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Journal of Pharmacokinetics and Pharmacodynamics
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Volume 46, October 2019, Issue 5, Pages 385-509
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1. Editorial to the themed issue on application of pharmacometrics to the development of drugs for rare diseases
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Peter Bonate.
2. FDA’s Office of Orphan Products Development: providing incentives to promote the development of products for rare diseases
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Soumya Patel, Katherine I. Miller Needleman.
3. Orphan drug development: the increasing role of clinical pharmacology
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Mariam A. Ahmed, Malek Okour…
4. Development and evaluation of a generic population pharmacokinetic model for standard half-life factor VIII for use in dose individualization
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Alanna McEneny-King, Pierre Chelle…
5. Routine clinical care data for population pharmacokinetic modeling: the case for Fanhdi/Alphanate in hemophilia A patients
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Pierre Chelle, Cindy H. T. Yeung…
6. Correction to: Routine clinical care data for population pharmacokinetic modeling: the case for Fanhdi/Alphanate in hemophilia A patients
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Pierre Chelle, Cindy H. T. Yeung…
7. Towards regulatory endorsement of drug development tools to promote the application of model-informed drug development in Duchenne muscular dystrophy
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Daniela J. Conrado, Jane Larkindale…
8. A physiologically-motivated model of cystic fibrosis liquid and solute transport dynamics across primary human nasal epithelia
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Florencio Serrano Castillo…
9. Modeling and simulation of the modified Rankin Scale and National Institutes of Health Stroke Scale neurological endpoints in intracerebral hemorrhage
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Rik Schoemaker, Satyaprakash Nayak…
10. A quantitative systems pharmacology model of colonic motility with applications in drug development
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Raibatak Das, Lucia Wille, Liming Zhang…
11. A modeling and simulation-based assessment of the impact of confounding factors on the readout of a sildenafil survival trial in pulmonary arterial hypertension
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Pascal Chanu, Xiang Gao, Rene Bruno…
