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Medicinal Chemistry Research
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1. Nitroheterocyclic derivatives: privileged scaffold for drug development against Chagas disease
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Tác giả
Cauê Benito Scarim, Chung Man Chin.
1. Synthetic compounds with sulfonamide moiety against Leishmaniasis: an overview
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Tác giả
Luiz C. S. Pinheiro, Maria de Lourdes G. Ferreira.
1. Nitrogenous phytoconstituents of genus Moringa: spectrophotometrical and pharmacological characteristics
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Tác giả
Alaadin E. El-Haddad, Eman M. El-Deeb, Mahmoud A. Koheil…
1. Advance in biological activities of natural guaiane-type sesquiterpenes
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Tác giả
Gang-Hua Ma, Kai-Xian Chen, Liu-Qiang Zhang, Yi-Ming Li.
1. Natural thiopeptides as a privileged scaffold for drug discovery and therapeutic development
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Tác giả
Xiaoqi Shen, Muhammad Mustafa, Yanyang Chen, Yingying Cao…
1. An overview of tubulin modulators deposited in protein data bank
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Tác giả
Haowei Guo, Xingcong Li, Ya Guo, Linlin Zhen
1. Synthesis and antimycobacterial evaluation of new 5-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-methyl-2-arylthiazole derivatives
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Tác giả
Vikas Shinde, Pramod Mahulikar, Pravin C. Mhaske…
1. Isolation of phenylpropanoid sucrose esters from the roots of Persicaria orientalis and their potential as inhibitors of melanogenesis
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Tác giả
Mohammad Nuruzzaman Masum, Siwattra Choodej, Kosei Yamauchi…
1. Quinazolines as inhibitors of chromatin-associated proteins in histones
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Tác giả
Frida S. Herrera-Vázquez, Francisco Hernández-Luis.
1. Determination of antioxidant capacity, phenolic acid composition and antiproliferative effect associated with phenylalanine ammonia lyase (PAL) activity in some plants naturally growing under salt stress
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Tác giả
Seda Şirin, Belma Aslım.
1. Mechanistic studies of the apoptosis induced by the macrocyclic natural product tetrandrine in MGC 803 cells
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Tác giả
Sai-Qi Wang, Hong-Lin Hou, Liang-Yu Bie, Cai-Yun Nie.
1. Dioscin-6’-O-acetate impairs migration of lung cancer cells through attenuations of MMP-2 and MMP-9 via NF-κB suppression
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Tác giả
Xuejiao Li, Jiachen Sun, Xia Li, Yujie Dai, Chengcheng Zhao.
2. Synthesis of dehydro-α-lapachones, α- and β-lapachones, and screening against cancer cell lines
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Tác giả
Caroline dos S. Moreira, Caroline D. Nicoletti.
2. Anxiolytic and anticonvulsant activity followed by molecular docking study of ceramides from the Red Sea sponge Negombata sp
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Nermeen A. Eltahawy, Amany K. Ibrahim, Mohamed S. Gomaa.
2. Synthesis, antimicrobial evaluation, and molecular docking of some new angular allylbenzochromone derivatives
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El-Sayed I. El-Desoky, Aya A. El-Sawi, Mohamed A. Abozeid…
2. Synthesis, in vitro antifungal evaluation and docking studies of novel derivatives of imidazoles and benzimidazoles
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Tác giả
Pegah Shojaei, Babak Mokhtari, Masoud Ghorbanpoor.
2. Sulfa drug analogs: new classes of N-sulfonyl aminated azines and their biological and preclinical importance in medicinal chemistry (2000–2018)
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Tác giả
Galal H. Elgemeie, Rasha A. Azzam, Rasha E. Elsayed.
2. Design, synthesis, bioactivity, and DFT calculation of 2-thiazolyl-hydrazone derivatives as influenza neuraminidase inhibitors
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Tác giả
Man-Ying Cui, Jian-Xia Nie, Zhong-Zhong Yan, Meng-Wu Xiao…
2. 3D-QSAR modeling of Phosphodiesterase-5 inhibitors: evaluation and comparison of the receptor- and ligand-based alignments
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Zan Jiang, Xuehua Zheng, Zhong Li, Shuqiong Pan…
2. Mohammad Nuruzzaman Masum, Siwattra Choodej, Kosei Yamauchi…
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Abdul Rahim, Riyaz Syed, Y. Poornachandra, M. Shaheer Malik…
2. Developmental perspectives of the drugs targeting enzyme-instigated inflammation: a mini review
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Tác giả
Parteek Prasher, Harish Mudila, Mousmee Sharma, Beena Khati.
2. A new triterpene diglycoside from the roots of Bupleurum chinense DC. and its inhibitory effect on adipogensis in 3T3-L1 cells
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Tác giả
Yujing Feng, Zhou-Wei Wu, Yanyan Luo, Liang Chen.
2. Oxymatrine improves L-arginine-induced acute pancreatitis related intestinal injury via regulating AKT/NFkB and claudins signaling
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Tác giả
Hui Zang, Zhiqiang Zhang, Qingfeng Liu, Huimin Xiao.
2. Synthesis, antimalarial, antiproliferative, and apoptotic activities of benzimidazole-5-carboxamide derivatives
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Tác giả
Jesús A. Romero, María E. Acosta, Neira D. Gamboa.
3. Design, synthesis, molecular docking, antimicrobial, and antioxidant activities of new phenylsulfamoyl carboxylic acids of pharmacological interest
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Tác giả
Melford C. Egbujor, Uchechukwu C. Okoro, Sunday Okafor.
3. Zunyimycin C inhibits the proliferation of lung cancer cells by inducing apoptosis through an AKT-related mechanism
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Tác giả
Wei Li, Jie Zheng, Wenhong Wang, Zhongming Qian, Yuxin Bao.
3. Design, synthesis, and biological evaluation of matrine derivatives possessing piperazine moiety as antitumor agents
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Tác giả
Yiming Xu, Pengyun Liang, Haroon ur Rashid, Lichuan Wu…
3. QSAR-guided pharmacophore modeling and subsequent virtual screening identify novel TYK2 inhibitor
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Tác giả
Elham Y. Al-Barghouthy, Areej Abuhammad, Mutasem O. Taha.
3. Synthesis, molecular docking, and apoptogenic efficacy of novel N-heterocycle analogs to target B-cell lymphoma 2/X-linked inhibitors of apoptosis proteins to regress melanoma
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Tác giả
Zabiulla Zabiulla, Vikas H. Malojirao…
3. Chiral amide derivatives of ricinoleic acid and 3-hydroxynonanoic acid synthesis and cytotoxic activity
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Tác giả
Sylwia Matysiak, Józef Kula, Alina Błaszczyk.
3. Synthesis and biological evaluation of novel chromonyl enaminones as α-glucosidase inhibitors
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Aarón Mendieta-Moctezuma, Catalina Rugerio-Escalona…
3. Anchorage of curcumin onto PVP enhances anti-tumor effect of curcumin
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Lifang Guo, Mingbiao Shi, Nan Song, Zirui Wan, He Liu…
3. Effect of chiral polyhydrochromenes on cannabinoid system
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Nikolai S. Li-Zhulanov, Irina V. Il’ina, Andrea Chicca…
3. Studies of NMR, molecular docking, and molecular dynamics simulation of new promising inhibitors of cruzaine from the parasite Trypanosoma cruzi
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Tác giả
Renato A. Costa, Jorddy N. Cruz, Fabiana C. A. Nascimento.
3. Identification of protein arginine methyltransferase 7 (PRMT7) inhibitor by virtual screening and biological evaluation in vitro
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Tác giả
Linlin Liu, Xiaoning Kai, Qingqing Chen, Ling Zhang.
3. Synthesis and antitumor activity evaluation of different 2,5-dialkyloxazolopyrano[3,2-c]quinolinone derivatives
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Tác giả
Hany M. Hassanin, Wafaa R. Abd Elmoneam, Mai A. Mostafa.
4. Synthesis and in silico and in vitro evaluation of trimethoxy-benzamides designed as anti-prion derivatives
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Tác giả
Raissa A. Conceição, Lucas M. Ascari, Natália C. Ferreira.
4. Chemical synthesis, molecular modeling and pharmacophore mapping of new pyrrole derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth
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Tác giả
Shrinivas D. Joshi, S. R. Prem Kumar, Sonali Patil.
4. FOXO signal activating alkaloids isolated from Ochrosia elliptica leaf cultivated in Egypt
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Tác giả
Rola M. Labib, Fazila Zulfiqar, Mohamed A. Ibrahim…
4. N, N’-disubstitutedphenyl-4-ethoxyl benzene-1, 3-disulfonamides: design, synthesis, and evaluation of anti-platelet aggregation activity
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Xin Chen, Xiujie Liu, kai Qiu, Xiang Xu, Caiwen Li…
4. Umbelliferone isolated from Zosima absinthifolia roots partially restored erectile dysfunction in streptozotocin-induced diabetic rats
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Songul Karakaya, Didem Yilmaz-Oral, Ceyda Sibel Kilic…
4. Synthesis and biological evaluation of ursolic acid derivatives containing an aminoguanidine moiety
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Jie Wu, Song Ma, Tian-Yi Zhang, Zhi-Yu Wei, Hui-Min Wang…
4. Design, synthesis and biological evaluation of alantolactone derivatives as potential anti-inflammatory agents
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Chetan Kumar, Anil Kumar, Yedukondalu Nalli, Waseem I. Lone…
4. The modulatory effect of green tea catechin on drug resistance in human ovarian cancer cells
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Dawid Przystupski, Olga Michel, Joanna Rossowska…
4. Design, synthesis and anticancer activities of halogenated Phenstatin analogs as microtubule destabilizing agent
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Tác giả
Shengquan Hu, Wuji Sun, Yeming Wang, Hong Yan.
4. Isolation, structural modification of macrophin from endophytic fungus Phoma macrostoma and their cytotoxic potential
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Tác giả
Yedukondalu Nalli, Palak Arora, Sameer Khan, Fayaz Malik.
4. Novel anti-cancer agents: design, synthesis, biological activity, molecular docking, and MD simulations of 2, 3, 4, 5-tetrahydro-1H-pyrido-[4,3-b]indole derivatives
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Tác giả
Yu Feng, Xingxing Teng, Jinhua Gu, Bangwei Yu, Yan Luo.
4. In vitro and in vivo studies of 5,7-dihydroxy flavones isolated from Alpinia galanga (L.) against human lung cancer and ascetic lymphoma
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Tác giả
S. Lakshmi, Sandra Suresh, B. S. Rahul, R. Saikant.
5. Synthesis and anti-endoplasmic reticulum stress activity of N-substituted-2-arylcarbonylhydrazinecarbothioamides
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Tác giả
Hoon Choi, Wheesahng Yun, Jung-hun Lee, Seoul Jang.
5. Synthesis, in vitro cytotoxicity and anti-platelet activity of new 1,3-bentzenedisulfonamides
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Tác giả
Liu Xiu-jie, Zhang Zhi-hao, Deng Qing-song, Chen Xin.
5. Discovery of 3-(thiophen/thiazole-2-ylthio)pyridine derivatives as multitarget anticancer agents
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Tác giả
Jiankang Zhang, Jianjun Xi, Ruoyu He, Rangxiao Zhuang…
5. Structure-activity relationship for vanilloid compounds from extract of Zingiber officinale var rubrum rhizomes: effect on extracellular melanogenesis inhibitory activity
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Tác giả
Kosei Yamauchi, Misaki Natsume, Kaho Yamaguchi…
5. Quinoline analogs of 2-aminoindane as potential central dopaminergic agents
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Jorge E. Angel, Ricardo D. Enriz, Katherindel C. Balza…
5. Aminoalkyl-substituted flavonoids: synthesis, cholinesterase inhibition, β-amyloid aggregation, and neuroprotective study
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Tác giả
Laleh Faraji, Hamid Nadri, Alireza Moradi…
5. Inhibition of melanin production by sesquiterpene lactones from Saussurea lappa and their analogues
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Tác giả
Siwattra Choodej, Khanitha Pudhom, Kosei Yamauchi…
5. Cell cycle arrest and induction of apoptosis of newly synthesized pyranoquinoline derivatives under microwave irradiation
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Tác giả
Ahmed M. Fouda, Ayman M. S. Youssef, Tarek H. Afifi…
5. Total synthesis of the linear and angular 3-methylated regioisomers of the marine natural product Kealiiquinone and biological evaluation of related Leucetta sp. alkaloids on human breast cancer
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Tác giả
César R. Solorio-Alvarado, Velayudham Ramadoss…
5. Design, synthesis, and biological evaluation of 1,3,5-trisubstituted pyrazoles as tyrosine kinase inhibitors
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Tác giả
Sinthiya J. Gawandi, Vidya G. Desai, Sunil G. Shingade.
5. Comparative α-glucosidase and α-amylase inhibition studies of rhodanine–pyrazole conjugates and their simple rhodanine analogues
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Tác giả
Parvesh Singh, Serisha Mothilal, Nagaraju Kerru.
5. Study on synthesis and biological effects of a series of 3,4-dihydroisoquinoline-2(1H)-carboxamide derivatives
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Tác giả
Zhi-Yang Fu, Qing-Hao Jin, Ya-Nan Xia, Hai-Ying Jiang.
6. Synthesis and anticancer effects of conjugates of doxorubicin and unsaturated fatty acids (LNA and DHA)
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Tác giả
Magdalena Mielczarek-Puta, Marta Struga, Piotr Roszkowski.
6. Synthesis of new 1,3,4-oxadiazole and benzothiazolylthioether derivatives of 4-arylmethylidene-3-substituted-isoxazol-5(4H)-one as potential antimycobacterial agents
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Tác giả
Abhijit P. Chavan, Rujuta R. Deshpande, Nandkumar A. Borade.
6. Synthesis and evaluation of antiviral activities of triterpenic conjugates with 2-aminobutan-1-ol as potent microbicidal agents
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Tác giả
Irina A. Tolmacheva, Ekaterina V. Igosheva…
6. Synthesis and in vitro activities on anti-platelet aggregation of 4-methoxy-1,3-phthalamidesamides and benzenedisulfonamides
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Tác giả
Guangling Chen, Chaoqing Wang, Zhihao Zhang, Xiujie Liu.
6. Synthesis and in vitro evaluation of substituted tetrahydroquinoline-isoxazole hybrids as anticancer agents
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Tác giả
Fausto M. Güiza, Yenny Bueno Duarte…
6. Synthesis and cytotoxic effects on pancreatic cancer cells of resveratrol analogs
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Tác giả
Barbara De Filippis, Laura De Lellis, Rosalba Florio…
6. Synthesis, biological evaluation, and molecular docking of dihydroflavonol derivatives as anti-inflammatory agents
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Tác giả
Yuanhang Xiang, Chunling Hu, Yuejie Zhang, Xiaochuan Ye.
6. Novel phthalamide derivatives as antihypertensive agents: rapid and clean synthesis, in silico and in vivo evaluation
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Tác giả
Erik Andrade-Jorge, Jessica E. Rodríguez…
6. New indole and indazole derivatives as potential antimycobacterial agents
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Tác giả
Violina T. Angelova, Tania Pencheva, Nikolay Vassilev…
6. Synthesis and anticancer activity of chalcone analogues with sulfonyl groups
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Tác giả
Jovana M. Muškinja, Adrijana Z. Burmudžija, Dejan D. Baskić.
6. Controlled release of losartan from acid- and heat-treated halloysite nanotubes
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Tác giả
Farid Moeinpour, Faezeh Soofivand.
6. Synthesis and antimicrobial evaluation of novel N-substituted 4-ethylsulfanyl-2-pyridones and triazolopyridines
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Tác giả
Rasha A. Azzam, Galal H. Elgemeie.
7. Screening for anticancer properties of thiazolidinedione compounds in a galactose media metastatic breast cancer cell model
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Tác giả
Pushkar Saralkar, Werner J. Geldenhuys.
7. Synthesis, cytotoxicity against cancer and normal cell lines of novel hydrazide–hydrazone derivatives bearing 5H-chromen-5-one
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Tác giả
Rafat M. Mohareb, Karam A. EL-Sharkawy.
7. Designing of novel ERRγ inverse agonists by molecular modeling studies of docking and 3D-QSAR on hydroxytamoxifen derivatives
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Tác giả
Rui Li, Yongli Du, Jingkang Shen.
7. Cytotoxicity of multicellular cancer spheroids, antibacterial, and antifungal of selected sulfonamide derivatives coupled with a salicylamide and/or anisamide scaffold
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Tác giả
Alaaeldin M. F. Galal, Walid Fayad, Walaa S. A. Mettwally…
7. Functional relaxant effect of 6,7-dipropoxy-2H-chromen-2-one is mainly by calcium channel blockade in ex vivo assay of tracheal rings
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Tác giả
Amanda Sánchez-Recillas, Samuel Estrada-Soto…
7. Evidence for the involvement of opioid receptor in Ajuga chamaepitys action in chemical and thermal models of pain in BALB/c mice
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Tác giả
Sahar M. Jaffal, Manal A. Abbas, Mohammad Alsalem…
7. Synthesis, in vitro urease inhibitory activity, and molecular docking studies of (perfluorophenyl)hydrazone derivatives
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Tác giả
Momin Khan, Ghulam Ahad, Abdul Manaf, Reshma Naz…
7. First report of antioxidative abeo-oleanenes from red seaweed Gracilaria salicornia as dual inhibitors of starch digestive enzymes
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Tác giả
Kajal Chakraborty, Tima Antony.
7. 4D-QSAR studies of CB2 cannabinoid receptor inverse agonists: a comparison to 3D-QSAR
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Tác giả
Houpan Zhang, Qiaoli Lv, Weidong Xu, Xiaoping Lai, Ya Liu…
7. Synthesis, computational evaluation and pharmacological assessment of acetylsalicylic esters as anti-inflammatory agents
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Tác giả
Raffaella Mancuso, Nadia Ferlazzo, Giorgio De Luca.
7. Green synthesis, antileishmanial activity evaluation, and in silico studies of new amino acid-coupled 1,2,4-triazoles
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Tác giả
Ahmed M. El-Saghier, Mounier A. Mohamed, Omyma A. Abd-Allah.
7. Synthesis, characterization, and in vitro anticancer evaluation of 2-substituted 5-arylsulfonyl-1,3-oxazole-4-carbonitriles
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Tác giả
Maryna V. Kachaeva, Stepan G. Pilyo, Victor V. Zhirnov.
8. Synthesis and cytotoxic activity of 3-amino substituted fusidane triterpenoids
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Tác giả
Elena V. Salimova, Elena V. Tret’yakova.
8. Design, synthesis, and anticonvulsant evaluation of 4-GABA-3-nitrocoumarines, 1-thiocoumarines, quinolone-2-ones, and their derivatives
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Tác giả
G. V. Mokrov, S. A. Litvinova, T. A. Voronina.
8. Structure-based lead optimization to improve the antifungal potency of the tetrahydroimidazo pyridine inhibitors targeted to Candida albicans dihydrofolate reductase and lanosterol 14-alpha-demethylase
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Tác giả
Srimai Vuppala, Ramesh Kumar Chitumalla, Bo Sun Joo…
8. Chemical constituents of the Vietnamese plants Dalbergia tonkinensis Prain and Cratoxylum formosum (Jack) Dyer in Hook and their DPPH radical scavenging activities
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Tác giả
Ninh The Son, Mari Kamiji, Tran Thu Huong, Miwa Kubo…
8. In vitro activity of novel derivatives of 1,3-oxazole-4-carboxylate and 1,3-oxazole-4-carbonitrile against human cytomegalovirus
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Tác giả
Maryna V. Kachaeva, Stepan G. Pilyo, Caroll B. Hartline…
8. Discovery of 7-bromo-1,4-dihydrothieno[3’,2’:5,6]thiopyrano[4,3-c]pyrazole-3-carboxamide derivatives as the potential epidermal growth factor receptors for tyrosine kinase inhibitors
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Tác giả
Qian Xie, Jingjing Wang, Miao Liu, Xin Wang, Di Jiao…
8. Synthesis and antitumor activity of pyrano[3,2-i]-fused camptothecin derivatives
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Tác giả
Bihong Hong, Guangrong Meng, Hanyi Tan, Jiajun Li…
8. Activation and inhibition effects of some natural products on human cytosolic CAI and CAII
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Tác giả
Sevki Adem, Ebru Akkemik, Hüseyin Aksit, Pınar Guller…
8. LC-MS-based metabolomic profiling of Lepidium coronopus water extract, anti-inflammatory and analgesic activities, and chemosystematic significance
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Tác giả
Ahmed Elkhateeb, Mona El-Shabrawy, Rehab F. Abdel-Rahman…
8. Novel fluorinated quaternary ammonium salts and their in vitro activity as trypanocidal agents
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Tác giả
Marisol López-Muñoz, Jessica Johanna Gomez-Peña.
8. The discovery of purine-based agents targeting triple-negative breast cancer and the αB-crystallin/VEGF protein–protein interaction
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Tác giả
Nelly A. Fosu-Mensah, Wen Jiang, Andrea Brancale, Jun Cai.
8. Design, synthesis, and biological evaluation of indole carboxylic acid esters of podophyllotoxin as antiproliferative agents
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Tác giả
Lei Zhang, Xian Zeng, Xiaodong Ren, Nengyin Tao.
9. Chroman-4-one hydrazones derivatives: synthesis, characterization, and in vitro and in vivo antileishmanial effects
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Tác giả
Yulieth Upegui, Karina Rios, Wiston Quiñones.
9. Multifunctional indanone–chalcone hybrid compounds with anti-β-amyloid (Aβ) aggregation, monoamine oxidase B (MAO-B) inhibition and neuroprotective properties against Alzheimer’s disease
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Tác giả
Keren Wang, Lintao Yu, Jian Shi, Wenmin Liu, Zhipei Sang.
9. Synthesis, in vitro assays, molecular docking, theoretical ADMET prediction, and evaluation of 4-methoxy-phenylthiazole-2-amine derivatives as acetylcholinesterase inhibitors
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Tác giả
Xiao-Zhong Zhang, Yuan Xu, Meng-Meng Jian, Kan Yang…
9. Different reactivity to glutathione but similar tumor cell toxicity of chalcones and their quinolinone analogues
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Tác giả
Giulio D. C. d’Oliveira, Jean M. F. Custodio…
9. Synthesis of oleanolic acid/ursolic acid/glycyrrhetinic acid-hydrogen sulfide donor hybrids and their antitumor activity
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Tác giả
Li-xin Sheng, Jia-yan Huang, Chun-mei Liu, Ju-zheng Zhang…
9. Design, synthesis and biological evaluation of novel indone derivatives as selective ERβ modulators
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Tác giả
Xi-Xi Liu, Mei-Lin Tang, Chen Zhong, Yun Tang, Jian-Ming Yu…
9. Antiproliferative activity of ursolic acid/glycyrrhetinic acid-uracil/thymine hybrids
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Tác giả
Li Sun, Xiang-Wu Chu, Chun-mei Liu, Li-Xin Sheng…
9. Exploration of synthetic antioxidant flavonoid analogs as acetylcholinesterase inhibitors: an approach towards finding their quantitative structure–activity relationship
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Tác giả
Abhijit Karmakar, Pravin Ambure, Tamanna Mallick…
9. Chemical composition, antioxidant, anti-lipooxygenase, antimicrobial, anti-parasite and cytotoxic activities of Polyalthia longifolia seed oil
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Tác giả
O. Atolani, E. T. Areh, O. S. Oguntoye, M. F. Zubair…
9. Dengue virus replication inhibition by dibenzothiepin derivatives
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Tác giả
Dragos P. Mihai, George M. Nitulescu, Jessica L. Smith.
9. Design, synthesis, antiproliferative and antibacterial evaluation of quinazolinone derivatives
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Tác giả
Hai-Xin Wang, Hai-Ying Liu, Wei Li, Shuai Zhang, Zheng Wu.
9. The tyrosinase-inhibitory effects of 2-phenyl-1,4-naphthoquinone analogs: importance of the (E)-β-phenyl-α,β-unsaturated carbonyl scaffold of an endomethylene type
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Tác giả
Sultan Ullah, Jinia Akter, Su J. Kim, Jungho Yang.
10. Microwave-assisted synthesis of 11-substituted-3,3-dimethyl-2,3,4,5,10,11-hexahydrodibenzo[b,e][1,4]diazepin-1-one derivatives catalysed by silica supported fluoroboric acid as potent antioxidant and anxiolytic agents
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Tác giả
Kavita Bhagat, Atamjit Singh, Suruchi Dhiman.
10. Macrocyclic effect on inhibitory activity: a modeling study on MerTK inhibitors
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Tác giả
Swapnil P. Bhujbal, Seketoulie Keretsu.
10. New pyranoquinoline derivatives as vascular-disrupting anticancer agents
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Tác giả
Florian Schmitt, Rainer Schobert, Bernhard Biersack.
10. Synthesis and anti-inflammatory activity of 1,2-3-substituted 2a1,4,5-triazacyclopenta[cd]indene derivatives
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Tác giả
Sumalatha Sanivarapu, Namratha Vaddiraju, Lakshmi Velide.
10. Green synthesis and 3D pharmacophore study of pyrimidine and glucoside derivatives with in vitro potential anticancer and antioxidant activities
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Tác giả
Mounir A. Salem, Mohamed S. Behalo, Eman Elrazaz.
10. Structure-activity relationships of novel dithiocarbamates containing α,β-unsaturated ketone fragment as potent anticancer agents
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Tác giả
Yuanqiang Wang, Ridong Li, Han Zhang, Zhiyong Zhang…
10. Oxindole-based chalcones: synthesis and their activity against glycation of proteins
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Tác giả
Ayesha Khan, Ajmal Khan, Umar Farooq, Muhammad Taha…
10. Synthesis of new 1-benzyl tetrahydropyridin-4-ylidene piperidinium salts and their antiplasmodial and antitrypanosomal activities
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Tác giả
Noor-ul-Amin Mohsin, Werner Seebacher, Patrick Hochegger…
10. Nano Sb2O3 catalyzed green synthesis, cytotoxic activity, and molecular docking study of novel α-aminophosphonates
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Tác giả
Sreelakshmi Poola, Maheshwara Reddy Nadiveedhi…
10. Design, synthesis and biological evaluation of some novel diastereoselective β-lactams bearing 2-mercaptobenzothiazole and benzoquinoline
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Tác giả
Nassim Borazjani, Aliasghar Jarrahpour, Javad Ameri Rad.
10. Syntheses and in silico pharmacokinetic predictions of glycosylhydrazinyl-pyrazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]triazolo[4,3-a]pyrimidines as anti-proliferative agents
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Tác giả
Kamal F. M. Atta, Omaima O. M. Farahat.
10. Correction to: Podophyllum derivatives containing fluorine atom in the 3-position of 2-aminopyridine improved the antitumor activity by inducing P53-dependent apoptosis
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Tác giả
Huai Wang.
11. Acetone effects on Buddleja scordioides polyphenol extraction process and assessment of their cellular antioxidant capacity and anti-inflammatory activity
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Tác giả
Cecilia Villegas-Novoa, José A. Gallegos-Infante.
11. Nitro derivatives and other compounds from sugar apple (Annona squamosa L.) leaves exhibit soluble epoxide hydrolase inhibitory activity
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Tác giả
Hong Xu Li, Seo Young Yang, Young Soo Kim, Hae Dong Jang.
11. In silico screening of anticholinesterase alkaloids for cyclooxygenase-2 (COX-2) and matrix metalloproteinase 8 (MMP-8) inhibitory potentials as multi-target inhibitors of Alzheimer’s disease
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Tác giả
Ahmed A. Ishola, Kayode E Adewole.
11. Novel chromenes and benzochromenes bearing arylazo moiety: molecular docking, in-silico admet, in-vitro antimicrobial and anticancer screening
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Tarek H. Afifi, Sayed M. Riyadh, Anwar A. Deawaly…
11. Pyrazole–chalcone derivatives as selective COX-2 inhibitors: design, virtual screening, and in vitro analysis
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Anelise F. Macarini, Thales U. C. Sobrinho, Gerusa W. Rizzi…
11. Viridicatol and viridicatin isolated from a shark-gill-derived fungus Penicilliumpolonicum AP2T1 as MMP-2 and MMP-9 inhibitors in HT1080 cells by MAPKs signaling pathway and docking studies
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Peng Liang, Yuan Yuan Zhang, Ping Yang, Stephanie Grond…
11. Lappaconitine sulfate induces apoptosis in human colon cancer HT-29 cells and down-regulates PI3K/AKT/GSK3β signaling pathway
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Danni Qu, Xuemei Zhang, Chunyan Sang, Yaqiong Zhou…
11. GC/MS analysis, and antioxidant and antimicrobial activities of alkaloids extracted by polar and apolar solvents from the stems of Anabasis articulata
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Nabila Belyagoubi-Benhammou, Larbi Belyagoubi…
11. Design, synthesis, cytotoxicity, and molecular modeling study of 2,4,6-trisubstituted pyrimidines with anthranilate ester moiety
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Kirill P. Cheremnykh, Victor A. Savelyev…
11. Novel 2-(substituted phenyl Imino)-5-benzylidene-4-thiazolidinones as possible non-ulcerogenic tri-action drug candidates: synthesis, characterization, biological evaluation And docking studies
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Pooja Chawla, Sourav Kalra, Raj Kumar, Ranjit Singh.
11. Retraction Note to: Rhodozepinone, a new antitrypanosomal azepino-diindole alkaloid from the marine sponge-derived bacterium Rhodococcus sp. UA13
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Yasmin Elsayed, John Refaat, Usama R. Abdelmohsen.
12. Paeoniflorigenone purified from Paeonia daurica roots potently inhibits viral and bacterial DNA polymerases: investigation by experimental validation and docking simulation
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Adem Demir, Halbay Turumtay, Mustafa Emirik, Cemal Sandalli.
12. Anticancer activities of novel Mannich bases against prostate cancer cells
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Serpil Demirci, Neslihan Demirbaş.
12. Synthesis and antitumor evaluation of novel fused heterocyclic 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives
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Xiao-Jia Liu, Hai-Ying Liu, Hai-Xin Wang, Yan-Ping Shi…
12. Novel isoxazole derivatives as potential antiparkinson agents: synthesis, evaluation of monoamine oxidase inhibitory activity and docking studies
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Neetu Agrawal, Pradeep Mishra.
12. 3D-QSAR, molecular docking, and new compound design of pyrimidine derivatives as Src small molecule inhibitors
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Jun-wei Wang, Ya-ting Deng, Han Chu, Juan Wang, Yong Hu…
12. Synthesis and bioassay of a new class of disubstituted 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles
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Mangali Madhu Sekhar, Gudi Yamini, Kuppi Reddy Gari Divya…
12. Oxidative stress induced apoptosis mediated anticancer activity of Rhus typhina fruits extract in human colon cancer
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Lan Wang, Ming Lu Xu, Ling Xin, Chi Ma, Guoying Yu…
12. Synthesis and antitumor activity of cyclic octapeptide, samoamide A, and its derivatives
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Fei Ge, Chi Zhang, Longbao Zhu, Wanzhen Li, Ping Song…
12. Design, synthesis and molecular docking studies of quinazolin-4-ones linked to 1,2,3-triazol hybrids as Mycobacterium tuberculosis H37Rv inhibitors besides antimicrobial activity
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Narendra Kumar Maddali, I. V. Kasi Viswanath*…
12. Design, synthesis, and antihypertensive activity of new pyrimidine derivatives endowing new pharmacophores
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Ahmed M. Farghaly, Omaima M. AboulWafa.
13. New antimalarial lanostane triterpenes from a new isolate of Egyptian Ganoderma species
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Amir E. Wahba, Ahmed K. A. El-Sayed, Amira A. El-Fala.
13. Antiaging activity, molecular docking, and prediction of percutaneous absorption parameters of quinoline–hydrazone hybrids
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Edison Osorio, Karent Bravo, Wilson Cardona, Andres Yepes.
13. Implementation of pharmacophore-based 3D QSAR model and scaffold analysis in order to excavate pristine ALK inhibitors
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Ramanathan K., Sayoni Maiti, Shanthi V., Woong-Hee Shin…
13. Synthesis and biological evaluation of novel disulfides incorporating 1,3,4-thiadiazole scaffold as promising antitumor agents
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Sha Li, Hai-Xin Wang, Hai-Ying Liu, Fen Jing, Xiao-Yun Fu…
13. Antiplatelet activity and TNF-α release inhibition of phthalimide derivatives useful to treat sickle cell anemia
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Rafael C. Chelucci, Isabela J. de Oliveira…
13. Correction to: Substituted phenyl containing 1,3,4-oxadiazole-2-yl-but-2-enamides: synthesis and preliminary evaluation as promising anticonvulsants
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Nadeem Siddiqui, Md. Jawaid Akhtar, M. Shahar Yar…
13. The comparison of semiempirical and ab initio molecular modeling methods in activity and property evaluation of selected antimicrobial sulfonamides
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Piotr Kawczak, Leszek Bober, Tomasz Bączek
13. Synthesis and in vitro biological evaluation of 1,3-bis-(1,2,3-triazol-1-yl)-propan-2-ol derivatives as antifungal compounds fluconazole analogues
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Armando Zambrano-Huerta, Damián David Cifuentes-Castañeda…
13. Design, synthesis, and biological evaluation of 2-(5-methyl-1H-pyrazol-1-yl) acetamide derivatives as androgen receptor antagonists
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Junze Dong, Jingya Zhang, Zilu Li, Solomon Asnake.
14. Synthesis of novel benzimidazole–oxadiazole derivatives as potent anticancer activity
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Ulviye Acar Çevik, Derya Osmaniye, Betül Kaya Çavuşoğlu.
14. In silico prediction of estrogen receptor subtype binding affinity and selectivity using 3D-QSAR and molecular docking
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Wenliang Jiang, Qinghua Chen, Bo Zhou, Fangfang Wang.
14. Green synthesis, molecular docking, anti-oxidant and anti-inflammatory activities of α-aminophosphonates
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Murali Sudileti, Venkataramaiah Chintha…
14. Design and synthesis of novel 4-hydrazone functionalized/1,2,4-triazole fused pyrido[2,3-d]pyrimidine derivatives, their evaluation for antifungal activity and docking studies
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Nooka Ratnam Appna, Ravi Kumar Nagiri, Raghu Babu Korupolu…
14. New fluoroquinolones/nitric oxide donor hybrids: design, synthesis and antitubercular activity
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Hossameldin A. Aziz, Gamal A. I. Moustafa, Samar H. Abbas…
14. Synthesis and anticancer effects of α-lipoic ester of alloxanthoxyletin
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Wioletta Olejarz, Małgorzata Wrzosek, Michał Jóźwiak…
14. Synthesis and anticancer activity evaluation of novel oxacalix[2]arene[2]pyrimidine derivatives
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Tonghui Huang, Xin Wu, Tianya Liu, Lin An, Xiaoxing Yin.
14. Identification and synthesis of low-molecular weight cholecystokinin B receptor (CCKBR) agonists as mediators of long-term synaptic potentiation
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Yanmei Zhang, Yican Wang, Yiping Guo, Jinxi Liao.
15. Structure-antioxidant activity relationships, QSAR, DFT calculation, and mechanisms of flavones and flavonols
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Hussein M. Ali, Isra H. Ali.
15. Antioxidant, antiproliferative and anti-inflammatory effects of Glaucium flavum fractions enriched in phenolic compounds
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Mondher Boulaaba, Feten Zar Kalai, Sarra Dakhlaoui.
15. Quercetin analogs with high fetal hemoglobin-inducing activity
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Wachirachai Pabuprapap, Yanisa Wassanatip, Pichit Khetkam…
15. Correlation study of antibacterial activity and spectrum of Penicillins through a structure-activity relationship analysis
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J. R. Morán-Díaz, H. A. Jiménez-Vázquez, R. Gómez-Pliego…
15. Design, synthesis, biological evaluation and molecular modeling of new coumarin derivatives as potent anticancer agents
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Eman A. Fayed, Rehab Sabour, Marwa F. Harras…
15. N2-Methylaurantiamide acetate: a new dipeptide from Mimusops elengi L. flowers
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Fadhila Utari, Mai Efdi, Masayuki Ninomiya, Kaori Tanaka…
15. Xenicanes attenuate pro-inflammatory 5-lipoxygenase: Prospective natural anti-inflammatory leads from intertidal brown seaweed Padina tetrastromatica
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Tima Antony, Kajal Chakraborty.
16. Identification of prodigious and under-privileged structural features for RG7834 analogs as Hepatitis B virus expression inhibitor
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Vijay H. Masand, Nahed N. E. El-Sayed, Vesna Rastija.
16. Synthesis and biological evaluation of asymmetrical diarylpentanoids as antiinflammatory, anti-α-glucosidase, and antioxidant agents
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Sze Wei Leong, Tahani Awin, Siti Munirah Mohd Faudzi.
16. Synthesis and biological evaluation of novel triazolyl 4-anilinoquinazolines as anticancer agents
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Hani Mutlak A. Hassan, Iuliana Denetiu, Salman A. Khan…
16. Potent anti-MRSA activity and synergism with aminoglycosides by flavonoid derivatives from the root barks of Morus alba, a traditional Chinese medicine
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Guo-Ying Zuo, Cui-Xian Yang, Zhao-Juan Ruan, Jun Han…
16. Preparation and biological evaluation of quinoline amines as anticancer agents and its molecular docking
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Kailasam N. Vennila, Kolandhaivel Prabha, Deval Sunny…
16. Correction to: Intracellular distribution of new tacrine analogues as a potential cause of their cytotoxicity against human neuroblastoma cells SH-SY5Y
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Lucia Krajòáková, Jana Pisarèiková, Ladislav Drajna…
16. Furanchalcone–biphenyl hybrids: synthesis, in silico studies, antitrypanosomal and cytotoxic activities
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Elisa García, Rodrigo Ochoa, Isabel Vásquez…
17. Synthesis and antimycobacterial activity of disubstituted benzyltriazoles
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Frans J. Smit, Ronnett Seldon, Janine Aucamp.
17. Synthesis, α-amylase inhibition and molecular docking study of bisindolylmethane sulfonamide derivatives
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Muhammad Taha, Tayyaba Noreen, Syahrul Imran, Fasial Nawaz.
17. New histone deacetylase inhibitors and anticancer agents from Curcuma longa
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Pakit Kumboonma, Thanaset Senawong, Somprasong Saenglee…
17. Chemical constituents from Ginkgo biloba L. male flowers and their biological activities
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Min Li, Zi-ming Xia, Bin Li, Ying Tian, Guang-jie Zhang…
17. A structure–activity relationship study of phenyl sesquiterpenoids on efflux inhibition against Staphylococcus aureus
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Zhong-Lin Sun, Tao Liu, Simon Gibbons, Qing Mu.
18. Synthesis, antimicrobial activity, and determination of the lipophilicity of ((cyclohex-3-enylmethylene)hydrazinyl)thiazole derivatives
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Anna Biernasiuk, Magdalena Kawczyńska, Anna Berecka-Rycerz.
18. Synthesis, sciatic nerve block activity evaluation and molecular docking of fluoro-substituted lidocaine analogs as local anesthetic agents
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Wen Li, Ying Yan, Yingjie Chang, Lina Ding, Hongmin Liu…
18. Synthetic 3-alkylpyridine alkaloid analogues as a new scaffold against leukemic cell lines: cytotoxic evaluation and mode of action
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Fernanda Cristina Gontijo Evangelista…
18. Fluorophenols bearing nitrogenated heterocycle moieties, a class of novel Keap1-Nrf2 protein-protein interaction inhibitors: synthesis, antioxidant stress screening and molecular docking
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Xiu E Feng, De Peng Kong, Shu Rong Ban, Rui Ge…
19. Synthesis, structural characterization, and cytotoxic evaluation of chalcone derivatives
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Paulo N. Bandeira, Telma L. G. Lemos, Hélcio S. Santos.
19. Insights into the c-Jun N-terminal kinase 3 (JNK3) inhibitors: CoMFA, CoMSIA analyses and molecular docking studies
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Yanda Liu, Yewei Xie, Yuanyuan Liu, Pengcheng Wang…
19. Screening of 1,2-furanonaphthoquinones 1,2,3-1H-triazoles for glycosidases inhibitory activity and free radical scavenging potential: an insight in anticancer activity
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Rafael F. Dantas, Mario R. Senger, Mariana F. C. Cardoso…
20. Antimalarial, antiproliferative, and apoptotic activity of quinoline-chalcone and quinoline-pyrazoline hybrids. A dual action
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Jaime E. Charris, Melina C. Monasterios, María E. Acosta.
20. Correction to: Synthesis, molecular docking, and apoptogenic efficacy of novel N-heterocycle analogs to target B-cell lymphoma 2/X-linked inhibitors of apoptosis proteins to regress melanoma
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Zabiulla, Vikas H. Malojirao, Yasser Hussein Eissa Mohammed…
21. Synthesis of novel α-aminophosphonates under microwave irradiation, biological evaluation as antiproliferative agents and apoptosis inducers
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Erika L. Loredo-Calderón, Carlos A. Velázquez-Martínez.
22. QSAR study of human epidermal growth factor receptor (EGFR) inhibitors: conformation-independent models
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Silvina E. Fioressi, Daniel E. Bacelo, Pablo R. Duchowicz.
23. Aryl azide-sulfonamide hybrids induce cellular apoptosis: synthesis and preliminary screening of their cytotoxicity in human HCT116 and A549 cancer cell lines
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Ahmed El-Kardocy, Muhamad Mustafa, Esam R. Ahmed.
