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Journal of Pharmacokinetics and Pharmacodynamics
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1. Journal editor’s final report
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William J. Jusko.
1. Editorial to the themed issue on application of pharmacometrics to the development of drugs for rare diseases
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Peter Bonate.
1. A translational platform PBPK model for antibody disposition in the brain
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Hsueh-Yuan Chang, Shengjia Wu…
1. Population pharmacokinetics of inotuzumab ozogamicin in relapsed/refractory acute lymphoblastic leukemia and non-Hodgkin lymphoma
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May Garrett, Ana Ruiz-Garcia…
1. Preface to Special Issue for Panos Macheras
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Robert R. Bies.
1. Development of a nonlinear hierarchical model to describe the disposition of deuterium in mother–infant pairs to assess exclusive breastfeeding practice
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Zheng Liu, Aly Diana, Christine Slater…
2. Computational framework for predictive PBPK-PD-Tox simulations of opioids and antidotes
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Carrie German, Minu Pilvankar.
2. FDA’s Office of Orphan Products Development: providing incentives to promote the development of products for rare diseases
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Soumya Patel, Katherine I. Miller Needleman.
2. Computer-assembled cross-species/cross-modalities two-pore physiologically based pharmacokinetic model for biologics in mice and rats
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Armin Sepp, Guy Meno-Tetang, Andrew Weber…
2. Challenge model of TNFα turnover at varying LPS and drug provocations
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Felix Held, Edmund Hoppe, Marija Cvijovic…
2. Panos Macheras: a pioneering scientist in pharmaceutical science
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Laszlo Endrenyi, Robert R. Bies
2. Benchmarking renin suppression and blood pressure reduction of direct renin inhibitor imarikiren through quantitative systems pharmacology modeling
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Yeshitila Gebremichael, Gezim Lahu…
3. Concentration–response modeling of ECG data from early-phase clinical studies to assess QT prolongation risk of contezolid (MRX-I), an oxazolidinone antibacterial agent
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Junzhen Wu, Kun Wang, Yuancheng Chen.
3. Orphan drug development: the increasing role of clinical pharmacology
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Mariam A. Ahmed, Malek Okour…
3. Automated proper lumping for simplification of linear physiologically based pharmacokinetic systems
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Shan Pan, Stephen B. Duffull.
3. Development of visual predictive checks accounting for multimodal parameter distributions in mixture models
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Usman Arshad, Estelle Chasseloup…
3. Reproducible pharmacokinetics
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John P. A. Ioannidis.
3. Variance based global sensitivity analysis of physiologically based pharmacokinetic absorption models for BCS I–IV drugs
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Nicola Melillo, Leon Aarons, Paolo Magni…
4. Tumor necrosis factor-mediated disposition of infliximab in ulcerative colitis patients
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Sophie E. Berends, Tamara J. van Steeg.
4. Development and evaluation of a generic population pharmacokinetic model for standard half-life factor VIII for use in dose individualization
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Alanna McEneny-King, Pierre Chelle…
4. Bayesian approach to investigate a two-state mixed model of COPD exacerbations
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Anna Largajolli, Misba Beerahee…
4. Population pharmacokinetics and pharmacodynamics of piperacillin in critically ill patients during the early phase of sepsis
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Waroonrat Sukarnjanaset…
4. Bioequivalence for highly variable drugs: regulatory agreements, disagreements, and harmonization
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Laszlo Endrenyi, Laszlo Tothfalusi.
4. Application of new measures of nonlinearity to parameter estimation and simulations in individual pharmacokinetic analyses
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Leonid Khinkis, Milburn Crotzer.
5. Mathematical modeling of the glucagon challenge test
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Saeed Masroor, Marloes G. J. van Dongen.
5. Routine clinical care data for population pharmacokinetic modeling: the case for Fanhdi/Alphanate in hemophilia A patients
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Pierre Chelle, Cindy H. T. Yeung…
5. Pitfalls of using numerical predictive checks for population physiologically-based pharmacokinetic model evaluation
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Anil R. Maharaj, Huali Wu…
5. Structural identifiability and sensitivity
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Athanassios Iliadis.
5. Ordinary differential equation approximation of gamma distributed delay model
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Wojciech Krzyzanski.
6. Pharmacokinetics-pharmacodynamics of sertraline as an antifungal in HIV-infected Ugandans with cryptococcal meningitis
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Ali A. Alhadab, Joshua Rhein, Lillian Tugume.
6. Correction to: Routine clinical care data for population pharmacokinetic modeling: the case for Fanhdi/Alphanate in hemophilia A patients
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Pierre Chelle, Cindy H. T. Yeung…
6. Operating characteristics of stepwise covariate selection in pharmacometric modeling
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Malidi Ahamadi, Anna Largajolli…
6. Accounting for inter-correlation between enzyme abundance: a simulation study to assess implications on global sensitivity analysis within physiologically-based pharmacokinetics
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Nicola Melillo, Adam S. Darwich, Paolo Magni…
6. Population pharmacokinetic analysis of danvatirsen supporting flat dosing switch
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Hongmei Xu, Xiao Tong, Ganesh Mugundu…
7. Cabozantinib exposure–response analyses of efficacy and safety in patients with advanced hepatocellular carcinoma
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Linh Nguyen, Sunny Chapel, Benjamin Duy Tran.
7. Towards regulatory endorsement of drug development tools to promote the application of model-informed drug development in Duchenne muscular dystrophy
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Daniela J. Conrado, Jane Larkindale…
7. Guiding dose selection of monoclonal antibodies using a new parameter (AFTIR) for characterizing ligand binding systems
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Sameed Ahmed, Miandra Ellis, Hongshan Li…
7. Understanding drug–drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs
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Leslie Z. Benet, Christine M. Bowman…
7. Modelling of oscillatory cortisol response in horses using a Bayesian population approach for evaluation of dexamethasone suppression test protocols
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Felix Held, Carl Ekstrand, Marija Cvijovic…
8. Handling underlying discrete variables with bivariate mixed hidden Markov models in NONMEM
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A. Brekkan, S. Jönsson, M. O. Karlsson.
8. A physiologically-motivated model of cystic fibrosis liquid and solute transport dynamics across primary human nasal epithelia
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Florencio Serrano Castillo…
8. Two-pore physiologically based pharmacokinetic model with de novo derived parameters for predicting plasma PK of different size protein therapeutics
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Zhe Li, Dhaval K. Shah.
8. Monte Carlo simulations in drug release
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Kosmas Kosmidis, George Dassios.
8. Indirect pharmacodynamic models for responses with circadian removal
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Vivaswath S. Ayyar, Wojciech Krzyzanski…
9. Impact of Phase 1 study design on estimation of QT interval prolongation risk using exposure–response analysis
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Nikolaos Tsamandouras, Sridhar Duvvuri.
9. Modeling and simulation of the modified Rankin Scale and National Institutes of Health Stroke Scale neurological endpoints in intracerebral hemorrhage
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Rik Schoemaker, Satyaprakash Nayak…
9. Population pharmacokinetic reanalysis of a Diazepam PBPK model: a comparison of Stan and GNU MCSim
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Periklis Tsiros, Frederic Y. Bois…
10. Cardiac risk assessment based on early Phase I data and PK-QTc analysis is concordant with the outcome of thorough QTc trials: an assessment based on eleven drug candidates
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Puneet Gaitonde, Yeamin Huh, Borje Darpo.
10. A quantitative systems pharmacology model of colonic motility with applications in drug development
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Raibatak Das, Lucia Wille, Liming Zhang…
10. Estimating parameters of nonlinear dynamic systems in pharmacology using chaos synchronization and grid search
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Nikhil Pillai, Sorell L. Schwartz, Thang Ho…
11. Correction to: Bayesian approach to investigate a two-state mixed model of COPD exacerbations
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Anna Largajolli, Misba Beerahee.
11. A modeling and simulation-based assessment of the impact of confounding factors on the readout of a sildenafil survival trial in pulmonary arterial hypertension
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Pascal Chanu, Xiang Gao, Rene Bruno…
