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Neurobiology of Aging

1. Editorial Advisory Board

Tác giả

1. Editorial Advisory Board

Tác giả

1. Editorial Advisory Board

Tác giả

1. Editorial Advisory Board

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1. Editorial Advisory Board

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1. Cover 2: Editorial Advisory Board

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1. Cover 2: Editorial Advisory Board

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1. Cover 2:Editorial Advisory Board

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1. Cover 2: Editorial Advisory Board

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1. Cover 2: Editorial Advisory Board

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1. Cover 2: Editorial Advisory Board

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1. Cover 2: Editorial Advisory Board

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2. Staging the cognitive continuum in prodromal Alzheimer's disease with episodic memory

Tác giả

Alexis Moscoso, Jesús Silva-Rodríguez, Jose Manuel Aldrey, Julia Cortés, Pablo Aguiar.

2. Estradiol treatment improves biological rhythms in a preclinical rat model of menopause

Tác giả

Weiling Yin, Jeremy C. Borniger, Xutong Wang, Sean M. Maguire, Andrea C. Gore.

2. Late-life brain perfusion after prenatal famine exposure

Tác giả

Susanne R. de Rooij, Henri J.M.M. Mutsaerts, Jan Petr, Iris Asllani, Tessa J. Roseboom.

2. Regional patterns of 18F-florbetaben uptake in presenilin 1 mutation carriers

Tác giả

Roser Sala-Llonch, Neus Falgàs, Beatriz Bosch, Guadalupe Fernández-Villullas, Raquel Sánchez-Valle.

2. Reduced serotonin receptors and transporters in normal aging adults: a meta-analysis of PET and SPECT imaging studies

Tác giả

Teresa M. Karrer, Casey L. McLaughlin, Carmela P. Guaglianone, Gregory R. Samanez-Larkin.

2. Reduced memory-related ongoing oscillatory activity in healthy older adults

Tác giả

Signe L. Winterling, Stephanie M. Shields, Michael Rose.

2. Early and late effects of maternal experience on hippocampal neurogenesis, microglia, and the circulating cytokine milieu

Tác giả

Rand S. Eid, Jessica A. Chaiton, Stephanie E. Lieblich, Tamara S. Bodnar, Liisa A.M. Galea.

2. Prestimulus and poststimulus oscillatory activity predicts successful episodic encoding for both young and older adults

Tác giả

Jon Strunk, Audrey Duarte.

2. Aging affects correlation within the V1 neuronal population in rhesus monkeys

Tác giả

Xuan Wang, Bing Zhang, Huan Wang, Jiachen Liu, Yifeng Zhou.

2. Loss of PINK1 causes age-dependent decrease of dopamine release and mitochondrial dysfunction

Tác giả

Lianteng Zhi, Qi Qin, Tanziyah Muqeem, Erin L. Seifert, Hui Zhang.

2. Key periods of cognitive decline in a nonhuman primate model of cognitive aging, the common marmoset (Callithrix jacchus)

Tác giả

Amirouche Sadoun, Maxime Rosito, Caroline Fonta, Pascal Girard.

2. Age-related differences in the activation of the mentalizing- and reward-related brain regions during the learning of others' true trustworthiness Atsunobu Suzuki, Mika Ueno, Kenta Ishikawa, Akihiro Kobayashi, ... Toshiharu Nakai

Tác giả

Atsunobu Suzuki, Mika Ueno, Kenta Ishikawa, Akihiro Kobayashi, Toshiharu Nakai.

3. Normative brain volumetry derived from different reference populations: impact on single-subject diagnostic assessment in dementia

Tác giả

Elisabeth J. Vinke, Wyke Huizinga, Martin Bergtholdt, Hieab H. Adams, Meike W. Vernooij.

3. Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology

Tác giả

Johannes Burtscher, Jean-Christophe Copin, João Rodrigues, Senthil T. Kumar, Hilal A. Lashuel.

3. Genetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents

Tác giả

Luiza Kvitko Axelrud, João Ricardo Sato, Marcos Leite Santoro, Fernanda Talarico, Giovanni Abrahão Salum.

3. Cyclic O3 exposure synergizes with aging leading to memory impairment in male APOE ε3, but not APOE ε4, targeted replacement mice

Tác giả

Chunsun Jiang, Luke T. Stewart, Hui-Chien Kuo, William McGilberry, Rui-Ming Liu.

3. Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-β and tau

Tác giả

Kelly R. Jacobs, Chai K. Lim, Kaj Blennow, Henrik Zetterberg, David B. Lovejoy.

3. Body mass trajectories and cortical thickness in middle-aged men: a 42-year longitudinal study starting in young adulthood

Tác giả

Carol E. Franz, Hong Xian, Daphne Lew, Sean N. Hatton, William S. Kremen.

3. Lentiviral vector–mediated overexpression of Klotho in the brain improves Alzheimer's disease–like pathology and cognitive deficits in mice

Tác giả

Chen-Ye Zeng, Ting-Ting Yang, Hong-Jing Zhou, Yue Zhao, Jun-Rong Du.

3. Cognitive aging is not created equally: differentiating unique cognitive phenotypes in “normal” adults

Tác giả

Kaitlin B. Casaletto, Fanny M. Elahi, Adam M. Staffaroni, Samantha Walters, Joel H. Kramer.

3. Neuroimaging findings and clinical trajectories of Lewy body disease in patients with MCI

Tác giả

Federico Massa, Dario Arnaldi, Francesca De Cesari, Nicola Girtler, Flavio Nobili.

3. Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain

Tác giả

Robert A. Whittington, László Virág, Maud Gratuze, Hilana Lewkowitz-Shpuntoff, Emmanuel Planel.

3. Functional signature of conversion of patients with mild cognitive impairment

Tác giả

Stefano Delli Pizzi, Miriam Punzi, Stefano L. Sensi, Alzheimer's Disease Neuroimaging Initiative.

3. Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

Tác giả

Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Maria Francesca De Pandis.

4. Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline

Tác giả

Namhee Kim, Lei Yu, Robert Dawe, Vladislav A. Petyuk, David A. Bennett.

4. Interaction between the progression of Alzheimer's disease and fractal degradation

Tác giả

Peng Li, Lei Yu, Jingyun Yang, Men-Tzung Lo, Kun Hu.

4. Age-related differences in the structural and effective connectivity of cognitive control: a combined fMRI and DTI study of mental arithmetic

Tác giả

Thomas Hinault, Kevin Larcher, Louis Bherer, Susan M. Courtney, Alain Dagher.

4. The relationship between domain-specific subjective cognitive decline and Alzheimer's pathology in normal elderly adults

Tác giả

Sepideh Shokouhi, Alexander C. Conley, Suzanne L. Baker, Kimberly Albert, Paul A. Newhouse.

4. Atrophy of hippocampal subfield CA2/3 in healthy elderly men is related to educational attainment

Tác giả

Lijuan Jiang, Xinyi Cao, Jiangling Jiang, Ting Li, Chunbo Li.

4. Evolution of brain atrophy subtypes during aging predicts long-term cognitive decline and future Alzheimer's clinical syndrome

Tác giả

Vincent Planche, Pierrick Coupé, Catherine Helmer, Mélanie Le Goff, Gwénaëlle Catheline.

4. Corticospinal control of normal and visually guided gait in healthy older and younger adults

Tác giả

Meaghan Elizabeth Spedden, Julia T. Choi, Jens Bo Nielsen, Svend Sparre Geertsen.

4. Event-related potentials associated with auditory attention capture in younger and older adults

Tác giả

Cassandra Morrison, Farooq Kamal, Kenneth Campbell, Vanessa Taler.

4. Seizures as an early symptom of autosomal dominant Alzheimer's disease

Tác giả

Jonathan Vöglein, Soheyl Noachtar, Eric McDade, Kimberly A. Quaid, Adrian Danek.

4. Age-dependent behavioral and biochemical characterization of single APP knock-in mouse (APPNL-G-F/NL-G-F) model of Alzheimer's disease

Tác giả

Jogender Mehla, Sean G. Lacoursiere, Valerie Lapointe, Bruce L. McNaughton, Majid H. Mohajerani.

4. Cortical atrophy pattern–based subtyping predicts prognosis of amnestic MCI: an individual-level analysis

Tác giả

Hee Jin Kim, Jong-Yun Park, Sang Won Seo, Young Hee Jung, Duk L. Na.

4. Blood acetylcholinesterase level is a potential biomarker for the early detection of cerebral amyloid deposition in cognitively normal individuals

Tác giả

Sun-Ho Han, Jong-Chan Park, Min Soo Byun, Dahyun Yi, Inhee Mook-Jung.

5. A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients

Tác giả

Rocío Pérez-González, Sébastien A. Gauthier, Ajay Sharma, Chelsea Miller, Efrat Levy.

5. The relationship between white matter hyperintensities and cognitive reference abilities across the life span

Tác giả

Ana R. Moura, Seonjoo Lee, Christian Habeck, Qolamreza Razlighi, Yaakov Stern.

5. Longitudinal cognitive decline in autosomal-dominant Alzheimer's disease varies with mutations in APP and PSEN1 genes

Tác giả

Ove Almkvist, Elena Rodriguez-Vieitez, Steinunn Thordardottir, Agneta Nordberg, Caroline Graff.

5. Lifespan normative data on rates of brain volume changes

Tác giả

Marco Battaglini, Giordano Gentile, Ludovico Luchetti, Antonio Giorgio, Nicola De Stefano.

5. Layer-specific axonal degeneration of serotonergic fibers in the prefrontal cortex of aged A53T α-synuclein–expressing mice

Tác giả

Jeanette Wihan, Janina Grosch, Liubov S. Kalinichenko, Christian P. Müller, Zacharias Kohl.

5. Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis

Tác giả

Hao Xiong, Suijun Chen, Lan Lai, Haidi Yang, Yiqing Zheng.

5. Oxytocin alters patterns of brain activity and amygdalar connectivity by age during dynamic facial emotion identification

Tác giả

Marilyn Horta, Maryam Ziaei, Tian Lin, Eric C. Porges, Natalie C. Ebner.

5. The influence of tau, amyloid, alpha-synuclein, TDP-43, and vascular pathology in clinically normal elderly individuals

Tác giả

Alexandra M. Wennberg, Jennifer L. Whitwell, Nirubol Tosakulwong, Stephen D. Weigand, Keith A. Josephs.

5. Screening of a neuronal cell model of tau pathology for therapeutic compounds

Tác giả

Marcus Pickhardt, Michele Tassoni, Philip Denner, Birgit Kurkowsky, Eckhard Mandelkow.

5. Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited

Tác giả

Alzheimer Network Aurélie Bussy, B. Joy Snider, Dean Coble, Chengjie Xiong, John C. Morris.

5. Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging

Tác giả

Delia Fuhrmann, David Nesbitt, Meredith Shafto, James B. Rowe, Rogier A. Kievit.

5. Aging alters envelope representations of speech-like sounds in the inferior colliculus

Tác giả

Aravindakshan Parthasarathy, Björn Herrmann, Edward L. Bartlett.

6. Subjective cognitive decline, brain imaging biomarkers, and cognitive functioning in patients with a history of vascular disease: the SMART-Medea study

Tác giả

Kim Blom, Huiberdina L. Koek, Maarten H.T. Zwartbol, Yolanda van der Graaf, Pieter A. Doevendans.

6. Biomarker-guided clustering of Alzheimer's disease clinical syndromes

Tác giả

Nicola Toschi, Simone Lista, Filippo Baldacci, Enrica Cavedo, Nadjia Younsi.

6. Transforming growth factor beta 1 signaling is altered in the spinal cord and muscle of amyotrophic lateral sclerosis mice and patients

Tác giả

Marco Meroni, Valeria Crippa, Riccardo Cristofani, Paola Rusmini, Mariarita Galbiati.

6. Synergism between fornix microstructure and beta amyloid accelerates memory decline in clinically normal older adults

Tác giả

Jennifer S. Rabin, Rodrigo D. Perea, Rachel F. Buckley, Keith A. Johnson, Trey Hedden.

6. Predicting Alzheimer's disease severity by means of TMS–EEG coregistration

Tác giả

Chiara Bagattini, Tuomas P. Mutanen, Claudia Fracassi, Rosa Manenti, Marta Bortoletto.

6. Longitudinal association between phosphatidylcholines, neuroimaging measures of Alzheimer's disease pathophysiology, and cognition in the Mayo Clinic Study of Aging

Tác giả

Danni Li, Clinton Hagen, Ashely R. Fett, Hai H. Bui, Michelle M. Mielke.

6. Age-related decrease in cortical excitability circadian variations during sleep loss and its links with cognition

Tác giả

Giulia Gaggioni, Julien Q.M. Ly, Vincenzo Muto, Sarah L. Chellappa, Gilles Vandewalle.

6. Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study

Tác giả

Arjan Blokland, Marlies A. Van Duinen, Anke Sambeth, Pim R.A. Heckman, Jos Prickaerts.

6. DNA methylation variability in Alzheimer's disease

Tác giả

Zhiguang Huo, Yun Zhu, Lei Yu, Jingyun Yang, Jinying Zhao.

6. Striking reduction in neurons and glial cells in anterior thalamic nuclei of older patients with Down syndrome

Tác giả

James C. Perry, Bente Pakkenberg, Seralynne D. Vann.

6. Phenotypic and functional differences between senescent and aged murine microglia

Tác giả

Milan R. Stojiljkovic, Quratul Ain, Tzvetanka Bondeva, Regine Heller, Otto W. Witte.

6. miR-125b promotes tau phosphorylation by targeting the neural cell adhesion molecule in neuropathological progression

Tác giả

Linyu Zhang, Hao Dong, Youwen Si, Nan Wu, Bo Meng.

7. Sulcal morphology in Alzheimer's disease: an effective marker of diagnosis and cognition

Tác giả

Maxime Bertoux, Julien Lagarde, Fabian Corlier, Lorraine Hamelin, Marie Sarazin.

7. Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers

Tác giả

Qin Chen, Bradley F. Boeve, Christopher G. Schwarz, Robert Reid, Kejal Kantarci.

7. Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson's disease

Tác giả

Calahorra J. García-Moreno, Montserrat Porta de la Riva, Esther Martínez-Lara, Eva Siles, Ana Cañuelo.

7. Mice heterozygous for the Cdh23/Ahl1 mutation show age-related deficits in auditory temporal processing

Tác giả

Alice L. Burghard, Nazli P. Morel, Douglas L. Oliver.

7. A quantitative model of human neurodegenerative diseases involving protein aggregation

Tác giả

Kasper P. Kepp.

7. Amyloid PET and cognitive decline in cognitively normal individuals: the SCIENCe project

Tác giả

Tessa Timmers, Rik Ossenkoppele, Sander C.J. Verfaillie, Chris W.J. van der Weijden, Bart N.M. van Berckel.

7. Interaction of nutrition and genetics via DNMT3L-mediated DNA methylation determines cognitive decline

Tác giả

Miles Flitton, Nicholas Rielly, Rhian Warman, Donald Warden, Helen Miranda Knight.

7. Age-related differences in neural spectral power during motor learning

Tác giả

Laura Milena Rueda-Delgado, Kirstin Friederike Heise, Andreas Daffertshofer, Dante Mantini, Stephan Patrick Swinnen.

7. Spatial updating deficits in human aging are associated with traces of former memory representations

Tác giả

Maayan Merhav, Martin Riemer, Thomas Wolbers.

7. Influence of hypertension on brain amyloid deposition and Alzheimer's disease signature neurodegeneration

Tác giả

So Yeon Jeon, Min Soo Byun, Dahyun Yi, Jun Ho Lee, Dong Young Lee.

7. A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases

Tác giả

Adam R. Smith, Rebecca G. Smith, Joe Burrage, Claire Troakes, Katie Lunnon.

7. Decreased cingulo-opercular network functional connectivity mediates the impact of aging on visual processing speed

Tác giả

Adriana L. Ruiz-Rizzo, Christian Sorg, Natan Napiórkowski, Julia Neitzel, Kathrin Finke.

8. Neural evidence for age-related differences in representational quality and strategic retrieval processes

Tác giả

Alexandra N. Trelle, Richard N. Henson, Jon S. Simons.

8. Association of white matter microstructural integrity with cognition and dementia

Tác giả

Melinda C. Power, Dan Su, Aozhou Wu, Robert I. Reid, ... Thomas H. Mosley.

8. Longitudinal brain atrophy patterns and neuropsychological performance in older adults with HIV-associated neurocognitive disorder compared with early Alzheimer's disease

Tác giả

Benedetta Milanini, Vishal Samboju, Yann Cobigo, Robert Paul, Victor Valcour.

8. The value of hippocampal volume, shape, and texture for 11-year prediction of dementia: a population-based study

Tác giả

Hakim C. Achterberg, Lauge Sørensen, Frank J. Wolters, Wiro J. Niessen, Marleen de Bruijne.

8. Associations between modifiable risk factors and white matter of the aging brain: insights from diffusion tensor imaging studies

Tác giả

Thomas M. Wassenaar, Kristine Yaffe, Ysbrand D. van der Werf, Claire E. Sexton.

8. Quantitative assessment of the intracranial vasculature in an older adult population using iCafe

Tác giả

Li Chen, Jie Sun, Daniel S. Hippe, Niranjan Balu, Chun Yuan.

8. Delayed daily activity and reduced NREM slow-wave power in the APPswe/PS1dE9 mouse model of Alzheimer's disease

Tác giả

Brianne A. Kent, Mateusz Michalik, Elliott G. Marchant, Kiana W. Yau, Haakon B. Nygaard.

8. Association of amyloid pathology with memory performance and cognitive complaints in cognitively normal older adults: a monozygotic twin study

Tác giả

Elles Konijnenberg, Anouk den Braber, Mara ten Kate, Jori Tomassen, Pieter Jelle Visser.

8. The longitudinal decline of white matter microstructural integrity in behavioral variant frontotemporal dementia and its association with executive function

Tác giả

Junhong Yu, Tatia M.C. Lee, Frontotemporal Lobar Degeneration Neuroimaging Initiative.

8. Disrupted structural and functional brain networks in Alzheimer's disease

Tác giả

Zhengjia Dai, Qixiang Lin, Tao Li, Xiao Wang, Huali Wang.

8. Image-guided phenotyping of ovariectomized mice: altered functional connectivity, cognition, myelination, and dopaminergic functionality

Tác giả

Cynthia Anckaerts, Jaana van Gastel, Valerie Leysen, Rukun Hinz, Annemie Van der Linden.

8. Alzheimer's disease and late-onset epilepsy of unknown origin: two faces of beta amyloid pathology

Tác giả

Cinzia Costa, Michele Romoli, Claudio Liguori, Lucia Farotti, Paolo Calabresi.

9. Benzodiazepine use and brain amyloid load in nondemented older individuals: a florbetapir PET study in the Multidomain Alzheimer Preventive Trial cohort

Tác giả

Thomas Desmidt, Julien Delrieu, Thibaud Lebouvier, Gabriel Robert, Vincent Camus.

9. Neural signatures of temporal regularity processing in sounds differ between younger and older adults

Tác giả

Björn Herrmann, Chad Buckland, Ingrid S. Johnsrude.

9. Age-related changes in cortical connectivity influence the neuromodulatory effects of transcranial electrical stimulation

Tác giả

Anna Fertonani, Cornelia Pirulli, Alice Bollini, Carlo Miniussi, Marta Bortoletto.

9. Visuomotor task acquisition is reduced by priming paired associative stimulation in older adults

Tác giả

George M. Opie, Brodie J. Hand, James P. Coxon, Michael C. Ridding, John G. Semmler.

9. Individual slow-wave morphology is a marker of aging

Tác giả

Péter P. Ujma, Péter Simor, Axel Steiger, Martin Dresler, Róbert Bódizs.

9. The effects of omega-3 fatty acid deficiency during development on oxidative fatty acid degradation during maturity in a mouse model of Alzheimer's disease

Tác giả

Ran Furman, Paul H. Axelsen.

9. Sleep EEG functional connectivity varies with age and sex, but not general intelligence

Tác giả

Péter P. Ujma, Boris N. Konrad, Péter Simor, Ferenc Gombos, Róbert Bódizs.

9. Prenatal noise stress aggravates cognitive decline and the onset and progression of beta amyloid pathology in a mouse model of Alzheimer's disease

Tác giả

Zahra Jafari, Megan Okuma, Hadil Karem, Jogender Mehla, Majid H. Mohajerani.

9. White matter in different regions evolves differently during progression to dementia

Tác giả

Mahsa Dadar, Josefina Maranzano, Simon Ducharme, D. Louis Collins, Alzheimer's Disease Neuroimaging Initiative.

9. Iron-related nigral degeneration influences functional topology mediated by striatal dysfunction in Parkinson's disease

Tác giả

Xiaojun Guan, Yuyao Zhang, Hongjiang Wei, Tao Guo, Minming Zhang.

9. Older adults fail to form stable task representations during model-based reversal inference

Tác giả

Dorothea Hämmerer, Philipp Schwartenbeck, Maria Gallagher, Thomas Henry Benedict FitzGerald, Raymond Joseph Dolan.

9. Beta amyloid deposition maps onto hippocampal and subiculum atrophy in dementia with Lewy bodies

Tác giả

Elijah Mak, Paul C. Donaghy, Elizabeth McKiernan, Michael J. Firbank, John T. O'Brien.

10. Neuropsychological and neurophysiological characterization of mild cognitive impairment and Alzheimer's disease in Down syndrome

Tác giả

Javier García-Alba, Federico Ramírez-Toraño, Susanna Esteba-Castillo, Ricardo Bruña, Alberto Fernández.

10. Regional brain atrophy predicts time to conversion to Alzheimer's disease, dependent on baseline volume

Tác giả

Hossein Tabatabaei-Jafari, Marnie E. Shaw, Erin Walsh, Nicolas Cherbuin, Alzheimer's Disease Neuroimaging Initiative (ADNI).

10. The neuritic plaque in Alzheimer's disease: perivascular degeneration of neuronal processes

Tác giả

Gurpreet Kaur Hansra, Glib Popov, Patricia O. Banaczek, Monica Vogiatzis, Karen M. Cullen.

10. ABAD/17β-HSD10 reduction contributes to the protective mechanism of huperzine a on the cerebral mitochondrial function in APP/PS1 mice

Tác giả

Xiaodan Xiao, Qingzhuang Chen, Xinhong Zhu, Yong Wang.

10. Loss of DmGluRA exacerbates age-related sleep disruption and reduces lifespan

Tác giả

Sarah Ly, Nirinjini Naidoo.

10. Reductions in GABA following a tDCS-language intervention for primary progressive aphasia

Tác giả

Ashley D. Harris, Zeyi Wang, Bronte Ficek, Kim Webster, Kyrana Tsapkini.

10. CNS luteinizing hormone receptor activation rescues ovariectomy-related loss of spatial memory and neuronal plasticity

Tác giả

Jeffrey A. Blair, Sabina Bhatta, Gemma Casadesus.

10. Par3 regulates polarized convergence between APP and BACE1 in hippocampal neurons

Tác giả

Miao Sun, Chengyu Huang, Hui Wang, Huaye Zhang.

10. Progressive signaling changes in the olfactory nerve of patients with Alzheimer's disease

Tác giả

Praveen Bathini, Antoine Mottas, Muriel Jaquet, Emanuele Brai, Lavinia Alberi.

10. Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Tác giả

Sami Gabbouj, Teemu Natunen, Hennariikka Koivisto, Kimmo Jokivarsi, Mikko Hiltunen.

10. In vivo visualization of age-related differences in the locus coeruleus

Tác giả

Kathy Y. Liu, Julio Acosta-Cabronero, Arturo Cardenas-Blanco, Clare Loane, Dorothea Hämmerer.

10. Increased posterior default mode network activity and structural connectivity in young adult APOE-ε4 carriers: a multimodal imaging investigation

Tác giả

Carl J. Hodgetts, Jonathan P. Shine, Huw Williams, Mark Postans, Kim S. Graham.

11. Plasma cortisol is associated with cerebral hypometabolism across the Alzheimer's disease spectrum

Tác giả

Miranka Wirth, Catharina Lange, Willem Huijbers, Alzheimer's Disease Neuroimaging Initiative.

11. Dynamic change of cognitive reserve: associations with changes in brain, cognition, and diagnosis

Tác giả

Brianne M. Bettcher, Alden L. Gross, Brandon E. Gavett, Keith F. Widaman, Dan Mungas.

11. miR-146a and miR-181a are involved in the progression of mild cognitive impairment to Alzheimer's disease

Tác giả

Abulaish Ansari, Elisabetta Maffioletti, Elena Milanesi, Moira Marizzoni, Luisella Bocchio-Chiavetto.

11. Short erythropoietin-derived peptide enhances memory, improves long-term potentiation, and counteracts amyloid beta–induced pathology

Tác giả

Oksana Dmytriyeva, Amor Belmeguenai, Laurent Bezin, Katia Soud, Stanislava Pankratova.

11. T2*-weighted MRI values correlate with motor and cognitive dysfunction in Parkinson's disease

Tác giả

Nicola Tambasco, Federico Paolini Paoletti, Andrea Chiappiniello, Viviana Lisetti, Paolo Calabresi.

11. Spatial gradients of healthy aging: a study of myelin-sensitive maps

Tác giả

Vyacheslav R. Karolis, Martina F. Callaghan, Chieh-En Jane Tseng, Thomas Hope, Marinella Cappelletti.

11. Intelligence moderates the relationship between age and inter-connectivity of resting state networks in older adults

Tác giả

Cutter A. Lindbergh, Yu Zhao, Jinglei Lv, Catherine M. Mewborn, L. Stephen Miller.

11. Is there a specific memory signature associated with Aβ-PET positivity in patients with amnestic mild cognitive impairment?

Tác giả

Clémence Tomadesso, Julie Gonneaud, Stéphanie Egret, Audrey Perrotin, Renaud La Joie.

11. External cueing facilitates auditory-motor integration for speech control in individuals with Parkinson's disease

Tác giả

Xiyan Huang, Hao Fan, Jingting Li, Jeffery A. Jones, Hanjun Liu.

11. Impairment in complex activities of daily living is related to neurodegeneration in Alzheimer's disease–specific regions

Tác giả

Roos J. Jutten, Ellen Dicks, Lieke Vermaat, Frederik Barkhof, Sietske A.M. Sikkes.

11. Brain age from the electroencephalogram of sleep

Tác giả

Haoqi Sun, Luis Paixao, Jefferson T. Oliva, Balaji Goparaju, M. Brandon Westover.

11. Dendritic spine remodeling accompanies Alzheimer's disease pathology and genetic susceptibility in cognitively normal aging

Tác giả

Benjamin D. Boros, Kelsey M. Greathouse, Marla Gearing, Jeremy H. Herskowitz.

12. Cerebrospinal fluid amyloid levels are associated with delayed memory retention in cognitively normal biomarker-negative older adults

Tác giả

Lok-Kin Yeung, Christiane Hale, Briana S. Last, Howard Andrews, Adam M. Brickman.

12. Differential activation of the mTOR/autophagy pathway predicts cognitive performance in APP/PS1 mice

Tác giả

Rasika S. Vartak, Alexis Rodin, Salvatore Oddo.

12. Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults

Tác giả

Rachel L. Nosheny, Philip S. Insel, Niklas Mattsson, Duygu Tosun, Michael W. Weiner.

12. Musical training improves the ability to understand speech-in-noise in older adults

Tác giả

Benjamin Rich Zendel, Greg L. West, Sylvie Belleville, Isabelle Peretz.

12. GABAergic and glutamatergic cells in the inferior colliculus dynamically express the GABAAR γ1 subunit during aging

Tác giả

Lauren C. Robinson, Oren Barat, Jeffrey G. Mellott.

12. Cue-related processing accounts for age differences in phasic alerting

Tác giả

Iris Wiegand, Myriam C. Sander.

12. Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline

Tác giả

Nicole C. Berchtold, G. Aleph Prieto, Michael Phelan, Daniel L. Gillen, Carl W. Cotman.

12. Associations of amygdala volume and shape with transactive response DNA-binding protein 43 (TDP-43) pathology in a community cohort of older adults

Tác giả

Nazanin Makkinejad, Julie A. Schneider, Junxiao Yu, Sue E. Leurgans, Konstantinos Arfanakis.

12. Age-related cortical signatures of human sleep electroencephalography

Tác giả

Véronique Latreille, Malo Gaubert, Jonathan Dubé, Jean-Marc Lina, Julie Carrier.

12. Social housing protects against age-related working memory decline independently of physical enrichment in rats

Tác giả

Victoria L. Templer, Taylor B. Wise, Victoria R. Heimer-McGinn.

12. High-fat diet worsens the impact of aging on microglial function and morphology in a region-specific manner

Tác giả

Sarah J. Spencer, Bashirah Basri, Luba Sominsky, Alita Soch, Ruth M. Barrientos

12. Frontoparietal cortical thickness mediates the effect of COMT Val158Met polymorphism on age-associated executive function

Tác giả

Giuseppe G. Miranda, Karen M. Rodrigue, Kristen M. Kennedy.

13. Supervised pathway analysis of blood gene expression profiles in Alzheimer's disease

Tác giả

Elaheh Moradi, Mikael Marttinen, Tomi Häkkinen, Mikko Hiltunen, Matti Nykter.

13. Pupillary dilation responses as a midlife indicator of risk for Alzheimer's disease: association with Alzheimer's disease polygenic risk

Tác giả

William S. Kremen, Matthew S. Panizzon, Jeremy A. Elman, Eric L. Granholm, Carol E. Franz.

13. Reduced cognitive performance in aged rats correlates with increased excitation/inhibition ratio in the dentate gyrus in response to lateral entorhinal input

Tác giả

Trinh Tran, Michelle Bridi, Ming Teng Koh, Michela Gallagher, Alfredo Kirkwood.

13. Identification of age- and gender-associated long noncoding RNAs in the human brain with Alzheimer's disease

Tác giả

Mei Cao, Huaqing Li, Jian Zhao, Juan Cui, Guoku Hu.

13. Longstanding psychological stress in relation to biomarkers of neuronal dysfunction in cerebrospinal fluid: a 25-year follow-up study in women

Tác giả

Lena Johansson, Simona Sacuiu, Silke Kern, Xinxin Guo, Ingmar Skoog.

13. ApoE and clusterin CSF levels influence associations between APOE genotype and changes in CSF tau, but not CSF Aβ42, levels in non-demented elderly

Tác giả

Rosalinde E.R. Slot, Maartje I. Kester, Argonde C. Van Harten, Wesley Jongbloed, Robert Veerhuis.

13. Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats Inmaculada

Tác giả

Pereda-Pérez, Azucena Valencia, Shishir Baliyan, Ángel Núñez, César Venero.

13. Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases

Tác giả

Claudio Babiloni, Claudio Del Percio, Maria Teresa Pascarelli, Roberta Lizio, Laura Bonanni.

13. Gray and white matter changes in presymptomatic genetic frontotemporal dementia: a longitudinal MRI study

Tác giả

Jessica L. Panman, Lize C. Jiskoot, Mark J.R.J. Bouts, Lieke H.H. Meeter, Janne M. Papma.

13. Pramipexole-induced impulsivity in mildparkinsonian rats: a model of impulse control disorders in Parkinson's disease

Tác giả

Haritz Jiménez-Urbieta, Belén Gago, Ana Quiroga-Varela, Tatiana Rodríguez-Chinchilla, María C. Rodríguez-Oroz.

13. Translating Alzheimer's disease–associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs

Tác giả

Yuriko Katsumata, Peter T. Nelson, Steven Estus, the Alzheimer's Disease Neuroimaging Initiative (ADNI), David W. Fardo.

13. Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories

Tác giả

Nahid Zokaei, Giedrė Čepukaitytė, Alexander G. Board, Clare E. Mackay, Anna Christina Nobre.

14. The role of education in a vascular pathway to episodic memory: brain maintenance or cognitive reserve?

Tác giả

Laura B. Zahodne, Elizabeth Rose Mayeda, Timothy J. Hohman, Evan Fletcher, Dan Mungas.

14. The expectation breakers

Tác giả

Molly V. Wagster, Jonathan W. King.

14. Odorants: a tool to provide nonpharmacological intervention to reduce anxiety during normal and pathological aging

Tác giả

Benedicte Ballanger, Kevin G. Bath, Nathalie Mandairon.

14. Age-related differences in the within-session trainability of hemodynamic parameters: a near-infrared spectroscopy–based neurofeedback study

Tác giả

Silvia Erika Kober, Robert Spörk, Günther Bauernfeind, Guilherme Wood.

14. Bridging the brain structure—brain function gap in prosodic speech processing in older adults

Tác giả

Nathalie Giroud, Matthias Keller, Sarah Hirsiger, Volker Dellwo, Martin Meyer.

14. Relevance of the interplay between amyloid and tau for cognitive impairment in early Alzheimer's disease

Tác giả

Maarten Timmers, Ina Tesseur, Jennifer Bogert, Henrik Zetterberg, Johannes Rolf Streffer.

14. Mild cognitive impairment reverters have a favorable cognitive prognosis and cortical integrity in Parkinson's disease

Tác giả

Seok Jong Chung, Yeong-Hun Park, Han Soo Yoo, Yang Hyun Lee, Phil Hyu Lee.

14. Fresh evidence for major brain gangliosides as a target for the treatment of Alzheimer's disease

Tác giả

Marina Dukhinova, Tatyana Veremeyko, Amanda W.Y. Yung, Inna S. Kuznetsova, Eugene D. Ponomarev.

14. Proinflammatory and anti-inflammatory cytokines in the CSF of patients with Alzheimer's disease and their correlation with cognitive decline

Tác giả

Ricardo Taipa, Sofia P. das Neves, Ana L. Sousa, Joana Fernandes, Nuno Sousa.

14. Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice

Tác giả

Charles E. Evans, Rhian S. Thomas, Thomas J. Freeman, Martha Hvoslef-Eide, Emma J. Kidd.

14. Postmitotic cell longevity–associated genes: a transcriptional signature of postmitotic maintenance in neural tissues

Tác giả

Atahualpa Castillo-Morales, Jimena Monzón-Sandoval, Araxi O. Urrutia, Humberto Gutiérrez.

14. Unveiling the olfactory proteostatic disarrangement in Parkinson's disease by proteome-wide profiling

Tác giả

Mercedes Lachén-Montes, Andrea González-Morales, Ibon Iloro, Felix Elortza, Enrique Santamaría.

15. Insulin and adipokine signaling and their cross-regulation in postmortem human brain

Tác giả

Hoau-Yan Wang, Ana W. Capuano, Amber Khan, Zhe Pei, Zoe Arvanitakis.

15. Brain reserve, cognitive reserve, compensation, and maintenance: operationalization, validity, and mechanisms of cognitive resilience

Tác giả

Yaakov Stern, Carol A. Barnes, Cheryl Grady, Richard N. Jones, Naftali Raz.

15. Contents Continued

Tác giả

15. Cross-sectional associations between [18F]GTP1 tau PET and cognition in Alzheimer's disease

Tác giả

Edmond Teng, Michael Ward, Paul T. Manser, Sandra Sanabria-Bohorquez, Robby M. Weimer.

15. SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy

Tác giả

Jiaqi Pang, Hao Xiong, Yongkang Ou, Haidi Yang, Yiqing Zheng.

15. Altered slow (<1 Hz) and fast (beta and gamma) neocortical oscillations in the 3xTg-AD mouse model of Alzheimer's disease under anesthesia

Tác giả

Patricia Castano-Prat, Lorena Perez-Mendez, Maria Perez-Zabalza, Coral Sanfeliu, Maria V. Sanchez-Vives.

15. Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid

Tác giả

Rachel F. Buckley, Elizabeth C. Mormino, Jasmeer Chhatwal, Aaron P. Schultz, Bernard J. Hanseeuw.

15. Downregulation of SNX27 expression does not exacerbate amyloidogenesis in the APP/PS1 Alzheimer's disease mouse model

Tác giả

Michael R. Milne, Lei Qian, Marion T. Turnbull, Genevieve Kinna, Elizabeth J. Coulson.

15. Clinical and biomarker changes in presymptomatic genetic frontotemporal dementia

Tác giả

Alberto Benussi, Stefano Gazzina, Enrico Premi, Maura Cosseddu, Barbara Borroni.

15. Creative aging: functional brain networks associated with divergent thinking in older and younger adults

Tác giả

Areeba Adnan, Roger Beaty, Paul Silvia, R. Nathan Spreng, Gary R. Turner.

15. Sex-dependent effect of the BDNF Val66Met polymorphism on executive functioning and processing speed in older adults: evidence from the health ABC study

Tác giả

Cindy K. Barha, Teresa Liu-Ambrose, John R. Best, Kristine Yaffe, Caterina Rosano.

15. Impaired perceptual integration and memory for unitized representations are associated with perirhinal cortex atrophy in Alzheimer's disease

Tác giả

Emma Delhaye, Mohamed Ali Bahri, Eric Salmon, Christine Bastin.

16. Retrograde axonal transport of BDNF and proNGF diminishes with age in basal forebrain cholinergic neurons

Tác giả

Arman Shekari, Margaret Fahnestock.

16. What are the threats to successful brain and cognitive aging?

Tác giả

Michela Gallagher, Ozioma C. Okonkwo, Susan M. Resnick, William J. Jagust, Peter R. Rapp.

16. Table of Contents Continued

Tác giả

16. Sex differences in brain aging and predictors of neurodegeneration in cognitively healthy older adults

Tác giả

Nicole M. Armstrong, Yang An, Lori Beason-Held, Jimit Doshi, Susan M. Resnick.

16. Internal model recalibration does not deteriorate with age while motor adaptation does

Tác giả

Koenraad Vandevoorde, Jean-Jacques Orban de Xivry.

16. Aging circadian rhythms and cannabinoids

Tác giả

Erik L. Hodges, Nicole M. Ashpole.

16. Frontal-subcortical behaviors during Alzheimer's disease in individuals with Down syndrome

Tác giả

Luciana Mascarenhas Fonseca, Guilherme Prado Mattar, Glenda Guerra Haddad, Aline Souza Gonçalves, Marcelo Queiroz Hoexter.

16. Age-dependent changes in clock neuron structural plasticity and excitability are associated with a decrease in circadian output behavior and sleep

Tác giả

Jack A. Curran, Edgar Buhl, Krasimira Tsaneva-Atanasova, James J.L. Hodge.

16. Amyloid deposition is associated with different patterns of hippocampal connectivity in men versus women

Tác giả

Minjie Wu, Rebecca C. Thurston, Dana L. Tudorascu, Helmet T. Karim, Howard J. Aizenstein.

16. Uric acid enhances longevity and endurance and protects the brain against ischemia

Tác giả

Roy G. Cutler, Simonetta Camandola, Neil H. Feldman, Jeong Seon Yoon, Mark P. Mattson.

16. In vivo hippocampal subfield shape related to TDP-43, amyloid beta, and tau pathologies

Tác giả

Veronika Hanko, Alexandra C. Apple, Kathryn I. Alpert, Kristen N. Warren, Lei Wang.

16. Effects of aging, high-fat diet, and testosterone treatment on neural and metabolic outcomes in male brown Norway rats

Tác giả

V. Alexandra Moser, Amy Christensen, Jiahui Liu, Amanda Zhou, Christian J. Pike.

17. Global expression profiling of cognitive level and decline in middle-aged monozygotic twins

Tác giả

Marianne Nygaard, Martin J. Larsen, Mads Thomassen, Matt McGue, Lene Christiansen.

17. What are the earlier life contributions to reserve and resilience?

Tác giả

Kristine B. Walhovd, Gareth R. Howell, Stuart J. Ritchie, Roger T. Staff, Carl W. Cotman.

17. Bilingualism and “brain reserve”: a matter of age

Tác giả

Stefan Heim, Johanna Stumme, Nora Bittner, Christiane Jockwitz, Svenja Caspers.

17. Exercise prevents obesity-induced cognitive decline and white matter damage in mice

Tác giả

Leah C. Graham, Weronika A. Grabowska, Yoona Chun, Shannon L. Risacher, Gareth R. Howell.

17. Impact of exercise training on physical and cognitive function among older adults: a systematic review and meta-analysis

Tác giả

Ryan S. Falck, Jennifer C. Davis, John R. Best, Rachel A. Crockett, Teresa Liu-Ambrose.

17. Genetics and molecular mechanisms of frontotemporal lobar degeneration: an update and future avenues

Tác giả

Raffaele Ferrari, Claudia Manzoni, John Hardy.

17. Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia

Tác giả

Timothy Rittman, Robin Borchert, Simon Jones, John van Swieten, Miren Zulaica.

17. Aged rats with preserved memory dynamically recruit hippocampal inhibition in a local/global cue mismatch environment

Tác giả

Audrey Branch, Amy Monasterio, Grace Blair, James J. Knierim, Rebecca P. Haberman.

17. Trajectories of cognitive decline differ in hippocampal sclerosis and Alzheimer's disease

Tác giả

Denis S. Smirnov, Douglas Galasko, Lawrence A. Hansen, Steven D. Edland, David P. Salmon.

17. CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum

Tác giả

Boris-Stephan Rauchmann, Thomas Schneider-Axmann, Panagiotis Alexopoulos, Robert Perneczky, Alzheimer's Disease Neuroimaging Initiative.

17. Lower mitochondrial DNA content but not increased mutagenesis associates with decreased base excision repair activity in brains of AD subjects

Tác giả

Daniela T. Soltys, Carolina P.M. Pereira, Fernanda T. Rowies, José M. Farfel, Nadja C. Souza-Pinto.

18. Older adults sacrifice response speed to preserve multisensory integration performance

Tác giả

Samuel A. Jones, Ulrik Beierholm, David Meijer, Uta Noppeney.

18. What are the later life contributions to reserve, resilience, and compensation?

Tác giả

Sara N. Burke, Elizabeth C. Mormino, Emily J. Rogalski, Claudia H. Kawas, Denise C. Park.

18. Temporal progression of Alzheimer's disease in brains and intestines of transgenic mice

Tác giả

Gunjan D. Manocha, Angela M. Floden, Nicole M. Miller, Abbie J. Smith, Colin K. Combs.

18. Analysis of pleiotropic genetic effects on cognitive impairment, systemic inflammation, and plasma lipids in the Health and Retirement Study

Tác giả

Michael W. Lutz, Ramon Casanova, Santiago Saldana, Maragatha Kuchibhatla, Kathleen M. Hayden.

18. ELS Ad 494

Tác giả

18. Using stem cell–derived neurons in drug screening for neurological diseases

Tác giả

Daniel Little, Robin Ketteler, Paul Gissen, Michael J. Devine.

18. Genetic analysis suggests high misassignment rates in clinical Alzheimer's cases and controls Valentina

Tác giả

Escott-Price, Emily Baker, Maryam Shoai, Ganna Leonenko, John Hardy.

18. Expression of neurogenic markers in Alzheimer's disease: a systematic review and metatranscriptional analysis

Tác giả

Ariana Gatt, Hyunah Lee, Gareth Williams, Sandrine Thuret, Clive Ballard.

18. Predictors of neurodegeneration differ between cognitively normal and subsequently impaired older adults

Tác giả

Nicole M. Armstrong, Yang An, Lori Beason-Held, Jimit Doshi, Susan M. Resnick.

18. Amyloid beta–positive subjects exhibit longitudinal network-specific reductions in spontaneous brain activity

Tác giả

Brian B. Avants, R. Matthew Hutchison, Alvydas Mikulskis, Cristian Salinas-Valenzuela, Ping Chiao.

18. Comparison of longitudinal Aβ in nondemented elderly and Down syndrome

Tác giả

Dana L. Tudorascu, Stewart J. Anderson, Davneet S. Minhas, Zheming Yu, Ann D. Cohen.

19. High dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage

Tác giả

Marie-Gabrielle Duperron, Christophe Tzourio, Sabrina Schilling, Yi-Cheng Zhu, Stéphanie Debette.

19. How do we validate approaches that aim to harness reserve to improve the aging brain?

Tác giả

Lon R. White, Patricia A. Boyle, Thomas C. Foster, Adam H. Gazzaley, John F. Disterhoft.

19. Pharmacological antagonism of histamine H2R ameliorated L-DOPA–induced dyskinesia via normalization of GRK3 and by suppressing FosB and ERK in PD

Tác giả

Mohamed Rafiuddin Ahmed, Mithya Jayakumar, Mohamed Sohail Ahmed, Alsu I. Zamaleeva, Jayakumar Rajadas,

19. An analog derived from phenylpropanoids ameliorates Alzheimer's disease–like pathology and protects mitochondrial function

Tác giả

Shichao Huang, Xin Cao, Yue Zhou, Fuchun Shi, Gang Pei.

19. Table of Contents Continued

Tác giả

19. Whole exome should be preferred over Sanger sequencing in suspected mitochondrial myopathy

Tác giả

Josef Finsterer.

19. Cognitive heterogeneity among community-dwelling older adults with cerebral small vessel disease

Tác giả

Ayan K. Dey, Vessela Stamenova, Agnes Bacopulos, Nivethika Jeyakumar, Brian Levine.

19. Increased cerebral blood volume in small arterial vessels is a correlate of amyloid-β–related cognitive decline

Tác giả

Jun Hua, SeungWook Lee, Nicholas I.S. Blair, Michael Wyss, Paul G. Unschuld.

19. 18F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia

Tác giả

Hanna Cho, Hee Jin Kim, Jae Yong Choi, Young Hoon Ryu, Chul Hyoung Lyoo.

19. The association between hearing impairment and neural envelope encoding at different ages

Tác giả

Tine Goossens, Charlotte Vercammen, Jan Wouters, Astrid van Wieringen.

19. Age-related differences in event-related potentials and pupillary responses in cued reaction time tasks

Tác giả

Maria J. Ribeiro, Miguel Castelo-Branco.

20. Co-activation of selective nicotinic acetylcholine receptors is required to reverse beta amyloid–induced Ca2+ hyperexcitation

Tác giả

Julianna L. Sun, Sarah A. Stokoe, Jessica P. Roberts, Matheus F. Sathler, Seonil Kim.

20. Innovative approaches in cognitive aging

Tác giả

Steven N. Austad, Marcelo A. Wood, Saul A. Villeda, Joel L. Voss, Marilyn Albert.

20. Late aging–associated increases in L-DOPA–induced dyskinesia are accompanied by heightened neuroinflammation in the hemi-parkinsonian rat

Tác giả

Kathryn Lanza, Amy E. Perkins, Terrence Deak, Christopher Bishop.

20. Delineating the topography of amyloid-associated cortical atrophy in Down syndrome

Tác giả

Elijah Mak, Concepcion Padilla, Tiina Annus, Liam R. Wilson, Anthony J. Holland.

20. Cover 4: Contents

Tác giả

20. Response to a letter to the editor

Tác giả

Elisa Rubino, Ming Zhang, Tiziana Mongini, Silvia Boschi, Innocenzo Rainero.

20. Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes after acute traumatic brain injury in mice

Tác giả

Rodney M. Ritzel, Sarah J. Doran, Ethan P. Glaser, Victoria E. Meadows, David J. Loane.

20. Multimodal MRI evaluation of parkinsonian limbic pathologies

Tác giả

Ernest W. Wang, Guangwei Du, Mechelle M. Lewis, Eun-Young Lee, Xuemei Huang.

20. CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits

Tác giả

Yang-Ping Shentu, Wen-Ting Hu, Qing Zhang, Yuda Huo, Rong Liu.

20. Neuroendocrine aging precedes perimenopause and is regulated by DNA methylation

Tác giả

Eliza R. Bacon, Aarti Mishra, Yiwei Wang, Maunil K. Desai, Roberta Diaz Brinton.

20. UNC13A polymorphism contributes to frontotemporal disease in sporadic amyotrophic lateral sclerosis

Tác giả

Katerina Placek, G. Michael Baer, Lauren Elman, Leo McCluskey, Corey T. McMillan.

21. Hippocampal pathology in amyotrophic lateral sclerosis: selective vulnerability of subfields and their associated projections

Tác giả

Foteini Christidi, Efstratios Karavasilis, Michail Rentzos, Georgios Velonakis, Peter Bede.

21. Contents Continued

Tác giả

21. A 4R tauopathy develops without amyloid deposits in aged cat brains

Tác giả

Luc Poncelet, Kunie Ando, Cristina Vergara, Salwa Mansour, Karelle Leroy.

21. Age- and disease-related cerebral white matter changes in patients with Parkinson's disease

Tác giả

Laura J. de Schipper, Anne Hafkemeijer, Mark J.R.J. Bouts, Jeroen van der Grond, Jacobus J. van Hilten.

21. Table of Contents Continued

Tác giả

21. Mutation profile of APP, PSEN1, and PSEN2 in Chinese familial Alzheimer's disease

Tác giả

Ying Gao, Ru-Jing Ren, Zi-Lin Zhong, Eric Dammer, Gang Wang.

21. Cholecystokinin and Alzheimer's disease: a biomarker of metabolic function, neural integrity, and cognitive performance

Tác giả

Alexandra Plagman, Siobhan Hoscheidt, Kelsey E. McLimans, Brandon Klinedinst, Auriel A. Willette.

21. Investigation of mitochondrial calcium uniporter role in embryonic and adult motor neurons from G93AhSOD1 mice

Tác giả

Vedrana Tadić, Adam Adam, Nadine Goldhammer, Janin Lautenschlaeger, Julian Grosskreutz.

21. Hippocampal transcriptome profiling combined with protein-protein interaction analysis elucidates Alzheimer's disease pathways and genes Jeroen G.J. van

Tác giả

Rooij, Lieke H.H. Meeter, Shami Melhem, Diana A.T. Nijholt, John C. van Swieten.

21. Effects of estrogen and aging on synaptic morphology and distribution of phosphorylated Tyr1472 NR2B in the female rat hippocampus

Tác giả

Elizabeth M. Waters, Sanoara Mazid, Mariana Dodos, Rishi Puri, Teresa A. Milner.

22. The relationship of age and DRD2 polymorphisms to frontostriatal brain activity and working memory performance

Tác giả

Xin Li, Lars Bäckman, Jonas Persson.

22. Contents

Tác giả

22. Targeted genetic analysis of cerebral blood flow imaging phenotypes implicates the INPP5D gene

Tác giả

Xiaohui Yao, Shannon L. Risacher, Kwangsik Nho, Andrew J. Saykin, Li Shen.

22. Age-dependent alterations of Kir4.1 expression in neural crest–derived cells of the mouse and human cochlea

Tác giả

Ting Liu, Gang Li, Kenyaria V. Noble, Yongxi Li, Hainan Lang.

22. Cover 4: Contents

Tác giả

22. Table of Contents (Continued from Cover 4).

Tác giả

22. Diet and biomarkers of Alzheimer's disease: a systematic review and meta-analysis

Tác giả

Edward Hill, Alicia M. Goodwill, Alexandra Gorelik, Cassandra Szoeke.

22. CHCHD10 is involved in the development of Parkinson's disease caused by CHCHD2 loss-of-function mutation p.T61I

Tác giả

Chengyuan Mao, Herui Wang, Haiyang Luo, Shuyu Zhang, Yuming Xu.

22. Extracellular vesicles, new actors in the search for biomarkers of dementias

Tác giả

Ana Gámez-Valero, Katrin Beyer, Francesc E. Borràs.

22. Neurometabolites and associations with cognitive deficits in mild cognitive impairment: a magnetic resonance spectroscopy study at 7 Tesla

Tác giả

Georg Oeltzschner, S. Andrea Wijtenburg, Mark Mikkelsen, Richard A.E. Edden, Gwenn S. Smith.

23. CRISPR/Cas9 does not facilitate stable expression of long C9orf72 dipeptides in mice

Tác giả

Sarah Ryan, Eleanor Hobbs, Sara Rollinson, Stuart M. Pickering-Brown.

23. Reduced sensory-evoked structural plasticity in the aging barrel cortex

Tác giả

Rebecca L. Voglewede, Kaeli M. Vandemark, Andrew M. Davidson, Annie R. DeWitt, Ricardo Mostany.

23. Table of Contents Continued

Tác giả

23. Cover 4 (Table of Contents 1st page)

Tác giả

23. Klotho allele status is not associated with Aβ and APOE ε4–related cognitive decline in preclinical Alzheimer's disease

Tác giả

Tenielle Porter, Samantha C. Burnham, Lidija Milicic, Greg Savage, Simon M. Laws.

23. Association between telomere length and cognitive ability in a community-based sample

Tác giả

Rishika Kaja, Stephanie M. Reyes, Heidi C. Rossetti, E. Sherwood Brown.

23. Relations between C9orf72 expansion size in blood, age at onset, age at collection and transmission across generations in patients and presymptomatic carriers

Tác giả

Clémence Fournier, Mathieu Barbier, Agnès Camuzat, Vincent Anquetil, Isabelle Le Ber.

23. Intrinsic neurocognitive network connectivity differences between normal aging and mild cognitive impairment are associated with cognitive status and age

Tác giả

Margot D. Sullivan, John A.E. Anderson, Gary R. Turner, R. Nathan Spreng, Alzheimer's Disease Neuroimaging Initiative.

24. Genetic analysis of PODXL gene in patients with familial and young-onset Parkinson's disease in a Taiwanese population

Tác giả

Szu-Ju Chen, Ruey-Meei Wu, Chang-Han Ho, Jay Cheng, Chin-Hsien Lin.

24. Association of PPP2R1A with Alzheimer's disease and specific cognitive domains

Tác giả

Justin Miron, Cynthia Picard, Anne Labonté, Daniel Auld, Judes Poirier.

24. Table of Contents

Tác giả

24. Unaltered prion disease in mice lacking developmental endothelial locus–1

Tác giả

Caihong Zhu, Zhihao Li, Bei Li, Manuela Pfammatter, Adriano Aguzzi.

24. A comprehensive screening of copy number variability in dementia with Lewy bodies

Tác giả

Celia Kun-Rodrigues, Tatiana Orme, Susana Carmona, Dena G. Hernandez, Jose Bras.

24. Association of NIPA1 repeat expansions with amyotrophic lateral sclerosis in a large international cohort

Tác giả

Gijs H.P. Tazelaar, Annelot M. Dekker, Joke J.F.A. van Vugt, Rick A. van der Spek, Michael A. van Es.

24. Genetic activation of parkin rescues TAF15-induced neurotoxicity in a Drosophila model of amyotrophic lateral sclerosis

Tác giả

Youngjo Kim, Hyung-Jun Kim, Sun Joo Cha, Hyun-Jun Choi, Kiyoung Kim.

25. Mutation analysis of LRP10 in Japanese patients with familial Parkinson's disease, progressive supranuclear palsy, and frontotemporal dementia

Tác giả

Kensuke Daida, Kenya Nishioka, Yuanzhe Li, Hiroyo Yoshino, Nobutaka Hattori.

25. Contents Continued

Tác giả

25. Genetic analysis of neurodegenerative diseases in a pathology cohort

Tác giả

Cornelis Blauwendraat, Olga Pletnikova, Joshua T. Geiger, Natalie A. Murphy, ... Sonja W. Scholz.

25. Frontotemporal dementia spectrum: first genetic screen in a Greek cohort

Tác giả

Eliana Marisa Ramos, Christos Koros, Deepika Reddy Dokuru, Victoria Van Berlo, Giovanni Coppola.

25. Evaluation of novel Parkinson's disease candidate genes in the Chinese population Elaine

Tác giả

Guo Yan Chew, Herty Liany, Louis C.S. Tan, Wing-Lok Au, Eng-King Tan.

25. Mutation analysis of KIF5A in Chinese amyotrophic lateral sclerosis patients

Tác giả

Kang Zhang, Qing Liu, Dongchao Shen, Hongfei Tai, Xue Zhang.

26. Novel amyloid precursor protein mutation, Val669Leu (“Seoul APP”), in a Korean patient with early-onset Alzheimer's disease

Tác giả

Eva Bagyinszky, Min Ju Kang, Vo Van Giau, KyuHwan Shim, SangYun Kim.

26. Contents

Tác giả

26. Presence of tau astrogliopathy in frontotemporal dementia caused by a novel Grn nonsense (Trp2*) mutation

Tác giả

Estrella Gómez-Tortosa, Yalda Baradaran-Heravi, Valentina González Alvarez, María José Sainz, Alberto Rábano Gutiérrez.

26. Genetic variants of PARK genes in Korean patients with early-onset

Tác giả

Parkinson's disease Jinyoung Youn, Chung Lee, Eungseok Oh, Jinse Park, Chang-Seok Ki.

26. Analysis of CACNA1A CAG repeat lengths in patients with familial

Tác giả

ALS David Brenner, Kathrin Müller, Regina Gastl, Martin Gorges, Albert C. Ludolph.

26. Striking phenotypic variation in a family with the P506S UBQLN2 mutation including amyotrophic lateral sclerosis, spastic paraplegia, and frontotemporal dementia

Tác giả

Soragia Athina Gkazi, Claire Troakes, Simon Topp, Jack W. Miller, Christopher E. Shaw.

27. A unique common ancestor introduced P301L mutation in MAPT gene in frontotemporal dementia patients from Barcelona (Baix Llobregat, Spain)

Tác giả

Leire Palencia-Madrid, Raquel Sánchez-Valle, Ierai Fernández de Retana, Sergi Borrego, Marian M. de Pancorbo.

27. Systematically analyzing rare variants of autosomal-dominant genes for sporadic Parkinson's disease in a Chinese cohort

Tác giả

Nannan Yang, Yuwen Zhao, Zhenhua Liu, Rui Zhang, Beisha Tang.

27. Polymorphisms in DNA methylation–related genes are linked to the phenotype of Machado-Joseph disease

Tác giả

Dongxue Ding, Chunrong Wang, Zhao Chen, Huirong Peng, Hong Jiang.

27. Two rare variants of the ANXA11 gene identified in Chinese patients with amyotrophic lateral sclerosis

Tác giả

Xiangyi Liu, Chujun Wu, Ji He, Nan Zhang, Dongsheng Fan.

27. EIF2AK3 variants in Dutch patients with Alzheimer's disease

Tác giả

Tsz Hang Wong, Sven J. van der Lee, Jeroen G.J. van Rooij, Lieke H.H. Meeter, John C. van Swieten.

28. Repeat variations in polyglutamine disease–associated genes and cognitive function in old age

Tác giả

Sarah L. Gardiner, Stella Trompet, Behnam Sabayan, Merel W. Boogaard, N. Ahmad Aziz.

28. HTT gene intermediate alleles in neurodegeneration: evidence for association with Alzheimer's disease

Tác giả

Manuel Menéndez-González, Jordi Clarimón, Irene Rosas-Allende, Marta Blázquez, Carmen Martínez.

28. Mutation screening of SLC52A3, C19orf12, and TARDBP in Iranian ALS patients

Tác giả

Marzieh Khani, Afagh Alavi, Hosein Shamshiri, Babak Zamani, Elahe Elahi.

28. No evidence for DNM3 as genetic modifier of age at onset in idiopathic Parkinson's disease

Tác giả

Victoria Berge-Seidl, Lasse Pihlstrøm, Zbigniew K. Wszolek, Owen A. Ross, Mathias Toft.

28. Relationship between variants of 17 newly loci and Parkinson's disease in a Chinese population

Tác giả

Xiang Chen, Yousheng Xiao, Wenyuan Guo, Miaomiao Zhou, Pingyi Xu.

29. C9orf72 and intracerebral hemorrhage

Tác giả

Isabel C. Hostettler, Manuel Bernal-Quiros, Andrew Wong, Nikhil Sharma, Henry Houlden.

29. Mutation screening in Chinese patients with familial Alzheimer's disease by whole-exome sequencing

Tác giả

Bin Jiang, Jiong Zhou, Hong-Lei Li, Yan-Gui Chen, Zhi-Ying Wu.

29. Contents Continued

Tác giả

29. CHCHD2 mutational screening in Brazilian patients with familial Parkinson's disease

Tác giả

Danielle D. Voigt, Caroline M. Nascimento, Ritiele B. de Souza, Pedro H. Cabello Acero, Márcia M.G. Pimentel.

29. APOE ɛ4, rs405509, and rs440446 promoter and intron-1 polymorphisms and dementia risk in a cohort of elderly Finns—Helsinki Birth Cohort Study

Tác giả

Ville Rantalainen, Jari Lahti, Eero Kajantie, Pentti Tienari, Katri Raikkonen.

30. Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment

Tác giả

Jeremy A. Elman, Matthew S. Panizzon, Mark W. Logue, Nathan A. Gillespie, William S. Kremen.

30. The association between repeat number in C9orf72 and phenotypic variability in Turkish patients with frontotemporal lobar degeneration

Tác giả

Ebru Erzurumluoglu, Oguz Cilingir, Belgin Demet Ozbabalik Adapinar, Basar Bilgic, Sevilhan Artan.

30. Cover 4: Contents

Tác giả

30. Contents Continued

Tác giả

30. Repeat length variations in ATXN1 and AR modify disease expression in Alzheimer's disease

Tác giả

Sarah L. Gardiner, Aster V.E. Harder, Yvonne J.M. Campman, Stella Trompet, N. Ahmad Aziz.

31. A patient with early-onset Alzheimer's disease with a novel PSEN1 p.Leu424Pro mutation

Tác giả

Gamze Guven, Nihan Erginel-Unaltuna, Bedia Samanci, Cagri Gulec, Basar Bilgic.

31. Genetic influence of plasma homocysteine on Alzheimer's disease

Tác giả

Donald John Lehmann, Mario Cortina-Borja.

31. Cover 4: Contents

Tác giả

31. Common and rare GCH1 variants are associated with Parkinson's disease

Tác giả

Uladzislau Rudakou, Bouchra Ouled Amar Bencheikh, Jennifer A. Ruskey, Lynne Krohn, Ziv Gan-Or.

32. One-carbon metabolism gene polymorphisms are associated with cognitive trajectory among African-American adults

Tác giả

May A. Beydoun, Salman M. Tajuddin, Danielle Shaked, Hind A. Beydoun, Alan B. Zonderman.

32. Contents Continued

Tác giả

32. ATXN2 intermediate repeat expansions influence the clinical phenotype in frontotemporal dementia

Tác giả

Elisa Rubino, Cecilia Mancini, Silvia Boschi, Patrizia Ferrero, Innocenzo Rainero.

33. Novel presenilin 1 mutation (p.Thr-Pro116-117Ser-Thr) in a Spanish family with early-onset Alzheimer's disease

Tác giả

Jose Antonio Blanco, Adrian Alonso, Jorge Blanco, Esther Rojo, Fernando Uribe.

33. Cover 4: Contents

Tác giả

33. Contents Continued

Tác giả

34. The role of C9orf72 in neurodegenerative disorders: a systematic review, an updated meta-analysis, and the creation of an online database

Tác giả

Chrysoula Marogianni, Dimitrios Rikos, Antonios Provatas, Katerina Dadouli, Georgia Xiromerisiou.

34. Cover 4: Contents

Tác giả

35. APOE effects on cognition from childhood to adolescence

Tác giả

Chandra A. Reynolds, Andrew Smolen, Robin P. Corley, Elizabeth Munoz, Sally J. Wadsworth.

36. Coexistence of variants in TBK1 and in other ALS-related genes elucidates an oligogenic model of pathogenesis in sporadic

Tác giả

ALS Serena Lattante, Paolo Niccolò Doronzio, Giuseppe Marangi, Amelia Conte, Mario Sabatelli.

37. Mendelian randomization indicates that TNF is not causally associated with Alzheimer's disease

Tác giả

Shea J. Andrews, Alison Goate.

38. Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects

Tác giả

Jonathan Vöglein, Michael Willem, Johannes Trambauer, Sonja Schönecker, Johannes Levin.

39. Population-based genome-wide association study of cognitive decline in older adults free of dementia: identification of a novel locus for the attention domain

Tác giả

M. Ilyas Kamboh, Kang-Hsien Fan, Qi Yan, Joanne C. Beer, Mary Ganguli.

40. Plasma microRNA profiling distinguishes patients with frontotemporal dementia from healthy subjects

Tác giả

Margherita Grasso, Paola Piscopo, Giuseppina Talarico, Leonardo Ricci, Annamaria Confaloni.

41. Tau aggregation and seeding analyses of two novel MAPT variants found in patients with motor neuron disease and progressive parkinsonism

Tác giả

Sachiko Nakayama, Shotaro Shimonaka, Montasir Elahi, Kenya Nishioka, Nobutaka Hattori.

42. Genome-wide association study identifies Alzheimer's risk variant in MS4A6A influencing cerebrospinal fluid sTREM2 levels

Tác giả

Xiao-He Hou, Yan-Lin Bi, Meng-Shan Tan, Wei Xu, Jin-Tai Yu.

43. Confirmation of high frequency of C9orf72 mutations in patients with frontotemporal dementia from Sweden

Tác giả

Linn Öijerstedt, Huei-Hsin Chiang, Jenny Björkström, Charlotte Forsell, Caroline Graff.

44. Association study of rs3846662 with Alzheimer's disease in a population-based cohort: the Cache County Study

Tác giả

Sage M. Wright, Samantha L. Jensen, Kristen L. Cockriel, Brian Davis, John S.K. Kauwe.

45. C9orf72 hexanucleotide repeat length in older population: normal variation and effects on cognition

Tác giả

Karri Kaivola, Anna Kiviharju, Lilja Jansson, Ville Rantalainen, Pentti J. Tienari.

46. Genetic analysis of DNA methylation and hydroxymethylation genes in Parkinson's disease

Tác giả

Li Shu, Lixia Qin, Shishi Min, Hongxu Pan, Qian Xu.

47. Identification of genetic heterogeneity of Alzheimer's disease across age

Tác giả

Min-Tzu Lo, Karolina Kauppi, Chun-Chieh Fan, Nilotpal Sanyal, Chi-Hua Chen.

48. Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging

Tác giả

Chin Hong Tan, Kathy A. Low, Antonio M. Chiarelli, Mark A. Fletcher, Monica Fabiani.

49. Age dependency of mGluR5 availability in 5xFAD mice measured by PET

Tác giả

Minkyung Lee, Hae-June Lee, Ye Ji Jeong, Se Jong Oh, Jae Yong Choi.

50. Effects of L-DOPA on quadripulse magnetic stimulation–induced long-term potentiation in older adults

Tác giả

Nobuyuki Tanaka, Ryosuke Tsutsumi, Yuichiro Shirota, Takahiro Shimizu, Ritsuko Hanajima.

51. Cerebral amyloid burden is associated with white matter hyperintensity location in specific posterior white matter regions

Tác giả

Nick A. Weaver, Thomas Doeven, Frederik Barkhof, J. Matthijs Biesbroek, Geert Jan Biessels.

52. Contents Continued

Tác giả

53. Contents

Tác giả