Natale, Luciano Pirone, Daniela Marasco, ... Marilisa Leone.
42. Synthesis and biological evaluation of pyrano[4,3-b][1]benzopyranone derivatives as monoamine oxidase and cholinesterase inhibitors
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Koichi Takao, Yuka Kubota, Hitoshi Kamauchi, Yoshiaki Sugita.
42. Synthesis of new thiazolo-pyrrolidine–(spirooxindole) tethered to 3-acylindole as anticancer agents
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Mohammad Shahidul Islam, Hussien Mansur Ghawas, Fardous F. El-Senduny, Abdullah Mohammed Al-Majid, ... Assem Barakat.
43. Antibacterial, antifungal and antioxidant activity of total polyphenols of Withania frutescens.L
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Abdelfattah El Moussaoui, Fatima Zahra Jawhari, Ahmed M. Almehdi, Hicham Elmsellem, ... Amina Bari.
43. Design, synthesis and molecular docking of novel pyrazolo[1,5-a][1,3,5]triazine derivatives as CDK2 inhibitors
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Khulood H. Oudah, Mazin A.A. Najm, Nermin Samir, Rabah A.T. Serya, Khaled A.M Abouzid.
43. Synthesis, molecular docking analysis and carbonic anhydrase I-II inhibitory evaluation of new sulfonamide derivatives
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Tác giả
Begüm Nurpelin Sağlık, Ulviye Acar Çevik, Derya Osmaniye, Serkan Levent, ... Zafer Asım Kaplancıklı.
43. Novel 12-hydroxydehydroabietylamine derivatives act as potent and selective butyrylcholinesterase inhibitors
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Anne Loesche, Jana Wiemann, Matthias Rohmer, Wolfgang Brandt, René Csuk.
43. Novel chromanone-dithiocarbamate hybrids as multifunctional AChE inhibitors with β-amyloid anti-aggregation properties for the treatment of Alzheimer’s disease
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Neng Jiang, Jiaoli Ding, Jing Liu, Xiaona Sun, ... Sai-Sai Xie.
43. Synthesis, characterization, anticancer evaluation and mechanisms of cytotoxic activity of novel 3-hydroxy-3-pyrrolin-2-ones bearing thenoyl fragment: DNA, BSA interactions and molecular docking study
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Nenad Joksimović, Jelena Petronijević, Nenad Janković, Dejan Baskić, ... Zorica Bugarčić.
43. Meglumine as a green, efficient and reusable catalyst for synthesis and molecular docking studies of bis(indolyl)methanes as antioxidant agents
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Bakthavatchala Reddy Nemallapudi, Grigory V. Zyryanov, Balakrishna Avula, Mallikarjuna Reddy Guda, ... Sravya Gundala.
43. Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening
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Dan Zhang, Jie Han, Wenchao Lu, Fulin Lian, ... Cheng Luo.
43. Design, synthesis and evaluation of d-amino acid-containing peptidomimetics targeting the polo-box domain of polo-like kinase 1
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Tác giả
Zhiyan Li, Zhenguo Zhang, Yanhong Chen, Shijun Tang, ... Cheng Jiang.
43. Antiproliferative 3-deoxysphingomyelin analogs: Design, synthesis, biological evaluation and molecular docking of pyrrolidine-based 3-deoxysphingomyelin analogs as anticancer agents
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Tác giả
Ahmed H.E. Hassan, Hye Rim Park, Yoon Mi Yoon, Hye In Kim, ... Yong Sup Lee.
43. Design, synthesis, and biological activities of 1-aryl-(3-(2-styryl)phenyl)prop-2-en-1-ones
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Soon Young Shin, Junho Lee, Jihyun Park, Youngshim Lee, ... Yoongho Lim.
43. Dioximes: Synthesis and biomedical applications
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Tác giả
Mohamed A. Motaleb, Adli A. Selim.
44. Anti-viral activity of compounds from Agrimonia pilosa and Galla rhois extract mixture
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Jeong Eun Kwon, Yeong-Geun Lee, Ji-Hun Kang, Yun-Feng Bai, ... Se Chan Kang.
44. Anti-inflammatory flavonoids from root bark of Broussonetia papyrifera in LPS-stimulated RAW264.7 cells
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Hyung Won Ryu, Mi Hyeon Park, Ok-Kyoung Kwon, Doo-Young Kim, ... Sei-Ryang Oh.
44. Design, synthesis, anticancer evaluation and docking studies of new pyrimidine derivatives as potent thymidylate synthase inhibitors
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Lamia H.T. Amin, Taghreed Z. Shawer, Abeer M. El-Naggar, Hend M.A. El-Sehrawi.
44. DNA interaction and photodynamic antitumor activity of transition metal mono-hydroxyl corrole
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Yan-Mei Sun, Waseem Akram, Fan Cheng, Ze-Yu Liu, ... Hai-Yang Liu.
44. Discovery of novel (+)-Usnic acid derivatives as potential anti-leukemia agents with pan-Pim kinases inhibitory activity
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Shuxiang Wang, Jie Zang, Min Huang, Lihong Guan, ... Linxiang Zhao.
44. Natural urease inhibitors from Aloe vera resin and Lycium shawii and their structural-activity relationship and molecular docking study
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Najeeb Ur Rehman, Ajmal Khan, Ahmed Al-Harrasi, Mohammed Khiat, ... Muhammad Riaz.
44. Semi-synthetic isoflavones as BACE-1 inhibitors against Alzheimer’s disease
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Giovanni Ribaudo, Paolo Coghi, Enrico Zanforlin, Betty Yuen Kwan Law, ... Vincent Kam Wai Wong.
44. New bis-thioglycosyl-1,1′-disulfides from Nasturtium officinale R. Br. and their anti-neuroinflammatory effect
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Tae Hyun Lee, Zahra Khan, Lalita Subedi, Sun Yeou Kim, Kang Ro Lee.
44. Pyrazoles containing thiophene, thienopyrimidine and thienotriazolopyrimidine as COX-2 selective inhibitors: Design, synthesis, in vivo anti-inflammatory activity, docking and in silico chemo-informatic studies
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Tác giả
Mai S. El-Shoukrofy, Heba A. Abd El Razik, Omaima M. AboulWafa, Aida E. Bayad, Ibrahim M. El-Ashmawy.
44. Design, synthesis, DNA assessment and molecular docking study of novel 2-(pyridin-2-ylimino)thiazolidin-4-one derivatives as potent antifungal agents
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Nadia Hanafy Metwally, Ibrahim Taha Radwan, Walaa Salah El-Serwy, Mohamed Ahmed Mohamed.
44. Novel dauricine derivatives suppress cancer via autophagy-dependent cell death
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Tác giả
Xiaobo Zhou, Yuan Qing Qu, Zhiyuan Zheng, Betty Yuen Kwan Law, ... Li-Ping Bai.
44. Bioactivity-based analysis and chemical characterization of anti-inflammatory compounds from Curcuma zedoaria rhizomes using LPS-stimulated RAW264.7 cells
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Tae Kyoung Lee, Tuy An Trinh, Seoung Rak Lee, Sil Kim, ... Ki Hyun Kim.
45. Identification of lipid-like salicylic acid-based derivatives as potent and membrane-permeable PTP1B inhibitors
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Liang Li, Mojdeh S. Tavallaie, Fangzhou Xie, Yu Xia, ... Lei Fu.
45. Variedly connected 1,8-naphthalimide-7-chloroquinoline conjugates: Synthesis, anti-mycobacterial and cytotoxic evaluation
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Tác giả
Shalini, Matt D. Johansen, Laurent Kremer, Vipan Kumar.
45. Synthesis and biological evaluation of bergenin-1,2,3-triazole hybrids as novel class of anti-mitotic agents
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P. Pavan Kumar, Bandi Siva, Banoth Venkateswara Rao, G. Dileep Kumar, ... K. Suresh Babu.
45. The green synthesis and molecular docking of novel N-substituted rhodanines as effective inhibitors for carbonic anhydrase and acetylcholinesterase enzymes
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Sinan Bayindir, Cuneyt Caglayan, Muhammet Karaman, İlhami Gülcin.
45. An NIR emitting styryl dye with large Stokes shift to enable co-staining study on zebrafish neuromast hair cells
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Lucas McDonald, Dipendra Dahal, Michael Konopka, Qin Liu, Yi Pang.
45. Exploration of N-alkyl-2-[(4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydroquinazolin-2-yl)thio]acetamide derivatives as anticancer and radiosensitizing agents
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Tác giả
Aiten M. Soliman, Mostafa M. Ghorab.
45. Synthesis and biological evaluation of new bisindole-imidazopyridine hybrids as apoptosis inducers
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Tác giả
Satish Sunkari, Srinivasa Reddy Bonam, A.V. Subba Rao, Sd Riyaz, ... Bathini Nagendra Babu.
45. Design, synthesis and biological evaluation of (E)-5-styryl-1,2,4-oxadiazoles as anti-tubercular agents
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Abhay Atmaram Upare, Pradip K. Gadekar, H. Sivaramakrishnan, Nishigandha Naik, ... S. Mohana Roopan.
45. Cytotoxic clerodane diterpenoids from the leaves of Casearia kurzii
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Jun Ma, Xueyuan Yang, Qi Zhang, Xuke Zhang, ... Yuanqiang Guo.
45. Design, synthesis and biological evaluation of novel β-pinene-based thiazole derivatives as potential anticancer agents via mitochondrial-mediated apoptosis pathway
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Yunyun Wang, Chenliang Wu, Qiangjian Zhang, Yu Shan, ... Shifa Wang.
45. Introduction of Z-GP scaffold into procarbazine reduces spermatoxicity and myelosuppression
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Tác giả
Rikang Wang, Chao Zhang, Chaojun Zheng, Huilan Li, ... Heru Chen.
45. 3-Aminobenzenesulfonamides incorporating acylthiourea moieties selectively inhibit the tumor-associated carbonic anhydrase isoform IX over the off-target isoforms I, II and IV
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Tanzeela Abdul Fattah, Silvia Bua, Aamer Saeed, Ghulam Shabir, Claudiu T. Supuran.
46. Two new unsaturated fatty acids from the mangrove rhizosphere soil-derived fungus Penicillium javanicum HK1-22
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Zhao-Yang Liang, Nan-Xing Shen, Yao-Yao Zheng, Jin-Tao Wu, ... Chang-Yun Wang.
46. Tyrosinase inhibitory effects of Vinca major and its secondary metabolites: Enzyme kinetics and in silico inhibition model of the metabolites validated by pharmacophore modelling
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Suat Sari, Burak Barut, Arzu Özel, Didem Şöhretoğlu.
46. Antifungal activity and tautomeric cyclization equilibria of formylphenylboronic acids
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Tác giả
Krzysztof M. Borys, Dorota Wieczorek, Kamila Pecura, Jacek Lipok, Agnieszka Adamczyk-Woźniak.
46. Substituted phenyl[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetates/acetamides as alkaline phosphatase inhibitors: Synthesis, computational studies, enzyme inhibitory kinetics and DNA binding studies
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Tác giả
Zafar Iqbal, Zaman Ashraf, Mubashir Hassan, Qamar Abbas, Erum Jabeen.
46. Design, synthesis and anticervical cancer activity of new benzofuran–pyrazol-hydrazono- thiazolidin-4-one hybrids as potential EGFR inhibitors and apoptosis inducing agents
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Tác giả
Hebat-Allah S. Abbas, Somaia S. Abd El-Karim.
46. Design, synthesis and molecular docking of 1,4-benzodioxane thiazolidinedione piperazine derivatives as FabH inhibitors
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Tác giả
Juan Sun, Wen He, Han-Yu Liu, Jie Qin, Chun-Lin Ye.
46. Introduction of amino moiety enhances the inhibitory potency of 1-tetralone chalcone derivatives against LPS-stimulated reactive oxygen species production in RAW 264.7 macrophages
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Pramila Katila, Aastha Shrestha, Aarajana Shrestha, Ritina Shrestha, ... Eung-Seok Lee.
46. Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent
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Elena Catanzaro, Francesca Seghetti, Cinzia Calcabrini, Angela Rampa, ... Carmela Fimognari.
46. Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones
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Monica Demurtas, Anna Baldisserotto, Ilaria Lampronti, Davide Moi, ... Valentina Onnis.
46. Synthesis, ADME, docking studies and in vivo anti-hyperglycaemic potential estimation of novel Schiff base derivatives from octadec-9-enoic acid
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Garima Kapoor, Dharam Pal Pathak, Rubina Bhutani, Asif Husain, ... Md. Azhar Iqbal.
46. Neuroprotective effects of triterpenoid saponins from Medicago sativa L. against H2O2-induced oxidative stress in SH-SY5Y cells
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Xue-Gui Liu, Yu-Qiu Sun, Jun Bian, Ting Han, ... Pin-Yi Gao.
47. Phenylpropanoid and dibenzofuran derivatives from Crataegus pinnatifida with antiproliferative activities on hepatoma cells
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Peng Zhao, Rui Guo, Yang-Yang Zhang, Hao Zhang, ... Shao-Jiang Song.
47. Discovery and optimization of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one derivatives as mTORC1/mTORC2 dual inhibitors
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Shengquan Hu, Zhichang Zhao, Hong Yan.
47. Multi-target 1,4-dihydropyridines showing calcium channel blockade and antioxidant capacity for Alzheimer’s disease therapy
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Rim Malek, Maciej Maj, Artur Wnorowski, Krzysztof Jóźwiak, ... Lhassane Ismaili.
47. Synthesis and biological evaluation of some new mono Mannich bases with piperazines as possible anticancer agents and carbonic anhydrase inhibitors
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Mehtap Tugrak, Halise Inci Gul, Kenjiro Bandow, Hiroshi Sakagami, ... Claudiu T. Supuran.
47. Structural basis of the inhibition of GH1 β-glucosidases by multivalent pyrrolidine iminosugars
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Macarena Martínez-Bailén, Elena Jiménez-Ortega, Ana T. Carmona, Inmaculada Robina, ... Antonio J. Moreno-Vargas.
47. Excavating precursors from the traditional Chinese herb Polygala tenuifolia and Gastrodia elata: Synthesis, anticonvulsant activity evaluation of 3,4,5-trimethoxycinnamic acid (TMCA) ester derivatives
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Zefeng Zhao, Yajun Bai, Jing Xie, Xufei Chen, ... Xiaohui Zheng.
47. New benzyl pyridinium derivatives bearing 2,4-dioxochroman moiety as potent agents for treatment of Alzheimer’s disease: Design, synthesis, biological evaluation, and docking study
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Marjan Mollazadeh, Maryam Mohammadi-Khanaposhtani, Afsaneh Zonouzi, Hamid Nadri, ... Mohammad Mahdavi.
47. Oxidative functionalization of a halimane diterpenoid achieved by fungal transformation
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Afif Felix Monteiro, Gabriela Marinho Righetto, Laura Vilar Simões, Larissa Costa de Almeida, ... Ian Castro-Gamboa
47. Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies
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Bahaa G.M. Youssif, Mamdouh F.A. Mohamed, Mohammad M. Al-Sanea, Amr H. Moustafa, ... Hesham A.M. Gomaa.
47. Structure-activity relationship of pyrazolo pyrimidine derivatives as inhibitors of mitotic kinesin Eg5 and anticancer agents
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P. Muthuraja, V. Veeramani, S. Prakash, M. Himesh, ... P. Manisankar.
47. Assessment of novel azaanthraquinone derivatives as potent multi-target inhibitors of inflammation and amyloid-β aggregation in Alzheimer’s disease
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Juan Wang, Wei Li, Jingfang Qin, Li Wang, ... Huang Tang.
48. Burkholderia cepacia lipase immobilization for hydrolytic reactions and the kinetic resolution of the non-equimolar mixtures of isomeric alcohols
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Zofia Hrydziuszko, Daniel Jan Strub, Karolina Labus, Jolanta Bryjak.
48. Juniperanol: First total synthesis and evaluation in Type 2 Diabetes disease
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A. Carrër, S. Turban, N. Provost, A. Caliez, ... V. Michelet.
48. Searching new structural scaffolds for BRAF inhibitors. An integrative study using theoretical and experimental techniques
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Ludmila E. Campos, Francisco M. Garibotto, Emilio Angelina, Jiri Kos, ... Ricardo D. Enriz.
48. Triazole substituted metal-free, metallo-phthalocyanines and their water soluble derivatives as potential cholinesterases inhibitors: Design, synthesis and in vitro inhibition study
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Tayfun Arslan, Nezaket Çakır, Turgut Keleş, Zekeriya Biyiklioglu, Murat Senturk.
48. Potent inhibition of acetylcholinesterase by sargachromanol I from Sargassum siliquastrum and by selected natural compounds
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Jae Pil Lee, Myung-Gyun Kang, Joon Yeop Lee, Jong Min Oh, ... Hoon Kim.
48. Synthesis, computational molecular docking analysis and effectiveness on tyrosinase inhibition of kojic acid derivatives
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Tác giả
Gülşah Karakaya, Aslı Türe, Ayşe Ercan, Selin Öncül, Mutlu Dilsiz Aytemir.
48. Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators
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Damiano Tanini, Antonella Capperucci, Claudiu T. Supuran, Andrea Angeli.
48. Chlorinated tacrine analogs: Design, synthesis and biological evaluation of their anti-cholinesterase activity as potential treatment for Alzheimer’s disease
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Hanan.M. Ragab, Mohamed Teleb, Hassan R. Haidar, Noha Gouda.
48. Design, synthesis, and DNA interaction studies of furo-imidazo[3.3.3]propellane derivatives: Potential anticancer agents
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Alaa A. Hassan, Ashraf A. Aly, Nasr K. Mohamed, Kamal M. El Shaieb, ... Tamer S. Kaoud.
48. Bioactive butylphthalide derivatives from Ligusticum chuanxiong
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Xu Zhang, Zi-ming Feng, Ya-nan Yang, Jian-shuang Jiang, Pei-cheng Zhang.
48. Proliferation inhibition of novel diphenylamine derivatives
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Ladislav Janovec, Jana Janočková, Mária Matejová, Eva Konkoľová, ... Mária Kožurková.
49. Bioconversion of xylose to xylonic acid via co-immobilized dehydrogenases for conjunct cofactor regeneration
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Karolina Bachosz, Karol Synoradzki, Maciej Staszak, Manuel Pinelo, ... Teofil Jesionowski.
49. Exploring antidiabetic potential of adamantyl-thiosemicarbazones via aldose reductase (ALR2) inhibition
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Muhammad Tariq Shehzad, Abdul Hameed, Mariya al-Rashida, Aqeel Imran, ... Jamshed Iqbal.
49. Novel steroidal 1,3,4-thiadiazines: Synthesis and biological evaluation in androgen receptor-positive prostate cancer 22Rv1 cells
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Anna S. Komendantova, Alexander M. Scherbakov, Alexander V. Komkov, Viktoriya V. Chertkova, ... Igor V. Zavarzin.
49. Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity
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Wagdy M. Eldehna, Mohamed A. Abdelrahman, Alessio Nocentini, Silvia Bua, ... Claudiu T. Supuran.
49. N-aryl-N’-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties
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Murat Bozdag, Giulio Poli, Andrea Angeli, Elena Lucarini, ... Claudiu T. Supuran.
49. Multifunctional nanoparticles from albumin for stimuli-responsive efficient dual drug delivery
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Hamed Nosrati, Fatemeh Abhari, Jalil Charmi, Soodabeh Davaran, Hossein Danafar.
49. Natural product-based design, synthesis and biological evaluation of 2′,3,4,4′-tetrahydrochalcone analogues as antivitiligo agents
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Hui Zhong, Jia Zhou, Xiao-Hong An, Ying-Rong Hua, ... Jing Shang.
49. Discovery of the Biginelli hybrids as novel caspase-9 activators in apoptotic machines: Lipophilicity, molecular docking study, influence on angiogenesis gene and miR-21 expression levels
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Nenad Janković, Jovana Trifunović Ristovski, Milan Vraneš, Aleksandar Tot, ... Zorica Bugarčić.
49. Bio-guided search of active indole alkaloids from Tabernaemontana catharinensis: Antitumour activity, toxicity in silico and molecular modelling studies
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Pauline Fagundes Rosales, Flavio Ferreira Marinho, Adriana Gower, Marilda Chiarello, ... Sidnei Moura.
49. Synthesis and bioactivities of pyrazoline benzensulfonamides as carbonic anhydrase and acetylcholinesterase inhibitors with low cytotoxicity
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Dilan Ozmen Ozgun, Halise Inci Gul, Cem Yamali, Hiroshi Sakagami, ... Claudiu T. Supuran.
49. Potential bioisosteres of β-uracilalanines derived from 1H-1,2,3-triazole-C-carboxylic acids
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Ewa Mironiuk-Puchalska, Włodzimierz Buchowicz, Piotr Grześkowiak, Patrycja Wińska, ... Mariola Koszytkowska-Stawińska.
50. Regioselective O-glycosylation of flavonoids by fungi Beauveria bassiana, Absidia coerulea and Absidia glauca
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Sandra Sordon, Jarosław Popłoński, Tomasz Tronina, Ewa Huszcza.
50. Design, synthesis, and biological evaluation of novel dual FFA1 (GPR40)/PPARδ agonists as potential anti-diabetic agents
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Zheng Li, Lijun Hu, Xuekun Wang, Zongtao Zhou, ... Luyong Zhang.
50. Synthesis of 3-indolylmethyl substituted (pyrazolo/benzo)triazinone derivatives under Pd/Cu-catalysis: Identification of potent inhibitors of chorismate mutase (CM)
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Gangireddy Sujeevan Reddy, Ampalam Venkata Snehalatha, Rebecca Kristina Edwin, Kazi Amirul Hossain, ... Manojit Pal.
50. Demethylbellidifolin isolated from Swertia bimaculate against human carboxylesterase 2: Kinetics and interaction mechanism merged with docking simulations
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Tian-Tian Liu, Xiao-Kui Huo, Xiang-Ge Tian, Jia-Hao Liang, ... Xiao-Chi Ma.
50. Discovery of pyrazolopyrimidine derivatives as potent BTK inhibitors with effective anticancer activity in MCL
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Fansheng Ran, Yang Liu, Meixia Liu, Daoguang Zhang, ... Guisen Zhao.
50. New perspective on the metabolism of AD-1 in vivo: Characterization of a series of dammarane-type derivatives with novel metabolic sites and anticancer mechanisms of active oleanane-type metabolites
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Meng Ding, Xude Wang, Yumeng Zhang, Weihui Yuan, ... Yuqing Zhao.
50. Dual targeting of PTP1B and glucosidases with new bifunctional iminosugar inhibitors to address type 2 diabetes
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Xhenti Ferhati, Camilla Matassini, Maria Giulia Fabbrini, Andrea Goti, ... Paolo Paoli.
50. Ligand based design and synthesis of pyrazole based derivatives as selective COX-2 inhibitors
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Manikanta Murahari, Vivek Mahajan, Sreenivasulu Neeladri, Maushmi S. Kumar, Y.C. Mayur.
50. Piperazine-azole-fluoroquinolone hybrids: Conventional and microwave irradiated synthesis, biological activity screening and molecular docking studies
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Arif Mermer, Ozlem Faiz, Ahmet Demirbas, Neslihan Demirbas, ... Sivakumar Arumugam.
50. One-pot four-component synthesis of thiazolidin-2-imines using CuI/ZnII dual catalysis: A new class of acetylcholinesterase inhibitors
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Syeda Aaliya Shehzadi, Imtiaz Khan, Aamer Saeed, Fayaz Ali Larik, ... Sung-Yum Seo.
50. Design, synthesis and in vitro apoptotic mechanism of novel pyrrolopyrimidine derivatives
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Zühal Kilic-Kurt, Filiz Bakar-Ates, Yeliz Aka, Ozgur Kutuk.
51. First biological conversion of chiral heterophosphonate derivative – Scaling and paths of conversion discussion
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Ewa Żymańczyk-Duda, Natalia Dunal, Małgorzata Brzezińska-Rodak, Angelika Osiewała, ... Monika Serafin-Lewańczuk.
51. Effects of Picrasma quassioides and its active constituents on Alzheimer's disease in vitro and in vivo
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Eryan Guo, Yunwei Hu, Tao Du, Huilin Zhu, ... Jian Xu.
51. The novel economical synthesis and antimicrobial activity of a trithiocarbonate derivative
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Yahia N. Mabkhot, Jamal M.A. Khaled, Mujeeb A.S. Sultan, Naiyf S.H.A. Alharbi, ... H. Algarni.
51. Synthesis and anticancer activity of bis-benzo[d][1,3]dioxol-5-yl thiourea derivatives with molecular docking study
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Reem A.K. Al-Harbi, Marwa A.M.Sh. El-Sharief, Samir Y. Abbas.
51. Novel imidazo[2,1-b][1,3,4]thiadiazole (ITD) hybrid compounds: Design, synthesis, efficient antibacterial activity and antioxidant effects
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Ebru Taflan, Hacer Bayrak, Mehtap Er, Şengül Alpay Karaoğlu, Arif Bozdeveci.
51. Evaluation of cytotoxic activity and genotoxicity of structurally well characterized potent cobalt(II) phen–based antitumor drug entities: An in vitro and in vivo approach
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Huzaifa Yasir Khan, Mohd Owais Ansari, G.G.H.A. Shadab, Sartaj Tabassum, Farukh Arjmand.
51. Synthesis, evaluation and docking of novel pyrazolo pyrimidines as potent p38α MAP kinase inhibitors with improved anti-inflammatory, ulcerogenic and TNF-α inhibitory properties
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Kanagasabai Somakala, Sana Tariq, Mohd. Amir.
51. Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2–p53 interaction
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Assem Barakat, Mohammad Shahidul Islam, Hussien Mansur Ghawas, Abdullah Mohammed Al-Majid, ... Hazem A. Ghabbour.
51. Wedtrilosides A and B, two new diterpenoid glycosides from the leaves of Wedelia trilobata (L.) Hitchc. with α-amylase and α-glucosidase inhibitory activities
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Nguyen Thi Luyen, Pham Thanh Binh, Pham Thi Tham, Ta Manh Hung, ... Nguyen Phuong Thao.
51. Antibody recognition by a novel microgel photonic crystal
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Na Sai, Zhong Sun, Yuntang Wu, Guowei Huang.
51. Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors
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Kuang-Feng Chu, Jen-Shin Song, Chiung-Tong Chen, Teng-Kuang Yeh, ... Jinq-Chyi Lee.
52. A facile lipase-catalyzed KR approach toward enantiomerically enriched homopropargyl alcohols
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Paweł Borowiecki, Maciej Dranka.
52. First example of Azo-Sulfa conjugated chromene moieties: Synthesis, characterization, antimicrobial assessment, docking simulation as potent class I histone deacetylase inhibitors and antitumor agents
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Rawda M. Okasha, Mosa Alsehli, Saleh Ihmaid, Sultan S. Althagfan, ... Tarek H. Afifi.
52. Labeling of VEGFR1D2 through oxime ligation
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Lucia De Rosa, Rossella Di Stasi, Laura Longhitano, Luca Domenico D'Andrea.
52. Potential chemical transformation of phosphinic acid derivatives and their applications in the synthesis of drugs
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Moaz M. Abdou, Rasha A. El-Saeed.
52. Recent advancement in the discovery and development of COX-2 inhibitors: Insight into biological activities and SAR studies (2008–2019)
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Vrinda Sharma, Parth Bhatia, Ozair Alam, Mohd. Javed Naim, ... Mukund Jha.
52. Selective cyclooxygenase inhibition and ulcerogenic liability of some newly prepared anti-inflammatory agents having thiazolo[4,5-d]pyrimidine scaffold
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Rania B. Bakr, Amira A. Ghoneim, Amany A. Azouz.
52. Antiproliferative effect, cell cycle arrest and apoptosis generation of novel synthesized anticancer heterocyclic derivatives based 4H-benzo[h]chromene
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Fawzia F. Alblewi, Rawda M. Okasha, Zainab M. Hritani, Hany M. Mohamed, ... Ahmed M. El-Agrody.
52. Design, synthesis, and cytotoxicity screening of 5-aryl-3-(2-(pyrrolyl) thiophenyl)-1, 2, 4-oxadiazoles as potential antitumor molecules on breast cancer MCF-7 cells
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Mohammed K. Abd el hameid, Manal R. Mohammed.
52. A molecular hybrid producing simultaneously singlet oxygen and nitric oxide by single photon excitation with green light
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Cristina Parisi, Mariacristina Failla, Aurore Fraix, Antonio Rescifina, ... Salvatore Sortino.
52. Identification of osimertinib (AZD9291) as a lysine specific demethylase 1 inhibitor
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Zhong-Rui Li, Feng-Zhi Suo, Bo Hu, Yan-Jia Guo, ... Hong-Min Liu.
52. Synthesis and biological evaluation of new quinoline derivatives as antileishmanial and antitrypanosomal agents
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Santiago N. Chanquia, Facundo Larregui, Vanesa Puente, Carlos Labriola, ... Guadalupe García Liñares.
53. Fermentation parameters and conditions affecting levan production and its potential applications in cosmetics
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Marta Domżał-Kędzia, Agnieszka Lewińska, Anna Jaromin, Marek Weselski, ... Marcin Łukaszewicz.
53. Molecular interaction of manganese based carbon monoxide releasing molecule (MnCORM) with human serum albumin (HSA)
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Pitchavel Vidhyapriya, Dhanaraj Divya, Bala. Manimaran, Natarajan Sakthivel.
53. New classes of carbazoles as potential multi-functional anti-Alzheimer’s agents
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Niloufar Choubdar, Mostafa Golshani, Leili Jalili-Baleh, Hamid Nadri, ... Mehdi Khoobi.
53. The stilbene derivatives, nucleosides, and nucleosides modified by stilbene derivatives
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Hanna Krawczyk.
53. Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives
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Archana Kumari, Rajesh K. Singh.
53. Synthesis and evaluation of Quinoline-3-carbonitrile derivatives as potential antibacterial agents
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Salman A. Khan, Abdullah M. Asiri, Hadi Mussa Basisi, Mohammad Asad, ... Mohmmad Younus Wani.
53. Multi-target-directed triazole derivatives as promising agents for the treatment of Alzheimer’s disease
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Anupamjeet Kaur, Sukhmani Mann, Amandeep Kaur, Nitesh Priyadarshi, ... Deepti Goyal.
53. Synthesis of novel chalcones through palladium-catalyzed CO cross-coupling reaction of bromo-chalcones with ethyl acetohydroxamate and their antiplasmodial evaluation against Plasmodium falcipuram in vitro
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Reeta, Rajendran Vinoth, T.M. Rangarajan, Ayushee, ... Manjula Singh.
53. Radicicol rescues yeast cell death triggered by expression of human α-synuclein and its A53T mutant, but not by human βA4 peptide and proapoptotic protein bax
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Asma Derf, Shilpa A. Verekar, Shreyans K. Jain, Sunil K. Deshmukh, ... Bhabatosh Chaudhuri.
53. Nitric oxide inhibitory limonoids as potential anti-neuroinflammatory agents from Swietenia mahagoni
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Zhaoyu Shi, Lijun An, Xueyuan Yang, Yaru Xi, ... Yuanqiang Guo.
53. Synthesis and biological evaluation of 1-benzyl-N-(2-(phenylamino)pyridin-3-yl)-1H-1,2,3-triazole-4-carboxamides as antimitotic agents
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Budaganaboyina Prasad, V. Lakshma Nayak, P.S. Srikanth, Mirza Feroz Baig, ... Ahmed Kamal.
54. The possible mechanism of the formation of silver nanoparticles by Penicillium cyclopium
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Ewelina Wanarska, Irena Maliszewska.
54. Anti-cancer activity of the cell membrane-permeable phytic acid prodrug
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Takuya Masunaga, Naoki Murao, Hiroshi Tateishi, Ryoko Koga, ... Mikako Fujita.
54. Iizukines C−E from a saline soil fungus Aspergillus iizukae
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Hui-Hui Kang, Mei-Jia Zhong, Li-Ying Ma, Xian-Guo Rong, ... Wei-Zhong Liu.
54. Synthesis and antitumor activity of three novel ginsenoside M1 derivatives with 3′-ester modifications
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Ke-Ke Li, Xiao-Mei Yan, Zheng-Ning Li, Qiu Yan, Xiao-Jie Gong.
54. Rational design, synthesis and biological evaluation of ubiquinone derivatives as IDO1 inhibitors
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Yuyang Ding, Fei Tang, Xiaoqian Xue, Jinfeng Luo, ... Jiancun Zhang.
54. Click chemistry-assisted synthesis of novel aminonaphthoquinone-1,2,3-triazole hybrids and investigation of their cytotoxicity and cancer cell cycle alterations
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Maryam Gholampour, Sara Ranjbar, Najmeh Edraki, Maryam Mohabbati, ... Mehdi Khoshneviszadeh.
54. Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS
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Bangjian Dong, Lijun An, Xueyuan Yang, Xuke Zhang, ... Yuanqiang Guo.
54. Discovery and synthesis of 2-amino-1-methyl-1H-imidazol-4(5H)-ones as GPCR ligands; an approach to develop breast cancer drugs via GPCR associated PAR1 and PI3Kinase inhibition mechanism
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S.R. Ashok, M.K. Shivananda, A. Manikandan, R. Chandrasekaran.
54. Synthesis, antioxidant and Aβ anti-aggregation properties of new ferulic, caffeic and lipoic acid derivatives obtained by the Ugi four-component reaction
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Mohamed Benchekroun, Irene Pachón-Angona, Vincent Luzet, Helene Martin, ... Lhassane Ismaili.
54. Synthesis and identification of novel pyridazinylpyrazolone based diazo compounds as inhibitors of human islet amyloid polypeptide aggregation
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Syed Usama Bin Farrukh, Ibrahim Javed, Abdul Qayyum Ather, Abdul-Hamid Emwas, ... Rahman Shah Zaib Saleem.
54. SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX
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Wagdy M. Eldehna, Mahmoud F. Abo-Ashour, Emanuela Berrino, Daniela Vullo, ... Claudiu T. Supuran.
55. Determination of mechanisms of action of active carbons as a feed additive
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Ewa Burchacka, Marcin Łukaszewicz, Marek Kułażyński.
55. Design and synthesis of novel pyridazinoquinazoline derivatives as potent VEGFR-2 inhibitors: In vitro and in vivo study
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Marwa G. El-Gazzar, Rania M. El-Hazek, Nashwa H. Zaher, Mona A. El-Ghazaly.
55. Strategy and validation of a structure-based method for the discovery of selective inhibitors of PAK isoforms and the evaluation of their anti-cancer activity
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Pei-Lu Song, Gang Wang, Yuan Su, Han-Xun Wang, ... Mao-Sheng Cheng.
55. Benzoxaboroles as dynamic covalent receptors for bioconjugation and transport of nucleosides and related drugs: Proof of action in HeLa cells
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Cecilia Samaniego Lopez, Jimena H. Martínez, Sofía L. Acebedo, Carla C. Spagnuolo.
55. Design, synthesis and evaluation of phenylfuroxan nitric oxide-donor phenols as potential anti-diabetic agents
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Yun-Dong Xie, Li-Hua Shao, Qiu-Tang Wang, Yue Bai, ... Xiao-Li Bian.
55. Structural modifications of 2,3-indolobetulinic acid: Design and synthesis of highly potent α-glucosidase inhibitors
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Elmira F. Khusnutdinova, Anastasiya V. Petrova, Ha Nguyen Thi Thu, Anh Le Thi Tu, ... Oxana B. Kazakova.
55. Design, synthesis and evaluation of 2-(indolylmethylidene)-2,3-dihydro-1-benzofuran-3-one and 2-(indolyl)-4H-chromen-4-one derivatives as novel monoamine oxidases inhibitors
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Koichi Takao, Shiori U, Hitoshi Kamauchi, Yoshiaki Sugita.
55. Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of β-glucocerebrosidase inhibition
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Macarena Martínez-Bailén, Ana T. Carmona, Athéna C. Patterson-Orazem, Raquel L. Lieberman, ... Antonio J. Moreno-Vargas.
55. Innovative nano-carriers in anticancer drug delivery-a comprehensive review
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Peng Dong, K.P. Rakesh, H.M. Manukumar, Yasser Hussein Eissa Mohammed, ... Hua-Li Qin.
55. Synthesis of a new disulfide Fmoc monomer for creating biologically susceptible linkages in peptide nucleic acid oligomers
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Tác giả
Brandon Campbell, Taylor Hood, Nathaniel Shank.
55. Synthesis and biological evaluation of new N-benzylpyridinium-based benzoheterocycles as potential anti-Alzheimer’s agents
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Naeimeh Salehi, Bi Bi Fatemeh Mirjalili, Hamid Nadri, Zahra Abdolahi, ... Mehdi Khoobi.
56. Reductive capabilities of different cyanobacterial strains towards acetophenone as a model substrate – Prospect of applications for chiral building blocks synthesis
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Ewa Żymańczyk-Duda, Agata Głąb, Monika Górak, Magdalena Klimek-Ochab, ... Agnieszka Śliżewska.
56. New carboxamides bearing benzenesulphonamides: Synthesis, molecular docking and pharmacological properties
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Florence Uchenna Eze, Uchechukwu Chris Okoro, David Izuchukwu Ugwu, Sunday N. Okafor.
56. Natural neuroprotective alkaloids from Stephania japonica (Thunb.) Miers
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Jiao Xiao, Tingyu Hao, Gang Chen, Junyu Song, ... Ning Li.
56. Identification of chebulinic acid as a dual targeting inhibitor of protein tyrosine phosphatases relevant to insulin resistance
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Sun-Young Yoon, Hyo Jin Kang, Dohee Ahn, Ji Young Hwang, ... Sang J. Chung.
56. Exploring the competence stimulating peptide (CSP) N-terminal requirements for effective ComD receptor activation in group1 Streptococcus pneumoniae
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Yifang Yang, Yftah Tal-Gan.
56. Synthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti Alzheimer agents and investigation of binding mechanism with acetylcholinesterase
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Jeelan Basha Shaik, Daniel Pushparaju Yeggoni, Yelamanda Rao Kandrakonda, Mohan Penumala, ... Damu Gangaiah Amooru.
56. Synthesis, biological evaluation and molecular modelling studies of 1,3,7,8-tetrasubstituted xanthines as potent and selective A2A AR ligands with in vivo efficacy against animal model of Parkinson’s disease
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Suman Rohilla, Ranju Bansal, Sonja Kachler, Karl-Norbert Klotz.
56. Alkene lactones from Persea fulva (Lauraceae): Evaluation of their effects on tumor cell growth in vitro and molecular docking studies
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Isabella Mary Alves Reis, Rodrigo Souza Conceição, Rafael Short Ferreira, Cleonice Creusa dos Santos, ... Alexsandro Branco.
56. Bioactive cytosporone derivatives isolated from the mangrove-derived fungus Dothiorella sp. ML002
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Cai-Juan Zheng, Guo-Lei Huang, Hai-Xia Liao, Rong-Qing Mei, ... Qing-Ying Zhang.
56. A new class of diamide scaffold: Design, synthesis and biological evaluation as potent antimitotic agents, tubulin polymerization inhibition and apoptosis inducing activity studies
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Khaled O. Mohamed, Islam Zaki, Ibrahim M. El-Deen, Mohammed K. Abdelhameid.
56. Synthesis and evaluation of new 4-oxoquinazolin-3(4H)-yl)benzoic acid and benzamide derivatives as potent antibacterial agents effective against multidrug resistant Staphylococcus aureus
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Srikanth Gatadi, Jitendra Gour, Manjulika Shukla, Grace Kaul, ... Srinivas Nanduri.
57. Hollow silica microspheres as robust immobilization carriers
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Wojciech Snoch, Mateusz Tataruch, Olga Zastawny, Ewelina Cichoń, ... Maciej Guzik.
57. Novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potent antitubulin agents: Design, multicomponent synthesis and antiproliferative activities
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Fang Yang, Liang-Zhentian Yu, Peng-Cheng Diao, Xie-Er Jian, ... Pei-Liang Zhao.
57. Tyrosine-based asymmetric urea ligand for prostate carcinoma: Tuning biological efficacy through in silico studies
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Sagnik Sengupta, Mena Asha Krishnan, Amit Pandit, Premansh Dudhe, ... Venkatesh Chelvam.
57. (±)-Meliviticines A and B: Rearranged prenylated acetophenone derivatives from Melicope viticina and their antimicrobial activity
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Wei Li, Li Rao, Yu Liu, Qian He, ... Chuan-Rui Zhang.
57. Identification of anti-inflammatory polyketides from the coral-derived fungus Penicillium sclerotiorin: In vitro approaches and molecular-modeling
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Zhaoming Liu, Pei Qiu, Hongju Liu, Jing Li, ... Zhigang She.
57. New phosphate derivatives of betulin as anticancer agents: Synthesis, crystal structure, and molecular docking study
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Elwira Chrobak, Monika Kadela-Tomanek, Ewa Bębenek, Krzysztof Marciniec, ... Stanisław Boryczka.
57. Eight new biflavonoids with lavandulyl units from the roots of Sophora flavescens and their inhibitory effect on PTP1B
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Hai-Wei Yan, Hui Zhu, Xiang Yuan, Ya-Nan Yang, ... Pei-Cheng Zhang.
57. Discovery of atorvastatin as a tetramer stabilizer of nuclear receptor RXRα through structure-based virtual screening
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Xin Wang, Shuyi Chong, Huiyun Lin, Zhiqiang Yan, ... Ying Su.
57. Synthesis and biological evaluation of new 2,4,6-trisubstituted pyrimidines and their N-alkyl derivatives
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Nuran Kahriman, Vildan Serdaroğlu, Kıvanç Peker, Ali Aydın, ... Nurettin Yaylı.
58. Synthesis of (E)-α,β-unsaturated carboxylic esters derivatives from cyanoacetic acid via promiscuous enzyme-promoted cascade esterification/Knoevenagel reaction
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Monika Wilk, Damian Trzepizur, Dominik Koszelewski, Anna Brodzka, Ryszard Ostaszewski.
58. Synthesis and biological evaluation of thiazolidine-2,4-dione-pyrazole conjugates as antidiabetic, anti-inflammatory and antioxidant agents
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Garima Bansal, Shamsher Singh, Vikramdeep Monga, Punniyakoti Veeraveedu Thanikachalam, Pooja Chawla.
58. Synthesis and application of a “turn on” fluorescent probe for glutathione based on a copper complex of coumarin hydrazide Schiff base derivative
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Guangjie He, Xiaobo Hua, Nan Yang, Linlin Li, ... Liguo Ji.
58. Amino acids conjugated quinazolinone-Schiff’s bases as potential antimicrobial agents: Synthesis, SAR and molecular docking studies
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K.P. Rakesh, H.K. Kumara, B.J. Ullas, J. Shivakumara, D. Channe Gowda.
58. Novel 9-(2-(1-arylethylidene)hydrazinyl)acridine derivatives: Target Topoisomerase 1 and growth inhibition of HeLa cancer cells
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Md Rafi Haider, Kamal Ahmad, Nadeem Siddiqui, Zulphikar Ali, ... M. Shahar Yar.
58. Tick-borne flavivirus reproduction inhibitors based on isoxazole core linked with adamantane
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Dmitry A. Vasilenko, Evgenia V. Dueva, Liubov I. Kozlovskaya, Nikolay A. Zefirov, ... Elena B. Averina.
58. Synthesis and characterization of CAPE derivatives as xanthine oxidase inhibitors with radical scavenging properties
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Wonbeen Choi, Valente Villegas, Hannah Istre, Ben Heppler, ... Stefan Paula.
58. Chiral resolution and neuroprotective activities of enantiomeric dihydrobenzofuran neolignans from the fruit of Crataegus pinnatifida
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Rui Guo, Tian-Ming Lv, Feng-Ying Han, Bin Lin, ... Shao-Jiang Song.
58. Syntheses, in vitro urease inhibitory activities of urea and thiourea derivatives of tryptamine, their molecular docking and cytotoxic studies
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Kanwal, Majid Khan, Arshia, Khalid Mohammed Khan, ... M. Iqbal Choudhary.
59. The influence of the isocyanoesters structure on the course of enzymatic Ugi reactions
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Monika Wilk, Anna Brodzka, Dominik Koszelewski, Arleta Madej, ... Ryszard Ostaszewski.
59. Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents
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Maksims Yevglevskis, Amit Nathubhai, Katty Wadda, Guat L. Lee, ... Matthew D. Lloyd.
59. New phenolic cinnamic acid derivatives as selective COX-2 inhibitors. Design, synthesis, biological activity and structure-activity relationships
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Daniela Ribeiro, Carina Poença, Carla Varela, João Janela, ... Fernanda M.F. Roleira.
59. Dipyridamole inhibits α-amylase/α-glucosidase at sub-micromolar concentrations; in-vitro, in-vivo and theoretical studies
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Sajjad Esmaeili, Sarwar Azizian, Bahareh Shahmoradi, Sajad Moradi, ... Reza Khodarahmi.
59. Discovery of new inhibitors against both NF-κB and osteoclastogenesis from in-house library with α, β-unsaturated-enone fragment
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Chao Zhao, Dane Huang, Ruyue Li, Jiake Xu, ... Jun Xu.
59. Design, synthesis and evaluation of N-hydroxypropenamides based on adamantane to overcome resistance in NSCLC
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Xuefei Bao, Yuhong Sun, Changshun Bao, Jiayu Zhang, ... Guoliang Chen.
59. Synthesis, characterization, crystal structure of the coordination polymer Zn(II) with thiosemicarbazone of glyoxalic acid and their inhibitory properties against some metabolic enzymes
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Mansura Huseynova, Ajdar Medjidov, Parham Taslimi, Mahizar Aliyeva.
60. The studies on chemoselective promiscuous activity of hydrolases on acylals transformations
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Dominik Koszelewski, Ryszard Ostaszewski.
60. Identification of novel small-molecule inhibitors of α-methylacyl-CoA racemase (AMACR; P504S) and structure-activity relationships
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Yoana D. Petrova, Katty Wadda, Amit Nathubhai, Maksims Yevglevskis, ... Matthew D. Lloyd.
60. Design, synthesis and evaluation of phthalazinone thiohydantoin-based derivative as potent PARP-1 inhibitors
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Yi Zhong, Ying Meng, Xi Xu, Lulu Zhao, ... Jinlei Bian.
60. Design, synthesis and molecular modeling studies on novel moxifloxacin derivatives as potential antibacterial and antituberculosis agents
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Aslı Türe, Necla Kulabaş, Serap İpek Dingiş, Kaan Birgül, ... İlkay Küçükgüzel.
60. In vitro and in silico studies of novel synthetic ACE-inhibitory peptides derived from Saccharomyces cerevisiae protein hydrolysate
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Mahta Mirzaei, Saeed Mirdamadi, Maliheh Safavi, Mahnaz Hadizadeh.
60. Synthesis of 5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one’s aryl Schiff base derivatives and investigation of carbonic anhydrase and cholinesterase (AChE, BuChE) inhibitory properties
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Tác giả
Musa Özil, Halis Türker Balaydın, Murat Şentürk.
60. Antibacterial activity against drug-resistant microbial pathogens of cytochalasan alkaloids from the arthropod-associated fungus Chaetomium globosum TW1-1
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Weixi Gao, Yan He, Fengli Li, Chenwei Chai, ... Yonghui Zhang.
61. Biotransformation of rapeseed meal leading to production of polymers, biosurfactants, and fodder
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Damian Konkol, Ida Szmigiel, Marta Domżał-Kędzia, Marek Kułażyński, ... Marcin Łukaszewicz.
61. NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum
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Lijun An, Yue Liang, Xueyuan Yang, Huimei Wang, ... Yuanqiang Guo.
61. Synthesis of novel (R)-4-fluorophenyl-1H-1,2,3-triazoles: A new class of α-glucosidase inhibitors
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Satya Kumar Avula, Ajmal Khan, Sobia Ahsan Halim, Zahra Al-Abri, ... Ahmed Al-Harrasi.
61. Synthesis and identification of quinoline derivatives as topoisomerase I inhibitors with potent antipsoriasis activity in an animal model
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Wen-Jin Zhang, Peng-Hui Li, Min-Cong Zhao, Yao-Hao Gu, ... Zhi-Yun Du.
61. Design and synthesis of novel PARP-1 inhibitors based on pyridopyridazinone scaffold
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Ghada F. Elmasry, Enayat E. Aly, Fadi M. Awadallah, Samir M. El-Moghazy.
61. Synthesis and structure-activity relationship of elastase inhibiting novel ethylated thiazole-triazole acetamide hybrids: Mechanistic insights through kinetics and computational contemplations
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Abdul Rehman Sadiq Butt, Muhammad Athar Abbasi, Aziz-ur-Rehman, Sabahat Zahra Siddiqui, ... Sung-Yum Seo.
61. Synthesis and DNA binding profile of monomeric, dimeric, and trimeric derivatives of crystal violet
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Omar Nuñez, Bianca Chavez, Ryan Shaktah, Paola Pereda Garcia, Thomas Minehan.
62. N-phosphonomethylglycine utilization by the psychrotolerant yeast Solicoccozyma terricola M 3.1.4.
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Natalia Stosiek, Agata Terebieniec, Adam Ząbek, Piotr Młynarz, ... Magdalena Klimek-Ochab.
62. Synthesis, biological evaluation and molecular docking analysis of novel benzopyrimidinone derivatives as potential anti-tyrosinase agents
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Sarra Chortani, Vijaykumar D. Nimbarte, Mabrouk Horchani, Hichem Ben Jannet, Anis Romdhane.
62. Synthesis, in silico and in vitro studies of new 1,4-dihydropiridine derivatives for antitumor and P-glycoprotein inhibitory activity
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Shirin Mollazadeh, Amirhossein Sahebkar, Fatemeh Kalalinia, Javad Behravan, Farzin Hadizadeh.
62. Identification of 10-dehydrooxyglycyuralin E as a selective human estrogen receptor alpha partial agonist
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Nao Saito, Keiko Kawase, Naoya Yamashita, Yingzhan Tang, ... Kiyomitsu Nemoto.
62. Unveiling novel diphenyl-1H-pyrazole based acrylates tethered to 1,2,3-triazole as promising apoptosis inducing cytotoxic and anti-inflammatory agents
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Mohemmed Faraz Khan, Tarique Anwer, Afroz Bakht, Garima Verma, ... Mohammad Shaquiquzzaman.
62. The management of diabetes mellitus-imperative role of natural products against dipeptidyl peptidase-4, α-glucosidase and sodium-dependent glucose co-transporter 2 (SGLT2)
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Ghulam Abbas, Ahmed Al Harrasi, Hidayat Hussain, Ahmed Hamaed, Claudiu T. Supuran.
62. Synthesis of N-benzyl substituted 1,4-imino-l-lyxitols with a basic functional group as selective inhibitors of Golgi α-mannosidase IIb
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Tomáš Klunda, Sergej Šesták, Juraj Kóňa, Monika Poláková.
63. Hydrolysis of surfactin over activated carbon
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Hanna Fałtynowicz, Paweł Hodurek, Jan Kaczmarczyk, Marek Kułażyński, Marcin Łukaszewicz.
63. Triazolopyridazine derivatives: Synthesis, cytotoxic evaluation, c-Met kinase activity and molecular docking
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Eman M. Ahmed, Nadia A. Khalil, Azza T. Taher, Rana H. Refaey, Yassin M. Nissan.
63. Bis-coumarins; non-cytotoxic selective urease inhibitors and antiglycation agents
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Uzma Salar, Arsalan Nizamani, Fizza Arshad, Khalid Mohammed Khan, ... M. Iqbal Choudhary.
63. Investigation of the interaction between salvianolic acid C and xanthine oxidase: Insights from experimental studies merging with molecular docking methods
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Hongjin Tang, Dongsheng Zhao.
63. 5-Thioxoimidazolidine-2-one derivatives: Synthesis, anti-inflammatory activity, analgesic activity, COX inhibition assay and molecular modelling study
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Marwa A.M.Sh. El-Sharief, Samir Y. Abbas, Ahmed M.Sh. El-Sharief, Nermien M. Sabry, ... Mardia T. El Sayed.
63. Synthesis of sulfonamide, amide and amine hybrid pharmacophore, an entry of new class of carbonic anhydrase II inhibitors and evaluation of chemo-informatics and binding analysis
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Attique Ahmed, Pervaiz Ali Channar, Aamer Saeed, Markus Kalesse, ... Sung-Yum Seo.
64. Design, synthesis, and biological activity of Plastoquinone analogs as a new class of anticancer agents
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Nilüfer Bayrak, Hatice Yıldırım, Mahmut Yıldız, Mohamed O. Radwan, ... Halil I. Ciftci.
64. cAMPS derivatives. A minireview over synthetic medicinal chemistry
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Kjell Undheim.
64. Chiral β-lactam-based integrin ligands through Lipase-catalysed kinetic resolution and their enantioselective receptor response
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Giulia Martelli, Paola Galletti, Monica Baiula, Luca Calcinari, ... Daria Giacomini.
64. Sanggenon O induced apoptosis of A549 cells is counterbalanced by protective autophagy
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Zhong-Rui Li, Ting Ma, Yan-Jia Guo, Bo Hu, ... Hong-Min Liu.
64. Evaluation of andrographolide-based analogs derived from Andrographis paniculata against Mythimna separata Walker and Tetranychus cinnabarinus Boisduval
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Ming Xu, Jianwei Xu, Meng Hao, Kong Zhang, ... Hui Xu.
65. Immunomodulatory activities of zinc(II)phthalocyanine on the mammalian macrophages through p38 pathway: Potential ex vivo immunomodulatory PDT reagents
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Tác giả
Abdulcelil Yüzer, Furkan Ayaz, Mine Ince.
65. Discovery of Michael acceptor containing 1,4-dihydropyridines as first covalent inhibitors of L-/T-type calcium channels
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Tác giả
Hande Aygün Cevher, David Schaller, Maria A. Gandini, Ozan Kaplan, ... Miyase Gözde Gündüz.
65. Synthesis of oxazolidinone from enantiomerically enriched allylic alcohols and determination of their molecular docking and biologic activities
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Ufuk Atmaca, Rüya Kaya, Halide Sedef Karaman, Murat Çelik, İlhami Gülçin.
65. Design and synthesis of parthenolide-SAHA hybrids for intervention of drug-resistant acute myeloid leukemia
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Weizhi Ge, Zhongquan Liu, Yu Sun, Tianpeng Wang, ... Quan Zhang.
65. Imidazolo and tryptophan-imidazolo hybrid derived ureas/thioureas as potent bioactive agents – SAR and molecular modelling studies
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H.K. Kumara, R. Suhas, D.M. Suyoga Vardhan, M. Shobha, D. Channe Gowda.
66. Discovery of 2-ethoxy-4-(methoxymethyl)benzamide derivatives as potent and selective PTP1B inhibitors
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Fangzhou Xie, Yaoyao Liang, Yu Xia, Shuhua Luo, ... Lei Fu.
66. A combined experimental and computational study on peptide nucleic acid (PNA) analogues of tumor suppressive miRNA-34a
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Valerio Piacenti, Emma Langella, Ida Autiero, John C. Nolan, ... Maria Moccia.
66. Cisplatin: The first metal based anticancer drug
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Tác giả
Sumit Ghosh.
66. Design, synthesis and evaluation of a novel metal chelator as multifunctional agents for the treatment of Alzheimer’s disease
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Yingying Wang, Yue Yang, Kwon Ho Hong, Yao Ning, ... Jin Cai.
66. Benzenesulfonamides incorporating nitrogenous bases show effective inhibition of β-carbonic anhydrases from the pathogenic fungi Cryptococcus neoformans, Candida glabrata and Malassezia globosa
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Silvia Bua, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran, Alessio Nocentini.
67. In vitro assessment of 3-alkoxy-5-nitroindazole-derived ethylamines and related compounds as potential antileishmanial drugs
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Álvaro Martín-Montes, Benjamín Aguilera-Venegas, Rosa Mª Morales-Martín, Rubén Martín-Escolano, ... Manuel Sánchez-Moreno.
67. Discovery of novel cage-like heterocyclic hybrids as anti-inflammatory agents through the inhibition of nitrite, PGE2 and TNF-α
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Raju Suresh Kumar, Paulrayer Antonisamy, Abdulrahman I. Almansour, Natarajan Arumugam, ... Kang-Beom Kwon.
67. Nimesulide analogues: From anti-inflammatory to antitumor agents
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Mafalda Catarro, João L. Serrano, Susana S. Ramos, Samuel Silvestre, Paulo Almeida.
67. Natural flavonoid α-glucosidase inhibitors from Retama raetam: Enzyme inhibition and molecular docking reveal important interactions with the enzyme active site
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Usman Ghani, Mohammad Nur-e-Alam, Muhammad Yousaf, Zaheer Ul-Haq, ... Adnan J. Al-Rehaily.
67. EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor
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Ahmed Elkamhawy, Ahmed H.E. Hassan, Sora Paik, Yong Sup Lee, ... Eun Joo Roh.
68. Curcumane C and (±)-curcumane D, an unusual seco-cadinane sesquiterpenoid and a pair of unusual nor-bisabolane enantiomers with significant vasorelaxant activity from Curcuma longa
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Ming-Ming Qiao, Fei Liu, Yu Liu, Li Guo, ... Liang Xiong.
68. 1,8-Substituted anthraquinones, anthrones and bianthrones as potential non-azole leads against fungal infections
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Murhaf Jalab, Megan E. Critchley, Charlotte M. Taylor, Clare L. Lawrence, Robert B. Smith.
68. Current development of 5-nitrofuran-2-yl derivatives as antitubercular agents
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Tác giả
Tilal Elsaman, Malik Suliman Mohamed, Magdi A. Mohamed.
68. Antioxidant and angiotensin-converting enzyme (ACE) inhibitory activity of thymosin alpha-1 (Thα1) peptide
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Tác giả
Jasmin Kharazmi-Khorassani, Ahmad Asoodeh, Hamid Tanzadehpanah.
68. Dibrefeldins A and B, A pair of epimers representing the first brefeldin A dimers with cytotoxic activities from Penicillium janthinellum
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Fanrong Zeng, Chunmei Chen, Ali Adhab Al Chnani, Qun Zhou, ... Yonghui Zhang.
69. Antiprotozoal activities of marine polyether triterpenoids
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Ana R. Díaz-Marrero, Atteneri López-Arencibia, Carlos J. Bethencout-Estrella, Francisco Cen-Pacheco, ... José J. Fernández.
69. Three new cyclopiane-type diterpenes from a deep-sea derived fungus Penicillium sp. YPGA11 and their effects against human esophageal carcinoma cells
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Zhongbin Cheng, Yuanli Li, Wei Xu, Wan Liu, ... Qin Li.
69. Naphthalimides in fluorescent imaging of tumor hypoxia – An up-to-date review
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Rashmi Kumari, Dhanya Sunil, Raghumani S. Ningthoujam.
69. Design, synthesis and biological evaluation of Helicobacter pylori inosine 5′-monophosphate dehydrogenase (HpIMPDH) inhibitors. Further optimization of selectivity towards HpIMPDH over human IMPDH2
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Chetan P. Shah, Gayathri Purushothaman, Vijay Thiruvenkatam, Sivapriya Kirubakaran, ... Prashant S. Kharkar.
69. Click-tailed benzenesulfonamides as potent bacterial carbonic anhydrase inhibitors for targeting Mycobacterium tuberculosis and Vibrio cholerae
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Silvia Bua, Sameh M. Osman, Sonia Del Prete, Clemente Capasso, ... Claudiu T. Supuran.
70. Synthesis and investigation of inhibitory activities of imidazole derivatives against the metallo-β-lactamase IMP-1
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Omid Khalili Arjomandi, Mahboubeh Kavoosi, Hadi Adibi.
70. New hexalactone derivatives and a pair of new oxaspiro-carbon epimeric glycosides from the fruits of Illicium lanceolatum
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Yang-Lan Liu, Xiao-Jing Wang, Ru-Bing Wang, Mi Li, ... Shuang-Gang Ma.
70. Chemical constituents from Vietnamese mangrove Calophyllum inophyllum and their anti-inflammatory effects
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Nguyen Van Thanh, Hyun-Jae Jang, Le Ba Vinh, Kieu Thi Phuong Linh, ... Seo Young Yang.
70. Synthesis and biological evaluation of coumarin-1,3,4-oxadiazole hybrids as selective carbonic anhydrase IX and XII inhibitors
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Sridhar Goud Narella, Mohammed Ghouse Shaik, Arifuddin Mohammed, Mallika Alvala, ... Claudiu T. Supuran.
70. Essay: Avoiding unfounded health claims on small molecules in scientific literature
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Bart I. Roman.
71. New cytotoxic tricycloalternarenes from fungus Alternaria brassicicola
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Fengli Li, Ying Tang, Weiguang Sun, Jiankun Guan, ... Yonghui Zhang.
71. FtsZ inhibitors as a new genera of antibacterial agents
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Tác giả
Swayansiddha Tripathy, Susanta Kumar Sahu.
71. An exhaustive compilation on chemistry of triazolopyrimidine: A journey through decades
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Pankaj Kumar Singh, Shalki Choudhary, Aanchal Kashyap, Himanshu Verma, ... Om Silakari.
71. Probing the antibacterial and anticancer potential of tryptamine based mixed ligand Schiff base Ruthenium(III) complexes
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Manzoor Ahmad Malik, Md Kausar Raza, Ovas Ahmad Dar, Amadudin, ... Athar Adil Hashmi.
71. Three new diterpenes and two new sesquiterpenoids from the endophytic fungus Trichoderma koningiopsis A729
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Shanchong Chen, Haohua Li, Yuchan Chen, Saini Li, ... Weimin Zhang.
72. Synthesis of Mitomycin C and decarbamoylmitomycin C N6 deoxyadenosine-adducts
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Maggie Zheng, Seokjin Hwang, Timothy Snyder, Jake Aquilina, ... Elise Champeil.
72. Small molecule HDAC inhibitors: Promising agents for breast cancer treatment
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Meiling Huang, Jian Zhang, Changjiao Yan, Xiaohui Li, ... Rui Ling.
72. Discovery of cycloneolignan enantiomers from Isatis indigotica Fortune with neuroprotective effects against MPP+-induced SH-SY5Y cell injury
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Yu-Fei Xi, Si-Fan Liu, Wei Hong, Xiao-Yu Song, ... Shao-Jiang Song.
72. Furofuran lignans as a new series of antidiabetic agents exerting α-glucosidase inhibition and radical scarvenging: Semisynthesis, kinetic study and molecular modeling
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Wisuttaya Worawalai, Titiruetai Doungwichitrkul, Warin Rangubpit, Panyakorn Taweechat, ... Preecha Phuwapraisirisan.
72. Design, synthesis and biological evaluation of coumarin-3-carboxamides as selective carbonic anhydrase IX and XII inhibitors
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Pavitra S. Thacker, Mallika Alvala, Mohammed Arifuddin, Andrea Angeli, Claudiu T. Supuran.
73. Design, synthesis and antifungal activity evaluation of isocryptolepine derivatives
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Jun-cai Li, Ren-xuan Wang, Yu Sun, Jia-kai Zhu, ... Xiao-fei Shang.
73. The influence of cationic dendrimers on antibacterial activity of phage endolysin against P. aeruginosa cells
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Karol Ciepluch, Barbara Maciejewska, Katarzyna Gałczyńska, Dorota Kuc-Ciepluch, ... Michał Arabski.
73. Phytosynthesis of silver nanoparticles using Mangifera indica flower extract as bioreductant and their broad-spectrum antibacterial activity
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Fuad Ameen, P. Srinivasan, T. Selvankumar, S. Kamala-Kannan, ... M. Govarthanan.
73. Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity and molecular modeling studies
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Mahmoud F. Abo-Ashour, Wagdy M. Eldehna, Alessio Nocentini, Hany S. Ibrahim, ... Claudiu T. Supuran.
73. Synthesis, neuroprotective and antioxidant capacity of PBN-related indanonitrones
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Alicia Jiménez-Almarza, Daniel Diez-Iriepa, Mourad Chioua, Beatriz Chamorro, ... José Marco-Contelles.
74. Bioactivity-based analysis and chemical characterization of hypoglycemic and antioxidant components from Artemisia argyi
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Jian-Qi Xiao, Wen-Yuan Liu, Hao-peng Sun, Wei Li, ... Jie Zhang.
74. Chalcone derivatives and their antibacterial activities: Current development
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Man Xu, Piye Wu, Fan Shen, Jiayou Ji, K.P. Rakesh.
74. Mechanistic investigation of anthocyanidin derivatives as α-glucosidase inhibitors
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Jang Hoon Kim, Hyo Young Kim, Chang Hyun Jin.
74. The significance of N-methylpicolinamides in the development of anticancer therapeutics: Synthesis and structure-activity relationship (SAR) studies
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Balakrishna Moku, Lekkala Ravindar, K.P. Rakesh, Hua-Li Qin.
75. Rational design of some substituted phenyl azanediyl (bis) methylene phosphonic acid derivatives as potential anticancer agents and imaging probes: Computational inputs, chemical synthesis, radiolabeling, biodistribution and gamma scintigraphy
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Mohammed A. Khedr, Hassan M. Rashed, Hamed Farag, Tamer M. Sakr.
75. Design, synthesis and antibacterial activity evaluation of moxifloxacin-amide-1,2,3-triazole-isatin hybrids
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Feng Gao, Lei Ye, Fangong Kong, Gang Huang, Jiaqi Xiao.
75. Evaluation of angularly condensed diquinothiazines as potential anticancer agents
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Małgorzata Jeleń, Krystian Pluta, Małgorzata Latocha, Beata Morak-Młodawska, ... Dariusz Kuśmierz.
76. Geranylated carbazole alkaloids with potential neuroprotective activities from the stems and leaves of Clausena lansium
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Yan-Ping Liu, Jia-Ming Guo, Xiao-Ping Wang, Yun-Yao Liu, ... Yan-Hui Fu.
76. Anti-inflammatory spiroaxane and drimane sesquiterpenoids from Talaromyces minioluteus (Penicillium minioluteum)
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Chunmei Chen, Weiguang Sun, Xiaorui Liu, Mengsha Wei, ... Yonghui Zhang.
76. Synthesis and biological evaluation of purine-pyrazole hybrids incorporating thiazole, thiazolidinone or rhodanine moiety as 15-LOX inhibitors endowed with anticancer and antioxidant potential
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Ola S. Afifi, Omaima G. Shaaban, Heba A. Abd El Razik, Shams El-Dine A. Shams El-Dine, ... Marwa M. Abu-Serie.
77. Optimization study towards more potent thiazolidine-2,4-dione IKK-β modulator: Synthesis, biological evaluation and in silico docking simulation
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Ahmed Elkamhawy, Nam youn Kim, Ahmed H.E. Hassan, Jung-eun Park, ... Eun Joo Roh.
77. Genetic dereplication of Trichoderma hypoxylon reveals two novel polycyclic lactones
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Lin Chen, HongBo Wu, Huan Liu, Erwei Li, ... Wen-Bing Yin.
77. Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma
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Belma Zengin Kurt, Aydan Dag, Berna Doğan, Serdar Durdagi, ... Fatih Sonmez.
78. Novel inhibitors of leukocyte transendothelial migration
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Tamar Getter, Raanan Margalit, Shirin Kahremany, Laura Levy, ... Arie Gruzman.
78. Xanthine oxidase inhibitors from an endophytic fungus Lasiodiplodia pseudotheobromae
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Sanjay Kumar, Amol Dilip Pagar, Furkan Ahmad, Vagish Dwibedi, ... Inder Pal Singh.
79. New triazinoindole bearing thiazole/oxazole analogues: Synthesis, α-amylase inhibitory potential and molecular docking study
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Fazal Rahim, Sundas Tariq, Muhammad Taha, Hayat Ullah, ... Syed Adnan Ali Shah.
79. Benzoxazinone-thiosemicarbazones as antidiabetic leads via aldose reductase inhibition: Synthesis, biological screening and molecular docking study
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Muhammad Tariq Shehzad, Aqeel Imran, Guy Sedar Singor Njateng, Abdul Hameed, ... Jamshed Iqbal.
80. Targeted 8-hydroxyquinoline fragment based small molecule drug discovery against neglected botulinum neurotoxin type F
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Ritika Chauhan, Vinita Chauhan, Priyanka Sonkar, Manorama Vimal, Ram Kumar Dhaked.
80. Eight new glycosides with hepatoprotective activity isolated from the aerial parts of Morinda parvifolia
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Xianming Su, Li Li, Hua Sun, Fan Zhang, ... Jie Kang.
81. Chemical constituents and synergistic anti-gout studies on Eurycoma longifolia and potential mechanisms evaluation based on systemic analysis approach
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Ying Liu, Lantao Lai, Yan Ju, Caihong Liu, Dali Meng.
81. Fluorescent labeling of ursolic acid with FITC for investigation of its cytotoxic activity using confocal microscopy
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Tatiana S. Frolova, Alla V. Lipeeva, Dmitry S. Baev, Sergey I. Baiborodin, ... Olga I. Sinitsyna.
82. Novel pyridazinone derivatives as butyrylcholinesterase inhibitors
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Yasemin Dundar, Ozge Kuyrukcu, Gokcen Eren, F. Sezer Senol Deniz, ... Ilkay Erdogan Orhan.
82. Synthesis, bioactivity and molecular modeling studies on potential anti-Alzheimer piperidinehydrazide-hydrazones
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Sulunay Parlar, Gozde Sayar, Ayse Hande Tarikogullari, Sumru Sozer Karadagli, ... Ulrike Holzgrabe.
83. Discovery of diverse diterpenoid scaffolds from Euphorbia antiquorum and their activity against RANKL-induced osteoclastogenesis
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Zhi-Yong Yin, Yan Dai, Pei Hua, Zhe-Jun Sun, ... Qiong Gu.
83. Promising anti-inflammatory effects of chalcones via inhibition of cyclooxygenase, prostaglandin E2, inducible NO synthase and nuclear factor κb activities
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Haroon ur Rashid, Yiming Xu, Nasir Ahmad, Yaseen Muhammad, Lisheng Wang.
84. Umbelliferone derivatives exert neuroprotective effects by inhibiting monoamine oxidase A, self-amyloidβ aggregation, and lipid peroxidation
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Su Hui Seong, Md Yousof Ali, Hyun Ah Jung, Jae Sue Choi.
84. Phenylsulfonyl piperazine bridged [1,3]dioxolo[4,5-g]chromenones as promising antiproliferative and antioxidant agents
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Rahul V. Patel, Bhupendra M. Mistry, Riyaz Syed, Nikhil M. Parekh, Han-Seung Shin.
85. Synthesis and biological evaluation of tetrazole derivatives as TNF-α, IL-6 and COX-2 inhibitors with antimicrobial activity: Computational analysis, molecular modeling study and region-specific cyclization using 2D NMR tools
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Phoebe F. Lamie, Ahmed F. Azmey.
85. Natural and semisynthetic oxyprenylated aromatic compounds as stimulators or inhibitors of melanogenesis
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Salvatore Genovese, Francesco Epifano, Philippe de Medina, Nicolas Caron, ... Serena Fiorito.
86. 2-Styrylchromone derivatives as potent and selective monoamine oxidase B inhibitors
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Koichi Takao, Saki Endo, Junko Nagai, Hitoshi Kamauchi, ... Yoshiaki Sugita.
86. Investigation of new quinoline derivatives as promising inhibitors of NTPDases: Synthesis, SAR analysis and molecular docking studies
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Komal Hayat, Saira Afzal, Altaf Saeed, Amna Murtaza, ... Abbas Hassan.
87. Design, synthesis, in-vitro evaluation and molecular docking studies of novel indole derivatives as inhibitors of SIRT1 and SIRT2
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Ramu Manjula, Nikhila Gokhale, Sruthi Unni, Prashant Deshmukh, ... Balasundaram Padmanabhan.
87. Glycopentanolones A-D, four new geranylated quinolone alkaloids from Glycosmis pentaphylla
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Yun-Hyeok Choi, Changon Seo, Wonsik Jeong, Ji Eun Lee, ... Seong Su Hong.
88. Discovery, molecular dynamic simulation and biological evaluation of structurally diverse cholinesterase inhibitors with new scaffold through shape-based pharmacophore virtual screening
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Hongyu Yang, Chenxi Du, Qihang Li, Tingkai Chen, ... Haopeng Sun.
88. Lithocarols A-F, six tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508
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Jianlin Xu, Zhaoming Liu, Yuchan Chen, Haibo Tan, ... Weimin Zhang.
89. Synthesis and investigation of polyhydroxylated pyrrolidine derivatives as novel chemotypes showing dual activity as glucosidase and aldose reductase inhibitors
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Lorenzo Guazzelli, Felicia D'Andrea, Stefania Sartini, Francesco Giorgelli, ... Concettina La Motta.
90. Synthesis, structural characterization and in vivo anti-diabetic evaluation of some new sulfonylurea derivatives in normal and silicate coated nanoparticle forms as anti-hyperglycemic agents
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Farid M. Sroor, Samir Y. Abbas, Wahid M. Basyouni, Khairy A.M. El-Bayouki, ... Ahmed A. Haroun.
91. Arylpropionic acid-derived NSAIDs: New insights on derivatization, anticancer activity and potential mechanism of action
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Ahmed M. Gouda, Eman A. Beshr, Faisal A. Almalki, Hadeel H. Halawah, ... Malak M. AlMatrafi.
92. Disulfide bridge as a linker in nucleic acids’ bioconjugation. Part I: An overview of synthetic strategies
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Anna R. Stasińska, Piotr Putaj, Marcin K. Chmielewski.
93. The role of long noncoding RNA in major human disease
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Xiaoli Zhang, Ruiyun Hong, Weiqiang Chen, Minwen Xu, Liefeng Wang.
94. Promising antibacterial agents against multidrug resistant Staphylococcus aureus
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Srikanth Gatadi, Y.V. Madhavi, Sidharth Chopra, Srinivas Nanduri.
95. Recent advances in the synthetic and medicinal perspective of quinolones: A review
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Prashant Dhiman, Nidhi Arora, Punniyakoti Veeraveedu Thanikachalam, Vikramdeep Monga.
96. Identification of potential inflammatory inhibitors from Aster tataricus
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Xiang Dong Su, Hyun-Jae Jang, Hong Xu Li, Young Ho Kim, Seo Young Yang.
97. New pyrimidine-benzoxazole/benzimidazole hybrids: Synthesis, antioxidant, cytotoxic activity, in vitro cyclooxygenase and phospholipase A2-V inhibition
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Mohamed A. Abdelgawad, Rania B. Bakr, Waqas Ahmad, Mohammad M. Al-Sanea, Heba A.H. Elshemy.
98. Design, synthesis and biological evaluation of some tetrazole acetamide derivatives as novel non-carboxylic PTP1B inhibitors
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Neelesh Maheshwari, Chandrabose Karthikeyan, Shraddha V. Bhadada, Amit K. Verma, ... Piyush Trivedi.
99. A novel adaptive fluorescent probe for cell labelling
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Anca G. Coman, Anca Paun, Codruta C. Popescu, Niculina D. Hădade, ... Mihaela Matache.
100. Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR
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Wei-Shuo Fang, De-yang Sun, Shuang Yang, Chen Cheng, ... Yinghong Wang.
