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Acta Pharmaceutica Sinica B
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1. Table of Contents
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1. Table of Contents
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Tác giả
1. Table of Contents
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Tác giả
1. Table of Contents
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Tác giả
1. Table of Contents
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Tác giả
1. Table of Contents
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2. Role of vitamin D receptor in the regulation of CYP3A gene expression
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Xuan Qin, Xin Wang.
2. Targeting the untargetable KRAS in cancer therapy
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Tác giả
Pingyu Liu, Yijun Wang, Xin Li.
2. Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2
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Liming Chen, Jose E. Manautou, Theodore P. Rasmussen, Xiao-bo Zhong.
2. Updated developments on molecular imaging and therapeutic strategies directed against necrosis
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Tác giả
Dongjian Zhang, Meng Gao, Qiaomei Jin, Yicheng Ni, Jian Zhang.
2. Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment
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Tác giả
Xu Wu, Wei Hu, Lan Lu, Yueshui Zhao, Mingxing Li.
2. Editor Profiles: Guest Editors of Special Issue on Enhancement of Dissolution and Oral Bioavailability of Poorly Water-soluble Drugs
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Tác giả
Wei Wu, Yi Lu, Jianping Qi.
3. Development and application of hyaluronic acid in tumor targeting drug delivery
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Tác giả
Zhijian Luo, Yan Dai, Huile Gao.
3. Structural simplification: an efficient strategy in lead optimization
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Tác giả
Shengzheng Wang, Guoqiang Dong, Chunquan Sheng.
3. Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application
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Tác giả
Qing Xia, Yongtai Zhang, Zhe Li, Xuefeng Hou, Nianping Feng.
3. Recent advances of microneedles for biomedical applications: drug delivery and beyond
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Jian Yang, Xinli Liu, Yunzhi Fu, Yujun Song.
3. Small molecules for fat combustion: targeting obesity
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Tác giả
Jingxin Liu, Yitao Wang, Ligen Lin.
3. Editorial: Persistent endeavors for the enhancement of dissolution and oral bioavailability
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Tác giả
Wei Wu, Yi Lu, Jianping Qi.
4. Current trends in drug metabolism and pharmacokinetics
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Tác giả
Yuhua Li, Qiang Meng, Mengbi Yang, Dongyang Liu, Huichang Bi.
4. Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins
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Ying Han, Zhonggao Gao, Liqing Chen, Lin Kang, You Han Bae.
4. Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway
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Tác giả
Can Hu, Xin Zhang, Wenying Wei, Ning Zhang, Qizhu Tang.
4. Targeting slug-mediated non-canonical activation of c-Met to overcome chemo-resistance in metastatic ovarian cancer cells
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Tác giả
Linlin Chang, Yan Hu, Yingying Fu, Tianyi Zhou, Bo Yang.
4. Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects
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Qihao Wu, Bastien Nay, Min Yang, Yeke Ni, Xuwen Li.
4. Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles
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Jinsong Tao, Shing Fung Chow, Ying Zheng.
5. Recent progress in drug delivery
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Tác giả
Chong Li, Jiancheng Wang, Yiguang Wang, Huile Gao, Yiguang Jin.
5. Inactivation of TFEB and NF-κB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion
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Huanmin Niu, Lilin Qian, Bin Sun, Wenjian Liu, Huiqing Yuan.
5. Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters
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Lulu Sun, Yuanyuan Pang, Xuemei Wang, Qing Wu, Changtao Jiang.
5. In vitro and in vivo activity of d-serine in combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus
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Qing Wang, Yuemeng Lv, Jing Pang, Xue Li, Xuefu You.
5. Recent progress and challenges in screening and characterization of UGT1A1 inhibitors
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Tác giả
Xia Lv, Yangliu Xia, Moshe Finel, Jingjing Wu, Ling Yang.
5. Advances in coamorphous drug delivery systems
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Qin Shi, Sakib M. Moinuddin, Ting Cai.
6. PEP06 polypeptide 30 is a novel cluster-dissociating agent inhibiting αv integrin/FAK/Src signaling in oral squamous cell carcinoma cells
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Gulnara Tuguzbaeva, Er Yue, Xi Chen, Lina He, Baofeng Yang.
6. Synergistic antitumor activity of artesunate and HDAC inhibitors through elevating heme synthesis via synergistic upregulation of ALAS1 expression
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Cai-Ping Chen, Kun Chen, Zhiqi Feng, Xiaoan Wen, Hongbin Sun.
6. Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3 inflammasome activation in LPS-induced vascular injury
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Xing Zhou, Yanjiao Wu, Lifeng Ye, Yunting Wang, Yang Chen.
6. Inhibition of FOXO3a/BIM signaling pathway contributes to the protective effect of salvianolic acid A against cerebral ischemia/reperfusion injury
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Junke Song, Wen Zhang, Jinhua Wang, Haiguang Yang, Guanhua Du.
6. Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathway
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Shanshan Qi, Lingyuan Guo, Shuzhen Yan, Robert J. Lee, Shuanglin Chen.
6. Adapting liposomes for oral drug delivery
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Haisheng He, Yi Lu, Jianping Qi, Quangang Zhu, Wei Wu.
7. Hypericin enhances β-lactam antibiotics activity by inhibiting sarA expression in methicillin-resistant Staphylococcus aureus
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Tác giả
Genzhu Wang, Liang Li, Xiukun Wang, Xue Li, Yan Q. Xiong.
7. Direct interaction of DNMT inhibitors to PrPC suppresses pathogenic process of prion
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Tác giả
Dae-Hwan Kim, Chunyan Ren, Chongsuk Ryou, Jiaojie Li.
7. Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3
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Tác giả
Dan Xiao, Yue Zhang, Rui Wang, Yujie Fu, Baofeng Yang.
7. Secalonic acid D induces cell apoptosis in both sensitive and ABCG2-overexpressing multidrug resistant cancer cells through upregulating c-Jun expression
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Tác giả
Hong Zhang, Liyan Huang, Liyang Tao, Jianye Zhang, Liwu Fu.
7. Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins
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Tác giả
Yuan Zhang, Zhihua Wang, Xiaoyao Ma, Shengnan Yang, Gang Bai.
7. Emerging transporter-targeted nanoparticulate drug delivery systems
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Tác giả
Hongyan Su, Yan Wang, Shuo Liu, Yue Wang, Qin Chen.
8. A one-step specific assay for continuous detection of sirtuin 2 activity
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Qi Dai, Zhihua Zheng, Fan Xia, Peiqing Liu, Min Li.
8. Improvement in affinity and thermostability of a fully human antibody against interleukin-17A by yeast-display technology and CDR grafting
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Wei Sun, Zhaona Yang, Heng Lin, Ming Liu, Bing Cui.
8. Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome
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Zhilei Wang, Guang Xu, Yuan Gao, Xiaoyan Zhan, Zhaofang Bai.
8. Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis
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Tác giả
Jiyu Zhou, Ningning Huang, Yitong Guo, Shuang Cui, Haiping Hao.
8. SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade
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Tác giả
Mingxia Zhao, Wenjie Guo, Yuanyuan Wu, Chenxi Yang, Yang Sun.
8. The effects of pH, surfactant, ion concentration, coformer, and molecular arrangement on the solubility behavior of myricetin cocrystals
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Tác giả
Shuzhen Ren, Mingyu Liu, Chao Hong, Guowen Li, Yan Xie.
9. Discovery of WS-157 as a highly potent, selective and orally active EGFR inhibitor
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Tác giả
Pengxing He, Shenghui Niu, Shuai Wang, Xiaojing Shi, Hongmin Liu.
9. Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes
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Tác giả
Feng Zhou, Jingtian Mei, Xiuguo Han, Hanjun Li, Tingting Tang.
9. Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway
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Tác giả
Yayun Liu, Wei Xu, Ting Zhai, Jiaojiao You, Yong Chen.
9. Aurone derivatives as Vps34 inhibitors that modulate autophagy
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Tác giả
Guodong Li, Joshua William Boyle, Chung-Nga Ko, Wu Zeng, Chung-Hang Leung.
9. The epigallocatechin gallate derivative Y6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo
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Yan Wen, Ruiqiang Zhao, Pranav Gupta, Yingfang Fan, Gang Liang.
9. Selenium-layered nanoparticles serving for oral delivery of phytomedicines with hypoglycemic activity to synergistically potentiate the antidiabetic effect
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Tác giả
Wenji Deng, Huan Wang, Baojian Wu, Xingwang Zhang.
10. Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET)
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Tác giả
Yu Lan, Ping Bai, Zude Chen, Ramesh Neelamegam, Changning Wang.
10. Cilastatin protects against imipenem-induced nephrotoxicity via inhibition of renal organic anion transporters (OATs)
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Tác giả
Xiaokui Huo, Qiang Meng, Changyuan Wang, Yanna Zhu, Kexin Liu.
10. Regulation of microbiota–GLP1 axis by sennoside A in diet-induced obese mice
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Tác giả
Jiamei Le, Xiaoying Zhang, Weiping Jia, Yong Zhang, Jianping Ye.
10. Bioactive A-ring rearranged limonoids from the root barks of Walsura robusta
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Tác giả
Faliang An, Xiaobing Wang, Minghua Yang, Jun Luo, Lingyi Kong.
10. LSD1 inhibition suppresses the growth of clear cell renal cell carcinoma via upregulating P21 signaling
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Tác giả
Liangsong Zhu, Jianfeng Wang, Wen Kong, Jiwei Huang, Jin Zhang.
10. Intestinal uptake of barley protein-based nanoparticles for β-carotene delivery
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Tác giả
Guangyu Liu, Ying Zhou, Lingyun Chen.
11. Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia
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Tác giả
Chenglin Wu, Cong Xi, Junhua Tong, Jing Zhao, Hong Liu.
11. Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1
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Tác giả
AlexanderJ. Trevarton, Yan Zhou, Dehua Yang, Gordon W. Rewcastle, Annette Lasham.
11. Up-regulation of glycolipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication
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Tác giả
Meng-Hao Huang, Hu Li, Rong Xue, Jianrui Li, Jiandong Jiang.
11. Develop a 3D neurological disease model of human cortical glutamatergic neurons using micropillar-based scaffolds
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Tác giả
Cheng Chen, Xin Dong, Kai-Heng Fang, Fang Yuan, Yan Liu.
11. Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents
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Tác giả
Jiabing Wang, Lili Huang, Chanchan Cheng, Ge Li, Jianzhang Wu.
11. Drug nanoclusters formed in confined nano-cages of CD-MOF: dramatic enhancement of solubility and bioavailability of azilsartan
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Tác giả
Yuanzhi He, Wei Zhang, Tao Guo, Guoqing Zhang, Jiwen Zhang.
12. Pulmonary immunization: deposition site is of minor relevance for influenza vaccination but deep lung deposition is crucial for hepatitis B vaccination
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Tác giả
Jasmine Tomar, Wouter F. Tonnis, Harshad P. Patil, Anne H. de boer, Wouter L.J. Hinrichs.
12. Upregulation of miR-489-3p and miR-630 inhibits oxaliplatin uptake in renal cell carcinoma by targeting OCT2
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Tác giả
Lu Chen, Le Chen, Zhiyuan Qin, Jinxiu Lei, Lushan Yu.
12. Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation
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Tác giả
Jing Lu, Jingyan Li, Yuehuai Hu, Zhen Guo, Peiqing Liu.
12. Safety and photochemotherapeutic application of poly(γ-glutamic acid)-based biopolymeric nanoparticle
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Tác giả
Dongyoon Kim, Quoc-Viet Le, Young Bong Kim, Yu-Kyoung Oh.
12. Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study
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Tác giả
Peng Wei, Bo Liu, Ruifeng Wang, Yinglei Gao, Bing Xiong.
12. Supersaturated polymeric micelles for oral silybin delivery: the role of the Soluplus–PVPVA complex
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Tác giả
Chunliu Zhu, Shuang Gong, Jinsong Ding, Miaorong Yu, Yong Gan.
13. Predicting complexation performance between cyclodextrins and guest molecules by integrated machine learning and molecular modeling techniques
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Tác giả
Qianqian Zhao, Zhuyifan Ye, Yan Su, Defang Ouyang.
13. MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate
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Tác giả
Sara Abdelfatah, Angela Berg, Qi Huang, Li Jun Yang, Thomas Efferth.
13. Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase 1 (LSD1/KDM1A)
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Tác giả
Zhonghua Li, Lina Ding, Zhongrui Li, Zhizheng Wang,Hongmin Liu.
13. Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma
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Tác giả
Xi Cao, Ying Hu, Shi Luo, Yuejing Wang, Zhirong Zhang.
13. Cytotoxic and antibacterial polyketide-indole hybrids synthesized from indole-3-carbinol by Daldinia eschscholzii
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Tác giả
Liping Lin, Nan Jiang, Huimin Wu, Yaning Mei, Renxiang Tan.
13. Development of carrier-free nanocrystals of poorly water-soluble drugs by exploring metastable zone of nucleation
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Tác giả
Xiaoting Ren, Jianping Qi, Wei Wu, Zongning Yin, Yi Lu.
14. Immunosuppressant mycophenolic acid biosynthesis employs a new globin-like enzyme for prenyl side chain cleavage
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Tác giả
Xiwei Chen, Lu Wang, Jinmei Zhang, Tao Jiang, Yi Zou.
14. High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care
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Tác giả
Jian Li, Olajide E. Olaleye, Xuan Yu, Weiwei Jia, Chuan Li.
14. Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with anti-inflammatory activity in Caco-2 cells
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Tác giả
Qinghao Jin, Jianqing Zhang, Jinjun Hou, Min Lei, Dean Guo.
14. Small interfering RNA delivery to the neurons near the amyloid plaques for improved treatment of Alzheimer׳s disease
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Tác giả
Qian Guo, Xiaoyao Zheng, Peng Yang, Xiaoying Pang, Xinguo Jiang.
14. Dual-targeting and microenvironment-responsive micelles as a gene delivery system to improve the sensitivity of glioma to radiotherapy
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Tác giả
Xiuxiu Jiao, Yuan Yu, Jianxia Meng, Mei He, Xueying Ding.
14. Preparation and characterization of multimodal hybrid organic and inorganic nanocrystals of camptothecin and gold
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Tác giả
Christin P. Hollis, Alan K. Dozier, Barbara L. Knutson, Tonglei Li.
15. Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma
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Tác giả
Xiyue Zhao, Xiaoyu Liu, Pengcheng Zhang, Yiran Liu, Yaping Li.
15. Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer
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Tác giả
Jiaojie Wei, Yang Long, Rong Guo, Xinlei Liu, Qin He.
15. Prussian blue nanosphere-embedded in situ hydrogel for photothermal therapy by peritumoral administration
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Tác giả
Jijun Fu, Bo Wu, Minyan Wei, Yugang Huang, Lingran Du.
15. Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy
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Tác giả
Lu Zhong, Lu Xu, Yanying Liu, Qingsong Li, Zhonggui He.
15. Cordycepin promotes browning of white adipose tissue through an AMP-activated protein kinase (AMPK)-dependent pathway
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Tác giả
Guihong Qi, Yue Zhou, Xiaopo Zhang, Jiaqi Yu, Peng Guo.
16. Actively priming autophagic cell death with novel transferrin receptor-targeted nanomedicine for synergistic chemotherapy against breast cancer
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Tác giả
Dong Mei, Binlong Chen, Bing He, Haibin Liu, Qiang Zhang.
16. GLUT1-mediated effective anti-miRNA21 pompon for cancer therapy
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Tác giả
Qin Guo, Chao Li, Wenxi Zhou, Xinli Chen, Chen Jiang.
16. Overcoming chemotherapy resistance via simultaneous drug-efflux circumvention and mitochondrial targeting
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Tác giả
Minglu Zhou, Lijia Li, Lian Li, Xi Lin, Yuan Huang.
16. Theranostic nanoparticles with tumor-specific enzyme-triggered size reduction and drug release to perform photothermal therapy for breast cancer treatment
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Tác giả
Rui Liu, Chuan Hu, Yuanyuan Yang, Jingqing Zhang, Huile Gao.
16. Noavel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms
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Tác giả
Shuqiang Chen, Guoqiang Dong, Shanchao Wu, Na Liu, Chunquan Sheng.
17. Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan
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Tác giả
Yiqiao Gao, Wei Li, Jiaqing Chen, Xu Wang, Fengguo Xu.
17. The dimerization of Δ9-tetrahydrocannabinolic acid A (THCA-A)
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Tác giả
Arben Cuadari, Federica Pollastro, Juan D. Unciti-Broceta, Diego Caprioglio, Giovanni Appendino.
17. Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy
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Tác giả
Caifang Gao, Jianming Liang, Ying Zhu, Chengli Ling, Jianxin Wang.
17. Combinatorial mutation on the β-glycosidase specific to 7-β-xylosyltaxanes and increasing the mutated enzyme production by engineering the recombinant yeast
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Jing-Jing Chen, Xiao Liang, Fen Wang, Yan-Hua Wen, Ping Zhu.
17. Redox-sensitive prodrug nanoassemblies based on linoleic acid-modified docetaxel to resist breast cancers
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Tác giả
Meng Li, Liwen Zhao, Tao Zhang, Yue Shu, Yongjun Wang.
18. Efficient lung cancer-targeted drug delivery via a nanoparticle/MSC system
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Tác giả
Xusheng Wang, Haiyan Chen, Xiaowei Zeng, Wenpeng Guo, Lin Mei.
18. New era of drug innovation in China
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Tác giả
Xuan Ye, Qingli Wang, Haixue Wang.
18. Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect
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Tác giả
Hangyi Wu, Miaorong Yu, Yunqiu Miao, Shufang He, Yong Gan.
18. Bioengineered miR-27b-3p and miR-328-3p modulate drug metabolism and disposition via the regulation of target ADME gene expression
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Tác giả
Xin Li, Ye Tian, Mei-Juan Tu, Pui Yan Ho, Ai-Ming Yu.
18. Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity
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Tác giả
Zhiqin Cao, Shaoyang Li, Jianming Lv, Hao Gao, Dan Hu.
19. Deep learning for in vitro prediction of pharmaceutical formulations
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Tác giả
Yilong Yang, Zhuyifan Ye, Yan Su, Qianqian Zhao, Defang Ouyang.
19. Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injuryIssued by China Food and Drug Administration
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Tác giả
Xiaohe Xiao, Jianyuan Tang, Yimin Mao, Xiuhui Li, Na An.
19. Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer
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20. Interaction between human serum albumin and cholesterol-grafted polyglutamate as the potential carriers of protein drugs
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Tác giả
Xiangxue Lyu, Qiufen Zhang, Dehai Liang, Yanbin Huang.
21. Exploring the utility of the Chasing Principle: influence of drug-free SNEDDS composition on solubilization of carvedilol, cinnarizine and R3040 in aqueous suspension
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Tác giả
ScheylaDaniela Siqueira Jørgensen, Thomas Rades, Huiling Mu, Kirsten Graeser, Anette Müllertz.
