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Current Opinion in Chemical Biology
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Volume 50
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1. Editorial Board
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2. Editorial overview: From the iceman to modern medicine
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Yimon Aye, Paul J Hergenrother.
3. The antimalarial screening landscape—looking beyond the asexual blood stage
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Sabrina Yahiya, Ainoa Rueda-Zubiaurre, Michael J Delves, Matthew J Fuchter, Jake Baum.
4. Construction of ligand assay systems by protein-based semisynthetic biosensors
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Seiji Sakamoto, Shigeki Kiyonaka, Itaru Hamachi.
5. Sphingolipids and membrane targets for therapeutics
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Robbie Loewith, Howard Riezman, Nicolas Winssinger.
6. Reactive-cysteine profiling for drug discovery
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Aaron J Maurais, Eranthie Weerapana.
7. Developing zebrafish disease models for in vivo small molecule screens
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Pui-Ying Lam, Randall T Peterson.
8. Using chemical inhibitors to probe AAA protein conformational dynamics and cellular functions
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Jonathan B Steinman, Tarun M Kapoor.
9. Modulating protein–protein interaction networks in protein homeostasis
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Mengqi Zhong, Gregory M Lee, Eline Sijbesma, Christian Ottmann, Michelle R Arkin.
10. Label-free target identification in drug discovery via phenotypic screening
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Hankum Park, Jaeyoung Ha, Seung Bum Park.
11. Recent advances in the development of HBV capsid assembly modulators
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Bhavitavya Nijampatnam, Dennis C Liotta
12. Targeting defective proteostasis in the collagenopathies
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Madeline Y Wong, Matthew D Shoulders.
13. Histone deacetylases as an epigenetic pillar for the development of hybrid inhibitors in cancer
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Giulia Stazi, Rossella Fioravanti, Antonello Mai, Andrea Mattevi, Sergio Valente.
14. Will morphing boron-based inhibitors beat the β-lactamases?
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Alen Krajnc, Pauline A Lang, Tharindi D Panduwawala, Jürgen Brem, Christopher J Schofield.
15. Targeted protein degradation: elements of PROTAC design
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Stacey-Lynn Paiva, Craig M Crews.
16. Pharmacokinetic–pharmacodynamic models that incorporate drug–target binding kinetics
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Fereidoon Daryaee, Peter J Tonge.
17. Genetically encoded fragment-based discovery
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Ratmir Derda, Simon Ng.
18. Natural products as chemical tools to dissect complex biology in C. elegans
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Rebecca A Butcher.
19. New players in phototherapy: photopharmacology and bio-integrated optoelectronics
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Johannes Morstein, Dirk Trauner.
