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The AAPS Journal
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Volume 21, Issue 1, January 2019
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1. Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools
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Tác giả
Sebastiaan C. Goulooze, Elke H. J. Krekels, Thomas Hankemeier.
2. Golimumab Dried Blood Spot Analysis (GOUDA): a Prospective Trial Showing Excellent Correlation with Venepuncture Samples and More Detailed Pharmacokinetic Information
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Tác giả
Iris Detrez, Ganel Schops, Jolien Lefrère, Sophie Tops, Gert Van Assche.
3. Measurement of IL-17AA and IL-17FF as Pharmacodynamic Biomarkers to Demonstrate Target Engagement in the Phase I Study of MCAF5352A
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Tác giả
Kun Peng, Yehong Wang, Ketevan Siradze, Rich Erickson.
4. The Assessment of Quality Attributes for Biosimilars: a Statistical Perspective on Current Practice and a Proposal
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Tác giả
Johanna Mielke, Franz Innerbichler, Martin Schiestl.
5. Overlooked Issues on Pharmacokinetics Data Interpretation of Protein Drugs—a Case Example of Erythropoietin
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Tác giả
Guohua An, Robert L. Schmidt, Donald M. Mock, Peter Veng-Pedersen.
6. Effect of the Plasticizer DEHP in Blood Collection Bags on Human Plasma Fraction Unbound Determination for Alpha-1-Acid Glycoprotein (AAG) Binding Drugs
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Tác giả
Nicholas Ingram, Christopher Dishinger, Jennifer Wood.
7. Approaches to Resolve False Reporting in Neutralizing Antibody Assays Caused by Reagent Leaching from Affinity Capture Elution Solid Phase
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Tác giả
Yuhong Xiang, John Kamerud, Jean Donley, Katrina Olson, Teresa Caiazzo.
8. In Vitro and In Vivo Efficacy of the Monocarboxylate Transporter 1 Inhibitor AR-C155858 in the Murine 4T1 Breast Cancer Tumor Model
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Tác giả
Xiaowen Guan, Mark A. Bryniarski, Marilyn E. Morris.
9. The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360
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Tác giả
Joseph W. Polli, Christopher R. McCurdy, Dale Eric Wurster.
10. Population Pharmacokinetics of AL-335 and Its Two Main Metabolites (ALS-022399, ALS-022227) in Monotherapy and in Combination with Odalasvir and/or Simeprevir
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Tác giả
Elodie Valade, Thomas N. Kakuda, Matthew W. McClure.
11. PBPK and its Virtual Populations: the Impact of Physiology on Pediatric Pharmacokinetic Predictions of Tramadol
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Tác giả
Huybrecht T’jollyn, An Vermeulen, Jan Van Bocxlaer.