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Drug Discovery Today
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Volume 24, Issue 1
Pages 1-360 (January 2019)
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1. Contents page 1
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Page i
2. Contents page 2
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Page ii
3. Renovation as innovation: is repurposing the future of drug discovery research?
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Arthur Neuberger, Nektarios Oraiopoulos, Donald L. Drakeman.
Nội dung
Pages 1-3
4. The Clinical Innovation Network: a policy for promoting development of drugs and medical devices in Japan
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Tác giả
Shunsuke Matsushita, Keisuke Tachibana, Masuo Kondoh.
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Pages 4-8
5. Drug-Induced Rhabdomyolysis Atlas (DIRA) for idiosyncratic adverse drug reaction management
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Zhining Wen, Yu Liang, Yingyi Hao, Brian Delavan.
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Pages 9-15
6. How soon will digital endpoints become a cornerstone for future drug development?
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Philip Boehme, Arne Hansen, Ronenn Roubenoff, Joseph Scheeren.
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Pages 16-19
7. Patent term restoration for top-selling drugs in the United
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States Reed F. Beall, Jonathan J. Darrow, Aaron S. Kesselheim.
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Pages 20-25
8. Translational in vitro research: integrating 3D drug discovery and development processes into the drug development pipeline
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Jens M. Kelm, Madhu Lal-Nag, Gurusingham Sitta Sittampalam, Marc Ferrer.
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Pages 26-30
9. Turning straw into gold: building robustness into gene signature inference
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Wilson Wen Bin Goh, Limsoon Wong.
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Pages 31-36
10. A well-tolerated and rapidly acting thiopurine for IBD?
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Timothy H.J. Florin, John D. Wright, Siddharth D. Jambhrunkar, Michael G. Henman, Amirali Popat.
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Pages 37-41
11. Considerations for implementing an informatics system to support biologics drug discovery
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Andrew P. LeBeau.
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Pages 42-45
12. Streamlining nonclinical drug development using the FDA 505(b)(2) new drug application regulatory pathway
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William F. Salminen, Marc E. Wiles, Ruth E. Stevens.
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Pages 46-56
13. Factors and situations influencing the value of patient preference studies along the medical product lifecycle: a literature review
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Eline van Overbeeke, Chiara Whichello, Rosanne Janssens, Jorien Veldwijk.
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Pages 57-68
14. Therapeutic potential of endogenous stem cells and cellular factors for scar-free skin regeneration
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Shibashish Giri, Hans-Günther Machens, Augustinus Bader.
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Pages 69-84
15. The use of nanoparticles as biomaterials in dentistry
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Ranjeet A. Bapat, Chaitanya P. Joshi, Prachi Bapat, Tanay V. Chaubal.
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Pages 85-98
16. 3D in vitro models of tumors expressing EGFR family receptors: a potent tool for studying receptor biology and targeted drug development
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Evgeniya A. Sokolova, Vladimir A. Vodeneev, Sergey M. Deyev, Irina V. Balalaeva.
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Pages 99-111
17. Bile acid homeostasis paradigm and its connotation with cholestatic liver diseases
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Tingting Yang, Ghulam Jilany Khan, Ziteng Wu, Xue Wang.
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Pages 112-128
18. Design strategies for chemical-stimuli-responsive programmable nanotherapeutics
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Muhammad Gulfam, Fitsum Feleke Sahle, Tao L. Lowe.
Nội dung
Pages 129-147
19. Peptide-based therapeutics: quality specifications, regulatory considerations, and prospects
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Shruti Rastogi, Shatrunajay Shukla, M. Kalaivani, Gyanendra Nath Singh.
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Pages 148-162
20. Micro- and nano-formulations for bioprinting and additive manufacturing
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Guillaume Bouguéon, Tina Kauss, Bérangère Dessane, Philippe Barthélémy, Sylvie Crauste-Manciet.
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Pages 163-178
21. Polycomb repressive complex 2 inhibitors: emerging epigenetic modulators
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Danishuddin, Naidu Subbarao, Mohammad Faheem, Shahper Nazeer Khan.
Nội dung
Pages 179-188
22. Cnidarian peptide neurotoxins: a new source of various ion channel modulators or blockers against central nervous systems disease
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Qiwen Liao, Yu Feng, Binrui Yang, Simon Ming-Yuen Lee.
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Pages 189-197
23. Functionalizing bioinks for 3D bioprinting applications
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Azraa Parak, Priyamvada Pradeep, Lisa C. du Toit, Pradeep Kumar.
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Pages 198-205
24. MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance
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Soo Jung Son, Renjie Huang, Christopher J. Squire, Ivanhoe K.H. Leung.
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Pages 206-216
25. Targeting intrinsically disordered proteins at the edge of chaos
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Hao Ruan, Qi Sun, Weilin Zhang, Ying Liu, Luhua Lai.
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Pages 217-227
26. Artificial intelligence and its potential in oncology
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Vaishali Y. Londhe, Bhavya Bhasin.
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Pages 228-232
27. microRNAs and cardiac stem cells in heart development and disease
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Bo Li, Xianmei Meng, Lubo Zhang.
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Pages 233-240
28. Src and podoplanin forge a path to destruction
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Harini Krishnan, W. Todd Miller, Francisco J. Blanco, Gary S. Goldberg.
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Pages 241-249
29. Copies of nonbiological complex drugs: generic, hybrid or biosimilar?
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Paolo Rocco, Umberto M. Musazzi, Silvia Franzè, Paola Minghetti.
Nội dung
Pages 250-255
30. Effects of antidiabetic drugs on NLRP3 inflammasome activity, with a focus on diabetic kidneys
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Habib Yaribeygi, Niki Katsiki, Alexandra E. Butler, Amirhossein Sahebkar.
Nội dung
Pages 256-262
31. New leads for drug repurposing against malaria
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Nila Madassary Pazhayam, Jyoti Chhibber-Goel, Amit Sharma.
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Pages 263-271
32. Advancing precision medicine with personalized drug screening
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Kirill Gorshkov, Catherine Z. Chen, Raisa E. Marshall, Nino Mihatov.
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Pages 272-278
33. Do urocortins have a role in treating cardiovascular disease?
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Ekaterini Chatzaki, Nikoleta Kefala, Ioannis Drosos, Fani Lalidou, Stavroula Baritaki.
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Pages 279-284
34. Safety differentiation: emerging competitive edge in drug development
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Marianne Uteng, Laszlo Urban, Dominique Brees, Patrick Y. Muller.
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Pages 285-292
35. Biosimilar medicines used for cancer therapy in Europe: a review
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Sofia B. Santos, José M. Sousa Lobo, Ana C. Silva.
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Pages 293-299
36. Small molecules for fat combustion: targeting thermosensory and satiety signals in the central nervous system
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Jingxin Liu, Ligen Lin.
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Pages 300-306
37. Fungal immunomodulatory proteins: characteristic, potential antitumor activities and their molecular mechanisms
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Qi-Zhang Li, Yu-Zhang Zheng, Xuan-Wei Zhou.
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Pages 307-314
38. Basic and practical concepts of radiopharmaceutical purification methods
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Sajjad Molavipordanjani, Vladimir Tolmachev, Seyed Jalal Hosseinimehr.
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Pages 315-324
39. Antithrombotic P2Y12 receptor antagonists: recent developments in drug discovery
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Younis Baqi, Christa E. Müller.
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Pages 325-333
40. Implications of human induced pluripotent stem cells in metabolic disorders: from drug discovery toward precision medicine Agustin Cota-Coronado, P. Berenice Ramírez-Rodríguez, Eduardo Padilla-Camberos, éNstor F. Díaz, ... N. Emmanuel Diaz-Martinez
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Pages 334-341
41. FoxO1–miRNA interacting networks as potential targets for mitochondrial diseases
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Prasanth Puthanveetil.
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Pages 342-349
42. Updates on the pathogenicity status of Pseudomonas aeruginosa
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Mohd W. Azam, Asad U. Khan.
Nội dung
Pages 350-359
