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Investigational New Drugs

1. Delineation of proapoptotic signaling of anthracene-shelled M2L4 metallacapsules and their synergistic activity with curcumin in cisplatin-sensitive and resistant tumor cell lines

Tác giả

Rositsa Mihaylova, Anife Ahmedova, Denitsa Momekova.

1. A novel humanized anti-PD-1 monoclonal antibody potentiates therapy in oral squamous cell carcinoma

Tác giả

Y. Cai, Fei Wang, Q. Liu, Z. Li, D. Li, Z. Sun.

1. The Monocarboxylate transporter inhibitor Quercetin induces intracellular acidification in a mouse model of Glioblastoma Multiforme: in-vivo detection using magnetic resonance imaging

Tác giả

Mohammed Albatany, Susan Meakin, Robert Bartha.

1. Hand-foot-skin reaction of grade ≥ 2 within sixty days as the optimal clinical marker best help predict survival in sorafenib therapy for HCC

Tác giả

Enxin Wang, Dongdong Xia, Wei Bai, Zhexuan Wang, Qiuhe Wang.

1. Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts

Tác giả

V. S. Pokrovsky, N. Yu Anisimova, D. Zh Davydov.

1. Optimising intratumoral treatment of head and neck squamous cell carcinoma models with the diterpene ester Tigilanol tiglate

Tác giả

Catherine M. E. Barnett, Natasa Broit, Pei-Yi Yap.

2. LEF1-AS1 contributes to proliferation and invasion through regulating miR-544a/ FOXP1 axis in lung cancer

Tác giả

Ansheng Wang, Chengling Zhao, Yuan Gao, Guixin Duan.

2. The bispecific anti-CD3 × anti-CD155 antibody mediates T cell immunotherapy for human prostate cancer

Tác giả

Huijun Zhao, Juan Ma, Ting Lei, Wanru Ma, Man Zhang.

2. Hexane partition from Annona crassiflora Mart. promotes cytotoxity and apoptosis on human cervical cancer cell lines

Tác giả

Viviane A. O. Silva, Ana Laura V. Alves, Marcela N. Rosa.

2. Chemosensitivity of various peritoneal cancer cell lines to HIPEC and PIPAC: comparison of an experimental duplex drug to standard drug regimens in vitro

Tác giả

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2. Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2

Tác giả

Tomoko Takimoto-Shimomura, Taku Tsukamoto, Saori Maegawa.

2. Inhibiting IL-2 signaling and the regulatory T-cell pathway using computationally designed peptides

Tác giả

Tammy Price-Troska, Zhi-Zhang Yang, David Diller.

3. GNS561, a new lysosomotropic small molecule, for the treatment of intrahepatic cholangiocarcinoma

Tác giả

Sonia Brun, Firas Bassissi, Cindy Serdjebi, Marie Novello.

3. Lurbinectedin (PM01183), a selective inhibitor of active transcription, effectively eliminates both cancer cells and cancer stem cells in preclinical models of uterine cervical cancer

Tác giả

Eriko Yokoi, Seiji Mabuchi, Kotaro Shimura, Naoko Komura.

3. Preclinical assessment of histone deacetylase inhibitor quisinostat as a therapeutic agent against esophageal squamous cell carcinoma

Tác giả

Lei Zhong, Shu Zhou, Rongsheng Tong, Jianyou Shi, Lan Bai.

3. Combination treatment of cancer cells with pan-Akt and pan-mTOR inhibitors: effects on cell cycle distribution, p-Akt expression level and radiolabelled-choline incorporation

Tác giả

Su Myat Phyu, Tim A. D. Smith.

3. Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells

Tác giả

Viviane A. O. Silva, Marcela N. Rosa, Vera Miranda-Gonçalves.

3. Human acute myeloid leukemia cells express Neurokinin-1 receptor, which is involved in the antileukemic effect of Neurokinin-1 receptor antagonists

Tác giả

A. Molinos-Quintana, P. Trujillo-Hacha, J. I. Piruat.

4. Synergistic effect and reduced toxicity by intratumoral injection of cytarabine-loaded hyaluronic acid hydrogel conjugates combined with radiotherapy on lung cancer

Tác giả

Juan Tang, Na Wang, JingBo Wu, PeiRong Ren, JunYang Li.

4. The novel PI3K inhibitor S1 synergizes with sorafenib in non-small cell lung cancer cells involving the Akt-S6 signaling

Tác giả

Juan Wang, Shumei Ma, Xiuhua Chen, Sanqi Zhang, Zhiyong Wang.

4. CDKI-73: an orally bioavailable and highly efficacious CDK9 inhibitor against acute myeloid leukemia

Tác giả

Muhammed H. Rahaman, Yingyi Yu, Longjin Zhong, Julian Adams.

4. Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model

Tác giả

Martin Perreault, René Maltais, Jenny Roy, Sylvain Picard.

4. Alteration of benzo(a)pyrene biotransformation by resveratrol in ApcMin/+ mouse model of colon carcinogenesis

Tác giả

Ashley C. Huderson, P. V. Rekha Devi, Mohammad S. Niaz.

4. Copper-tolfenamic acid: evaluation of stability and anti-cancer activity

Tác giả

Myrna Hurtado, Umesh T. Sankpal, Jaya Chhabra.

5. A phthalimidoalkanamide derived novel DNMT inhibitor enhanced radiosensitivity of A549 cells by inhibition of homologous recombination of DNA damage

Tác giả

Hyun-Cheol Kang, Eui Kyu Chie, Hak Jae Kim, Jin Ho Kim.

5. Caffeic acid phenethyl ester exerts apoptotic and oxidative stress on human multiple myeloma cells

Tác giả

Elizabeth Hernandez Marin, Hana Paek, Mei Li, Yesung Ban.

5. E6201, an intravenous MEK1 inhibitor, achieves an exceptional response in BRAF V600E-mutated metastatic malignant melanoma with brain metastases

Tác giả

Hani M. Babiker, Sara A. Byron, William P. D. Hendricks.

5. HER-targeted tyrosine kinase inhibitors enhance response to trastuzumab and pertuzumab in HER2-positive breast cancer

Tác giả

Alexandra Canonici, Laura Ivers, Neil T. Conlon.

5. Inhibition of SHP2 by new compounds induces differential effects on RAS/RAF/ERK and PI3K/AKT pathways in different cancer cell types

Tác giả

Cijo George Vazhappilly, Ekram Saleh, Wafaa Ramadan.

5. Discovering simple phenylboronic acid and benzoxaborole derivatives for experimental oncology – phase cycle-specific inducers of apoptosis in A2780 ovarian cancer cells

Tác giả

Mateusz Psurski, Agnieszka Łupicka-Słowik.

6. A high-throughput drug screen identifies auranofin as a potential sensitizer of cisplatin in small cell lung cancer

Tác giả

Xiaoli Liu, Wei Wang, Yanping Yin, Ming Li, Hong Li.

6. The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines

Tác giả

Malgorzata Kucinska, Helena Mieszczak.

6. Relationship between expression of XRCC1 and tumor proliferation, migration, invasion, and angiogenesis in glioma

Tác giả

Peng-jin Mei, Jin Bai, Fa-an Miao, Zhong-lin Li, Chen Chen.

6. A natural compound derivative P-13 inhibits STAT3 signaling by covalently inhibiting Janus kinase 2

Tác giả

Hui Huang, Junxing Niu, Fei Wang, Lihong Hu, Qiang Yu.

6. The marine natural product Scalarin inhibits the receptor for advanced glycation end products (RAGE) and autophagy in the PANC-1 and MIA PaCa-2 pancreatic cancer cell lines

Tác giả

Esther Amalia Guzmán, Tara Peterson Pitts, Maria Cristina Diaz.

6. Immuno-therapeutic potential of Schistosoma mansoni and Trichinella spiralis antigens in a murine model of colon cancer

Tác giả

Maha M. Eissa, Cherine A. Ismail, Mervat Z. El-Azzouni.

7. Increased DKC1 expression in glioma and its significance in tumor cell proliferation, migration and invasion

Tác giả

Fa-an Miao, Kun Chu, Hai-rong Chen, Meng Zhang, Pei-cong Shi.

7. A mediator of phosphorylated Smad2/3, evodiamine, in the reversion of TAF-induced EMT in normal colonic epithelial cells

Tác giả

Wanbin Yang, Xiuli Gong, Xiulian Wang, Chao Huang.

7. A phase I study of the vascular endothelial growth factor inhibitor Vatalanib in combination with Pemetrexed disodium in patients with advanced solid tumors

Tác giả

Fen Wang, Julian Molina, Daniel Satele, Jun Yin, Vun-Sin Lim.

7. A first-in-human phase 1a study of the bispecific anti-DLL4/anti-VEGF antibody navicixizumab (OMP-305B83) in patients with previously treated solid tumors

Tác giả

Antonio Jimeno, Kathleen N. Moore, Michael Gordon.

7. Characterization and phase I study of CLR457, an orally bioavailable pan-class I PI3-kinase inhibitor

Tác giả

James J. Harding, Todd M. Bauer, Daniel S. W. Tan.

7. Preclinical study of the antitumor effect of sphingosine-1-phosphate receptor 1 antibody (S1PR1-antibody) against human breast cancer cells

Tác giả

Shujun Xiao, Jian Yang.

8. Novel palladium (II) complexes with tetradentate thiosemicarbazones. Synthesis, characterization, in vitro cytotoxicity and xanthine oxidase inhibition

Tác giả

Dilşad Özerkan, Onur Ertik, Buşra Kaya, Serap Erdem Kuruca.

8. A novel tetravalent bispecific antibody targeting programmed death 1 and tyrosine-protein kinase Met for treatment of gastric cancer

Tác giả

Weihua Hou, Qingyun Yuan, Xingxing Yuan, Yuxiong Wang, Wei Mo.

8. Mass balance, routes of excretion, and pharmacokinetics of investigational oral [14C]-alisertib (MLN8237), an Aurora A kinase inhibitor in patients with advanced solid tumors

Tác giả

Xiaofei Zhou, Sandeepraj Pusalkar, Swapan K. Chowdhury.

8. Phase 1 trial of enzalutamide in combination with gemcitabine and nab-paclitaxel for the treatment of advanced pancreatic cancer

Tác giả

Amit Mahipal, Sri Harsha Tella, Anuhya Kommalapati.

8. A phase Ib study of BGJ398, a pan-FGFR kinase inhibitor in combination with imatinib in patients with advanced gastrointestinal stromal tumor

Tác giả

Ciara M. Kelly, Alexander N. Shoushtari, Li-Xuan Qin.

8. The poly (ADP-ribose) polymerase inhibitor rucaparib suppresses proliferation and serves as an effective radiosensitizer in cervical cancer

Tác giả

Mei Tang, Qiuli Liu, Leyuan Zhou, Ling Chen, Xueqing Yang.

9. Clinical outcomes of advanced stage cancer patients treated with sequential immunotherapy in phase 1 clinical trials

Tác giả

Dylan J. Martini, Yuan Liu, Julie M. Shabto, Colleen Lewis.

9. The availability of drug by liposomal drug delivery

Tác giả

Evelien A. W. Smits, José A. Soetekouw, Ebel H. E. Pieters.

9. First-in-human phase I study of the microtubule inhibitor plocabulin in patients with advanced solid tumors

Tác giả

Elena Elez, Carlos Gomez-Roca, Arturo Soto Matos-Pita.

9. Phase I/II study of everolimus combined with mFOLFOX-6 and bevacizumab for first–line treatment of metastatic colorectal cancer

Tác giả

G. Weldon Gilcrease, David D. Stenehjem, Mark L. Wade.

9. Phase I study of S-1 plus paclitaxel combination therapy as a first-line treatment in elderly patients with advanced non-small cell lung cancer

Tác giả

Yusuke Chihara, Koji Date, Yoshizumi Takemura, Nobuyo Tamiya.

9. Two phase I, pharmacokinetic, and pharmacodynamic studies of DFP-10917, a novel nucleoside analog with 14-day and 7-day continuous infusion schedules

Tác giả

Kamalesh Sankhala, Chris H. Takimoto, Alain C. Mita.

10. Phase I study of TAS-121, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, in patients with non-small-cell lung cancer harboring EGFR mutations

Tác giả

Makoto Nishio, Haruyasu Murakami, Yuichiro Ohe, Toyoaki Hida.

10. Modulator of the PI3K/Akt oncogenic pathway affects mTOR complex 2 in human adenocarcinoma cells

Tác giả

Blair P. Curless, Nne E. Uko, Diane F. Matesic.

10. A phase I study of the safety and tolerability of VLX600, an Iron Chelator, in patients with refractory advanced solid tumors

Tác giả

Kabir Mody, Aaron S. Mansfield, Lalitha Vemireddy.

10. Survival outcome and prognostic model of patients with colorectal cancer on phase 1 trials Audrey

Tác giả

E. Kam, Gopichand Pendurti, Umang H. Shah.

10. A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma

Tác giả

Tycel Phillips, Paul M. Barr, Steven I. Park, Kathryn Kolibaba.

10. Phase Ib study of pevonedistat, a NEDD8-activating enzyme inhibitor, in combination with docetaxel, carboplatin and paclitaxel, or gemcitabine, in patients with advanced solid tumors

Tác giả

A Craig Lockhart, Todd M. Bauer, Charu Aggarwal, Carrie B. Lee.

11. Population pharmacokinetic analysis of AR-67, a lactone stable camptothecin analogue, in cancer patients with solid tumors

Tác giả

Fei Tang, Eleftheria Tsakalozou, Susanne M. Arnold, Chee M. Ng.

11. MICONIDINE acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells

Tác giả

Mariana Franzoni Maioral, Natália Marceli Stefanes.

11. Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer

Tác giả

Alexandra Leary, Christophe Le Tourneau, Andrea Varga.

11. Canadian Cancer Trials Group (CCTG) IND215: A phase Ib study of Selumetinib in patients with untreated advanced or metastatic NSCLC who are receiving standard chemotherapy regimens

Tác giả

J. R. Goffin, G. Nicholas, M. Mates, D. Tu, E. Chen.

11. A phase I study of the farnesyltransferase inhibitor Tipifarnib in combination with the epidermal growth factor tyrosine kinase inhibitor Erlotinib in patients with advanced solid tumors

Tác giả

Khalid Jazieh, Julian Molina, Jacob Allred, Jun Yin, Joel Reid.

11. A phase Ib study of sonidegib (LDE225), an oral small molecule inhibitor of smoothened or Hedgehog pathway, in combination with docetaxel in triple negative advanced breast cancer patients: GEICAM/2012–12 (EDALINE) study

Tác giả

Manuel Ruiz-Borrego, Begoña Jimenez, Silvia Antolín.

12. Phase II trial of continuous treatment with sunitinib in patients with high-risk (BCG-refractory) non-muscle invasive bladder cancer

Tác giả

Haris Zahoor, Maria C. Mir, Pedro C. Barata.

12. MiR-181a, a new regulator of TGF-β signaling, can promote cell migration and proliferation in gastric cancer

Tác giả

Shaohua Ge, Haiyang Zhang, Ting Deng, Wu Sun, Tao Ning.

12. A phase 1 trial of Vorinostat in combination with concurrent chemoradiation therapy in the treatment of advanced staged head and neck squamous cell carcinoma

Tác giả

Theodoros N. Teknos, J. Grecula, A. Agrawal, M. O. Old.

12. First-in-human phase 1 study of novel dUTPase inhibitor TAS-114 in combination with S-1 in Japanese patients with advanced solid tumors

Tác giả

Toshihiko Doi, Kiyotaka Yoh, Kohei Shitara, Hideaki Takahashi.

12. Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer

Tác giả

Laura W. Goff, Nilofer S. Azad, Stacey Stein.

12. Phase I study of resminostat, an HDAC inhibitor, combined with S-1 in patients with pre-treated biliary tract or pancreatic cancer

Tác giả

Masafumi Ikeda, Izumi Ohno, Hideki Ueno, Shuichi Mitsunaga.

13. A multicenter, prospective phase II trial of gemcitabine plus axitinib in patients with renal cell carcinoma with a predominant sarcomatoid component Inkeun

Tác giả

Park, Hyo Jin Lee, Woo Kyoon Bae, Shinkyo Yoon.

13. Screening, identification of prostate cancer urinary biomarkers and verification of important spots

Tác giả

Huijun Zhao, Xuhong Zhao, Ting Lei, Man Zhang.

13. Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers

Tác giả

Lisa Seitz, Lixia Jin, Manmohan Leleti, Devika Ashok.

13. Increasing complexity in oncology phase I clinical trials Laeeq

Tác giả

Malik, David Lu.

13. Pazopanib with low fat meal (PALM) in advanced renal cell carcinoma

Tác giả

Melissa A. Reimers, Maryann M. Shango.

13. A phase 1b study of transforming growth factor-beta receptor I inhibitor galunisertib in combination with sorafenib in Japanese patients with unresectable hepatocellular carcinoma

Tác giả

Masafumi Ikeda, Manabu Morimoto, Masaomi Tajimi, Koichi Inoue.

14. A randomized phase 2 trial of the efficacy and safety of a novel topical povidone-iodine formulation for Cancer therapy-associated Paronychia

Tác giả

Kara D. Capriotti, Milan Anadkat, Jennifer Choi.

14. Sensitization of colorectal cancer to irinotecan therapy by PARP inhibitor rucaparib

Tác giả

Titto Augustine, Radhashree Maitra, Jinghang Zhang, Jay Nayak.

14. A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors

Tác giả

David C. Smith, Rashmi Chugh, Amita Patnaik.

14. The influence of prior ramucirumab treatment on the clinical activity of FOLFIRI as third-line therapy in patients with metastatic gastric Cancer

Tác giả

Giandomenico Roviello, Roberto Petrioli, Pietro Rosellini.

14. Phase I/II study evaluating the safety and clinical efficacy of temsirolimus and bevacizumab in patients with chemotherapy refractory metastatic castration-resistant prostate cancer

Tác giả

Pedro C. Barata, Matthew Cooney, Prateek Mendiratta.

14. Phase Ib trial combining capecitabine, erlotinib and bevacizumab in pancreatic adenocarcinoma - REBECA trial

Tác giả

Christian Dittrich, Robert Königsberg, Martina Mittlböck.

15. Early depth of tumor shrinkage and treatment outcomes in non-small cell lung cancer treated using Nivolumab

Tác giả

Hayato Kawachi, Daichi Fujimoto, Takeshi Morimoto.

15. Biodistribution, pharmacokinetics and radioimmunotherapy of 188Re-cetuximab in NCI-H292 human lung tumor-bearing nude mice

Tác giả

Ya-Jen Chang, Chung-Li Ho, Kai-Hung Cheng, Wan-I Kuo.

15. Apatinib, a novel VEGFR inhibitor plus docetaxel in advanced lung adenocarcinoma patients with wild-type EGFR: a phase I trial

Tác giả

Jian-Chun Duan, Zhi-Jie Wang, Lin Lin, Jun-Ling Li, Yan Wang.

15. Switch maintenance therapy with S-1 after induction therapy with carboplatin and nanoparticle albumin-bound paclitaxel in advanced lung squamous cell carcinoma

Tác giả

Norimichi Akiyama, Masato Karayama, Naoki Inui, Hideki Yasui.

15. A phase II trial of gemcitabine, S-1 and LV combination (GSL) therapy in patients with advanced pancreatic cancer

Tác giả

Kei Saito, Hiroyuki Isayama, Yousuke Nakai, Naminatsu Takahara.

15. Absorption, metabolism, and excretion of the antiemetic rolapitant, a selective neurokinin-1 receptor antagonist, in healthy male subjects

Tác giả

Zhi-Yi Zhang, Jing Wang, Vikram Kansra, Xiaodong Wang.

16. Efficacy and safety of pembrolizumab as first-line therapy in advanced non-small cell lung cancer with at least 50% PD-L1 positivity: a multicenter retrospective cohort study (HOPE-001)

Tác giả

Motohiro Tamiya, Akihiro Tamiya, Kazutaka Hosoya.

16. The rhenium(I)-diselenoether anticancer drug targets ROS, TGF-β1, VEGF-A, and IGF-1 in an in vitro experimental model of triple-negative breast cancers

Tác giả

Philippe Collery, Vijay Veena, Adhikesavan Harikrishnan.

16. A phase 2, open-label study of brentuximab vedotin in patients with CD30-expressing solid tumors

Tác giả

Jeffrey P. Sharman, Jennifer J. Wheler, Lawrence Einhorn.

16. Eribulin, trastuzumab, and pertuzumab as first-line therapy for patients with HER2-positive metastatic breast cancer: a phase II, multicenter, collaborative, open-label, single-arm clinical trial

Tác giả

Kenichi Inoue, Jun Ninomiya, Tsuyoshi Saito, Katsuhiko Okubo.

16. Efficacy and safety of the combination of metformin, everolimus and exemestane in overweight and obese postmenopausal patients with metastatic, hormone receptor-positive, HER2-negative breast cancer: a phase II study

Tác giả

Clinton Yam, Francisco J. Esteva, Miral M. Patel.

16. First-in-human study of the anti-HB-EGF antibody U3-1565 in subjects with advanced solid tumors

Tác giả

Kathleen N. Moore, Johanna C. Bendell, Patricia M. LoRusso.

17. Ramucirumab as a second line therapy for advanced HCC: a significant achievement or a wasted opportunity for personalised therapy?

Tác giả

Giandomenico Roviello, Navid Sohbani, Roberto Petrioli.

17. The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines

Tác giả

Rafał Krętowski, Danuta Drozdowska, Beata Kolesińska.

17. Phase II study of avelumab in multiple relapsed/refractory germ cell cancer

Tác giả

M. Mego, D. Svetlovska, M. Chovanec, M. Rečkova, K. Rejlekova.

17. The metronomic all-oral DEVEC is an effective schedule in elderly patients with diffuse large b-cell lymphoma

Tác giả

M. Christina Cox, Sabrina Pelliccia, Luigi Marcheselli.

17. IMRT combined with S-1 concurrent chemoradiotherapy in locally advanced nasopharyngeal carcinoma: a prospective phase II study

Tác giả

Tao Lv, Yujie Wang, Dan Ou, Peiyao Liu, Songbing Qin.

17. Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma

Tác giả

Kimmie Ng, Andrew Hendifar, Alexander Starodub, Jorge Chaves.

18. Axitinib pharmacologic therapeutic monitoring reveals severe under-exposure despite titration in patients with metastatic renal cell carcinoma

Tác giả

G. Beinse, A. Hulin, Benoit Rousseau.

18. In vitro and in vivo cytotoxic activity and human serum albumin interaction for a methoxy-styryl-thiosemicarbazone

Tác giả

Otávio Augusto Chaves, Isabela S. de Castro.

18. A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma

Tác giả

Hao Xie, Jun Yin, Manisha H. Shah, Michael E. Menefee.

18. Randomized phase II trial of neoadjuvant everolimus in patients with high-risk localized prostate cancer

Tác giả

Vadim S. Koshkin, Maria C. Mir, Pedro Barata, Anita Gul.

18. Sarcoid-like reaction mimicking disease progression in an ALK-positive lung cancer patient receiving lorlatinib

Tác giả

Francesco Facchinetti, Letizia Gnetti, Valeria Balestra.

18. Global trends in the distribution of cancer types among patients in oncology phase I trials, 1991–2015

Tác giả

Kota Itahashi, Toshio Shimizu, Takafumi Koyama, Shunsuke Kondo….

19. Cellular uptake evaluation of pentagamaboronon-0 (PGB-0) for boron neutron capture therapy (BNCT) against breast cancer cells

Tác giả

Adam Hermawan, Ratna Asmah Susidarti, Ratna Dwi Ramadani.

19. Nifuroxazide induces apoptosis, inhibits cell migration and invasion in osteosarcoma

Tác giả

Yi Luo, Anqi Zeng, Aiping Fang, Linjiang Song, Chen Fan.

19. Efficacy and safety of lanreotide in Korean patients with metastatic, well-differentiated gastroenteropancreatic-neuroendocrine tumors: a retrospective analysis

Tác giả

Junho Kang, Changhoon Yoo, Hee-Sang Hwang, Seung-Mo Hong.

19. Multicenter retrospective analysis of the safety and efficacy of regorafenib after progression on sorafenib in Korean patients with hepatocellular carcinoma

Tác giả

Changhoon Yoo, Joong-Won Park, Yoon Jun Kim, Do Young Kim.

19. Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model

Tác giả

Weijing Cai, Ranjala Ratnayake, Michael H. Gerber, Qi-Yin Chen.

19. Advanced development of ErbB family-targeted therapies in osteosarcoma treatment

Tác giả

Wei Wang, Hua-fu Zhao, Teng-fei Yao, Hao Gong.

20. Discovery and anticancer evaluation of a formononetin derivative against gastric cancer SGC7901 cells

Tác giả

Jian-Ning Yao, Xue-Xiu Zhang, Yan-Zhen Zhang, Jia-Heng Li.

20. Lopinavir-NO, a nitric oxide-releasing HIV protease inhibitor, suppresses the growth of melanoma cells in vitro and in vivo

Tác giả

Svetlana Paskas, Emanuela Mazzon, Maria Sofia Basile.

20. Cyclodextrin polymers decorated with RGD peptide as delivery systems for targeted anti-cancer chemotherapy

Tác giả

Maurizio Viale, Rita Tosto, Valentina Giglio.

20. Clinical outcomes of patients with G1/G2 neuroendocrine tumors arising from foregut or hindgut treated with somatostatin analogs: a retrospective study

Tác giả

Hanae Ida, Yoshitaka Honma, Hidekazu Hirano, Hirokazu Shoji.

20. Long-term adverse event: inflammatory orbitopathy induced by pembrolizumab in a patient with metastatic melanoma

Tác giả

Charlée Nardin, Sophie Borot, Marie-Astride Beaudoin.

20. Leptomeningeal recurrence after long-term alectinib therapy for non-small cell lung cancer harboring an EML4-ALK fusion protein

Tác giả

Takahisa Kawamura, Haruyasu Murakami, Haruki Kobayashi.

21. Correction to: Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway

Tác giả

Piming Zhao, Ana E. Aguilar, Joanna Y. Lee, Lucy A. Paul.

21. Modified ingenol semi-synthetic derivatives from Euphorbia tirucalli induce cytotoxicity on a large panel of human cancer cell lines

Tác giả

Viviane A. O Silva, Marcela N. Rosa, Olga Martinho.

21. Inhibition of AKT signalling by benzoxazine derivative LTUR6 through the modulation of downstream kinases

Tác giả

Rejitha Suraj, Jasim Al-Rawi, Christopher Bradley.

21. Safety and efficacy of immune checkpoint inhibitors for end-stage renal disease patients undergoing dialysis: a retrospective case series and literature review

Tác giả

Hyeon Cheun, Miso Kim, Hajeong Lee, Kook-Hwan Oh, Bhumsuk Keam.

21. Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity

Tác giả

Lisa M. Oppegard, Justine L. Delgado, Chaitanya A. Kulkarni.

21. Antitumor evaluation of novel phenothiazine derivatives that inhibit migration and tubulin polymerization against gastric cancer MGC-803 cells

Tác giả

Nan Liu, Zhe Jin, Jing Zhang, Jianjun Jin.

22. Correction to: Inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa B, Akt and p53 in rat mammary tumors

Tác giả

Preeti Roy, Jasmine George, Smita Srivastava, Shilpa Tyagi.

22. Bispecific anti-CD3 x anti-B7-H3 antibody mediates T cell cytotoxic ability to human melanoma in vitro and in vivo

Tác giả

Juan Ma, Tengfei Shang, Pan Ma, Xin Sun, Jin Zhao, Ximing Sun.

22. An orally antitumor chalcone hybrid inhibited HepG2 cells growth and migration as the tubulin binding agent

Tác giả

Wang Yan, Chen Xiangyu, Li Ya, Wang Yu, Xu Feng.

22. Prognostic factors in patients with metastatic or recurrent pancreatic cancer treated with first-line nab-paclitaxel plus gemcitabine: implication of inflammation-based scores

Tác giả

Inhwan Hwang, Jihoon Kang, Hei Nga Natalie Ip, Jae Ho Jeong.

22. Identification of differentially expressed genes and signaling pathways using bioinformatics in interstitial lung disease due to tyrosine kinase inhibitors targeting the epidermal growth factor receptor

Tác giả

Yuan Lu, Ang Li, Xiaofeng Lai, Jun Jiang, Lihong Zhang.

22. Acknowledgement of Reviewers 2018

Tác giả

23. The antitumor efficacy of monomeric disintegrin obtustatin in S-180 sarcoma mouse model

Tác giả

Narine Ghazaryan, Naira Movsisyan, Joana Catarina Macedo.

23. Durable response to the ALK inhibitor alectinib in inflammatory myofibroblastic tumor of the head and neck with a novel SQSTM1–ALK fusion: a case report

Tác giả

Kazunori Honda, Shigenori Kadowaki, Kyoko Kato, Nobuhiro Hanai.

23. Correction to: Phase II study of sunitinib in Japanese patients with unresectable or metastatic, well-differentiated pancreatic neuroendocrine tumor

Tác giả

Tetsuhide Ito, Takuji Okusaka, Toshirou Nishida, Kenji Yamao.

24. A phase I study of the antibody drug conjugate ASG-5ME, an SLC44A4-targeting antibody carrying auristatin E, in metastatic castration-resistant prostate cancer

Tác giả

Deaglan McHugh, Mario Eisenberger, Elisabeth I. Heath.

24. Correction to: A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl-XL

Tác giả

Jung Jin Hwang, Yong Sook Kim, Taelim Kim, Mi Joung Kim.

24. Correction to: Eribulin, trastuzumab, and pertuzumab as first-line therapy for patients with HER2-positive metastatic breast cancer: a phase II, multicenter, collaborative, open-label, single-arm clinical trial Correction to: Eribulin, trastuzumab, and pe

Tác giả

Correction to: Eribulin, trastuzumab, and pertuzumab as first-line therapy for patients with HER2-positive metastatic breast cancer: a phase II, multicenter, collaborative, open-label, single-arm clinical trial Kenichi Inoue, Jun Ninomiya, Tsuyoshi Saito

25. A phase I study of ontuxizumab, a humanized monoclonal antibody targeting endosialin, in Japanese patients with solid tumors

Tác giả

Toshihiko Doi, Takeshi Aramaki, Hirofumi Yasui, Kei Muro.

25. Correction to: Phase Ib/II study of gemcitabine, nab-paclitaxel, and pembrolizumab in metastatic pancreatic adenocarcinoma

Tác giả

Glen J. Weiss, Lisa Blaydorn, Julia Beck.

26. Chemotherapy in pregnancy: exploratory study of the effects of paclitaxel on the expression of placental drug transporters

Tác giả

Paul Berveiller, Olivier Mir, Séverine A. Degrelle.

27. The drug lag and associated factors for orphan anticancer drugs in Japan compared to the United States

Tác giả

Hiroki Nakayama, Naoki Matsumaru, Katsura Tsukamoto.

28. Significant differences on submission lag following regulation reform for registration of novel therapeutic drugs in Taiwan

Tác giả

I-Chen Sun.

29. Human antigen R and drug resistance in tumors

Tác giả

Fenghai Zhou, Fa Zhang, Chuan Zhou, Mengtian Liang.