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Drug Discovery Today
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Volume 24, Issue 5
Pages 1067-1228 (May 2019)
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1. Contents page 1
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Page i
2. Contents page 2
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Page ii
3. Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery
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Nicola Colclough, Kan Chen, Peter Johnström, Markus Fridén, Dermot F. McGinnity.
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Pages 1067-1073
4. Capturing and applying knowledge to guide compound optimisation
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Matthew Segall, Tamsin Mansley, Peter Hunt, Edmund Champness.
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Pages 1074-1080
5. Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design
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Marc O’Reilly, Anne Cleasby, Thomas G. Davies, Richard J. Hall.
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Pages 1081-1086
6. The search for biosimilars and biobetters
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Scott W. Burchiel, Rob Aspbury, James Munday.
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Pages 1087-1091
7. Therapeutic implications of novel peptides targeting ER–mitochondria Ca2+-flux systems
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Martijn Kerkhofs, Geert Bultynck, Tim Vervliet, Giovanni Monaco.
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Pages 1092-1103
8. Nanoemulsions in CNS drug delivery: recent developments, impacts and challenges
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Zahra Karami, Mohammad Reza Saghatchi Zanjani, Mehrdad Hamidi.
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Pages 1104-1115
9. Harnessing nucleic acid-based therapeutics for atherosclerotic cardiovascular disease: state of the art
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Fatemeh Vahdat Lasemi, Maryam Mahjoubin Tehran, Seyed Hamid Aghaee-Bakhtiari, Amin Jalili.
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Pages 1116-1131
10. Where are we with monoclonal antibodies for multidrug-resistant infections?
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Michael J. McConnell.
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Pages 1132-1138
11. New targets for HIV drug discovery
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Ana C. Puhl, Alfredo Garzino Demo, Vadim A. Makarov, Sean Ekins.
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Pages 1139-1147
12. The next level in chemical space navigation: going far beyond enumerable compound libraries
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Torsten Hoffmann, Marcus Gastreich.
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Pages 1148-1156
13. ADMET modeling approaches in drug discovery
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Leonardo L.G. Ferreira, Adriano D. Andricopulo.
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Pages 1157-1165
14. Neuropharmacokinetics: a bridging tool between CNS drug development and therapeutic outcome
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Swati Chaturvedi, Mamunur Rashid, Mohd Yaseen Malik, Arun Agarwal.
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Pages 1166-1175
15. Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 1)
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Serge Mignani, João Rodrigues, René Roy, Xiangyang Shi.
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Pages 1176-1183
16. Exploration of biomedical dendrimer space based on in-vivo physicochemical parameters: Key factor analysis (Part 2)
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Serge Mignani, João Rodrigues, René Roy, Xiangyang Shi.
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Pages 1184-1192
17. Therapy for glioblastoma: is it working?
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Edward D. Zanders, Fredrik Svensson, David S. Bailey.
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Pages 1193-1201
18. The role of mitochondrial DNA in breast tumors
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Marjolein J.A. Weerts, Stefan Sleijfer, John W.M. Martens.
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Pages 1202-1208
19. Walking a tightrope: drug discovery in visceral leishmaniasis
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Rafael Balaña-Fouce, M. Yolanda Pérez Pertejo, Bárbara Domínguez-Asenjo, Camino Gutiérrez-Corbo, Rosa M. Reguera.
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Pages 1209-1216
20. Organ-on-a-chip technology: turning its potential for clinical benefit into reality
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Malcolm Haddrick, Peter B. Simpson.
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Pages 1217-1223
21. Expanding the activity spectrum of antiviral agents
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Aleksandr Ianevski, Petter I. Andersen, Andres Merits, Magnar Bjørås, Denis Kainov.
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Pages 1224-1228