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1. Development of In Vitro–In Vivo Correlation for Upadacitinib Extended-Release Tablet Formulation
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Tác giả
Mohamed-Eslam F. Mohamed, Sheryl Trueman, Ahmed A. Othman, Jian-Hwa Han.
1. Correction to: Metabolic Profile of 3-Acetyl-11-Keto-β-Boswellic Acid and 11-Keto-β-Boswellic Acid in Human Preparations In Vitro, Species Differences, and Bioactivity Variation
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Tác giả
Yonglei Cui, Xiangge Tian, Jing Ning, Chao Wang, Zhenlong Yu, Yan Wang.
1. “Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy
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Tác giả
Bart Hens, Maura Corsetti, Marival Bermejo, Raimar Löbenberg.
1. Induction and Impact of Anti-Drug Responses Elicited by a Human Recombinant Coagulation Factor FXaI16L in Preclinical Species
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Tác giả
Chuenlei Parng, Michael Bolt, Debra D. Pittman, Teresa Caiazzo.
1. Moringa Isothiocyanate Activates Nrf2: Potential Role in Diabetic Nephropathy
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Tác giả
David Cheng, Linbo Gao, Shan Su, Davit Sargsyan, Renyi Wu, Ilya Raskin.
1. Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools
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Tác giả
Sebastiaan C. Goulooze, Elke H. J. Krekels, Thomas Hankemeier.
2. Inhibition of Hepatic CYP2D6 by the Active N-Oxide Metabolite of Sorafenib
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Tác giả
Michael Murray, Tina B. Gillani, Tristan Rawling, Pramod C. Nair.
2. Reconciling Human-Canine Differences in Oral Bioavailability: Looking beyond the Biopharmaceutics Classification System
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Tác giả
Marilyn N. Martinez, Ayman El-Kattan, Elias Awji, Mark Papich.
2. A Bounded Integer Model for Rating and Composite Scale Data
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Tác giả
Gustaf J. Wellhagen, Maria C. Kjellsson, Mats O. Karlsson.
2. Dissolution Chamber for Small Drug Delivery System in the Periodontal Pocket
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Tác giả
Wei Ren, Michael Murawsky, Terri La Count, Apipa Wanasathop, Xin Hao.
2. Activation of Protein Kinase A Stimulates SUMOylation, Expression, and Transport Activity of Organic Anion Transporter 3
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Tác giả
Haoxun Wang, Jinghui Zhang, Guofeng You.
2. Golimumab Dried Blood Spot Analysis (GOUDA): a Prospective Trial Showing Excellent Correlation with Venepuncture Samples and More Detailed Pharmacokinetic Information
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Tác giả
Iris Detrez, Ganel Schops, Jolien Lefrère, Sophie Tops, Gert Van Assche.
3. Optimization of Cancer Treatment in the Frequency Domain
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Tác giả
Pascal Schulthess, Vivi Rottschäfer, James W. T. Yates.
3. Cellular Uptake and Distribution of Gemini Surfactant Nanoparticles Used as Gene Delivery Agents
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Tác giả
Wei Jin, Mays Al-Dulaymi, Ildiko Badea, Scot C. Leary, Jeveria Rehman.
3. Correction to: A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®
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Tác giả
Alison Betts, Nahor Haddish-Berhane, Dhaval K. Shah.
3. CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies
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Tác giả
Jonathan P. Mochel, Stephen C. Ekker, Chad M. Johannes.
3. Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link—a Workshop Summary Report
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Tác giả
Tycho Heimbach, Sandra Suarez-Sharp, Maziar Kakhi, Nico Holmstock.
3. Measurement of IL-17AA and IL-17FF as Pharmacodynamic Biomarkers to Demonstrate Target Engagement in the Phase I Study of MCAF5352A
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Tác giả
Kun Peng, Yehong Wang, Ketevan Siradze, Rich Erickson.
4. Retrospective Analysis of Bioanalytical Method Validation Approaches in Biosimilar Biological Product Development
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Tác giả
O. N. Obianom, Theingi M. Thway, S. J. Schrieber, O. O. Okusanya.
4. Evaluation of Assumptions Underpinning Pharmacometric Models
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Tác giả
Qing-Xi Ooi, Daniel F. B. Wright, Geoffrey K. Isbister.
4. Translational Quantitative Systems Pharmacology in Drug Development: from Current Landscape to Good Practices
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Tác giả
Jane P. F. Bai, Justin C. Earp, Venkateswaran C. Pillai.
4. Bacteriophage PEV20 and Ciprofloxacin Combination Treatment Enhances Removal of Pseudomonas aeruginosa Biofilm Isolated from Cystic Fibrosis and Wound Patients
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Tác giả
Rachel Yoon Kyung Chang, Theerthankar Das, Jim Manos, Elizabeth Kutter.
4. Incurred Sample Reanalysis: Time to Change the Sample Size Calculation?
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Tác giả
Piotr J. Rudzki, Przemysław Biecek, Michał Kaza.
4. The Assessment of Quality Attributes for Biosimilars: a Statistical Perspective on Current Practice and a Proposal
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Tác giả
Johanna Mielke, Franz Innerbichler, Martin Schiestl.
5. Fit-for-Purpose Quality Control System in Continuous Bioanalysis During Long-Term Pediatric Studies
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Tác giả
Mohsin Ali, Jutta Tins, Bjoern B. Burckhardt.
5. TCPro: an In Silico Risk Assessment Tool for Biotherapeutic Protein Immunogenicity
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Tác giả
Osman N. Yogurtcu, Zuben E. Sauna, Joseph R. McGill, Million A. Tegenge
5. Anti-drug Antibody Assay Conditions Significantly Impact Assay Screen and Confirmatory Cut-Points
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Tác giả
Boris Gorovits, Ying Wang, Liang Zhu, Marcela Araya, John Kamerud.
5. HER3-Targeted Affibodies with Optimized Formats Reduce Ovarian Cancer Progression in a Mouse Xenograft Model
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Tác giả
John S. Schardt, Madeleine Noonan-Shueh, Jinan M. Oubaid.
5. Estimation of Solid Tumor Doubling Times from Progression-Free Survival Plots Using a Novel Statistical Approach
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Tác giả
Katherine Kay, Keith Dolcy, Robert Bies, Dhaval K. Shah.
5. Overlooked Issues on Pharmacokinetics Data Interpretation of Protein Drugs—a Case Example of Erythropoietin
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Tác giả
Guohua An, Robert L. Schmidt, Donald M. Mock, Peter Veng-Pedersen.
6. How Transporters Have Changed Basic Pharmacokinetic Understanding
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Tác giả
Leslie Z. Benet, Christine M. Bowman, Jasleen K. Sodhi.
6. Optimizing Dose-Finding Studies for Drug Combinations Based on Exposure-Response Models
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Tác giả
Theodoros Papathanasiou, Anders Strathe, Rune Viig Overgaard.
6. Skin Delivery and Irritation Potential of Phenmetrazine as a Candidate Transdermal Formulation for Repurposed Indications
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Tác giả
Ying Jiang, Kevin S. Murnane, Sonalika A. Bhattaccharjee.
6. Trial Design and Statistical Considerations on the Assessment of Pharmacodynamic Similarity
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Tác giả
Peijuan Zhu, Chyi-Hung Hsu, Jason Liao, Steven Xu, Liping Zhang.
6. Multiplexed Gene Expression as a Characterization of Bioactivity for Interferon Beta (IFN-β) Biosimilar Candidates: Impact of Innate Immune Response Modulating Impurities (IIRMIs)
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Tác giả
Eduardo F. Mufarrege, Lydia A. Haile, Marina Etcheverrigaray.
6. Effect of the Plasticizer DEHP in Blood Collection Bags on Human Plasma Fraction Unbound Determination for Alpha-1-Acid Glycoprotein (AAG) Binding Drugs
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Tác giả
Nicholas Ingram, Christopher Dishinger, Jennifer Wood.
7. On the Comparison of Methods in Analyzing Bounded Outcome Score Data
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Tác giả
Chuanpu Hu.
7. Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1
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Tác giả
Lora Hamuro, Giridhar S. Tirucherai, Sean M. Crawford, Akbar Nayeem.
7. Estimating In Vivo Fractional Contribution of OATP1B1 to Human Hepatic Active Uptake by Mechanistically Modeling Pharmacogenetic Data
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Tác giả
Rui Li.
7. Neutralizing Antibody Assay Development with High Drug and Target Tolerance to Support Clinical Development of an Anti-TFPI Therapeutic Monoclonal Antibody
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Tác giả
Yuhong Xiang, Chuenlei Parng, Katrina Olson, Elena Seletskaia.
7. Development of a New Inhaler for High-Efficiency Dispersion of Spray-Dried Powders Using Computational Fluid Dynamics (CFD) Modeling
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Tác giả
Worth Longest, Dale Farkas.
7. Approaches to Resolve False Reporting in Neutralizing Antibody Assays Caused by Reagent Leaching from Affinity Capture Elution Solid Phase
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Tác giả
Yuhong Xiang, John Kamerud, Jean Donley, Katrina Olson, Teresa Caiazzo.
8. Comparison of Bevacizumab Quantification Results in Plasma of Non-small Cell Lung Cancer Patients Using Bioanalytical Techniques Between LC-MS/MS, ELISA, and Microfluidic-based Immunoassay
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Tác giả
Noriko Iwamoto, Megumi Takanashi, Takashi Shimada, Jiichiro Sasaki.
8. Modeling Combined Anti-Inflammatory Effects of Dexamethasone and Tofacitinib in Arthritic Rats
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Tác giả
Ruihong Yu, Dawei Song, Debra C DuBois, Richard R. Almon.
8. Population Pharmacokinetic Modeling in the Presence of Missing Time-Dependent Covariates: Impact of Body Weight on Pharmacokinetics of Paracetamol in Neonates
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Tác giả
Wojciech Krzyzanski, Sarah F. Cook, Melanie Wilbaux.
8. Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells
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Tác giả
Madhav Sachar, Edward J. Kelly, Jashvant D. Unadkat.
8. Systemic Bioequivalence Is Unlikely to Equal Target Site Bioequivalence for Nanotechnology Oncologic Products
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Tác giả
Jessie L.-S. Au, Ze Lu, Roberto A. Abbiati, M. Guillaume Wientjes.
8. In Vitro and In Vivo Efficacy of the Monocarboxylate Transporter 1 Inhibitor AR-C155858 in the Murine 4T1 Breast Cancer Tumor Model
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Tác giả
Xiaowen Guan, Mark A. Bryniarski, Marilyn E. Morris.
9. A Fit-for-Purpose Method for the Detection of Human Antibodies to Surface-Exposed Components of BMS-986263, a Lipid Nanoparticle-Based Drug Product Containing a siRNA Drug Substance
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Tác giả
Uma Kavita, Wendy Miller, Qin C. Ji, Renuka C. Pillutla.
9. Mind the Gaps: Ontogeny of Human Brain P-gp and Its Impact on Drug Toxicity
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Tác giả
Jean-Marie Nicolas, Elizabeth C. M. de Lange.
9. Interfacial Stress in the Development of Biologics: Fundamental Understanding, Current Practice, and Future Perspective
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Tác giả
Jinjiang Li, Mary E. Krause, Xiaodong Chen, Yuan Cheng, Weiguo Dai.
9. Translational Framework Predicting Tumour Response in Gemcitabine-Treated Patients with Advanced Pancreatic and Ovarian Cancer from Xenograft Studies
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Tác giả
Maria Garcia-Cremades, Celine Pitou, Philip W. Iversen.
9. The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360
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Tác giả
Joseph W. Polli, Christopher R. McCurdy, Dale Eric Wurster.
10. Model-Informed Drug Development Approach Supporting Approval of Adalimumab (HUMIRA) in Adolescent Patients with Hidradenitis Suppurativa: a Regulatory Perspective
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Tác giả
Youwei Bi, Jiang Liu, Jie Wang, Roselyn E. Epps, David Kettl.
10. A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®
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Tác giả
Alison Betts, Nahor Haddish-Berhane, Dhaval K. Shah.
10. Theoretical Considerations for Direct Translation of Unbound Liver-to-Plasma Partition Coefficient from In Vitro to In Vivo
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Tác giả
Zhenhong Li, Li Di, Tristan S. Maurer.
10. Predicting Overall Survival and Progression-Free Survival Using Tumor Dynamics in Advanced Breast Cancer Patients
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Tác giả
Hyeong-Seok Lim, Wan Sun, Kourosh Parivar, Diane Wang.
10. Population Pharmacokinetics of AL-335 and Its Two Main Metabolites (ALS-022399, ALS-022227) in Monotherapy and in Combination with Odalasvir and/or Simeprevir
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Tác giả
Elodie Valade, Thomas N. Kakuda, Matthew W. McClure.
11. Reduced Systemic and Brain Exposure with Inhibited Liver Metabolism of Carbamazepine After Its Long-Term Combination Treatment with Piperine for Epilepsy Control in Rats
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Tác giả
Tianjing Ren, Min Xiao, Mengbi Yang, Jiajia Zhao, Yufeng Zhang.
11. Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension
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Tác giả
Maxime Le Merdy, Jianghong Fan, Michael B. Bolger, Viera Lukacova.
11. Simulating the Impact of Elevated Levels of Interleukin-6 on the Pharmacokinetics of Various CYP450 Substrates in Patients with Neuromyelitis Optica or Neuromyelitis Optica Spectrum Disorders in Different Ethnic Populations
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Tác giả
Krishna K. Machavaram, Chihiro Endo-Tsukude, Kimio Terao.
11. Dissolution Testing in Drug Product Development: Workshop Summary Report
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Tác giả
Andreas Abend, David Curran, Jesse Kuiper, Xujin Lu, Hanlin Li.
11. PBPK and its Virtual Populations: the Impact of Physiology on Pediatric Pharmacokinetic Predictions of Tramadol
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Tác giả
Huybrecht T’jollyn, An Vermeulen, Jan Van Bocxlaer.
12. Quality Controls in Ligand Binding Assays: Recommendations and Best Practices for Preparation, Qualification, Maintenance of Lot to Lot Consistency, and Prevention of Assay Drift
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Tác giả
Mitra Azadeh, Perceval Sondag, Ying Wang, Maribeth Raines.
12. Nanomaterial-Based Modulation of Tumor Microenvironments for Enhancing Chemo/Immunotherapy
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Tác giả
Quoc-Viet Le, Juhan Suh, Yu-Kyoung Oh.
12. Effect of Dibasic Calcium Phosphate Incorporation on Cellulose Nanocrystal/Chitosan Hydrogel Properties for the Treatment of Vertebral Compression Fractures
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Tác giả
Soheila Ali Akbari Ghavimi, Ethan S. Lungren, Jessica L. Stromsdorfer.
12. Quantitative Prediction of Human Hepatic Clearance for P450 and Non-P450 Substrates from In Vivo Monkey Pharmacokinetics Study and In Vitro Metabolic Stability Tests Using Hepatocytes
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Tác giả
Haruka Nishimuta, Takao Watanabe, Kiyoko Bando.
13. Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples
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Tác giả
Cindy Yanfei Li, Chelsea Hosey-Cojocari, Abdul Basit.
13. In Vitro Metabolism and Hepatic Intrinsic Clearance of the Synthetic Cannabinoid Receptor Agonist JWH-122 and Its Four ω-Halogenated Analogues
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Tác giả
Anders Bork Davidsen, Marie Mardal, Kristian Linnet.
13. A Receiver Operating Characteristic Framework for Non-adherence Detection Using Drug Concentration Thresholds—Application to Simulated Risperidone Data in Schizophrenic Patients
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Tác giả
Carlos Pérez-Ruixo, Bart Remmerie, Juan José Peréz-Ruixo, An Vermeulen.
13. PBPK Absorption Modeling: Establishing the In Vitro–In Vivo Link—Industry Perspective
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Tác giả
Cordula Stillhart, Xavier Pepin, Christophe Tistaert, David Good.
14. Compensated Hydroxyl Radical Protein Footprinting Measures Buffer and Excipient Effects on Conformation and Aggregation in an Adalimumab Biosimilar
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Tác giả
Sandeep K. Misra, Ron Orlando, Scot R. Weinberger, Joshua S. Sharp.
14. Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography
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Tác giả
Irene Hernández Lozano, Rudolf Karch, Martin Bauer, Matthias Blaickner.
14. Pharmacokinetic Properties of Humanized IgG1 and IgG4 Antibodies in Preclinical Species: Translational Evaluation
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Tác giả
Mohammad Tabrizi, Divas Neupane, Sophia E. Elie, Harish Shankaran.
14. Tumor-Targeted Chemoimmunotherapy with Immune-Checkpoint Blockade for Enhanced Anti-Melanoma Efficacy
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Tác giả
Man Li, Yuting Yang, Chaoqun Xu, Jiaojie Wei, Yingke Liu, Xingli Cun.
15. A Tangeretin Derivative Inhibits the Growth of Human Prostate Cancer LNCaP Cells by Epigenetically Restoring p21 Gene Expression and Inhibiting Cancer Stem-like Cell Proliferation
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Tác giả
Guor-Jien Wei, Yen-Hsiang Chao, Yen-Chen Tung, Tien-Yuan Wu.
15. A Novel Method for Analysing Frequent Observations from Questionnaires in Order to Model Patient-Reported Outcomes: Application to EXACT® Daily Diary Data from COPD Patients
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Tác giả
Eva Germovsek, Claire Ambery, Shuying Yang, Misba Beerahee.
15. Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method
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Tác giả
E. A. M. Calvier, E. H. J. Krekels, T. N. Johnson, A. Rostami-Hodjegan.
15. What Does it Take to Make Model-Informed Precision Dosing Common Practice? Report from the 1st Asian Symposium on Precision Dosing
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Tác giả
Thomas M. Polasek, Amin Rostami-Hodjegan, Dong-Seok Yim, Masoud Jamei.
16. Sensitivity of Pegfilgrastim Pharmacokinetic and Pharmacodynamic Parameters to Product Differences in Similarity Studies
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Tác giả
Ari Brekkan, Luis Lopez-Lazaro, Elodie L. Plan, Joakim Nyberg.
16. Biodegradable Thermosensitive PLGA-PEG-PLGA Polymer for Non-irritating and Sustained Ophthalmic Drug Delivery
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Tác giả
Pui Shan Chan, Jia Wen Xian, Qingqing Li, Chun Wai Chan.
16. Variability Attribution for Automated Model Building
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Tác giả
Moustafa M. A. Ibrahim, Rikard Nordgren, Maria C. Kjellsson.
16. Survival Prolongation Index as a Novel Metric to Assess Anti-Tumor Activity in Xenograft Models
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Tác giả
Fiona Chandra, Lihi Zaks, Andy Zhu.
17. Characterization and Quantification of an Fc-FGF21 Fusion Protein in Rat Serum Using Immunoaffinity LC-MS
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Tác giả
Fengping Li, Yan Weng, Guodong Zhang, Xiaogang Han, Dongmei Li.
17. Effect of Grapefruit Juice Intake on Serum Level of the Endogenous CYP3A4 Metabolite 4β-Hydroxycholesterol—an Interaction Study in Healthy Volunteers
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Tác giả
Caroline Gjestad, Kristine Hole, Tore Haslemo, Ulf Diczfalusy.
17. Dissolution Edge Charts for Immediate Release Products and Their Applications: a Simulation Study to Aid the Setting of Specifications
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Tác giả
John Z. Duan.
17. Sorafenib N-Oxide Is an Inhibitor of Human Hepatic CYP3A4
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Tác giả
Sussan Ghassabian, Tina B. Gillani, Tristan Rawling, Severine Crettol.
18. Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway
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Tác giả
Hsiao-Chen Dina Kuo, Renyi Wu, Shanyi Li, Anne Yuqing Yang, Ah-Ng Kong.
18. Targeting Cancer Via Resveratrol-Loaded Nanoparticles Administration: Focusing on In Vivo Evidence
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Tác giả
Ana Cláudia Santos, Irina Pereira, Mariana Magalhães.
18. A Reappraisal of Sedimentation Nonideality Coefficients for the Analysis of Weak Interactions of Therapeutic Proteins
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Tác giả
Sumit K. Chaturvedi, Peter Schuck.
18. Scientific Considerations for the Review and Approval of First Generic Mometasone Furoate Nasal Suspension Spray in the United States from the Bioequivalence Perspective
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Tác giả
Qing Liu, Mohammad Absar, Bhawana Saluja, Changning Guo.
19. Determination of IL-23 Pharmacokinetics by Highly Sensitive Accelerator Mass Spectrometry and Subsequent Modeling to Project IL-23 Suppression in Psoriasis Patients Treated with Anti-IL-23 Antibodies
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Tác giả
Ting-Ting Zhang, Junli Ma, Kenneth R. Durbin, Timothy Montavon.
19. Report of the AAPS Guidance Forum on the FDA Draft Guidance for Industry: “Drug Products, Including Biological Products, that Contain Nanomaterials”
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Tác giả
Jon S. B. de Vlieger, Daan J. A. Crommelin, Katherine Tyner.
19. Model-Based Conditional Weighted Residuals Analysis for Structural Model Assessment
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Tác giả
Moustafa M. A. Ibrahim, Sebastian Ueckert, Svetlana Freiberga.
19. Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells
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Tác giả
Xiaowen Guan, Vivian Rodriguez-Cruz, Marilyn E. Morris.
20. A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children
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Tác giả
Janneke M. Brussee, Elke H. J. Krekels, Elisa A. M. Calvier.
20. Fc-Fusion Drugs Have FcγR/C1q Binding and Signaling Properties That May Affect Their Immunogenicity
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Tác giả
H. A. Daniel Lagassé, Hartmut Hengel, Basil Golding, Zuben E. Sauna.
20. A Density-Changing Centrifugation Method for Efficient Separation of Free Drugs from Drug-Loaded Particulate Delivery Systems
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Tác giả
Lu Han, Hongyan Zhan, Xun Sun, Zhi-Rong Zhang, Li Deng.
20. Evaluation of a Particulate Breast Cancer Vaccine Delivered via Skin
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Tác giả
Lipika Chablani, Suprita A. Tawde, Archana Akalkotkar.
21. Population Pharmacokinetics and Pharmacodynamics of Apixaban Linking Its Plasma Concentration to Intrinsic Activated Coagulation Factor X Activity in Japanese Patients with Atrial Fibrillation
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Tác giả
Satoshi Ueshima, Daiki Hira, Chiho Tomitsuka, Miki Nomura, Yuuma Kimura.
21. Report on the AAPS Immunogenicity Guidance Forum
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Tác giả
Heather Myler, Boris Gorovits, Kelli Phillips, Viswanath Devanarayan.
21. First-Principles and Empirical Approaches to Predicting In Vitro Dissolution for Pharmaceutical Formulation and Process Development and for Product Release Testing
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Tác giả
Nikolay Zaborenko, Zhenqi Shi, Claudia C. Corredor.
22. A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer
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Tác giả
Mohammad Jafarnejad, Chang Gong, Edward Gabrielson, Imke H. Bartelink.
22. In Vitro and In Vivo Co-delivery of siRNA and Doxorubicin by Folate-PEG-Appended Dendrimer/Glucuronylglucosyl-β-Cyclodextrin Conjugate
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Tác giả
Ahmed Fouad Abdelwahab Mohammed, Taishi Higashi, Keiichi Motoyama.
23. Guidance for Rifampin and Midazolam Dosing Protocols To Study Intestinal and Hepatic Cytochrome P450 (CYP) 3A4 Induction and De-induction
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Tác giả
Asha J Kapetas, Michael J Sorich, A David Rodrigues, Andrew Rowland.
23. Fetal Concentrations of Budesonide and Fluticasone Propionate: a Study in Mice
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Tác giả
Syedsaoud Zaidi, Mong-Jen Chen, Daniel T. Lee, Elsa Neubart, Pär Ewing.
24. Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies
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Tác giả
Andrea Treyer, Mohammed Ullah, Neil Parrott, Birgit Molitor.
25. Anti-drug Antibody Assay Validation: Improved Reporting of the Assay Selectivity via Simpler Positive Control Recovery Data Analysis
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Tác giả
Boris Gorovits, Marcela Araya Roldan, Daniel Baltrukonis, Chun-Hua Cai.
