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JACC: Basic to Translational Science
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1. Editorial Board
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1. Editorial Board
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1. Editorial Board
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1. Editorial Board
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1. Editorial Board
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1. Editorial Board
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1. Editorial Board
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1. Editorial Board
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2. A Novel Biological Strategy for Myocardial Protection by Intracoronary Delivery of Mitochondria: Safety and Efficacy
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Borami Shin, Mossab Y. Saeed, Jesse J. Esch, Alvise Guariento, James D. McCully.
2. Instructions For Authors
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2. First-in-Man Study of a Cardiac Extracellular Matrix Hydrogel in Early and Late Myocardial Infarction Patients
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Jay H. Traverse, Timothy D. Henry, Nabil Dib, Amit N. Patel, Karen L. Christman.
2. Comparative Transcriptomics of Ex Vivo, Patient-Derived Endothelial Cells Reveals Novel Pathways Associated With Type 2 Diabetes Mellitus
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Joshua A. Beckman, Sean P. Doherty, Zachary B. Feldman, Emily S. Banks, Jonathan D. Brown.
2. Female Authorship in Preclinical Cardiovascular Research: Temporal Trends and Influence on Experimental Design
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Alisha Labinaz, Jeffrey A. Marbach, Richard G. Jung, Robert Moreland, F. Daniel Ramirez.
2. Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy
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Agnes Koczo, Amy Marino, Arun Jeyabalan, Uri Elkayam, Ilan S. Wittstein.
2. Celecoxib Is Associated With Dystrophic Calcification and Aortic Valve Stenosis
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Meghan A. Bowler, Michael A. Raddatz, Camryn L. Johnson, Brian R. Lindman, W. David Merryman.
2. Instructions For Authors
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3. The New Promise of Mitochondrial Transplantation for Myocardial Recovery∗
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W.H. Wilson Tang.
3. Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus: Results of the OPTIMUS-5 Study
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Francesco Franchi, Fabiana Rollini, Victor Kairouz, Jose Rivas Rios, Dominick J. Angiolillo.
3. Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy
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Toshiyuki Ko, Kanna Fujita, Seitaro Nomura, Yukari Uemura, Issei Komuro.
3. Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin
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Rio P. Juni, Diederik W.D. Kuster, Max Goebel, Michiel Helmes, Victor W.M. van Hinsbergh
3. Sex Differences in Science: Do We Have a Problem?∗
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Eva van Rooij, Nanette H. Bishopric.
3. To Breastfeed or Not to Breastfeed With Peripartum Cardiomyopathy∗
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Zoltan Arany, Arthur M. Feldman.
3. Off Target But on Track to New Strategies to Mitigate Calcific Aortic Valve Disease∗
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Dwight A. Towler.
3. Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis
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Heather L. Teague, Nevin J. Varghese, Lam C. Tsoi, Amit K. Dey, Nehal N. Mehta.
4. Associations of Interleukin-5 With Plaque Development and Cardiovascular Events
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Anki Knutsson, Harry Björkbacka, Pontus Dunér, Gunnar Engström, Jan Nilsson.
4. Platelet Function Testing and Clinical Outcomes: Connecting the Dots∗
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David J. Schneider.
4. DNA Damage Prediction Tool in Dilated Cardiomyopathy: Don’t Go Breaking My Heart∗
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Jesus Jimenez, Stacey L. Rentschler.
4. Empagliflozin and Protecting Microvascular Support of Heart Mechanics: SGLT2 Inhibition or More?∗
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Chris Sorel Mantsounga, Alan R. Morrison.
4. Malondialdehyde Conjugated With Albumin Induces Pro-Inflammatory Activation of T Cells Isolated From Human Atherosclerotic Plaques Both Directly and Via Dendritic Cell–Mediated Mechanism
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Mizanur Rahman, Johnny Steuer, Peter Gillgren, Ákos Végvári, Johan Frostegård.
4. Inflammasome-Driven Interleukin-1α and Interleukin-1β Production in Atherosclerotic Plaques Relates to Hyperlipidemia and Plaque Complexity
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Xintong Jiang, Feilong Wang, Yajuan Wang, Anton Gisterå, Zhong-qun Yan.
4. Elamipretide Improves Mitochondrial Function in the Failing Human Heart
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Kathryn C. Chatfield, Genevieve C. Sparagna, Sarah Chau, Elisabeth K. Phillips, Brian L. Stauffer.
4. SGLT2 Inhibitor, Canagliflozin, Attenuates Myocardial Infarction in the Diabetic and Nondiabetic Heart
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Ven G. Lim, Robert M. Bell, Sapna Arjun, Maria Kolatsi-Joannou, Derek M. Yellon.
5. Interleukin 5 Contributes to Human Atherosclerosis Development But not to Thrombotic Complications
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Hafid Ait-Oufella, Soraya Taleb, Alain Tedgui.
5. Gene Therapy Rescues Cardiac Dysfunction in Duchenne Muscular Dystrophy Mice by Elevating Cardiomyocyte Deoxy-Adenosine Triphosphate
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Stephen C. Kolwicz, John K. Hall, Farid Moussavi-Harami, Xiolan Chen, Guy L. Odom.
5. JAK2V617F-Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure
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Soichi Sano, Ying Wang, Yoshimitsu Yura, Miho Sano, Kenneth Walsh.
5. Platelet Acetyl-CoA Carboxylase Phosphorylation: A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients
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Shakeel Kautbally, Sophie Lepropre, Marie-Blanche Onselaer, Astrid Le Rigoleur, Christophe Beauloye.
5. Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes
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Lorenzo R. Sewanan, Jonas Schwan, Jonathan Kluger, Jinkyu Park, Stuart G. Campbell.
5. Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats
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Shin Yajima, Shigeru Miyagawa, Satsuki Fukushima, Yoshiki Sakai, Yoshiki Sawa.
5. Targeting Mitochondrial Function in Heart Failure: Makes Sense But Will it Work?∗
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Tác giả
Muhammad Shahzeb Khan, Javed Butler.
5. Empagliflozin Improves Diastolic Function in a Nondiabetic Rodent Model of Heart Failure With Preserved Ejection Fraction
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Kim A. Connelly, Yanling Zhang, Aylin Visram, Andrew Advani, Richard E. Gilbert.
6. Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment
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Ricardo A. García, Bruce R. Ito, John A. Lupisella, Nancy A. Carson, Francisco J. Villarreal.
6. Emerging Therapies for Dystrophic Cardiomyopathy∗
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Daniel J. Garry, Tamas Alexy.
6. A New Murine Model of Clonal Hematopoiesis Investigates JAK2V617F in Heart Failure∗
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Tác giả
Aniruddh P. Patel, Pradeep Natarajan.
6. Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart
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Tác giả
Shohei Ikeda, Risa Mukai, Wataru Mizushima, Peiyong Zhai, Junichi Sadoshima.
6. Role of the Extracellular Matrix in the Pathogenesis of Hypertrophic Cardiomyopathy∗
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Tác giả
Ali J. Marian.
6. Cathepsin A Mediates Ventricular Remote Remodeling and Atrial Cardiomyopathy in Rats With Ventricular Ischemia/Reperfusion
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Tác giả
Mathias Hohl, Katharina Erb, Lisa Lang, Sven Ruf, Dominik Linz.
6. Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure
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Chen Gao, Shuxun Vincent Ren, Junyi Yu, Ulysis Baal, Yibin Wang.
6. The Growing Case for Use of SGLT2i in Heart Failure: Additional Benefits of Empagliflozin in a HFpEF Rodent Model∗
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Chae-Myeong Ha, Adam R. Wende.
7. Therapeutic Treatment Approaches Post–Myocardial Infarction: A Bias Toward Formyl Peptide Receptor Agonists∗
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Rysa Zaman, Slava Epelman.
7. Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy: A Translational Study
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Raffaele Coppini, Cecilia Ferrantini, Josè Manuel Pioner, Lorenzo Santini, Mark V. Sherrid.
7. Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction
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Yuya Ide, Takahiro Horie, Naritatsu Saito, Shin Watanabe, Koh Ono.
7. The Hippo in the Clinic: An Ancient Signaling Pathway That Regulates Growth and Development Confronts a Modern Pandemic of Obesity, Diabetes, and Heart Failure∗
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Tác giả
Sheldon H. Gottlieb.
7. A Mechanism for Statin-Induced Susceptibility to Myopathy
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Sabine Lotteau, Niklas Ivarsson, Zhaokang Yang, Damien Restagno, Sarah Calaghan.
7. Cathepsin A Inhibitors to Treat Heart Disease: Much Potential, Many Questions∗
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Tác giả
Randy T. Cowling.
7. Modulation of Glucagon Signaling: A Metabolic Approach for Heart Failure?∗
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Tác giả
Alessandro Pocai.
7. Cardiomyocyte SMAD4-Dependent TGF-β Signaling is Essential to Maintain Adult Heart Homeostasis
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Tác giả
Prachi Umbarkar, Anand P. Singh, Manisha Gupte, Vipin K. Verma, Hind Lal.
8. Seipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction
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Bo Bai, Wulin Yang, Yanyun Fu, Hannah Lee Foon, Yu Wang.
8. Out With the Old and in With the New: Not So Fast in Hypertrophic Cardiomyopathy∗
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Tác giả
Martin S. Maron.
8. The Art of War in Drug Development∗
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Tác giả
Taro Kariya, Kiyotake Ishikawa.
8. Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid–CB1-R Signaling
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Janos Paloczi, Csaba Matyas, Resat Cinar, Zoltan V. Varga, Pal Pacher.
8. A Novel Mechanism to Explain Statin-Associated Skeletal Muscle Symptoms∗
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Tác giả
Paul D. Thompson, Beth Taylor.
8. Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice
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Hiromichi Ueda, Osamu Yamaguchi, Manabu Taneike, Yasuhiro Akazawa, Kinya Otsu.
8. Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine
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Alexis R. Cole, Dorothy A. Perry, Ali Raza, Arthur P. Nedder, John N. Kheir.
8. It’s a SMAD, SMAD World: Cell Type–Specific SMAD Signaling in the Heart∗
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Tác giả
Amy D. Bradshaw.
9. The Bslc2–/– Mouse: Adding a Missing Phenotype to the Repertoire of HFpEF Animal Models∗
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Tác giả
Fadi N. Salloum, Stefano Toldo.
9. Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Age-Related Cardiac Dysfunction: Hope for Better Aging?
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Paola C. Rosas, Chad M. Warren, Heidi A. Creed, Jerome P. Trzeciakowski, Carl W. Tong.
9. Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway
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Mathilde Prud’homme, Maxime Coutrot, Thibault Michel, Louis Boutin, Matthieu Legrand.
9. The Detrimental Effects of Alcohol and Cannabinoids on Cardiovascular Function∗
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Tác giả
Fabrizio Montecucco, Federico Carbone.
9. Adaptive Reductions in Left Ventricular Diastolic Compliance Protect the Heart From Stretch-Induced Stunning
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Tác giả
Brian R. Weil, George Techiryan, Gen Suzuki, Filip Konecny, John M. Canty.
9. Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine
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Ambra Albertario, Megan M. Swim, Eltayeb Mohamed Ahmed, Dominga Iacobazzi, Massimo Caputo.
9. Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure
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George T. Gardner, Joshua G. Travers, Jiang Qian, Guan-Sheng Liu, Evangelia G. Kranias.
9. Bioactive Materials Facilitating Targeted Local Modulation of Inflammation
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Richard P. Tan, Alex H.P. Chan, Simon Wei, Miguel Santos, Steven G. Wise.
10. CFTR Therapeutics Normalize Cerebral Perfusion Deficits in Mouse Models of Heart Failure and Subarachnoid Hemorrhage
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Darcy Lidington, Jessica C. Fares, Franziska E. Uhl, Danny D. Dinh, Steffen-Sebastian Bolz.
10. Unraveling the Molecular Mechanism of Action of Empagliflozin in Heart Failure With Reduced Ejection Fraction With or Without Diabetes
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Oriol Iborra-Egea, Evelyn Santiago-Vacas, Salva R. Yurista, Josep Lupón, Antoni Bayés-Genís.
10. The Kidney, Bone Marrow, and Heart Connection in Acute Kidney Injury: Role of Galecin-3∗
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Yang Chen, John C. Burnett.
10. Atrial Myopathy
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Mark J. Shen, Rishi Arora, José Jalife.
10. Repetitive Acute Hemodynamic Load: Progression From Systolic Decompensation to Cellular/Extracellular Compensation to Diastolic Decompensation∗
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Michael R. Zile, Catalin F. Baicu, Ryan J. Tedford.
10. Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction
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Wei Wang, Liyan Zhang, Pavan K. Battiprolu, Arata Fukushima, Gary D. Lopaschuk.
10. Putting the Heat on Cardiac Fibrosis: Hsp20 Regulates Myocyte-To-Fibroblast Crosstalk∗
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Jennifer L. Major, Timothy A. McKinsey.
10. miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease
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Suzanne M. Eken, Tinna Christersdottir, Greg Winski, Traimate Sangsuwan, Lars Maegdefessel.
11. Targeting Muscles in the Brain to Enhance Cerebral Perfusion∗
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Tác giả
Jin-Moo Lee, Abhinav Diwan, Gregory J. Zipfel.
11. Empagliflozin and HFrEF: Known and Possible Benefits of NHE1 Inhibition∗
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Tác giả
Seungho Jun, Miguel A. Aon, Nazareno Paolocci.
11. A Molecularly Detailed NaV1.5 Model Reveals a New Class I Antiarrhythmic Target
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Jonathan D. Moreno, Wandi Zhu, Kathryn Mangold, Woenho Chung, Jonathan R. Silva.
11. Current Education of Physicians: Lost in Translation?
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Tác giả
Andrew I. Schafer, Douglas L. Mann.
11. Neuromodulation for the Treatment of Heart Rhythm Disorders
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Tác giả
Nathan H. Waldron, Marat Fudim, Joseph P. Mathew, Jonathan P. Piccini.
11. Metabolic Coupling as a Therapeutic Strategy for Heart Failure∗
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Tác giả
Martin E. Young.
11. Characterization of a Unique Form of Arrhythmic Cardiomyopathy Caused by Recessive Mutation in LEMD2
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Tác giả
Nelly Abdelfatah, Ruping Chen, Henry J. Duff, Colette M. Seifer, Brenda Gerull.
11. Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction
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Laura E. Vainio, Zoltán Szabó, Ruizhu Lin, Johanna Ulvila, Risto Kerkelä.
12. Cardiac Versus Renal Response to Volume Expansion in Preclinical Systolic Dysfunction With PDEV Inhibition and BNPCardiac Versus Renal Response to Volume Expansion in Preclinical Systolic Dysfunction With PDEV Inhibition and BNP
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Siu-Hin Wan, Isabel Torres-Courchoud, Paul M. McKie, Joshua P. Slusser, Horng H. Chen.
12. Limitations of Animal Studies for Predicting Toxicity in Clinical Trials: Is it Time to Rethink Our Current Approach?
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Tác giả
Gail A. Van Norman.
12. How to Boost Efficacy of a Sodium Channel Blocker: The Devil Is in the Details∗
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Tác giả
Madison B. Nowak, Vrishti M. Phadumdeo, Seth H. Weinberg.
12. Full Issue PDF
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12. Unsaturated Fatty Acids to Improve Cardiorespiratory Fitness in Patients With Obesity and HFpEF: The UFA-Preserved Pilot Study
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Salvatore Carbone, Hayley E. Billingsley, Justin M. Canada, Dinesh Kadariya, ... Antonio Abbate.
12. Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure
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T. Dylan Olver, Jenna C. Edwards, Thomas J. Jurrissen, Adam B. Veteto, Craig A. Emter.
12. Glucagon-Like Peptide-1-Mediated Cardioprotection Does Not Reduce Right Ventricular Stunning and Cumulative Ischemic Dysfunction After Coronary Balloon Occlusion
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Joel P. Giblett, Richard G. Axell, Paul A. White, Muhammad Aetesam-Ur-Rahman, Stephen P. Hoole.
12. Connecting the Dots for Connective Tissue Growth Factor Roles in Cardiac Wound Healing After Myocardial Infarction∗
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Tác giả
Taben M. Hale, Merry L. Lindsey.
13. Paradoxical Cardiorenal Responses Following Acute Vasodilator/Natriuretic Treatment in Presystolic Heart Failure: Should We Be Surprised?
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Tác giả
Tamar S. Polonsky, George L. Bakris.
13. Telomeres as Therapeutic Targets in Heart Disease
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Tác giả
Jih-Kai Yeh, Mei-Hsiu Lin, Chao-Yung Wang.
13. Angiopoietin-Like 3: From Discovery to Therapeutic Gene Editing
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Tác giả
Xiao Wang, Kiran Musunuru.
13. JACC: Basic to Translational Science: The End of the Beginning
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Tác giả
Douglas L. Mann.
13. Cardiometabolic Heart Failure and HFpEF: Still Chasing Unicorns∗
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Tác giả
Thomas E. Sharp, David J. Lefer, Steven R. Houser.
13. Cardiac Nuclear High-Mobility Group Box 1 Ameliorates Pathological Cardiac Hypertrophy by Inhibiting DNA Damage Response
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Tác giả
Tetsuya Takahashi, Tetsuro Shishido, Daisuke Kinoshita, Ken Watanabe, Masafumi Watanabe.
13. Circulating Pro-Vascular Progenitor Cell Depletion During Type 2 Diabetes: Translational Insights Into the Prevention of Ischemic Complications in Diabetes
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Daniella C. Terenzi, Mohammed Al-Omran, Adrian Quan, Hwee Teoh, David A. Hess.
14. Epigenetics in Cardiac Hypertrophy and Heart Failure
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Tác giả
Chia-Feng Liu, W.H. Wilson Tang.
14. Breastfeeding in Patients With Heart Failure: Lack of Evidence and Consensus
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Tác giả
Tobias Koenig, Denise Hilfiker-Kleiner, Johann Bauersachs.
14. Full Issue PDF
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14. Full Issue PDF
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14. Reduced Lipoprotein(a) Associated With the Apolipoprotein E2 Genotype Confers Cardiovascular Protection in Familial Hypercholesterolemia
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Valentin Blanchard, Mikaël Croyal, Ilya Khantalin, Stéphane Ramin-Mangata, Gilles Lambert.
14. Nuclear Hmgb1: The Fix for the Failing Heart∗
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Tác giả
Angela Raucci, Maurizio C. Capogrossi.
14. Dipeptidyl Peptidase-4 Inhibition Prevents Vascular Calcification by Potentiating the Insulin-Like Growth Factor-1 Signaling Pathway
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Olivier Varennes, Aurélien Mary, Giampiero Bricca, Saïd Kamel, Jeremy Bellien.
15. Correction
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15. Reply: Breastfeeding in Patients With Heart Failure: Lack of Evidence and Consensus
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Agnes Koczo, Amy Marino, Dennis M. McNamara.
15. Phase II Trials in Drug Development and Adaptive Trial Design
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Tác giả
Gail A. Van Norman.
15. Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective
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Tác giả
Gregory Aubert, David Y. Barefield, Alexis R. Demonbreun, Mohun Ramratnam, Elizabeth M. McNally.
15. Chest Compressions During Sustained Inflation During Cardiopulmonary Resuscitation in Newborn Infants Translating Evidence From Animal Studies to the Bedside
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Georg M. Schmölzer.
16. Full Issue PDF
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16. Can One Person Make a Difference?: Remembering the Remarkable Life and Career of Alfred Bove
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Tác giả
Douglas L. Mann.
16. Emerging Therapeutics for the Treatment of Light Chain and Transthyretin Amyloidosis
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Kathleen W. Zhang, Keith E. Stockerl-Goldstein, Daniel J. Lenihan.
16. Overcoming Barriers to Development of Novel Therapies for Cardiovascular Disease: Insights From the Oncology Drug Development Experience
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Aarif Y. Khakoo, Nicole R. Yurgin, Paul R. Eisenberg, Gregg C. Fonarow.
16. Therapeutic Genome Editing in Cardiovascular Diseases
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David M. German, Shoukhrat Mitalipov, Anusha Mishra, Sanjiv Kaul.
17. Full Issue PDF
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17. Fibroblasts in the Infarcted, Remodeling, and Failing Heart
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Tác giả
Claudio Humeres, Nikolaos G. Frangogiannis.
17. Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury
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Tác giả
Evelyne M. Houang, Jason Bartos, Benjamin J. Hackel, Timothy P. Lodge, Joseph M. Metzger.
17. What Are the Off-Target Effects of Plan “S” For Translational Investigators?
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Tác giả
Douglas L. Mann.
18. Q4 Vital Signs: Can Machine Learning Protect Patients From the Machinery of Modern Medicine?
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Tác giả
Douglas L. Mann.
18. JACC: Basic to Translational Science 2018 Young Author Award Winner
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Tác giả
Douglas L. Mann.
18. Correction
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19. Full Issue PDF
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19. Scott Gottlieb’s Resignation as FDA Commissioner Is a Loss for Translational Medicine
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Douglas L. Mann.
19. Full Issue PDF
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20. Full Issue PDF
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