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Bioorganic Chemistry
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Volume 86, Pages 1-714 (May 2019), Hidden issue
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1. Editorial Board
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2. Issue TOC
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3. Design, synthesis and biological evaluation of certain CDK2 inhibitors based on pyrazole and pyrazolo[1,5-a] pyrimidine scaffold with apoptotic activity
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Ghada M.E. Ali, Diaa A. Ibrahim, Amira M. Elmetwali, Nasser S.M. Ismail.
4. A combinatorial approach of structure-based virtual screening and molecular dynamics simulation towards the discovery of a highly selective inhibitor for VP9 coat protein of Banna virus
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Parikshit Moitra.
5. Discovery of a novel series of hDHODH inhibitors with anti-pulmonary fibrotic activities
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Kuan Lu, Yanfang Zhao, Guodong Wu, Hao Hu, ... Yuyang Jiang.
6. Aminoalkoxyfluorenones and aminoalkoxybiphenyls: DNA binding modes
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Svitlana O. Zanoza, Kyrylo O. Klimenko, George V. Maltzev, Tetiana I. Bykova, ... Mikhail L. Bondarev.
7. Trifluoromethylated carboline compounds targeting DNA: Synthesis, binding and anti-proliferative effects on human cancer cell lines
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Sarita Sarkar, Olga I. Shmatova, Valentine G. Nenajdenko, Kakali Bhadra.
8. New thiazol-hydrazono-coumarin hybrids targeting human cervical cancer cells: Synthesis, CDK2 inhibition, QSAR and molecular docking studies
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Tác giả
Somaia S. Abd El-Karim, Yasmin M. Syam, Ahmed M. El Kerdawy, Tamer M. Abdelghany.
9. Identification of ortho-naphthoquinones as anti-AML agents by highly efficient oxidation of phenols
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Huidan Huang, Ming Yan, Jianqiu Chen, Biao Yuan, ... Chongjiang Cao.
10. Synthesis and evaluation of novel fused pyrimidine derivatives as GPR119 agonists
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Yuanying Fang, Lijuan Xiong, Jianguo Hu, Shaokun Zhang, ... Zunhua Yang.
11. 3-Hydroxyisoindolin-1-one derivates: Synthesis by palladium-catalyzed CH activation as BRD4 inhibitors against human acute myeloid leukemia (AML) cells
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Pan Chen, Yifei Yang, Lingyun Yang, Jiping Tian, ... Huibin Zhang.
12. Synthesis of 5-enamine-4-thiazolidinone derivatives with trypanocidal and anticancer activity
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Serhii Holota, Anna Kryshchyshyn, Halyna Derkach, Yaroslava Trufin, ... Roman Lesyk.
13. Hydroxyl alkyl ammonium ionic liquid assisted green and one-pot regioselective access to functionalized pyrazolodihydropyridine core and their pharmacological evaluation
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Divyang M. Patel, Mayank G. Sharma, Ruturajsinh M. Vala, Irene Lagunes, ... Hitendra M. Patel.
14. Design, molecular docking and synthesis of novel 5,6-dichloro-2-methyl-1H-benzimidazole derivatives as potential urease enzyme inhibitors
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Emre Menteşe, Mustafa Emirik, Bahar Bilgin Sökmen.
15. Structures and biological evaluation of phenylpropanoid derivatives from Murraya koenigii
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Qinge Ma, Rongrui Wei, Ming Yang, Xiaoying Huang, ... Yalun Su.
16. Design, synthesis and biological evaluation of N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide derivatives as novel P-glycoprotein inhibitors reversing multidrug resistance
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Qianqian Qiu, Jiaqi Zhou, Wei Shi, Mutta Kairuki, ... Hai Qian.
17. Mono- or di-substituted imidazole derivatives for inhibition of acetylcholine and butyrylcholine esterases
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Burak Kuzu, Meltem Tan, Parham Taslimi, İlhami Gülçin, ... Nurettin Menges.
18. Synthesis of substituted biphenyl methylene indolinones as apoptosis inducers and tubulin polymerization inhibitors
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Kavitha Donthiboina, Pratibha Anchi, P.V. Sri Ramya, Shailaja Karri, ... Ahmed Kamal.
19. Discovery of potent PTP1B inhibitors via structure-based drug design, synthesis and in vitro bioassay of Norathyriol derivatives
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Wenjie Xue, Jinlong Tian, Xiang Simon Wang, Jie Xia, Song Wu.
20. COX-1/COX-2 inhibition assays and histopathological study of the new designed anti-inflammatory agent with a pyrazolopyrimidine core
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Eman K.A. Abdelall, Phoebe F. Lamie, Amira K.M. Ahmed, EL-Shaymaa EL-Nahass.
21. Antimicrobial characteristics and biocompatibility of the surgical sutures coated with biosynthesized silver nanoparticles
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Tuba Baygar, Nurdan Sarac, Aysel Ugur, Inci Rana Karaca.
22. Cordatols A–D, four new anti-inflammatory bis-monoterpenoids from Illigera cordata
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Min Zhou, Ruiqi Zhang, Xiaoli Zeng, Shengyong Zhang, ... Xiangzhong Huang.
23. Natural product inspired allicin analogs as novel anti-cancer agents
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Ishani Bhaumik, Kunal Pal, Utsab Debnath, Parimal Karmakar, ... Anup Kumar Misra.
24. Synthesis of water soluble pentacyclic dihydroxyterpene carboxylic acid derivatives coupled amino acids and their inhibition activities on α-glucosidase
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Zhen Zeng, Xiaoli Yin, Xueyuan Wang, Wuying Yang, ... Yanping Hong.
25. Synthesis and bioevaluation of 6-chloropyridazin-3-yl hydrazones and 6-chloro-3-substituted-[1,2,4]triazolo[4,3-b]pyridazines as cytotoxic agents
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Mamta, Ranjana Aggarwal, Rachna Sadana, Jeziel Ilag, Garima Sumran.
26. Tyrosinase and α-glucosidase inhibitory potential of compounds isolated from Quercus coccifera bark: In vitro and in silico perspectives
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Suat Sari, Burak Barut, Arzu Özel, Ayşe Kuruüzüm-Uz, Didem Şöhretoğlu.
27. Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes
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Kaan Kucukoglu, Halise Inci Gul, Parham Taslimi, Ilhami Gulcin, Claudiu T. Supuran.
28. Toward a treatment of diabesity: Rational design, synthesis and biological evaluation of benzene-sulfonamide derivatives as a new class of PTP-1B inhibitors
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Nagat Ghareb, Norhan M. El-Sayed, Reda Abdelhameed, Koji Yamada, Mohamed Saleh Elgawish.
29. Discovery of new organoselenium compounds as antileishmanial agents
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Abdul-Malek S. Al-Tamimi, Mikel Etxebeste-Mitxeltorena, Carmen Sanmartín, Antonio Jiménez-Ruiz, ... Claudiu T. Supuran.
30. Targeting cyclic nucleotide phosphodiesterase 5 (PDE5) in brain: Toward the development of a PET radioligand labeled with fluorine-18
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Barbara Wenzel, Jianrong Liu, Sladjana Dukic-Stefanovic, Winnie Deuther-Conrad, ... Aurelie Maisonial-Besset.
31. Sesquiterpenoids from the roots of Inula helenium inhibit acute myelogenous leukemia progenitor cells
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Yahui Ding, Wenwei Pan, Junqing Xu, Tianpeng Wang, ... Quan Zhang.
32. Discovery of novel chalcone-dithiocarbamates as ROS-mediated apoptosis inducers by inhibiting catalase
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Dong-Jun Fu, Jia-Huan Li, Jia-Jia Yang, Ping Li, ... Sai-Yang Zhang.
33. Anti-inflammatory drug approach: Synthesis and biological evaluation of novel pyrazolo[3,4-d]pyrimidine compounds
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Noor Atatreh, Amal M. Youssef, Mohammad A. Ghattas, Mohammad Al Sorkhy, ... Alaa S. Abd-El-Aziz.
34. Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing
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Silvia Gobbi, Qingzhong Hu, Giacomo Foschi, Elena Catanzaro, ... Alessandra Bisi.
35. Discovery, synthesis and molecular corroborations of medicinally important novel pyrazoles; drug efficacy determinations through in silico, in vitro and cytotoxicity validations
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P. Thangarasu, A. Manikandan, S. Thamaraiselvi.
36. Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors
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Tác giả
Fikret Turkan, Adnan Cetin, Parham Taslimi, Muhammet Karaman, İlhami Gulçin.
37. Purification and biochemical characterization of a novel copper, zinc superoxide dismutase from liver of camel (Camelus dromedarius): An antioxidant enzyme with unique properties
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Abdelbasset Chafik, Abdelkhalid Essamadi, Safinur Yildirim Çelik, Ahmet Mavi.
38. Design, synthesis and molecular docking of pyrazolo [3,4d] thiazole hybrids as potential anti-HIV-1 NNRT inhibitors
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H.M. Kasralikar, S.C. Jadhavar, S.V. Goswami, N.S. Kaminwar, S.R. Bhusare.
39. In vitro activity of steroidal dendrimers on Trypanosoma cruzi epimastigote form with PAMAM dendrons modified by “click” chemistry
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Laura Juárez-Chávez, Socorro Pina-Canseco, Delia Soto-Castro, Rosa Santillan, ... Eduardo Pérez-Campos.
40. Synthesis and structure-activity relationship of tyrosinase inhibiting novel bi-heterocyclic acetamides: Mechanistic insights through enzyme inhibition, kinetics and computational studies
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Abdul Rehman Sadiq Butt, Muhammad Athar Abbasi, Aziz-ur-Rehman, Sabahat Zahra Siddiqui, ... Sung-Yum Seo.
41. Investigation on the effect of alkyl chain linked mono-thioureas as Jack bean urease inhibitors, SAR, pharmacokinetics ADMET parameters and molecular docking studies
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Fayaz Ali Larik, Muhammad Faisal, Aamer Saeed, Pervaiz Ali Channar, ... Sung-Yum Seo.
42. Synthesis, crystal structure and biological evaluation of new phosphoramide derivatives as urease inhibitors using docking, QSAR and kinetic studies
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Khodayar Gholivand, Mahsa Pooyan, Fahimeh Mohammadpanah, Foroogh Pirastefar, ... Ahmad Mani-Varnosfaderani.
43. Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening
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Dan Zhang, Jie Han, Wenchao Lu, Fulin Lian, ... Cheng Luo.
44. New bis-thioglycosyl-1,1′-disulfides from Nasturtium officinale R. Br. and their anti-neuroinflammatory effect
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Tae Hyun Lee, Zahra Khan, Lalita Subedi, Sun Yeou Kim, Kang Ro Lee.
45. Design, synthesis and biological evaluation of (E)-5-styryl-1,2,4-oxadiazoles as anti-tubercular agents
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Abhay Atmaram Upare, Pradip K. Gadekar, H. Sivaramakrishnan, Nishigandha Naik, ... S. Mohana Roopan.
46. Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent
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Elena Catanzaro, Francesca Seghetti, Cinzia Calcabrini, Angela Rampa, ... Carmela Fimognari.
47. Oxidative functionalization of a halimane diterpenoid achieved by fungal transformation
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Afif Felix Monteiro, Gabriela Marinho Righetto, Laura Vilar Simões, Larissa Costa de Almeida, ... Ian Castro-Gamboa
48. Chlorinated tacrine analogs: Design, synthesis and biological evaluation of their anti-cholinesterase activity as potential treatment for Alzheimer’s disease
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Hanan.M. Ragab, Mohamed Teleb, Hassan R. Haidar, Noha Gouda.
49. Discovery of the Biginelli hybrids as novel caspase-9 activators in apoptotic machines: Lipophilicity, molecular docking study, influence on angiogenesis gene and miR-21 expression levels
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Nenad Janković, Jovana Trifunović Ristovski, Milan Vraneš, Aleksandar Tot, ... Zorica Bugarčić.
50. Ligand based design and synthesis of pyrazole based derivatives as selective COX-2 inhibitors
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Manikanta Murahari, Vivek Mahajan, Sreenivasulu Neeladri, Maushmi S. Kumar, Y.C. Mayur.
51. Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2–p53 interaction
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Assem Barakat, Mohammad Shahidul Islam, Hussien Mansur Ghawas, Abdullah Mohammed Al-Majid, ... Hazem A. Ghabbour.
52. Design, synthesis, and cytotoxicity screening of 5-aryl-3-(2-(pyrrolyl) thiophenyl)-1, 2, 4-oxadiazoles as potential antitumor molecules on breast cancer MCF-7 cells
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Mohammed K. Abd el hameid, Manal R. Mohammed.
53. Synthesis of novel chalcones through palladium-catalyzed CO cross-coupling reaction of bromo-chalcones with ethyl acetohydroxamate and their antiplasmodial evaluation against Plasmodium falcipuram in vitro
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Reeta, Rajendran Vinoth, T.M. Rangarajan, Ayushee, ... Manjula Singh.
54. Discovery and synthesis of 2-amino-1-methyl-1H-imidazol-4(5H)-ones as GPCR ligands; an approach to develop breast cancer drugs via GPCR associated PAR1 and PI3Kinase inhibition mechanism
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S.R. Ashok, M.K. Shivananda, A. Manikandan, R. Chandrasekaran.
55. Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of β-glucocerebrosidase inhibition
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Macarena Martínez-Bailén, Ana T. Carmona, Athéna C. Patterson-Orazem, Raquel L. Lieberman, ... Antonio J. Moreno-Vargas.
56. Alkene lactones from Persea fulva (Lauraceae): Evaluation of their effects on tumor cell growth in vitro and molecular docking studies
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Isabella Mary Alves Reis, Rodrigo Souza Conceição, Rafael Short Ferreira, Cleonice Creusa dos Santos, ... Alexsandro Branco.
57. Eight new biflavonoids with lavandulyl units from the roots of Sophora flavescens and their inhibitory effect on PTP1B
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Hai-Wei Yan, Hui Zhu, Xiang Yuan, Ya-Nan Yang, ... Pei-Cheng Zhang.
58. Synthesis and characterization of CAPE derivatives as xanthine oxidase inhibitors with radical scavenging properties
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Wonbeen Choi, Valente Villegas, Hannah Istre, Ben Heppler, ... Stefan Paula.
59. Design, synthesis and evaluation of N-hydroxypropenamides based on adamantane to overcome resistance in NSCLC
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Xuefei Bao, Yuhong Sun, Changshun Bao, Jiayu Zhang, ... Guoliang Chen.
60. Synthesis of 5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one’s aryl Schiff base derivatives and investigation of carbonic anhydrase and cholinesterase (AChE, BuChE) inhibitory properties
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Musa Özil, Halis Türker Balaydın, Murat Şentürk.
61. Synthesis and structure-activity relationship of elastase inhibiting novel ethylated thiazole-triazole acetamide hybrids: Mechanistic insights through kinetics and computational contemplations
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Abdul Rehman Sadiq Butt, Muhammad Athar Abbasi, Aziz-ur-Rehman, Sabahat Zahra Siddiqui, ... Sung-Yum Seo.
62. The management of diabetes mellitus-imperative role of natural products against dipeptidyl peptidase-4, α-glucosidase and sodium-dependent glucose co-transporter 2 (SGLT2)
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Tác giả
Ghulam Abbas, Ahmed Al Harrasi, Hidayat Hussain, Ahmed Hamaed, Claudiu T. Supuran.
63. Synthesis of sulfonamide, amide and amine hybrid pharmacophore, an entry of new class of carbonic anhydrase II inhibitors and evaluation of chemo-informatics and binding analysis
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Attique Ahmed, Pervaiz Ali Channar, Aamer Saeed, Markus Kalesse, ... Sung-Yum Seo.
64. Evaluation of andrographolide-based analogs derived from Andrographis paniculata against Mythimna separata Walker and Tetranychus cinnabarinus Boisduval
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Ming Xu, Jianwei Xu, Meng Hao, Kong Zhang, ... Hui Xu.
65. Imidazolo and tryptophan-imidazolo hybrid derived ureas/thioureas as potent bioactive agents – SAR and molecular modelling studies
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H.K. Kumara, R. Suhas, D.M. Suyoga Vardhan, M. Shobha, D. Channe Gowda.
66. Benzenesulfonamides incorporating nitrogenous bases show effective inhibition of β-carbonic anhydrases from the pathogenic fungi Cryptococcus neoformans, Candida glabrata and Malassezia globosa
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Silvia Bua, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran, Alessio Nocentini.
67. EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor
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Ahmed Elkamhawy, Ahmed H.E. Hassan, Sora Paik, Yong Sup Lee, ... Eun Joo Roh.
68. Dibrefeldins A and B, A pair of epimers representing the first brefeldin A dimers with cytotoxic activities from Penicillium janthinellum
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Fanrong Zeng, Chunmei Chen, Ali Adhab Al Chnani, Qun Zhou, ... Yonghui Zhang.
69. Click-tailed benzenesulfonamides as potent bacterial carbonic anhydrase inhibitors for targeting Mycobacterium tuberculosis and Vibrio cholerae
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Silvia Bua, Sameh M. Osman, Sonia Del Prete, Clemente Capasso, ... Claudiu T. Supuran.
70. Essay: Avoiding unfounded health claims on small molecules in scientific literature
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Tác giả
Bart I. Roman.
71. Three new diterpenes and two new sesquiterpenoids from the endophytic fungus Trichoderma koningiopsis A729
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Shanchong Chen, Haohua Li, Yuchan Chen, Saini Li, ... Weimin Zhang.
72. Design, synthesis and biological evaluation of coumarin-3-carboxamides as selective carbonic anhydrase IX and XII inhibitors
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Tác giả
Pavitra S. Thacker, Mallika Alvala, Mohammed Arifuddin, Andrea Angeli, Claudiu T. Supuran.
73. Synthesis, neuroprotective and antioxidant capacity of PBN-related indanonitrones
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Alicia Jiménez-Almarza, Daniel Diez-Iriepa, Mourad Chioua, Beatriz Chamorro, ... José Marco-Contelles.
74. The significance of N-methylpicolinamides in the development of anticancer therapeutics: Synthesis and structure-activity relationship (SAR) studies
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Tác giả
Balakrishna Moku, Lekkala Ravindar, K.P. Rakesh, Hua-Li Qin.
