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Drug Discovery Today
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Volume 24, Issue 3
Pages 665-930 (March 2019)
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1. Contents page 1
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Page i
2. Contents page 2
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Page ii
3. Contents page 3
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Page iii
4. Behavior, experience, skill, and training (BEST): a four-pillar framework for career development in science
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Rebecca Ashkenazy.
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Pages 665-667
5. An approach towards enhancement of a screening library: The Next Generation Library Initiative (NGLI) at Bayer — against all odds?
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Markus Follmann, Hans Briem, Andreas Steinmeyer, Alexander Hillisch.
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Pages 668-672
6. When more isn’t merrier: pharmaceutical alliance networks and breakthrough innovation
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John Qi Dong, Killian J. McCarthy.
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Pages 673-677
7. Acceleration of rare disease therapeutic development: a case study of AGIL-AADC
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Sonya Das, Samuel Huang, Andrew W. Lo
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Pages 678-684
8. Emerging role of histone deacetylase inhibitors as anti-breast-cancer agents
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Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon.
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Pages 685-702
9. TGFβ and BMPRII signalling pathways in the pathogenesis of pulmonary arterial hypertension
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Birger Tielemans, Marion Delcroix, Catharina Belge, Rozenn Quarck.
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Pages 703-716
10. Quality-by-design approach as a systematic tool for the development of nanopharmaceutical products
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Sarwar Beg, Mahfoozur Rahman, Kanchan Kohli.
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Pages 717-725
11. Repurposing host-based therapeutics to control coronavirus and influenza virus
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Cui-Cui Li, Xiao-Jia Wang, Hwa-Chain Robert Wang.
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Pages 726-736
12. Paving the way for successful islet encapsulation
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Nikos Dimitrioglou, Maria Kanelli, Efstathia Papageorgiou, Theodore Karatzas, Dimitris Hatziavramidis.
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Pages 737-748
13. Functionalized nanographene oxide in biomedicine applications: bioinspired surface modifications, multidrug shielding, and site-specific trafficking
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Hao Cheng, Khalid Gadora, Zhen Wang, Huaqing Zhang.
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Pages 749-762
14. Characterization of circulating tumor cells as a reflection of the tumor heterogeneity: myth or reality?
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Hannah K. Brown, Marta Tellez-Gabriel, Pierre-François Cartron, François M. Vallette.
Nội dung
Pages 763-772
15. Artificial intelligence in drug development: present status and future prospects
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Kit-Kay Mak, Mallikarjuna Rao Pichika.
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Pages 773-780
16. Computational modeling for formulation design
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Chetan Hasmukh Mehta, Reema Narayan, Usha Y. Nayak.
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Pages 781-788
17. The drug repurposing landscape from 2012 to 2017: evolution, challenges, and possible solutions
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Prasanthi Polamreddy, Nandu Gattu.
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Pages 789-795
18. Pharmaceutical cocrystals: from serendipity to design to application
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Oisin N. Kavanagh, Denise M. Croker, Gavin M. Walker, Michael J. Zaworotko.
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Pages 796-804
19. Efficient drug discovery by rational lead hybridization based on crystallographic overlay
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Shuo Zhang, Jian Zhang, Ping Gao, Lin Sun.
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Pages 805-813
20. Post-translational modification of ESKAPE pathogens as a potential target in drug discovery
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Vishvanath Tiwari
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Pages 814-822
21. Hurdles in gene therapy regulatory approval: a retrospective analysis of European Marketing Authorization Applications
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Marta Carvalho, Ana Paula Martins, Bruno Sepodes.
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Pages 823-828
22. The use of fast photochemical oxidation of proteins coupled with mass spectrometry in protein therapeutics discovery and development
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Jing Li, Guodong Chen.
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Pages 829-834
23. Ultrasmall iron oxide nanoparticles: synthesis, surface modification, assembly, and biomedical applications
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Cong Song, Wenjie Sun, Yunchao Xiao, Xiangyang Shi.
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Pages 835-844
24. Gastric-acid-mediated drug–drug interactions with direct-acting antiviral medications for hepatitis C virus infection: clinical relevance and mitigation strategies
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Guo Yu, Yi Zheng, Yichao Yu, Guo-Fu Li, Hartmut Derendorf.
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Pages 845-857
25. Solid nanoparticles for oral antimicrobial drug delivery: a review
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Aun Raza, Fekade Bruck Sime, Peter J. Cabot, Faheem Maqbool.
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Pages 858-866
26. Orphan drugs: major development challenges at the clinical stage
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Diogo A. Fonseca, Inês Amaral, Ana Catarina Pinto, Maria Dulce Cotrim.
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Pages 867-872
27. Surface-engineered multimodal magnetic nanoparticles to manage CNS diseases
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Asahi Tomitaka, Ajeet Kaushik, Bhavesh D. Kevadiya, Insiya Mukadam.
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Pages 873-882
28. A unified mapping framework of multifaceted pharmacodynamic responses to hypertension interventions
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Qian Wang, Jingwen Gan, Kun Wei, Scott A. Bercel.
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Pages 883-889
29. Adverse drug reactions on sexual functioning: a systematic overview
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Rineke Gordijn, Martina Teichert, Melianthe P.J. Nicolai, Henk W. Elzevier, Henk-Jan Guchelaar.
30. Fullerene-based delivery systems
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Houman Kazemzadeh, Masoud Mozafari
Nội dung
Pages 898-905
31. Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor
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Sergio C. Chai, Wenwei Lin, Yongtao Li, Taosheng Chen.
Nội dung
Pages 906-915
32. Phosphinic acids: current status and potential for drug discovery
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Tác giả
Moaz M. Abdou, Paul M. O’Neill, Eric Amigues, Magdalini Matziari.
Nội dung
Pages 916-929
