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Drug Discovery Today: Technologies
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1. Protein degradation for drug discovery
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Tác giả
Alessio Ciulli, William Farnaby.
2. A critical evaluation of the approaches to targeted protein degradation for drug discovery
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Tác giả
Rajesh Chopra, Amine Sadok, Ian Collins.
3. PROteolysis TArgeting Chimeras (PROTACs) — Past, present and future
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Tác giả
Mariell Pettersson, Craig M. Crews.
4. Cereblon modulators: Low molecular weight inducers of protein degradation
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Tác giả
Philip P. Chamberlain, Brian E. Cathers.
5. SNIPERs—Hijacking IAP activity to induce protein degradation
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Tác giả
Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata.
6. Small-molecule PROTAC degraders of the Bromodomain and Extra Terminal (BET) proteins — A review
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Tác giả
Chao-Yie Yang, Chong Qin, Longchuan Bai, Shaomeng Wang.
7. Targeted protein degradation mechanisms
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Yi Zhang, Christine Loh, Jesse Chen, Nello Mainolfi.
8. Monitoring and deciphering protein degradation pathways inside cells
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Danette L. Daniels, Kristin M. Riching, Marjeta Urh.
9. Targeted protein degradation in vivo with Proteolysis Targeting Chimeras: Current status and future considerations
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Gillian F. Watt, Paul Scott-Stevens, Lu Gaohua.
10. Identification and characterization of cancer vulnerabilities via targeted protein degradation
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Cristina Mayor-Ruiz, Georg E. Winter.
11. Ligand-induced genetic degradation as a tool for target validation
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Aisha Yesbolatova, Yusuke Tominari, Masato T. Kanemaki.
12. Advanced proteomics approaches to unravel protein homeostasis
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Paola Grandi, Marcus Bantscheff.
13. Structurally-defined deubiquitinase inhibitors provide opportunities to investigate disease mechanisms
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Tác giả
Ingrid E. Wertz, Jeremy M. Murray.
