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The AAPS Journal
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Volume 21, Issue 4, July 2019
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1. “Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy
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Tác giả
Bart Hens, Maura Corsetti, Marival Bermejo, Raimar Löbenberg.
2. A Bounded Integer Model for Rating and Composite Scale Data
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Tác giả
Gustaf J. Wellhagen, Maria C. Kjellsson, Mats O. Karlsson.
3. Correction to: A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®
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Tác giả
Alison Betts, Nahor Haddish-Berhane, Dhaval K. Shah.
4. Translational Quantitative Systems Pharmacology in Drug Development: from Current Landscape to Good Practices
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Tác giả
Jane P. F. Bai, Justin C. Earp, Venkateswaran C. Pillai.
5. Anti-drug Antibody Assay Conditions Significantly Impact Assay Screen and Confirmatory Cut-Points
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Tác giả
Boris Gorovits, Ying Wang, Liang Zhu, Marcela Araya, John Kamerud.
6. Skin Delivery and Irritation Potential of Phenmetrazine as a Candidate Transdermal Formulation for Repurposed Indications
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Tác giả
Ying Jiang, Kevin S. Murnane, Sonalika A. Bhattaccharjee.
7. Estimating In Vivo Fractional Contribution of OATP1B1 to Human Hepatic Active Uptake by Mechanistically Modeling Pharmacogenetic Data
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Tác giả
Rui Li.
8. Population Pharmacokinetic Modeling in the Presence of Missing Time-Dependent Covariates: Impact of Body Weight on Pharmacokinetics of Paracetamol in Neonates
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Tác giả
Wojciech Krzyzanski, Sarah F. Cook, Melanie Wilbaux.
9. Mind the Gaps: Ontogeny of Human Brain P-gp and Its Impact on Drug Toxicity
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Tác giả
Jean-Marie Nicolas, Elizabeth C. M. de Lange.
10. A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®
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Tác giả
Alison Betts, Nahor Haddish-Berhane, Dhaval K. Shah.
11. Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension
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Tác giả
Maxime Le Merdy, Jianghong Fan, Michael B. Bolger, Viera Lukacova.
12. Nanomaterial-Based Modulation of Tumor Microenvironments for Enhancing Chemo/Immunotherapy
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Tác giả
Quoc-Viet Le, Juhan Suh, Yu-Kyoung Oh.
13. In Vitro Metabolism and Hepatic Intrinsic Clearance of the Synthetic Cannabinoid Receptor Agonist JWH-122 and Its Four ω-Halogenated Analogues
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Tác giả
Anders Bork Davidsen, Marie Mardal, Kristian Linnet.
14. Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography
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Tác giả
Irene Hernández Lozano, Rudolf Karch, Martin Bauer, Matthias Blaickner.
15. A Novel Method for Analysing Frequent Observations from Questionnaires in Order to Model Patient-Reported Outcomes: Application to EXACT® Daily Diary Data from COPD Patients
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Tác giả
Eva Germovsek, Claire Ambery, Shuying Yang, Misba Beerahee.
16. Biodegradable Thermosensitive PLGA-PEG-PLGA Polymer for Non-irritating and Sustained Ophthalmic Drug Delivery
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Tác giả
Pui Shan Chan, Jia Wen Xian, Qingqing Li, Chun Wai Chan.
17. Effect of Grapefruit Juice Intake on Serum Level of the Endogenous CYP3A4 Metabolite 4β-Hydroxycholesterol—an Interaction Study in Healthy Volunteers
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Tác giả
Caroline Gjestad, Kristine Hole, Tore Haslemo, Ulf Diczfalusy.
18. Targeting Cancer Via Resveratrol-Loaded Nanoparticles Administration: Focusing on In Vivo Evidence
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Tác giả
Ana Cláudia Santos, Irina Pereira, Mariana Magalhães.
19. Report of the AAPS Guidance Forum on the FDA Draft Guidance for Industry: “Drug Products, Including Biological Products, that Contain Nanomaterials”
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Tác giả
Jon S. B. de Vlieger, Daan J. A. Crommelin, Katherine Tyner.
20. Fc-Fusion Drugs Have FcγR/C1q Binding and Signaling Properties That May Affect Their Immunogenicity
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Tác giả
H. A. Daniel Lagassé, Hartmut Hengel, Basil Golding, Zuben E. Sauna.
21. Report on the AAPS Immunogenicity Guidance Forum
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Tác giả
Heather Myler, Boris Gorovits, Kelli Phillips, Viswanath Devanarayan.
22. In Vitro and In Vivo Co-delivery of siRNA and Doxorubicin by Folate-PEG-Appended Dendrimer/Glucuronylglucosyl-β-Cyclodextrin Conjugate
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Tác giả
Ahmed Fouad Abdelwahab Mohammed, Taishi Higashi, Keiichi Motoyama.
23. Fetal Concentrations of Budesonide and Fluticasone Propionate: a Study in Mice
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Tác giả
Syedsaoud Zaidi, Mong-Jen Chen, Daniel T. Lee, Elsa Neubart, Pär Ewing.
