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Acta Pharmaceutica Sinica B
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Volume 9, Issue 2
Pages 203-454 (March 2019)
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1. Table of Contents
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2. Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment
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Xu Wu, Wei Hu, Lan Lu, Yueshui Zhao, Mingxing Li.
3. Small molecules for fat combustion: targeting obesity
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Jingxin Liu, Yitao Wang, Ligen Lin.
4. Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects
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Qihao Wu, Bastien Nay, Min Yang, Yeke Ni, Xuwen Li.
5. Recent progress and challenges in screening and characterization of UGT1A1 inhibitors
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Xia Lv, Yangliu Xia, Moshe Finel, Jingjing Wu, Ling Yang.
6. Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathway
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Shanshan Qi, Lingyuan Guo, Shuzhen Yan, Robert J. Lee, Shuanglin Chen.
7. Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins
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Yuan Zhang, Zhihua Wang, Xiaoyao Ma, Shengnan Yang, Gang Bai.
8. SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade
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Mingxia Zhao, Wenjie Guo, Yuanyuan Wu, Chenxi Yang, Yang Sun.
9. The epigallocatechin gallate derivative Y6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo
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Yan Wen, Ruiqiang Zhao, Pranav Gupta, Yingfang Fan, Gang Liang.
10. LSD1 inhibition suppresses the growth of clear cell renal cell carcinoma via upregulating P21 signaling
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Liangsong Zhu, Jianfeng Wang, Wen Kong, Jiwei Huang, Jin Zhang.
11. Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents
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Jiabing Wang, Lili Huang, Chanchan Cheng, Ge Li, Jianzhang Wu.
12. Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study
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Peng Wei, Bo Liu, Ruifeng Wang, Yinglei Gao, Bing Xiong.
13. Cytotoxic and antibacterial polyketide-indole hybrids synthesized from indole-3-carbinol by Daldinia eschscholzii
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Liping Lin, Nan Jiang, Huimin Wu, Yaning Mei, Renxiang Tan.
14. Dual-targeting and microenvironment-responsive micelles as a gene delivery system to improve the sensitivity of glioma to radiotherapy
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Xiuxiu Jiao, Yuan Yu, Jianxia Meng, Mei He, Xueying Ding.
15. Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy
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Lu Zhong, Lu Xu, Yanying Liu, Qingsong Li, Zhonggui He.
16. Theranostic nanoparticles with tumor-specific enzyme-triggered size reduction and drug release to perform photothermal therapy for breast cancer treatment
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Rui Liu, Chuan Hu, Yuanyuan Yang, Jingqing Zhang, Huile Gao.
17. Redox-sensitive prodrug nanoassemblies based on linoleic acid-modified docetaxel to resist breast cancers
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Meng Li, Liwen Zhao, Tao Zhang, Yue Shu, Yongjun Wang.
18. Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity
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Zhiqin Cao, Shaoyang Li, Jianming Lv, Hao Gao, Dan Hu.
19. Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer
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