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Volume 21, Issue 2, March 2019
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1. Moringa Isothiocyanate Activates Nrf2: Potential Role in Diabetic Nephropathy
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Tác giả
David Cheng, Linbo Gao, Shan Su, Davit Sargsyan, Renyi Wu, Ilya Raskin.
2. Activation of Protein Kinase A Stimulates SUMOylation, Expression, and Transport Activity of Organic Anion Transporter 3
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Tác giả
Haoxun Wang, Jinghui Zhang, Guofeng You.
3. Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link—a Workshop Summary Report
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Tác giả
Tycho Heimbach, Sandra Suarez-Sharp, Maziar Kakhi, Nico Holmstock.
4. Incurred Sample Reanalysis: Time to Change the Sample Size Calculation?
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Tác giả
Piotr J. Rudzki, Przemysław Biecek, Michał Kaza.
5. Estimation of Solid Tumor Doubling Times from Progression-Free Survival Plots Using a Novel Statistical Approach
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Tác giả
Katherine Kay, Keith Dolcy, Robert Bies, Dhaval K. Shah.
6. Multiplexed Gene Expression as a Characterization of Bioactivity for Interferon Beta (IFN-β) Biosimilar Candidates: Impact of Innate Immune Response Modulating Impurities (IIRMIs)
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Tác giả
Eduardo F. Mufarrege, Lydia A. Haile, Marina Etcheverrigaray.
7. Development of a New Inhaler for High-Efficiency Dispersion of Spray-Dried Powders Using Computational Fluid Dynamics (CFD) Modeling
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Tác giả
Worth Longest, Dale Farkas.
8. Systemic Bioequivalence Is Unlikely to Equal Target Site Bioequivalence for Nanotechnology Oncologic Products
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Tác giả
Jessie L.-S. Au, Ze Lu, Roberto A. Abbiati, M. Guillaume Wientjes.
9. Translational Framework Predicting Tumour Response in Gemcitabine-Treated Patients with Advanced Pancreatic and Ovarian Cancer from Xenograft Studies
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Tác giả
Maria Garcia-Cremades, Celine Pitou, Philip W. Iversen.
10. Predicting Overall Survival and Progression-Free Survival Using Tumor Dynamics in Advanced Breast Cancer Patients
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Tác giả
Hyeong-Seok Lim, Wan Sun, Kourosh Parivar, Diane Wang.
11. Dissolution Testing in Drug Product Development: Workshop Summary Report
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Tác giả
Andreas Abend, David Curran, Jesse Kuiper, Xujin Lu, Hanlin Li.
12. Quantitative Prediction of Human Hepatic Clearance for P450 and Non-P450 Substrates from In Vivo Monkey Pharmacokinetics Study and In Vitro Metabolic Stability Tests Using Hepatocytes
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Tác giả
Haruka Nishimuta, Takao Watanabe, Kiyoko Bando.
13. PBPK Absorption Modeling: Establishing the In Vitro–In Vivo Link—Industry Perspective
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Tác giả
Cordula Stillhart, Xavier Pepin, Christophe Tistaert, David Good.
14. Tumor-Targeted Chemoimmunotherapy with Immune-Checkpoint Blockade for Enhanced Anti-Melanoma Efficacy
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Tác giả
Man Li, Yuting Yang, Chaoqun Xu, Jiaojie Wei, Yingke Liu, Xingli Cun.
15. What Does it Take to Make Model-Informed Precision Dosing Common Practice? Report from the 1st Asian Symposium on Precision Dosing
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Tác giả
Thomas M. Polasek, Amin Rostami-Hodjegan, Dong-Seok Yim, Masoud Jamei.
16. Survival Prolongation Index as a Novel Metric to Assess Anti-Tumor Activity in Xenograft Models
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Tác giả
Fiona Chandra, Lihi Zaks, Andy Zhu.
17. Sorafenib N-Oxide Is an Inhibitor of Human Hepatic CYP3A4
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Tác giả
Sussan Ghassabian, Tina B. Gillani, Tristan Rawling, Severine Crettol.
18. Scientific Considerations for the Review and Approval of First Generic Mometasone Furoate Nasal Suspension Spray in the United States from the Bioequivalence Perspective
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Tác giả
Qing Liu, Mohammad Absar, Bhawana Saluja, Changning Guo.
19. Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells
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Tác giả
Xiaowen Guan, Vivian Rodriguez-Cruz, Marilyn E. Morris.
20. Evaluation of a Particulate Breast Cancer Vaccine Delivered via Skin
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Tác giả
Lipika Chablani, Suprita A. Tawde, Archana Akalkotkar.
