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Current Opinion in Chemical Biology
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1. Bacterial carbohydrate diversity — a Brave New World
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Barbara Imperiali.
1. Editorial Board
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1. Editorial Board
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1. Editorial Board
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1. Editorial Board
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1. Editorial Board
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2. Chemoenzymatic synthesis of glycoproteins
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Antony J Fairbanks.
2. Editorial overview: Mammalian synthetic biology: from devices to multicellular systems
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Hirohide Saito, Yohei Yokobayashi.
2. Editorial overview: Recent advance in chemical genetics and chemical epigenetics
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Xiaoguang Lei, Xiang David Li..
2. Editorial overview: From the iceman to modern medicine
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Yimon Aye, Paul J Hergenrother.
2. Editorial overview: New pieces in the redox puzzle: oxidative and reductive transformations in biotechnology
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Kylie A Vincent, Bettina M Nestl
2. Editorial overview: Untangling proteome organization in space and time
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Ileana M Cristea, Kathryn S Lilley.
3. New discoveries in bacterial N-glycosylation to expand the synthetic biology toolbox
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Harald Nothaft, Christine M Szymanski.
3. Synthetic developmental biology: build and control multicellular systems
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Mo R Ebrahimkhani, Miki Ebisuya.
3. Chemical and biophysical methods to explore dynamic mechanisms of chromatin silencing
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Iuliia Boichenko, Beat Fierz.
3. The antimalarial screening landscape—looking beyond the asexual blood stage
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Sabrina Yahiya, Ainoa Rueda-Zubiaurre, Michael J Delves, Matthew J Fuchter, Jake Baum.
3. Biocatalytic hydrogen atom transfer: an invigorating approach to free-radical reactions
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Yuji Nakano, Kyle F Biegasiewicz, Todd K Hyster.
3. Chemical proteomics for subcellular proteome analysis
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Hao Zhu, Tomonori Tamura, Itaru Hamachi.
4. An overview of activity-based probes for glycosidases
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Liang Wu, Zachary Armstrong, Sybrin P Schröder, Casper de Boer, ... Gideon J Davies.
4. Mammalian gene circuits with biomolecule-responsive RNA devices
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Hideyuki Nakanishi, Hirohide Saito.
4. The roles of microRNAs in epigenetic regulation
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Qian Yao, Yuqi Chen, Xiang Zhou.
4. Construction of ligand assay systems by protein-based semisynthetic biosensors
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Seiji Sakamoto, Shigeki Kiyonaka, Itaru Hamachi.
4. Enzymatic CH functionalizations for natural product synthesis
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Fuzhuo Li, Xiao Zhang, Hans Renata
4. Chemical cross-linking with mass spectrometry: a tool for systems structural biology
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Juan D Chavez, James E Bruce.
5. New insights into lipopolysaccharide assembly and export
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Ryan P Sweeney, Todd L Lowary.
5. CRISPR/Cas-based devices for mammalian synthetic biology
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Tackhoon Kim, Timothy K Lu.
5. Updates on the epigenetic roles of sirtuins
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Tatsiana Kosciuk, Miao Wang, Jun Young Hong, Hening Lin.
5. Sphingolipids and membrane targets for therapeutics
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Robbie Loewith, Howard Riezman, Nicolas Winssinger.
5. Biomimetic cofactors and methods for their recycling
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Ioannis Zachos, Claudia Nowak, Volker Sieber.
5. Understanding molecular mechanisms of disease through spatial proteomics
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Sandra Pankow, Salvador Martínez-Bartolomé, Casimir Bamberger, John R Yates.
6. Chemical tools to characterize peptidoglycan synthases
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Atsushi Taguchi, Daniel Kahne, Suzanne Walker.
6. Engineering cell–cell communication networks: programming multicellular behaviors
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Satoshi Toda, Nicholas W Frankel, Wendell A Lim.
6. Epigenetic regulation by endogenous metabolite pharmacology
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Rhushikesh A Kulkarni, David C Montgomery, Jordan L Meier.
6. Reactive-cysteine profiling for drug discovery
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Aaron J Maurais, Eranthie Weerapana.
6. Selective CH bond functionalization with engineered heme proteins: new tools to generate complexity
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Ruijie K Zhang, Xiongyi Huang, Frances H Arnold.
6. Surfaceome nanoscale organization and extracellular interaction networks
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Damaris Bausch-Fluck, Emanuela Sara Milani, Bernd Wollscheid.
7. Lectin antagonists in infection, immunity, and inflammation
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Joscha Meiers, Eike Siebs, Eva Zahorska, Alexander Titz.
7. Protein-based parts and devices that respond to intracellular and extracellular signals in mammalian cells
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Federica Cella, Velia Siciliano.
7. Chemical biology approaches targeting the actin cytoskeleton through phenotypic screening
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Nicole S Bryce, Edna C Hardeman, Peter W Gunning, John G Lock.
7. Developing zebrafish disease models for in vivo small molecule screens
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Pui-Ying Lam, Randall T Peterson.
7. Identification and development of amino acid oxidases
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Yasuhisa Asano, Kazuyuki Yasukawa
7. Location is everything: protein translocations as a viral infection strategy
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Katelyn C Cook, Ileana M Cristea.
8. The continuing expansion of CAZymes and their families
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Marie-Line Garron, Bernard Henrissat.
8. DNA event recorders send past information of cells to the time of observation
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Soh Ishiguro, Hideto Mori, Nozomu Yachie.
8. Genie in a bottle: controlled release helps tame natural polypharmacology?
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Marcus JC Long, Xuyu Liu, Yimon Aye.
8. Using chemical inhibitors to probe AAA protein conformational dynamics and cellular functions
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Jonathan B Steinman, Tarun M Kapoor.
8. Whole-cell based synthetic enzyme cascades—light and shadow of a promising technology
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Florian Rudroff.
8. Getting to know the neighborhood: using proximity-dependent biotinylation to characterize protein complexes and map organelles
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Anne-Claude Gingras, Kento T Abe, Brian Raught.
9. Molecular mechanisms regulating O-linked N-acetylglucosamine (O-GlcNAc)–processing enzymes
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Dustin T. King, Alexandra Males, Gideon J. Davies, David J. Vocadlo.
9. DNA barcodes evolve for high-resolution cell lineage tracing
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Nanami Masuyama, Hideto Mori, Nozomu Yachie.
9. Identification and characterization of ‘readers’ for novel histone modifications
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Shuai Zhao, Yuan Yue, Yuanyuan Li, Haitao Li.
9. Modulating protein–protein interaction networks in protein homeostasis
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Mengqi Zhong, Gregory M Lee, Eline Sijbesma, Christian Ottmann, Michelle R Arkin.
9. How to make the reducing power of H2 available for in vivo biosyntheses and biotransformations
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Lars Lauterbach, Oliver Lenz.
9. Proteomics of nucleocytoplasmic partitioning
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Thao Nguyen, Nishant Pappireddi, Martin Wühr.
10. The physical organic chemistry of glycopyranosyl transfer reactions in solution and enzyme-catalyzed
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Cinzia Colombo, Andrew J Bennet.
10. Aptamer-based and aptazyme-based riboswitches in mammalian cells
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Yohei Yokobayashi.
10. Chemically induced cell fate reprogramming and the acquisition of plasticity in somatic cells
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Yang Zhao.
10. Label-free target identification in drug discovery via phenotypic screening
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Hankum Park, Jaeyoung Ha, Seung Bum Park.
10. Advances and opportunities for the design of self-sufficient and spatially organized cell-free biocatalytic systems
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Claudia Schmid-Dannert, Fernando López-Gallego.
10. Protein identification strategies in MALDI imaging mass spectrometry: a brief review
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Daniel J Ryan, Jeffrey M Spraggins, Richard M Caprioli.
11. Chemically engineered glycan-modified cancer vaccines to mobilize skin dendritic cells
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Sanne Duinkerken, R. Eveline Li, Floortje J. van Haften, Tanja D. de Gruijl, ... Yvette van Kooyk.
11. Mammalian synthetic biology by CRISPRs engineering and applications
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Kenta Katayama, Hitoshi Mitsunobu, Keiji Nishida.
11. Editorial overview: Advances and future prospects of molecular imaging for studying and quantifying biological processes
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Philipp Kukura, Sua Myong.
11. Recent advances in the development of HBV capsid assembly modulators
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Bhavitavya Nijampatnam, Dennis C Liotta
11. Recent preparative applications of redox enzymes
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Christopher K Prier, Birgit Kosjek.
11. Regulation of phagosome functions by post-translational modifications: a new paradigm
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Paul Dean, Tiaan Heunis, Anetta Härtlova, Matthias Trost.
12. Photocrosslinking probes for capture of carbohydrate interactions
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Han Wu, Jennifer Kohler.
12. Synthetic biomolecules: from blind watchmakers to synthetic biologists
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Johan Winne, Annemieke Madder.
12. Whispering-gallery mode (WGM) sensors: review of established and WGM-based techniques to study protein conformational dynamics
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Simona Frustaci, Frank Vollmer.
12. Targeting defective proteostasis in the collagenopathies
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Madeline Y Wong, Matthew D Shoulders.
12. Fungal PQQ-dependent dehydrogenases and their potential in biocatalysis
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Kouta Takeda, Kiwamu Umezawa, Anikó Várnai, Vincent GH Eijsink, ... Nobuhumi Nakamura.
12. Dynamics of protein complex components
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David G Rattray, Leonard J Foster.
13. Modeling catalytic reaction mechanisms in glycoside hydrolases
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Joan Coines, Lluís Raich, Carme Rovira.
13. Natural product derived privileged scaffolds in drug discovery
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Emma K Davison, Margaret A Brimble.
13. Image scanning microscopy
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Ingo Gregor, Jörg Enderlein.
13. Histone deacetylases as an epigenetic pillar for the development of hybrid inhibitors in cancer
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Giulia Stazi, Rossella Fioravanti, Antonello Mai, Andrea Mattevi, Sergio Valente.
13. Shedding light on biocatalysis: photoelectrochemical platforms for solar-driven biotransformation
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Jinhyun Kim, Chan Beum Park.
13. The subcellular organisation of Saccharomyces cerevisiae
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Daniel JH Nightingale, Aikaterini Geladaki, Lisa M Breckels, Stephen G Oliver, Kathryn S Lilley.
14. Probing microscopic conformational dynamics in folding reactions by measuring transition paths
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Noel Q Hoffer, Michael T Woodside.
14. Tag and release: strategies for the intracellular cleavage of protein conjugates
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Alice Leonie Baumann, Christian Peter Richard Hackenberger.
14. Strategies for increasing the throughput of super-resolution microscopies
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Dora Mahecic, Ilaria Testa, Juliette Griffié, Suliana Manley.
14. Will morphing boron-based inhibitors beat the β-lactamases?
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Alen Krajnc, Pauline A Lang, Tharindi D Panduwawala, Jürgen Brem, Christopher J Schofield.
14. Editorial overview: Emergent lessons from the elements of life
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Kyle M Lancaster.
14. Cysteine reactivity across the subcellular universe
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Daniel W Bak, Tyler J Bechtel, Julia A Falco, Eranthie Weerapana.
15. Shedding light on complexity of protein–protein interactions in cancer
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Tae-Young Yoon, Hong-Won Lee.
15. The role of bacterial lipid diversity and membrane properties in modulating antimicrobial peptide activity and drug resistance
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Tzong-Hsien Lee, Vinzenz Hofferek, Frances Separovic, Gavin E Reid, Marie-Isabel Aguilar.
15. Functional super-resolution microscopy of the cell
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Rui Yan, Bowen Wang, Ke Xu.
15. Targeted protein degradation: elements of PROTAC design
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Stacey-Lynn Paiva, Craig M Crews.
15. Reactive sulfur species (RSS): persulfides, polysulfides, potential, and problems
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Nathanael Lau, Michael D Pluth.
15. A bright future: optogenetics to dissect the spatiotemporal control of cell behavior
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Alexander G Goglia, Jared E Toettcher.
16. Dynamic bonds and their roles in mechanosensing
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Cheng Zhu, Yunfeng Chen, Lining Arnold Ju.
16. Nucleic acid enzymes based on functionalized nucleosides
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Marcel Hollenstein.
16. Extending fluorescence microscopy into anaerobic environments
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Hannah E Chia, E Neil G Marsh, Julie S Biteen.
16. Pharmacokinetic–pharmacodynamic models that incorporate drug–target binding kinetics
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Fereidoon Daryaee, Peter J Tonge.
16. Insights into the physiology of ammonia-oxidizing microorganisms
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Lisa Y Stein.
16. Signal enhanced proteomics: a biological perspective on dissecting the functional organisation of cell proteomes
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Dalila Bensaddek, Armel Nicolas, Angus I. Lamond.
17. Mechanics and structural stability of the collagen triple helix
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Michael WH Kirkness, Kathrin Lehmann, Nancy R Forde.
17. Towards functional de novo designed proteins
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William M Dawson, Guto G Rhys, Derek N Woolfson.
17. High-speed atomic force microscopy
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Toshio Ando.
17. Genetically encoded fragment-based discovery
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Ratmir Derda, Simon Ng.
17. Metal regulation of metabolism
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Arnold J Bloom.
17. Assessing sub-cellular resolution in spatial proteomics experiments
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Laurent Gatto, Lisa M. Breckels, Kathryn S. Lilley.
18. Single-molecule manipulation quantification of site-specific DNA binding
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Xiaodan Zhao, Shiwen Guo, Chen Lu, Jin Chen, ... Jie Yan.
18. Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics
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Jacques Saarbach, Pramod M Sabale, Nicolas Winssinger.
18. Single-molecule trapping and measurement in solution
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Maria I Bespalova, Sushanta Mahanta, Madhavi Krishnan.
18. Natural products as chemical tools to dissect complex biology in C. elegans
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Rebecca A Butcher.
18. Role of rare earth elements in methanol oxidation
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Nunzia Picone, Huub JM Op den Camp.
18. Proteomic-based approaches to cardiac development and disease
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Kerry M Dorr, Frank L Conlon.
19. How do DNA-bound proteins leave their binding sites? The role of facilitated dissociation
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Aykut Erbaş, John F Marko.
19. Silicone grafted bioactive peptides and their applications
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Julie Martin, Jean Martinez, Ahmad Mehdi, Gilles Subra.
19. Visualizing transcription: key to understanding gene expression dynamics
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Ineke Brouwer, Tineke L Lenstra.
19. New players in phototherapy: photopharmacology and bio-integrated optoelectronics
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Johannes Morstein, Dirk Trauner.
19. Trending topics and open questions in anaerobic ammonium oxidation
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Stijn H Peeters, Laura van Niftrik.
20. Emerging technologies in mechanotransduction research
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Ghaidan A Shamsan, David J Odde.
20. Reactive modifications of DNA nucleobases for labelling, bioconjugations, and cross-linking
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Ivana Ivancová, Denise-Liu’ Leone, Michal Hocek.
20. Can single molecule localization microscopy detect nanoclusters in T cells?
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Kristen Feher, James M Halstead, Jesse Goyette, Katharina Gaus.
20. A role for phosphorus redox in emerging and modern biochemistry
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Matthew Pasek.
21. Towards biological applications of nanophotonic tweezers
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Ryan P. Badman, Fan Ye, Michelle D. Wang.
21. Bifunctional chemical probes inducing protein–protein interactions
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Chiara Maniaci, Alessio Ciulli.
21. Recent developments in spontaneous Raman imaging of living biological cells
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Bianca Durrant, Matthew Trappett, Dustin Shipp, Ioan Notingher.
21. The emergence of nitric oxide in the biosynthesis of bacterial natural products
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Jonathan D Caranto.
22. Peptides and peptidomimetics as inhibitors of protein–protein interactions involving β-sheet secondary structures
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José Laxio Arenas, Julia Kaffy, Sandrine Ongeri.
22. Sulfur-dependent microbial lifestyles: deceptively flexible roles for biochemically versatile enzymes
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Edward J Crane.
